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Search results for: MECHANISM DESIGN
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Cam mechanism designing with account of the technological load and energy costs
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The methodology of design of satellite working mechanism of positive displacement machine
PublicationIn this paper is described a methodology of design of satellite mechanism consisting of two noncircular gears (externally toothed rotor and internally toothed curvature) and circular gears (satellites). In the presented methodology is assumed that the rotor pitch line is known, and the curvature pitch line is necessary to designate. The presented methodology applies to mechanisms for which the number of the curvature humps is at...
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New Low-Cost Video Camera Pointing Mechanism for Stratospheric Balloons: Design and Operational Tests
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The chaperone-usher pathway of bacterial adhesin biogenesis - from molecular mechanism to strategies of anti-bacterial prevention and modern vaccine design
PublicationSystem chaperone-usher (białko opiekuńcze-białko kanałotwórcze) warunkuje biogenezę powierzchniowych struktur adhezyjnych, odpowiedzialnych za wirulencję wielu bakterii gram-ujemnych. Powyższy mechanizm został zbadany na poziomie strukturalnym w przypadku różnych gatunków bakterii patogennych. Celem powyższej pracy było przedstawienie molekularnego mechanizmu biogenezy struktur adhezyjnych na bazie systemu chaperone-usher. Otrzymane...
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Mechanism of Li nucleation at graphite anodes and mitigation strategies
PublicationLithium metal plating is a critical safety issue in Li-ion cells with graphite anodes, and contributes significantly to ageing, drastically limiting the lifetime and inducing capacity loss. Nonetheless, the nucleation mechanism of metallic Li on graphite anodes is still poorly understood. But in-depth understanding is needed to rationally design mitigation measures. In this work, we conducted FirstPrinciples studies to elucidate...
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Moisture damage mechanism and material selection of HMA with amine antistripping agent
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Hyperelastic Microcantilever AFM: Efficient Detection Mechanism Based on Principal Parametric Resonance
PublicationThe impetus of writing this paper is to propose an efficient detection mechanism to scan the surface profile of a micro-sample using cantilever-based atomic force microscopy (AFM), operating in non-contact mode. In order to implement this scheme, the principal parametric resonance characteristics of the resonator are employed, benefiting from the bifurcation-based sensing mechanism. It is assumed that the microcantilever is made...
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Analysis of load carrying capacity and destruction mechanism of an intermediate anchorage steel plate for pillar jib crane
PublicationPillar jib cranes are often mounted to existing floors with the use of an intermediate anchorage steel plate instead of using independent foundations, what is shown in the figure. Standards for steel design provide only basic rules for the design of such an intermediate plate. This study presents a simple design approach by using a numerical model in order to analyze different parameters that have significant influence in the anchorage...
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Forced vibrations in a dynamic system that is damped by a mechanism that trans-pass through its singular position
PublicationIn the paper, vibrations of a hybrid multibody-continuous system are investigated. For all the mechanical devices, effective damping methods are crucial in the design process. To obtain it, installation of viscous dampers or elasto-viscous elements is dominant. In the paper, an alternative method is investigated. It is based on modal disparity. To describe the method briefly, when structural damping is present in continuous systems,...
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Utilizing Genome-Wide mRNA Profiling to Identify the Cytotoxic Chemotherapeutic Mechanism of Triazoloacridone C-1305 as Direct Microtubule Stabilization
PublicationRational drug design and in vitro pharmacology profiling constitute the gold standard in drug development pipelines. Problems arise, however, because this process is often dicult due to limited information regarding the complete identification of a molecule’s biological activities. The increasing aordability of genome-wide next-generation technologies now provides an excellent opportunity to understand a compound’s diverse eects...
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New Design of Axial Piston Pump with Displaced Swash Plate Axis of Rotation for Hydro-Mechanical Transmissions
PublicationThis paper presents a prototype design of an axial piston pump with displaced swash plate axis of rotation in two directions of discharge with electronic control intended for installation on a hydraulic-mechanical gearbox dedicated to working machines. The effect of displacement of the swash plate rotation axis on dead space volume and volumetric efficiency is presented. The construction and principle of operation of the capacity...
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Mechanism of Binding of Antifungal Antibiotic Amphotericin B to Lipid Membranes: An Insight from Combined Single-Membrane Imaging, Microspectroscopy, and Molecular Dynamics
PublicationAmphotericin B is a lifesaving polyene antibiotic used in the treatment of systemic mycoses. Unfortunately, the pharmacological applicability of this drug is limited because of its severe toxic side effects. At the same time, the lack of a well-defined mechanism of selectivity hampers the efforts to rationally design safer derivatives. As the drug primarily targets the biomembranes of both fungi and humans, new insights into the...
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Design of a microrobotic wrist for needle laparoscopic surgery
PublicationThe paper addresses the design of a micro wrist for needle laparoscopic surgery (needlescopy) using MEMS technology and an original 3 degree of freedom, 3D architecture. Advancement in needlescopy drives the development of multi-dof micro-tools 1-2mmin diameter with 3D mobility but standard available fabricationtechniques are for 2.5D structures. The paper discusses thedevelopment steps and design solutions for the realization...
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FINANCIAL MECHANISM OF THE INSURANCE BUSINESS
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Mechanism of the phase transitions in MnAs
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Robustness of the Rotor-router Mechanism
PublicationW pracy rozważano model eksploracji grafu nieskierowanego przez pojedynczego agenta, w którym sterowanie agentem odbywa się zgodnie z zasadą ''rotor-router'' (inaczej: ''Propp machine''). Przeanalizowano czas stabilizacji agenta do trajektorii w postaci cyklu Eulera w przypadku wystąpienia zaburzeń w grafie: usunięcie krawędzi, dodanie krawędzi, lokalna zamiana portów
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The methodology of design of axial clearances compensation unit in hydraulic satellite displacement machine and their experimental verification
PublicationA new methodology of calculating the dimensions of the axial clearance compensation unit in the hydraulic satellite displacement machine is described in this paper. The methods of shaping the compensation unit were also proposed and described. These methods were used to calculate the geometrical dimensions of the compensation field in an innovative prototype of a satellite hydraulic motor. This motor is characterized by the fact...
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Design and material selection for a patient transport device in field hospitals
PublicationACKGROUND: A major cause of patient and hospital worker injuries occurs transferring patients between two planes. The main aim of this paper was to propose a design of patient’s lift and transfer apparatus for use in field hospitals. The assumption was to design lightweight, durable and ergonomic device using innovative material. The authors concentrated on partial elimination of manual lifting in order to device could work both...
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Establishing the allosteric mechanism in CRISPR‐Cas9
PublicationAllostery is a fundamental property of proteins, which regulates biochemical information transfer between spatially distant sites. Here, we report on the critical role of molecular dynamics (MD) simulations in discovering the mechanism of allosteric communication within CRISPR‐Cas9, a leading genome editing machinery with enormous promises for medicine and biotechnology. MD revealed how allostery intervenes during at least three...
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Design of Intelligent Low-Voltage Load Switch for Remote Control System in Smart Grid
PublicationCurrent low-voltage load switches do not support remote disconnect/connect and real-time monitoring of a disconnect/connect state. Addressing to these issues, this paper presents a low-voltage load switch for a smart remote control system, which uses a one-chip microcontroller board and a DC step motor drive mechanism and provides the feedback on the switch status also. Arrears disconnect and full-pay connect control is implemented...
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Fast multi-objective design optimization of microwave and antenna structures using data-driven surrogates and domain segmentation
PublicationPurpose Strategies and algorithms for expedited design optimization of microwave and antenna structures in multi-objective setup are investigated. Design/methodology/approach Formulation of the multi-objective design problem oriented towards execution of the population-based metaheuristic algorithm within the segmented search space is investigated. Described algorithmic framework exploit variable fidelity modeling, physics- and...
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Importance of Conjugation of the Bile Salt on the Mechanism of Lipolysis
PublicationWe aim to advance the discussion on the significance of the conjugation of bile salts (BS) in our organism. We hypothesize that conjugation influences the rate of lipolysis. Since the rate of lipolysis is a compound parameter, we compare the effect of conjugation on four surface parameters, which contribute to the rate. Since deconjugation is due to gut microbiota, we hypothesize that microbiota may affect the rate of lipolysis....
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Mechanism for sonocoating a polymer surface with nano-hydroxyapatite
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Mechanism for Damage to DNA by Low-Energy Electrons
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Mechanism of hydroxyl radicals formation on the reduced rutile
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Quality negotiation mechanism for e-learning platforms
PublicationZarządzanie jakością w aplikacjach działających w środowiskach sieci WEB opiera się na zadaniach związanych z wykrywaniem jakości połączenia klient - serwer oraz na optymalnym przydziale zasobów wedle jakości takowego połączenia. Optymalne zarządzanie jakością zależy od wypracowanego kompromisu pomiędzy jakością łącza a jakości transportowanego łączem zasobu. Artykuł opisuje możliwy do implementacji mechanizm odpowiedzialny za...
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Phonon Mechanism of the Magnetostructural Phase Transition in MnAs
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MOLECULAR SIMULATIONS OF NEOCARZINOSTATIN CHROMOPHORE RELEASE MECHANISM
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Depression as a civilization-deformed adaptation and defence mechanism
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The Niching Mechanism in the Evolutionary Method of Path Planning
PublicationThis paper presents the concept of the niching mechanism in the evolutionary method of path planning. The problem is considered based on the example of a ship path planning. In this method the diversity of individuals is tested in respect to their physical distance, not the fitness function value. The researches show that such an approach increases effectiveness of solution space exploration, what results in a final solution with...
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ANALYSIS OF THE PUNCHING FAILURE MECHANISM IN WORKING PLATFORMS
PublicationPaper presents an analysis of the shear failure mechanism which occurs from the punching of a working platform layer in relation to its thickness, grain size arrangement and mechanical properties, taking into consideration the interaction with soft subgrade. The study is based on the observations of performance of natural scale structures (Streefkerk) and the results of model investigations numerically represented with the use...
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The Role of the Natural Antioxidant Mechanism in Sperm Cells
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P92 steel and inconel 617 alloy welds joint produced using ERNiCr-3 filler with GTAW process: Solidification mechanism, microstructure, mechanical properties and residual stresses
PublicationThe objective of the current study was to analyse the microstructure, mechanical characteristics, and residual stresses of a dissimilar welded joint (DWJ) made of P92 steel and the Inconel alloy 617 (IN617) using the gas tungsten arc welding (GTAW) method. The ERNiCr-3 filler was selected to produce the conventional V groove (VG) and narrow V groove (NVG) butt joint. The filler deficient zones in the weldments, such as the filler...
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Mechanism of Osmolyte Stabilization–Destabilization of Proteins: Experimental Evidence
PublicationIn this work, we investigated the influence of stabilizing (N,N,N-trimethylglycine) and destabilizing (urea) osmolytes on the hydration spheres of biomacromolecules in folded forms (trpzip-1 peptide and hen egg white lysozyme─hewl) and unfolded protein models (glycine─GLY and N-methylglycine─NMG) by means of infrared spectroscopy. GLY and NMG were clearly limited as minimal models for unfolded proteins and should be treated with...
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Light-Modulated Sunscreen Mechanism in the Retina of the Human Eye
PublicationThe functioning of the human eye in the extreme range of light intensity requires a combination of the high sensitivity of photoreceptors with their photostability. Here, we identify a regulatory mechanism based on dynamic modulation of light absorption by xanthophylls in the retina, realized by reorientation of pigment molecules induced by trans–cis photoisomerization. We explore this photochemically switchable system using chromatographic...
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Minimising the Churn Out of the Service by Using a Fairness Mechanism
PublicationThe paper proposes an algorithm of bandwidth distribution, ensuring fairness to end-users in computer networks. The proposed algorithm divides users into satisfied and unsatisfied users. It provides fairness in terms of quality of experience (QoE) for satisfied users and quality of service (QoS) for unsatisfied users. In this paper, we present detailed comparisons relevant to service providers to show the advantages of the proposed...
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Impedance Investigations of the Mechanism of Oxygen Evolution on Composite Electrodes
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Kinematic analysis of crank -cam mechanism of process equipment
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Implementation mechanism of impact investing in the post-conflict regions
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A New Epigenetic Mechanism of Temozolomide Action in Glioma Cells
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Refinements to the Utah–Washington Mechanism of Electron Capture Dissociation
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Mechanism of the fatigue cracks development in bearing slide layer
PublicationNa podstawie literatury przedstawiono wybrane problemy dotyczące powiązania wytrzymałości zmęczeniowej łożysk ślizgowych ze strukturą i charakterystyką materiału tworzącego warstwę ślizgową panwi.W szczególności analizowano mechanizm inicjacji i propagacji pęknięć zmęczeniowych jako zależną nie tylko od wzorca obciążenia dynamicznego, lecz również od geometrii i struktury warstwy ślizgowej.Wyróżniono dwa typy pęknięć: strukturalne...
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Glucocorticoids Inhibit Wound Healing: Novel Mechanism of Action
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Toward elucidation of delithiation mechanism of zinc-substituted LiFePO4
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Silo music — Mechanism of dynamic flow and structure interaction
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The Effect of Temperature on Wear Mechanism of the AlCrN Coated Components
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A self-optimization mechanism for generalized adaptive notch smoother
PublicationTracking of nonstationary narrowband signals is often accomplished using algorithms called adaptive notch filters (ANFs). Generalized adaptive notch smoothers (GANSs) extend the concepts of adaptive notch filtering in two directions. Firstly, they are designed to estimate coefficients of nonstationary quasi-periodic systems, rather than signals. Secondly, they employ noncausal processing, which greatly improves their accuracy and...
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The mechanism of grouting action under the base of bored pile
PublicationThe grouting under the base of bored pile is carried out in order to reduce pile settlement and improve its bearing capacity. The principal aim of grouting is to introduce an initial force between the soil and the pile base. In non-cohesive soil, the grouting can also enlarge the pile base area and therefore improve the base resistance. The example of static load tests on instrumented bored piles installed with and without grouting...
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Evaluating Asymmetric N-Grams as Spell-Checking Mechanism
PublicationTypical approaches to string comparing marks two strings as either different or equal without taking into account any similarity measures. Being able to judge similarity is however required for spelling error corrections, as we want to find the best match for a given word. In this paper we present a bi2quadro-grams method for spelling errors correction. The method proposed uses different n-grams dimension for the source (checked)...
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Degradation kinetics and mechanism of pentoxifylline by ultraviolet activated peroxydisulfate
PublicationDegradation of pentoxifylline (PTX) by sodium peroxydisulfate (SPDS) assisted by UV irradiation has been investigated in deionized water. The treatment was more favorable over direct photolysis or peroxydisulfate oxidation alone. The effects of various parameters, including different dosage of oxidant agent, PTX concentration, initial solution pH levels, and the presence of inorganic ions like chloride, nitrate and carbonate have...