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Search results for: REGENARATIVE MEDICINE
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Attitudes of Lazarski University Medical Students towards Disaster Medicine; Questionnaire Survey
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CHITOSAN-DERIVATIVES IN COMBINATIONS WITH SELECTED PORPHYRINOIDS AS NOVEL HYBRID MATERIALS FOR MEDICINE AND PHARMACY
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Optical-Spectrometry-Based Method for Immunosuppressant Medicine Level Detection in Aqueous Solutions
PublicationIn this paper, an investigation into detecting immunosuppressive medicine in aqueous solutions using a spectrometry-based technique is described. Using optical transmissive spectrometry, absorbance measurements in the spectra range from 250 nm to 1000 nm were carried out for different cyclosporine A (CsA) concentrations in aqueous solutions. The experiment was conducted for samples both with and without interferent substances—glucose...
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Changes in gene methylation patterns in neonatal murine hearts: Implications for the regenerative potential
PublicationBackground The neonatal murine heart is able to regenerate after severe injury; this capacity however, quickly diminishes and it is lost within the first week of life. DNA methylation is an epigenetic mechanism which plays a crucial role in development and gene expression regulation. Under investigation here are the changes in DNA methylation and gene expression patterns which accompany the loss of regenerative potential. Results The...
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Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice
PublicationThe ear pinna is a complex tissue consisting of the dermis, cartilage, muscles, vessels, and nerves. Ear pinna healing is a model of regeneration in mammals. In some mammals, including rabbits, punch wounds in the ear pinna close spontaneously; in common-use laboratory mice, they remain for life. Agents inducing ear pinna healing are potential regenerative drugs. We tested the effects of selected bioactive agents on 2 mm ear pinna...
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Molecular characteristics of community-associated methicillin-resistant Staphylococcus aureus strains for clinical medicine
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Nanoparticle Tracking Analysis of Urinary Extracellular Vesicle Proteins as a New Challenge in Laboratory Medicine
PublicationUrinary extracellular vesicle (uEV) proteins may be used as specific markers of kidney damage in various pathophysiological conditions. The nanoparticle-tracking analysis (NTA) appears to be the most useful method for the analysis of uEVs due to its ability to analyze particles below 300 nm. The NTA method has been used to measure the size and concentration of uEVs and also allows for a deeper analysis of uEVs based on their protein...
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Physics Comes to the Aid of Medicine—Clinically-Relevant Microorganisms through the Eyes of Atomic Force Microscope
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Effects of Laser Remelting at Cryogenic Conditions on Microstructure and Wear Resistance of the Ti6Al4V Alloy Applied in Medicine
PublicationThe titanium and its alloys can be subjected to surface treatment, including laser treatment. In this work a new laser treatment at cryogenic conditions of Ti6Al4V alloy has been described. The work has been aimed at establishing whether such surface treatment could be suitable for implants working under wear in biological corrosive environment. The remelting has been made with the use of CO2 continuous work laser at laser power...
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Genome-wide DNA methylation profiling of the regenerative MRL/MpJ mouse and two normal strains
PublicationAims We aimed to identify the pivotal differences in the DNA methylation profiles between the regeneration capable MRL/MpJ mouse and reference mouse strains. Materials and Methods Global DNA methylation profiling was performed in ear pinnae, bone marrow, spleen, liver, heart from uninjured adult females of the MRL/MpJ and C57BL/6J and BALB/c. Results and conclusion A number of differentially methylated regions distinguishing between...
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Monitoring Regenerative Heat Exchanger in Steam Power Plant by Making Use of the Recurrent Neural Network
PublicationArtificial Intelligence algorithms are being increasingly used in industrial applications. Their important function is to support operation of diagnostic systems. This paper pesents a new approach to the monitoring of a regenerative heat exchanger in a steam power plant, which is based on a specific use of the Recurrent Neural Network (RNN). The proposed approach was tested using real data. This approach can be easily adapted to...
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The evolution of education spaces - from plan as generator to regenerative architecture, virtual rooms and green campuses
PublicationThe study programmes are often considered the main formative factors in the process of educating future architects. Another highly influential component is the architectural characteristics of learning spaces, and consequently the impact of the physical built environment on the quality of education has been widely discussed. However, not often do we realise that the characteristics of education spaces correlate with the organisational...
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COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?
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Immunoscore, circulating tumor cells and human-derived organoids as potential predictive tools in personalized cancer medicine
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In Vitro and In Vivo Imaging-Based Evaluation of Doxorubicin Anticancer Treatment in Combination with the Herbal Medicine Black Cohosh
PublicationAs a substitution for hormone replacement therapy, many breast cancer patients use black cohosh (BC) extracts in combination with doxorubicin (DOX)-based chemotherapy. In this study, we evaluated the viability and survival of BC- and DOX-treated MCF-7 cells. A preclinical model of MCF-7 xenografts was used to determine the influence of BC and DOX administration on tumor growth and metabolism. The number of apoptotic cells after...
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Trustworthy Applications of ML Algorithms in Medicine - Discussion and Preliminary Results for a Problem of Small Vessels Disease Diagnosis.
PublicationML algorithms are very effective tools for medical data analyzing, especially at image recognition. Although they cannot be considered as a stand-alone diagnostic tool, because it is a black-box, it can certainly be a medical support that minimize negative effect of human-factors. In high-risk domains, not only the correct diagnosis is important, but also the reasoning behind it. Therefore, it is important to focus on trustworthiness...
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Increase of the effective energy from the radiant tube equipped with regenerative system in comparison with conventional recuperative system
PublicationPrzedstawiono wyniki badań eksperymentalnych spalania HiTAC (High Temperature Air Combustion) z użyciem rury promieniującej w celu porównania systemu palników regeneracyjnych z konwencjonalnym systemem rekuperacyjnym.
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Application of Navigated Ultrasound for Assessment of the Anterior Pelvic Plane in Patients With Degenerative Hip Diseases
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Updated principles of prevention, diagnosis and treatment of COVID-19 in children in Poland – recommendations for paediatricians and family medicine doctors
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Is it time to update the Recommendations of the Polish Society of Forensic Medicine and Criminology on the collection of post-mortem material for toxicological analysis?
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Thermal Tomography in Medicine. 9th European Congress of Thermology, Kraków, 29.05-01.06.2003. Tomografia termiczna w medycynie.
PublicationArtykuł prezentuje możliwości zastosowań techniki tomografii termicznej w aplikacjach medycznych. Dyskutowane są możliwości i ograniczenia prezentowanej metody w odniesieniu do organizmów żywych.
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Neotenic phenomenon in gene expression in the skin of Foxn1- deficient (nude) mice - a projection for regenerative skin wound healing
PublicationMouse fetuses up to 16 day of embryonic development and nude (Foxn1- deficient) mice are examples of animals that undergo regenerative (scar-free) skin healing. The expression of transcription factor Foxn1 in the epidermis of mouse fetuses begins at embryonic day 16.5 which coincides with the transition point from scar-free to scar-forming skin wound healing. In the present study, we tested the hypothesis that Foxn1 expression...
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Sequence variants of p21 gene of the MRL/MpJ mouse: a possible association with the deficit of p21 protein and regenerative phenotype.
PublicationThe MRL/MpJ mouse is known for its enhanced regeneration abilities that manifested themselves by scarless ear-hole wound closure. The deficit of p21 found in the MRL is associated with the regenerative capacity as the p21 gene knockout in a mouse strain unrelated to the MRL mouse results in an ear-hole closure effect, similar to that observed in the MRL mouse. Cdkn1a gene encodes p21 protein, a cyclin-dependent kinase inhibitor,...
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Medyczne serwisy internetowe w promocji wysokiego zaufania.
PublicationW artykule poddano dyskusji problematykę internetowej reklamy leków w aspekcie kosztów, efektywności, postrzegania i akceptacji przekazu reklamowego. Porównując wydajność kampanii reklamowych zamawianych w portach medycznych z promocją leków prowadzoną we własnym serwisie tematycznym. Na przykładzie praktycznego wdrożenia serwisu dla lekarzy wykazano korzyści marketingowe wynikające z prowadzenia własnych stron tematycznych...
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Innovative ICT Platform for Emerging eHealth Services: Towards Overcoming Technical and Social Barriers and Solving Grand Challenges in Medicine
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The determination of elements in herbal teas and medicinal plant formulations and their tisanes
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Health risks from consumption of medicinal plant dietary supplements
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Lithium biofortification of medicinal mushrooms Agrocybe cylindracea and Hericium erinaceus
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Human carnosinases: A brief history, medicinal relevance, and in silico analyses
PublicationCarnosine, an endogenous dipeptide, has been found to have a plethora of medicinal properties, such as antioxidant, antiageing, and chelating effects, but with one downside: a short half-life. Carnosinases and two hydrolytic enzymes, which remain enigmatic, are responsible for these features. Hence, here we emphasize why research is valuable for better understanding crucial concepts like ageing, neurodegradation, and cancerogenesis,...
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Perspectives of Hospital Pharmacists Towards Biosimilar Medicines: A Survey of Polish Pharmacy Practice in General Hospitals
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Recommendations of the Polish Paediatric Society, the Polish Society of Vaccinology, and the Polish Society of Family Medicine on meningococcal vaccinations in children and adults in Poland
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Complementary and alternative medicine (CAM) use among patients with cancer undergoing palliative care: A pilot study of a single institution in Poland.
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Treatment of insomnia in older adults. Recommendations of the Polish Sleep Research Society, Polish Society of Family Medicine and the Polish Psychiatric Association
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Magnetic nanocomposites for biomedical applications
PublicationTissue engineering and regenerative medicine have solved numerous problems related to the repair and regeneration of damaged organs and tissues arising from aging, illnesses, and injuries. Nanotechnology has further aided tissue regeneration science and has provided outstanding opportunities to help disease diagnosis as well as treat damaged tissues. Based on the most recent findings, magnetic nanostructures (MNSs), in particular,...
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Ragged Robin (Lychnis flos-cuculi) - a plant with potential medicinal value
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Inhibitory Effect of Eugenol and trans‐Anethole Alone and in Combination with Antifungal Medicines on Candida albicans Clinical Isolates
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Wyszukiwanie artykułów medycznych w MEDLINE z wykorzystaniem UMLS
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Hybridization of valuation procedures as a medicine supporting the real estate market and sustainable land use development during the covid-19 pandemic and afterwards
PublicationCurrently we are facing the pandemic situation that occur all over the world. Regardless the country or even the region, the negative consequences that are expected could be very big and the level of crisis is not predictable. This situation is the challenge for the real estate market as well. Due to this fact, the authors believe that there is the time when deep transformation of approaches, procedures and awareness related to...
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Studies of the mechanism of metal metal dusting of 10CrMo9-10 steel after 10 years of operation in trhe semi-regenerative catalytic reformer
PublicationThe study showed that metal dusting mechanism of 10CrMo9-10 steel operated in industrial environment differs from models developed in laboratories. Significant differences lie in the fact that the models developed in laboratories only assume the formation of metastable carbide M3C, while studies have shown that the formation of M3C carbides is associated with the transformation of primary carbides and in the next stage is preceded...
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From creative writing, virtual environments to nature-based solutions: linking research and education to facilitate transition from sustainable to regenerative cities
PublicationChallenges related to the climate crisis and its consequences, such as rising sea levels, urban heat islands or floods, engender pressure on architectural education. Sustainable design often inclines to regenerative one - an emerging trend focused on the restorative power of architecture. The question appears upon the tools and methods that would facilitate both students and academics to address new challenges. This article offers...
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An energetic analysis of a gas turbine with regenerative heating using turbine extraction at intermediate pressure - Brayton cycle advanced according to Szewalski's idea
PublicationIn this paper, a modification of a simple gas turbine into the Brayton cycle with regenerative heating, using turbine extraction at intermediate pressure, is presented. The main concept of the retrofitting is based on the transfer of heat from the turbine exhaust gases to the air entering the combustion chamber. The extracted gas transfers heat to air via the divided regenerative heat exchanger and after that is compressed and...
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Medycyna rodzinna w preferencjach studentów medycyny z Gdańska i Poznania = Family medicine in preferences of medical students from Gdańsk and Poznań
PublicationZainteresowanie studentów mmedycyną rodzinną w ostatnich dziesięciu latach.
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Callus of American ginseng (Panax quinquefolius) as a source of ginsenosides – medicinal secondary metabolites
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Jerusalem artichoke (Helianthus tuberosus L.) as a medicinal plant and its natural products
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Application of deep eutectic solvents for separation and determination of bioactive compounds in medicinal plants
PublicationThe medicinal plants industry, particularly in regard to products rich in biologically active substances for maintaining health, has grown by leaps and bounds in the last decade, with sales of over-the-counter drugs containing these substances growing by billions of dollars. Attention has thus also been paid to the safety and effectiveness of these medicines. We are currently witnessing a rapid increase in the number of publications...
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Discovery of small-molecule regenerative drugs using a model of complex tissue injury in mice. Transcriptomic responses of neurodevelopmental genes during pharmacologically induced regeneration
PublicationDespite significant development in regenerative medicine, there is a deficit of effective therapies for wound healing and tissue regeneration. Research performed using animal wound models allows for a better understanding of this complex process, searching for compounds with pro-regenerative properties, and assessing their efficacy and safety. Unfortunately, the lack of adequate preclinical models proves to be an issue as no animal...
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Some Common Medicinal Plants with Antidiabetic Activity, Known and Available in Europe (A Mini-Review)
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Dysphania schraderiana (Schult.) Mosyakin & Clemants – An overlooked medicinal and ritual plant used in Poland
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Understanding element composition of medicinal plants used in herbalism—A case study by analytical atomic spectrometry
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Guidelines of the Polish Psychiatric Association – Wroclaw Division, the Polish Society of Family Medicine and the College of Family Physicians in Poland for diagnosis and treatment of depressive disorders in primary health care
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