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Search results for: RATIONAL DRUG DESIGN
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International architectural - urban - landscape design workshops to strengthen students’ education, capabilities and mobility
PublicationFive international architectural/urban/landscape workshops in Poland and Portugal between 2011 and 2015 are discussed in this article. The general aims of the workshops were to plan to connect divided city spaces, to harmonise them and make them attractive for different uses. The main task was to create in multicultural groups of students the vision of sustainable development in the context of architecture, urban and landscape...
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Implementation of multicriteria decision analysis in design of experiment for dispersive liquid-liquid microextraction optimization for chlorophenols determination
PublicationA novel and efficient approach to optimization of extraction step prior the chromatographic determination of nine chlorinated phenols is described. It is based on the combination of design of experiments and multicriteria decision analysis. Such an approach is used to optimize dispersive liquid-liquid microextraction procedure for the determination of 9 chlorophenols in water samples. Three parameters are optimized – sample volume,...
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Selected aspects of the design of artificial organs
e-Learning Coursesdla III stopnia EiT+IBM
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On Accelerated Metaheuristic-Based Electromagnetic-Driven Design Optimization of Antenna Structures Using Response Features
PublicationDevelopment of present-day antenna systems is an intricate and multi-step process requiring, among others, meticulous tuning of designable (mainly geometry) parameters. Concerning the latter, the most reliable approach is rigorous numerical optimization, which tends to be re-source-intensive in terms of computing due to involving full-wave electromagnetic (EM) simu-lations. The cost-related issues are particularly pronounced whenever...
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ADAPTATION OF ENGINEERING FEA-BASED ALGORITHMS TO LCF FAILURE AND MATERIAL DATA PREDICTION IN OFFSHORE DESIGN
PublicationThere is an ever growing industrial demand for quantitative assessment of fatigue endurance of critical structural details. Although FEA-based calculations have become a standard in engineering design, problems involving the Low-To-Medium cycle range (101-104) remain challenging. This paper presents an attempt to optimally choose material data, meshing density and other algorithm settings in the context of recent design of the...
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Rapid multi-criterial design of microwave components with robustness analysis by means of knowledge-based surrogates
PublicationManufacturing tolerances and uncertainties concerning material parameters, e.g., operating conditions or substrate permittivity are detrimental to characteristics of microwave components. The knowledge of relations between acceptable parameter deviations (not leading to violation of design specifications) and the nominal performance (not considering uncertainties), and is therefore indispensable. This paper proposes a multi-objective...
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Innovative Urban Blue Space Design in a Changing Climate: Transition Models in the Baltic Sea Region
PublicationWaterfront areas in cities are subject to constant changes. The desire to integrate the transformed waterside areas with the urban fabric involves shaping high-quality public spaces related to water, which are often referred to as urban blue spaces (UBS). The aim of the research was to examine the transformation processes of urban waterfront areas in the Baltic Sea Region and identify emerging transition models and types of blue...
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Computer-Aided Design of Railroad Horizontal Arc Areas in Adapting to Satellite Measurements
PublicationThis paper presents a method of designing railway sections located in horizontal arcs. The adopted procedure is universal, i.e., it creates the possibility of varying both the type and the length of the assumed transition curves. This means that the applied analytical formulas apply to the boundary conditions of the transition curves and all of the simplifications widely existing in common algorithms have been eliminated. The presented...
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An Attempt to Develop a Model Selection Algorithm of Computer Simulation during the Design Process of Mechanical Response of Any Mechanical Body
PublicationIn the literature, there are algorithms associated with the design of simulations of technological processes, in which the material model has always been defined previously. However, in none of the studies of computer simulation modelling of technological processes known to the authors of this article, is there a detailed description of how the algorithm, or the selection of plastic model used, is subject to this process. This...
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An attempt to develop a model selection algorithm of computer simulation during the design process of mechanical response of any mechanical body
Publicationn the literature, there are algorithms associated with the design of simulations of technological processes, in which the material model has always been defined previously. However, in none of the studies of computer simulation modelling of technological processes known to the authors of this article, is there a detailed description of how the algorithm, or the selection of plastic model used, is subject to this process. This article...
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Design of a Coplanar Waveguide-Fed Wideband Compact-Size Circularly Polarized Antenna and polarization-sense alteration
PublicationThis paper presents the design and validation of a geometrically simple circularly polarized(CP) structure featuring flat gain in the sub-6 GHz 5th generation spectrum. The proposed structure is based on coplanar-waveguide-fed, modified wide slot etched in the ground plane. For generating CP waves, the coplanar ground planes are designed with slight asymmetry in both the horizontal and vertical directions. Furthermore, the ground...
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Design of a SiC based triple active bridge ceil for a multi-megawatt DC-DC converter
PublicationThe paper describes the design methodology of a novel Triple Active Bridge cell used as the building block for modular DC-DC converters. The intended application is for Medium Voltage Direct Current grids, such as the DC collector for offshore wind farms. The latest generation of SiC MOSFET semiconductors is utilized to operate in the medium frequency range while optimizing the efficiency. The dimensioning of the main cell components,...
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Blade Section Prpfile Array Lifting Surface Design Method for Marine Screw Propeller Blade
PublicationThe lifting surface model is widely used in screw propeller design and analysis applications. It serves as a reliable tool for determination of the propeller blade mean line and pitch distribution. The main idea of this application was to determine the blade shape that would satisfy the kinematic boundary condition on its surface with the prescribed bound circulation distribution over it. In this paper a simplified lifting surface...
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Expedited Yield-Driven Design of High-Frequency Structures by Kriging Surrogates in Confined Domains
PublicationUncertainty quantification is an important aspect of engineering design, also pertaining to the development and performance evaluation of high-frequency structures systems. Manufacturing tolerances as well as other types of uncertainties, related to material parameters (e.g., substrate permittivity) or operating conditions (e.g., bending) may affect the characteristics of antennas or microwave devices. For example, in the case...
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Calculation Program Supporting Switched Capacitor DC-DC Charge Pump Design (CP Design Calculator) - PartI: Preface
PublicationPrzedmiot badań i motywy podjęcia pracy. Metoda badawcza. Nota historyczna nt. konwertera Fibonacciego (Fibonacci multiplier) i pompy ładunkowej Makowskiego ("Makowski charge pump"). Przewidywane cele pracy. Podziękowania
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Computer aided machine design 2022/23
e-Learning Courses -
Interior Design | semestr IV | grupa ENG
e-Learning CoursesCelem kursu jest przybliżenie zagadnień związanych z projektowaniem wnętrz.Studenci opracować będą projekty wnętrz dla istniejących mieszkań zlokalizowanych na wybranych gdańskich blokowiskach.Zajęcia odbywają się w trybie konsultacji i krótkich wykładów.
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Urban Design Project III 2021/22
e-Learning CoursesNOWY - Nowy Świat 2.0 – BUILDING THE HEART OF AN ACTIVE NEIGHBORHOOD Friday 13.15-16.00 dr hab. inż. arch. J. Martyniuk – Pęczek, prof. uczelni arch. Rana Rizi
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Machines Design 1, PG_00055075 2023/24
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Software Systems Design 2024 kopia 2
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Prediploma Design Studio SAUP 2023/24
e-Learning Courses -
Machine Design 3, PG_00042104 2023/24
e-Learning Courses -
Low-cost multi-criterial design optimization of compact microwave passives using constrained surrogates and dimensionality reduction
PublicationDesign of contemporary microwave circuits is a challenging task. Typically, it has to take into account several performance requirements and constraints. The design objectives are often conflicting and their simultaneous improvement may not be possible; instead, compromise solutions are to be sought. Representative examples are miniaturized microwave passives where reduction of the circuit size has a detrimental effect on its electrical...
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Rapid and Reliable Re-Design of Miniaturized Microwave Passives by Means of Concurrent Parameter Scaling and Intermittent Local Tuning
PublicationRe-design of microwave passive components for the assumed operating frequencies or substrate parameters is an important yet a tedious process. It requires simultaneous tuning of relevant circuit variables, often over broad ranges thereof, to ensure satisfactory performance of the system. If the operating conditions at the available design are distant from the intended ones, local optimization is typically insufficient, whereas...
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A Generalized SDP Multi-Objective Optimization Method for EM-Based Microwave Device Design
PublicationIn this article, a generalized sequential domain patching (GSDP) method for efficient multi-objective optimization based on electromagnetics (EM) simulation is proposed. The GSDP method allowing fast searching for Pareto fronts for two and three objectives is elaborated in detail in this paper. The GSDP method is compared with the NSGA-II method using multi-objective problems in the DTLZ series, and the results show the GSDP method...
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Improving the procedure of probabilistic load testing design of typical bridges based on structural response similarities
PublicationThis paper concerns load testing of typical bridge structures performed prior to operation. In-situ tests of a two-span post-tensioned bridge loaded with three vehicles of 38-ton mass each formed the input of this study. On the basis of the results of these measurements, an advanced FEM model of the structure was developed for which the sensitivity analysis was performed for chosen uncertainty sources. Three uncorrelated random...
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Efficient Surrogate Modeling and Design Optimization of Compact Integrated On-Chip Inductors Based on Multi-Fidelity EM Simulation Models
PublicationHigh-performance and small-size on-chip inductors play a critical role in contemporary radio-frequency integrated circuits. This work presents a reliable surrogate modeling technique combining low-fidelity EM simulation models, response surface approximations based on kriging interpolation, and space mapping technology. The reported method is useful for the development of broadband and highly accurate data-driven models of integrated...
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Design and Optimization of Metamaterial-Based 5G Millimeter Wave Antenna for Gain Enhancement
PublicationIn this brief, a low profile, broadband, high-gain antenna array based on optimized metamaterials (MMs) with dual-beam radiation is reported for 5G millimeters wave (mm-wave) applications. The design is a simple bow tie operating at a 5G band of 28 GHz. It consists of two bow ties with substrate integrated waveguide (SIW)-based power splitter. A broad impedance bandwidth of 26.3−29.8 GHz is obtained by appropriately combining the...
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Amino-modified mesoporous silica SBA-15 as bifunctional drug delivery system for cefazolin: Release profile and mineralization potential
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Aminopropyl-functionalized mesoporous silica SBA-15 as drug carrier for cefazolin: adsorption profiles, release studies, and mineralization potential
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Monolithic polydimethylsiloxane-modified silica composites prepared by a low-temperature sol–gel micromolding technique for controlled drug release
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Preliminary Investigation of the Antibacterial Activity of Antitumor Drug 3-Amino-1,2,4-Benzotriazine-1,4-Dioxide (Tirapazamine) and its Derivatives
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Core/shell structured silica spheres with controllable thickness of mesoporous shell and its adsorption, drug storage and release properties
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Expression of Osteoblast-Specific Factor 2 (OSF-2, Periostin) Is Associated with Drug Resistance in Ovarian Cancer Cell Lines
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PTPRK Expression Is Downregulated in Drug Resistant Ovarian Cancer Cell Lines, and Especially in ALDH1A1 Positive CSCs-Like Populations
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Transport Mechanism of Paracetamol (Acetaminophen) in Polyurethane Nanocomposite Hydrogel Patches—Cloisite® 30B Influence on the Drug Release and Swelling Processes
PublicationThis article describes the swelling and release mechanisms of paracetamol in polyurethane nanocomposite hydrogels containing Cloisite® 30B (organically modified montmorillonite). The transport mechanism, swelling and release processes of the active substance in nanocomposite matrix were studied using gravimetric and UV-Vis spectroscopic methods. Swelling and release processes depend on the amount of clay nanoparticles in these...
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Development and Validation of a Gas Chromatography Method for the Trace Level Determination of Allylamine in Sevelamer Hydrochloride and Sevelamer Carbonate Drug Substances
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A Concept of Mechatronic design for a Surveillance of Dynamic Systems
PublicationW publikacji przedstawiono zastosowanie koncepcji projektowania mechatronicznego w nadzorowaniu systmów dynamicznych. W szczególności są to aktywne nadzorowanie drgań podczas frezowania oraz nadzorowanie ruchu platformy 3-kołowej. Przy tworzeniu opisywanych rozwiązań zastosowano techniki projektowania wirtualnego, symulacjje komputerowe jaki w technice Hardware-in-the-Loop. W pracy zamieszczono także przykładowe wyniki badań eksperymentalnych...
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Introducing Design for Disassembly Concept to the MSc Curricula
Publication11th International Technology, Education and Development Conference
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Design of Microwave-Based Angular Displacement Sensor
PublicationThis letter presents a novel microwave-based rotation sensor having a wide dynamic range to detect and measure the angular displacement in terms of the change in resonant frequency. The proposed sensor is based on the microstrip technology, where a rotor comprised of a complementary splitring resonator (CSRR) placed on the ground plane of the microstrip line is free to rotate around its axis. The mechanical rotation of CSRR determines...
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Optimization issues in distributed computing systems design
PublicationIn recent years, we observe a growing interest focused on distributed computing systems. Both industry and academia require increasing computational power to process and analyze large amount of data, including significant areas like analysis of medical data, earthquake, or weather forecast. Since distributed computing systems – similar to computer networks – are vulnerable to failures, survivability mechanisms are indispensable...
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Protection System Design of Induction Motor for Industries
PublicationThe fundamental and durable structures of induction motor, as well as their low manufacturing cost, make them popular components in a wide range of current applications. Providing a safety net for employees is a must-have for businesses. This project’s motivation for improvement is to provide industrial motors, lift motors, pumps, and so on with safety. An induction motor’s primary goal is to protect it from problems, such as...
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Protection System Design of Induction Motor for Industries
PublicationThe fundamental and durable structures of induction motor, as well as their low manufacturing cost, make them popular components in a wide range of current applications. Providing a safety net for employees is a must-have for businesses. This project’s motivation for improvement is to provide industrial motors, lift motors, pumps, and so on with safety. An induction motor’s primary goal is to protect it from problems, such as...
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Interactive design system for provisioning of customized houses
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Alternative shaper: a model for automatic design generation
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2D inverse method of turbomachinery stage design
Publication1. How 2D model for turbomachinery stages has developed historically. 2. Recent understanding of physical background of 2D model. 3. Curvilinear system of non-orthogonal coordinates in the application to 2D model. 4. Set of basic equations. 5. Closing conditions for the inverse problem. 6. Examples of solutions a)
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Stirling engine design effects on performance indicies.
PublicationW pracy przedstawiono analizę wpływu wybranych parametrów konstrukcyjnych silnika Stirlinga MAC-02 na jego własności eksploatacyjne. Przyjmując maksimum mocy jako kryterium optymalizacji badano jaki wpływ na wybrane wskaźniki jakości (moc i sprawność) oraz optymalizowane parametry konstrukcyjne silnika (wymiary wymiennika cieplnego oraz parametry układu korbowego) mają ograniczenia nałożone na ciepło dostarczane oraz długość...
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Design of knowledge based systems in environmental engineering.
PublicationW pracy omawia się konstrukcję samo narastającego modelu rozmytego zarządzania przedsięwzięciami informatycznymi, stosowanego do wspomagania wytwarzania systemów opartych na wiedzy. Proponowany model służy w szczególności do zarządzania zmianami finansowania i czasu realizacji projektów. Opiera się on na eksperymentalnej regułowej wiedzy, pochodzącej z realizacji zarządzania przedsięwzięciami informatycznymi, na teorii systemów...
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Control theory methods in diagnostic system design
PublicationPraca dotyczy zastosowania wybranych metod teorii sterowania do syntezy al-gorytmów detekcji uszkodzeń. Algorytmy takie, stanowiące istotną gałąźwspółczesnej diagnostyki technicznej obiektów dynamicznych, w swej istocieopierają się na rozwiązaniach odpowiednich zadań odpornego wyznaczania wek-torów resztowych, czyli ważonych błędów oszacowań wyjściadanego obiektu dy-namicznego (nadzorowanego procesu). Na treść pracy...
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Hygienic design of pumps, homogenisers and dampening devices.
PublicationPrzedstawiono wymagania dotyczące materiałów oraz ich przygotowania, a także dla powierzchni wewnętrznych i zewnętrznych urządzeń takich jak pompy, homogenizatory i nawilżacze oraz ich elementów, zwłaszcza wielu typów uszczelnień, ze względu na ich zastosowanie do produkcji żywności w warunkach sanitarno-higienicznych i maksymalne wyeliminowanie zagożeń dla jakości podczas jej wytwarzania w różnorodnych procesach technologicznych.