Search
Search results for: T CELLS
-
Enhanced Suppressive Activity of Regulatory T Cells in the Microenvironment of Malignant Pleural Effusions
Publication -
H-2D products do not affect lysis of Kk target cells by Kk-specific cytotoxic T cells
Publication -
Adoptive Cell Therapy—Harnessing Antigen-Specific T Cells to Target Solid Tumours
Publication -
Cell-Based Therapies with T Regulatory Cells
Publication -
Retinoic acid‐induced autoantigen‐specific type 1 regulatory T cells suppress autoimmunity
Publication -
Monoubiquitinated Histone H1B Is Required for Antiviral Protection in CD4+T Cells Resistant to HIV-1
Publication -
Lung CD4 Tissue-Resident Memory T Cells Mediate Adaptive Immunity Induced by Previous Infection of Mice with Bordetella pertussis
Publication -
Bystander activation of Bordetella pertussis‐induced nasal tissue‐resident memory CD4 T cells confers heterologous immunity to Klebsiella pneumoniae
Publication -
Therapy with CD4+CD25+ T regulatory cells – should we be afraid of cancer?
Publication -
Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization
Publication -
Keratinocyte-derived small extracellular vesicles supply antigens for CD1a-resticted T cells and promote their type 2 bias in the context of filaggrin insufficiency
PublicationIntroduction: Exosome-enriched small extracellular vesicles (sEVs) are nanosized organelles known to participate in long distance communication between cells, including in the skin. Atopic dermatitis (AD) is a chronic inflammatory skin disease for which filaggrin (FLG) gene mutations are the strongest genetic risk factor. Filaggrin insufficiency affects multiple cellular function, but it is unclear if sEV-mediated cellular communication...
-
The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part I: Treg properties and functions
Publication -
IL-17–Producing Innate and Pathogen-Specific Tissue Resident Memory γδ T Cells Expand in the Lungs of Bordetella pertussis–Infected Mice
Publication -
A Specific CD44lo CD25lo Subpopulation of Regulatory T Cells Inhibits Anti-Leukemic Immune Response and Promotes the Progression in a Mouse Model of Chronic Lymphocytic Leukemia
Publication -
Inhibition of T-type calcium channel disrupts Akt signaling and promotes apoptosis in glioblastoma cells.
PublicationGlioblastoma multiforme (GBM) are brain tumors that are exceptionally resitant to both radio- and chemotherapy regimens and novel approaches to treatment are needed. T-type calcium channels are one type of low voltage-gated channel (LVCC) involved in embryonic cell proliferation and differentiation; however they are often over-expressed in tumors, including GBM. In this study, we found that inhibition of T-type Ca channels in GBM...
-
The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part II: The Treg role in skin diseases pathogenesis
Publication -
Anti-PD-1 inhibits Foxp3+ Treg cell conversion and unleashes intratumoural effector T cells thereby enhancing the efficacy of a cancer vaccine in a mouse model
Publication -
The Potential Mechanism of Tiliroside-Dependent Inhibition of t-Butylhydroperoxide-Induced Oxidative Stress in Endometrial Carcinoma Cells
Publication -
The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part III: Polymorphisms of genes involved in Tregs’ activation and function
Publication -
A Pertussis Outer Membrane Vesicle-Based Vaccine Induces Lung-Resident Memory CD4 T Cells and Protection Against Bordetella pertussis, Including Pertactin Deficient Strains
Publication -
Identification of X-DING-CD4, a new member of human DING protein family that is secreted by HIV-1 resistant CD4+ T cells and has anti-viral activity
Publication -
Combination of ABT-737 and resveratrol enhances DNA damage and apoptosis in human T-cell acute lymphoblastic leukemia MOLT-4 cells
Publication -
Successful Treatment of Persistent SARS-CoV-2 Infection in a B-Cell Depleted Patient with Activated Cytotoxic T and NK Cells: A Case Report
Publication -
Immunization with whole cell but not acellular pertussis vaccines primes CD4 T RM cells that sustain protective immunity against nasal colonization with Bordetella pertussis
Publication -
Investigations on the immunosuppressive activity of derivatives of mycophenolic acid in immature dendritic cell
PublicationThe main activity of mycophenolic acid (MPA) and its analogs is the inhibition of proliferation of T cells. Here, we hypothesized that MPA and its conjugates inhibits also the activity of antigen-presenting cells (APC) including dendritic cells (DCs). We tested the effect of novel amino acid derivatives of MPA and conjugates of MPA with acridines/acridones on DCs by flow cytometry, ELISA and MLR assay. Both acridines/acridone derivatives...
-
Recovery of silver metallization from damaged silicon cells
PublicationMetallization is one of the key process steps to fabricate solar cells with high performance in a cost-effective way. Majority of photovoltaic solar cell manufacturing uses thick film screen print metallization with Ag containing paste to produce solar cells. The average lifetime of PV modules can be expected to be more than 25 years. The disposal of PV systems will become a problem in view of the continually increasing production...
-
Featuring Semitransparent p–i–n Perovskite Solar Cells for High-Efficiency Four-Terminal/Silicon Tandem Solar Cells
PublicationTwo issues need to be resolved when fabricating p–i–n semitransparent perovskite solar cells (ST-PVSCs) for four-terminal (4 T) perovskite/silicon tandem solar cells: 1) damage to the underlying absorber (MAPbI3), electron transporting layer ([6,6]-phenyl-C61-butyric acid methyl ester, PCBM), and work function (WF) modifier (polyethylenimine, PEI), resulting from the harsh sputtering conditions for the transparent electrodes (TEs)...
-
Heat recovery from the hybrid photovoltaic tile – experimental studies with the solar light simulator
PublicationConsidering the current development of micro-cogeneration energy sources, supported by the national prosumer policy and the act on the renewable energy sources, there is a great demand for the effective solar technologies. In this area, the photovoltaic cells with a combined conversion of the solar radiation energy into the electrical and thermal energy (PV/T cells) seem to be attractive. They are already widely available and treated...
-
O07 Filaggrin insufficiency renders keratinocyte-derived small extracellular vesicles capable of affecting CD1a-mediated T-cell responses and promoting allergic inflammation
PublicationThe association between FLG loss-of-function mutations and the development of atopic dermatitis (AD) indicates that filaggrin is critical to skin barrier function; the mutations are also linked to additional allergic manifestations, but it is unknown how the skin may influence inflammation in distant tissues. Here we investigated the impact of filaggrin insufficiency on keratinocyte-derived exosome-enriched small extracellular...
-
Immunological response of sheep to injections of plasmids encoding Toxoplasma gondii SAG1 and ROP1 genes
PublicationInfection with the intracellular protozoan parasite Toxo¬plasma gondii (T. gondii) causes health problems to both humans and livestock and has a large economic impact worldwide. The immune response in sheep following infection with T. gondii was evaluated using six different combinations of plasmid DNA, recombinant antigen and adjuvant. Sheep were generally vaccinated twice by intramuscular injection with plasmid DNA containing...
-
Detection of Toxoplasma gondii in meat - available techniques
PublicationToxoplasma gondii, which belongs to the phylum Apicomplexa, is an absolute intercellular parasite that infects a wide range of hosts, including warm-blooded animals and humans. An infection with this parasite causes toxoplasmosis, which in most cases remains latent. However, this disease is a major threat to immunocompromised people and pregnant women. In extreme cases, it can damage nervous system or case fatal abortion. Infected...
-
A compact seven-section rat-race hybrid coupler incorporating pbg cells
PublicationA conventional rat-race coupler has been doubly miniaturized: (i) characteristic impedances and electrical lengths of microstrip sections have been adequately modified as the first step of size reduction and (ii) T-shaped PBG cells have been implemented to diminish strip section length as the second step of circuit rat-race couplerminiaturization. The experimental results show good agreement with theoretical characteristics. Furthermore,...
-
The influence of Nigella sativa essential oil on proliferation, activation, and apoptosis of human T lymphocytes in vitro
PublicationIn previous work, we tested the immunomodulatory effect of Nigella sativa (NS) fatty oil. Our results demonstrated that unrefined, obtained by cold pressing black cumin seed oil inhibited lymphocytes’ proliferation and induced their apoptosis in a dose-dependent manner. In this study, we examined the immunomodulatory properties of essential oil (EO) obtained from the NS seeds by hydrodistillation and its two main constituents:...
-
Induction of immune responses in sheep by vaccination with liposome-entrapped DNA complexes encoding Toxoplasma gondii MIC3 gene
PublicationToxoplasma gondii is a parasite that has been extensively studied due to its medical and veterinary importance in terminating pregnancies. Consequently, a satisfactory vaccine is required to control itsadverse effects on pregnant animals. The microneme protein, MIC3, is a major adhesion protein that binds to the surface of host cells and parasites, and is therefore a potential vaccine against T. gondii.The viability of MIC3 as...
-
Unravelling the role of electron–hole pair spin in exciton dissociation in squaraine-based organic solar cells by magneto-photocurrent measurements
PublicationA high absorption coefficient and narrow absorption bands in squaraine (SQ) dyes have resulted in rapidly growing interest in them as a donor material in photovoltaic devices. The exciton dissociation process in organic systems proceeds via a multistep mechanism where the electron–hole pairs (charge transfer states) involved in the current generation process determine the recombination losses and subsequently limit the overall...
-
Existence of Two Periodic Solutions to General Anisotropic Euler-Lagrange Equations
PublicationAbstract. This paper is concerned with the following Euler-Lagrange system d/dtLv(t,u(t), ̇u(t)) =Lx(t,u(t), ̇u(t)) for a.e.t∈[−T,T], u(−T) =u(T), Lv(−T,u(−T), ̇u(−T)) =Lv(T,u(T), ̇u(T)), where Lagrangian is given by L=F(t,x,v) +V(t,x) +〈f(t),x〉, growth conditions aredetermined by an anisotropic G-function and some geometric conditions at infinity.We consider two cases: with and without forcing termf. Using a general version...
-
Prime-Boost Vaccination with Toxoplasma Lysate Antigen, but Not with a Mixture of Recombinant Protein Antigens, Leads to Reduction of Brain Cyst Formation in BALB/c Mice
PublicationIntroduction Infection with the ubiquitous parasite Toxoplasma gondii is a threat for immunocompro- mised patients and pregnant women and effective immune-prophylaxis is still lacking. Methods Here we tested a mixture of recombinant T . gondii antigens expressed in different develop- mental stages, i.e., SAG1, MAG1 and GRA7 (SMG), and a lysate derived from T . gondii tachyzoites (TLA) for prophylactic vaccination against cyst formation....
-
Photovoltaic module temperature stabilization with the use of phase change materials
PublicationThe worldwide growth of photovoltaics (PVs) has formed an exponential curve for more than four decades. During this period of time, PVs have evolved from a pure niche market of small-scale applications towards becoming a mainstream electricity source. The influence of temperature on the electrical parameters of crystalline silicon solar cells and solar modules is well described in the literature. In order to diminish these effects,...
-
Mountain pass solutions to Euler-Lagrange equations with general anisotropic operator
PublicationUsing the Mountain Pass Theorem we show that the problem \begin{equation*} \begin{cases} \frac{d}{dt}\Lcal_v(t,u(t),\dot u(t))=\Lcal_x(t,u(t),\dot u(t))\quad \text{ for a.e. }t\in[a,b]\\ u(a)=u(b)=0 \end{cases} \end{equation*} has a solution in anisotropic Orlicz-Sobolev space. We consider Lagrangian $\Lcal=F(t,x,v)+V(t,x)+\langle f(t), x\rangle$ with growth conditions determined by anisotropic G-function and some geometric conditions...
-
T-colorings, divisibility and circular chromatic number
PublicationLet T be a T-set, i.e., a finite set of nonnegative integers satisfying 0 ∈ T, and G be a graph. In the paper we study relations between the T-edge spans espT (G) and espd⊙T (G), where d is a positive integer and d ⊙ T = {0 ≤ t ≤ d (max T + 1): d |t ⇒ t/d ∈ T} . We show that espd⊙T (G) = d espT (G) − r, where r, 0 ≤ r ≤ d − 1, is an integer that depends on T and G. Next we focus on the case T = {0} and show that espd⊙{0} (G) =...
-
Characteristics of La0.8Sr0.2Ga0.8Mg0.2O3-delta -supported micro-tubular solid oxide fuel cells with bi-layer and tri-layer electrolytes
PublicationIn this study, La0.8Sr0.2Ga0.8Mg0.2O3−δ (LSGM)-supported micro tubular solid oxide fuel cells (T-SOFCs) with two different configurations, one containing an LSGM–Ce0.6La0.4O2−δ (LDC) bi-layer electrolyte (Cell A) and one containing an LDC–LSGM–LDC tri-layer electrolyte (Cell B), were fabricated using extrusion and dip-coating. After optimizing the paste formulation for extrusion, the flexural strength of the dense and uniform LSGM...
-
Characteristics of La 0.8 Sr 0.2 Ga 0.8 Mg 0.2 O 3-δ -supported micro-tubular solid oxide fuel cells with LaCo 0.4 Ni 0.6-x Cu x O 3-δ cathodes
PublicationIn this study, micro-tubular solid oxide fuel cells (T-SOFCs) with extruded La0.8Sr0.2Ga0.8Mg0.2O3-δ (LSGM) electrolyte as the mechanical support and LaCo0.4Ni0.6O3-δ (LCNO) or LaCo0.4Ni0.4Cu0.2O3-δ (LCNCO) as cathodes were prepared and characterized. Partial substitution of Cu for the Ni-ion positions in the LCNO lattices was found to significantly enhance the densification and accelerate the grain growth. The porosity-corrected...
-
On asymptotic periodicity of kernel double Markovian operators
PublicationIt is proved that a kernel, doubly Markovian operator T is asymptotically periodic if and only if its deterministic σ-field Σd(T)(equivalently Σd(T∗)) is finite. It follows that kernel doubly Markovian operator T is asymptotically periodic if and only if T∗ is asymptotically periodic.
-
Beyond Antioxidant Activity: Redox Properties of Catechins May Affect Changes in the DNA Methylation Profile—The Example of SRXN1 Gene
PublicationThe role of catechins in the epigenetic regulation of gene expression has been widely studied; however, if and how this phenomenon relates to the redox properties of these polyphenols remains unknown. Our earlier study demonstrated that exposure of the human colon adenocarcinoma HT29 cell line to these antioxidants affects the expression of redox-related genes. In particular, treatment with (−)-epigallocatechin (EGC) downregulated...
-
Almost homoclinics for nonautonomous second order Hamiltonian systems by a variational approach
PublicationW artykule badamy problem istnienia rozwiązań prawie homoklinicznych dla nieautonomicznych układów Hamiltona w R^n z potencjałem V(t,x) postaci -1/2(L(t)x,x)+W(t,x) oraz zaburzeniem f(t) (ang. forcing term) z L^2. Zakładamy, że L jest funkcją ciągłą z prostej w zbiór macierzy kwadratowych nxn taką, że macierze L(t) są symetryczne i dodatnio określone jednostajnie względem zmiennej t. Potencjał W(t,x) jest klasy C^1 i nadkwadratowy...
-
Homoclinic solutions for a class of the second order Hamiltonian systems
PublicationW niniejszej pracy badamy istnienie orbit homoklinicznych dlaukładu Hamiltonowskiego drugiego rzędu: q^{..} + V_{q}(t,q) = f(t), gdzie V z iloczynu kartezjańskiego R x R^{n} do R jest postaciV(t,q) = -K(t,q) + W(t,q). Zakładamy, ze V jest T-okresowe ze względuna zmienną t, K spełnia tzw. ''pinching'' warunek, W jest superliniowew nieskończoności, a norma f w L^{2} jest wystarczająco mała.Orbitę homokliniczną takiego układu znajdujemy...
-
Novel amides of mycophenolic acid and some heterocyclic derivatives as immunosuppressive agents
PublicationThe group of new amide derivatives of mycophenolic acid (MPA) and selected heterocyclic amines was synthesised as potential immunosuppressive agents functioning as inosine-5'-monophosphate dehydrogenase (IMPDH) uncompetitive inhibitors. The synthesis employed uronium-type activating system (TBTU/HOBt/DIPEA) while or phosphonic acid anhydride method (T3P/Py) facilitating amides to be obtained in moderate to excellent yields without...
-
Products of Photo- and Thermochemical Rearrangement of 19-Membered di-tert-Butyl-Azoxybenzocrown
PublicationThe preparation and characterization of products of the photochemical and thermochemical rearrangements of 19-membered azoxybenzocrowns with two, bulky, tert-butyl substituents in benzene rings in the para positions to oligooxyethylene fragments (meta positions to azoxy group, i.e., t-Bu-19-Azo-O have been presented. In photochemical rearrangement, two colored typical products were expected, i.e., 19-membered o-hydroxy-m,m′-di-tert-butyl-azobenzocrown...
-
Higher platelet counts correlate to tumour progression and can be induced by intratumoural stroma in non-metastatic breast carcinomas
PublicationBackground Platelets support tumour progression. However, their prognostic significance and relation to circulating tumour cells (CTCs) in operable breast cancer (BrCa) are still scarcely known and, thus, merit further investigation. Methods Preoperative platelet counts (PCs) were compared with clinical data, CTCs, 65 serum cytokines and 770 immune-related transcripts obtained using the NanoString technology. Results High normal...
-
Reactivity of Phosphanylphosphinidene Complex of Tungsten(VI) toward Phosphines: A New Method of Synthesis of catena-Polyphosphorus Ligands
PublicationThe reactivity of an anionic phosphanylphosphinidene complex of tungsten(VI), [(2,6-i-Pr2C6H3N)2(Cl)- W(η2-t-Bu2P=P)]Li·3DME toward PMe3, halogenophosphines, and iodine was investigated. Reaction of the starting complex with Me3P led to formation of a new neutral phosphanylphosphinidene complex, [( 2,6-i-Pr2C6H3N)2(Me3P)W(η2-t-Bu2P=P)]. Reactions with halogenophosphines yielded new catena-phosphorus complexes. From reaction with...