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Search results for: DRUGI GRADIENT
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Drug-drug interaction potential of antitumor acridine agent C-1748: The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7
PublicationBackground The compound 9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine (C-1748), the promising antitumor agent developed in our laboratory was determined to undergo phase I metabolic pathways. The present studies aimed to know its biotransformation with phase II enzymes – UDP-glucuronosyltransferases (UGTs) and its potential to be engaged in drug-drug interactions arising from the modulation of UGT activity. Methods UGT-mediated...
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Biopolymer based nanomaterials in drug delivery systems: A review
PublicationDrug delivery systems (DDS) are used to achieve a higher therapeutic effects of a pharmaceutical drug or natural compound in a specific diseased site with minimal toxicological effect and these systems consists of liposomes, microspheres, gels, prodrugs and many. Nanotechnology is a rapidly developing multi-disciplinary science that ensures the fabrication of the polymers to nanometer scale for various medical applications. Uses...
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Feasibility study of a Raman spectroscopic route to drug detection
PublicationWe present an surface-enhanced Raman spectroscopy (SERS) approach for detection of drugs of abuse in whole human blood. We utilize a near infrared laser with 830 nm excitation wavelength in order to reduce the influence of fluorescence on the spectra of blood. However, regular plasmon resonance peak of plasmonic nanoparticles, such as silver or gold fall in a much lower wavelength regime about 400 nm. Therefore, we have shifted...
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Stability analysis of nanobeams in hygrothermal environment based on a nonlocal strain gradient Timoshenko beam model under nonlinear thermal field
PublicationThis article is dedicated to analyzing the buckling behavior of nanobeam subjected to hygrothermal environments based on the principle of the Timoshenko beam theory. The hygroscopic environment has been considered as a linear stress field model, while the thermal environment is assumed to be a nonlinear stress field based on the Murnaghan model. The size-dependent effect of the nanobeam is captured by the nonlocal strain gradient...
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Relation of the polymorphism of cyp51A sequence and the susceptibility of Aspergillus fumigatus isolates to triazoles determined by commercial gradient test (Etest) and by reference methods
PublicationThe aim of this study was to evaluate the accuracy of commercial gradient test (Etest) in the detection of triazole resistant Aspergillus fumigatus isolates using reference microdilution methods and the analysis of sequences of the cyp 51A gene. The study was performed on twenty clinical isolates which were identified as Aspergillus fumigatus based on the DNA sequences of the ITS1-2 fragment of ribosomal DNA and the β-tubulin gene,...
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Comparative Study on Effects of Thermal Gradient Direction on Heat Exchange between a Pure Fluid and a Nanofluid: Employing Finite Volume Method
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Cancer stem cells in drug resistance and drug screening: can we exploit the cancer stem cell paradigm in search for new antitumor agents?
PublicationPraca przedstawia przegląd literatury dotyczącej hipotezy komórek pierwotnych nowotworu, w szczególności w ich oporności na istniejące terapie. Dyskutowane jest także zagadnienie możliwości wykorzystania wiedzy o tych komórkach do konstrukcji nowych testów do badań przesiewowych in vitro w celu poszukiwania nowych leków przeciwnowotworowych.
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Bariery techniczne polskiego odcinka Międzynarodowej Drogi Wodnej E-70.
PublicationW zeszycie przedstawiono główne bariery techniczne śródlądowej drogi wodnej E-70 na odcinkach Kostrzyn-Bydgoszcz, Fordon-Ujście Wisły, Nogat i Szkarpawa, ich aktualny stan oraz perspektywy rozwoju.
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Fentanyl and its derivatives as a group of new psychoactive substances (designer drugs)
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Strategia zmniejszania liczby i skutków wypadnięcia pojazdu z drogi
PublicationWypadnięcie z drogi, czyli wywrócenie się pojazdu lub najechanie na drzewo lub słup to jedna z głównych przyczyn wypadków drogowych. Wypadki tego typu charakteryzują się bardzo wysoką ciężkością. Przyczynia się do tego brak stref bezpieczeństwa w otoczeniu dróg. W artykule opisano strategie ograniczenia tego typu zdarzeń. Przedstawiono również efektywność tych rozwiązań oraz ogólne uwarunkowania zmniejszania ciężkości wypadków...
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Wykorzystanie transportowe drogi wodnej E-70 - marzenie czy konieczność?
PublicationPrzedstawiono przesłanki wskazujace konieczność rozwoju polskiej żeglugi śródlądowej w zakresie obsługi portów kontenerowych oraz towarów masowych. Wskazano kierunki polityki inwestycyjnejoraz uwarunkowania w zakresie rewitalizacji i rozwoju dróg wodnych ze szczególnym uwzględnieniem zespołu portowego Gdańsk -Gdynia oraz odcinka Dolnej Wisły.
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Wpływ drzew w koronie drogi na bezpieczeństwo użytkowników dróg
PublicationW referacie przedstawiono problem wystepowania wypadków związanych z najechaniem na drzewo. Problem ten występuje w Polsce głównie w województwach północnych i zachodnich, co jest związane ze specyficznymi cechami sieci drogowej tego obszaru. Referat przedstawia negatywny wpływ drzew rosnących w koronie drogi na bezpieczeństwo ruchu drogowego oraz określa metody zapobiegania wypadkom związanym z najechaniem na drzewo. Ze względu...
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Assessment of sleep disorders and use of psychoactive drugs among Polish students
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New data on antihypertensive drugs and risk of cancer: should we worry?
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TIME to face the reality about evening dosing of antihypertensive drugs in hypertension
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Możliwości wyznaczania kąta nachylenia drogi z wykorzystaniem systemu GPS
PublicationW pracy przedstawiona została metoda korekty sygnału wysokości pochodzącego z systemu GPS umożliwiająca wyeliminowanie nagłych zmian wysokości, które nie występują w rzeczywistości, a są następstwem odbić lub zaniku sygnału pochodzącego z nadajników satelitarnych. Parametrem charakteryzującym zakres korekty oryginalnego sygnału jest kąt dopuszczalnego pochylenia drogi, który powinien być dobierany ze względu na analizowany typ...
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Expression of alternatively spliced variants of the Dclk1 gene is regulated by psychotropic drugs
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Wyznaczanie drogi tarcia w łożyskach łopat kierowniczych turbin wodnych
PublicationW referacie omówiono wpływ warunków pracy łożysk łopat kierownic turbin wodnych na trwałość stosowanych w nich materiałów bezsmarowych. Wykazano, że trwałość łożyska zależy nie tylko od jego odporności na zużycie ale także od warunków pracy, szczególnie od drogi tarcia jaką pokonuje w trakcie eksploatacji. Zużywanie łożysk czopów łopat kierownicy zachodzi podczas ruchów związanych z uruchamianiem i zatrzymywaniem maszyny, ruchów...
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An Assessment of RASSCF and TDDFT Energies and Gradients on an Organic Donor−Acceptor Dye Assisted by Resonance Raman Spectroscopy
PublicationThe excitation energies and gradients in the ground and the first excited state of a novel donor−(π- bridge)−acceptor 4-methoxy-1,3-thiazole-based chromophore were investigated by means of MS-RASPT2/RASSCF and TDDFT in solution. Within both methods, the excitation energies strongly depend on the employed equilibrium structures, whose differences can be rationalized in terms of bond length alternation indexes. It is shown that functionals with...
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Phosphorus pools and internal loading in a eutrophic lake with gradients in sediment geochemistry created by land use in the watershed
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ANALYSIS OF CLIMATIC ZONES IN POLAND WITH REGARD TO ASPHALT PERFORMANCE GRADING
PublicationTowards the end of the last century a new system of bitumen grading was developed and implemented as part of the American Strategic Highway Research Program (SHRP). Its aim was to better adjust the testing methods and requirements for road bitumens to the actual conditions in which those bitumens serve in road pavements. Currently in Poland, similarly as in the other EU countries, road bitumens are tested and classified with regard...
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STUDENTS' PERCEPTION OF E-GRADING: INFORMATICS COURSE CASE STUDY
PublicationUsing computers for grading can simplify work for teachers. However it is a sensitive part of their work and must be performed carefully. More information is required on students' reception and opinions about e-grading. This paper is a case study of e-grading used in Informatics course and discusses results obtained from surveying the students after being graded by a teacher and a computer.
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Diatomaceous earth as a drug-loaded carrier in a glass-ionomer cement
PublicationThe effect of a natural filler (diatomaceous earth [DE], a promising drug-delivery agent) and its content was investigated on the performance of a model glass-ionomer cement (GIC). Three sample series, differing in DE content (0, 2.5 and 5 wt%), were prepared using a commercial GIC as a matrix (3M Ketac Molar Easymix). The resultant surface microhardness and roughness, wear performance, and compressive strength of the samples were...
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Synthetic strategies in construction of organic macromolecular carrier–drug conjugates
PublicationMany metabolic inhibitors, considered potential antimicrobial or anticancer drug candidates, exhibit verylimited ability to cross the biological membranes of target cells. The restricted cellular penetration ofthose molecules is often due to their highhydrophilicity. One of the possible solutions to this problem is aconjugation of an inhibitor with a molecular organic nanocarrier. The conjugate thus formed should beable to penetrate...
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Effective Drug Concentration and Selectivity Depends on Fraction of Primitive Cells
PublicationPoor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has been driving the search for more active and specific compounds. In this work, we show how cell density-dependent stage culture profiles can be used in drug development workflows to achieve more robust drug activity (IC50 and EC50) results. Using flow cytometry and light microscopy, we characterized the cytological stage profiles of the HL-60-,...
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Pharmaceutical and forensic drug applications of chiral supercritical fluid chromatography
PublicationTHE SUPERCRITICAL FLUID IS AN EXCELLENT CHOICE AS THE CHROMATOGRAPHIC MOBILE PHASE BECAUSE IT ALLOWS RAPID SEPARATION WITH HIGH EFFICIENCY AND APPLICATIONS INVOLVING ENANTIORESOLUTION ARE COMMON. SUPERCRITICAL FLUID CHROMATOGRAPHY (SFC) IS INCREASINGLY USED FOR ANALYTICAL, SEMI-PREPARATIVE AND PREPARATIVE PURIFICATION OF CHIRAL COMPOUNDS, INCLUDING PRODUCTION OF ENANTIOMERS THAT ARE MAINLY ENCOUNTERED DURING DRUG DEVELOPMENT. SFC...
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Chitosan-Based Nanoparticles as Effective Drug Delivery Systems—A review
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Mesoporous silica nanoflakes – Biocompatibility, cellular uptake and drug transport
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Recent Advances in Polymer-Based Vaginal Drug Delivery Systems
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Controlled Drug Release by the Pore Structure in Polydimethylsiloxane Transdermal Patches
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Filling of Carbon Nanotubes: Containers for Magnetic Probes and Drug Delivery
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The Role of miRNA-7 in the Biology of Cancer and Modulation of Drug Resistance
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Chemometrics of bi-heterocyclic kind of drug specimens in the THz domain
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On well-posedness of the first boundary-value problem within linear isotropic Toupin–Mindlin strain gradient elasticity and constraints for elastic moduli
PublicationWithin the linear Toupin–Mindlin strain gradient elasticity we discuss the well-posedness of the first boundary-value problem, that is, a boundary-value problem with Dirichlet-type boundary conditions on the whole boundary. For an isotropic material we formulate the necessary and sufficient conditions which guarantee existence and uniqueness of a weak solution. These conditions include strong ellipticity written in terms of higher-order...
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Torsional stability capacity of a nano-composite shell based on a nonlocal strain gradient shell model under a three-dimensional magnetic field
PublicationThis paper considers a single-walled composite nano-shell (SWCNS) exposed in a torsional critical stability situation. As the magnetic field affects remarkably nanostructures in the small size, a three-dimensional magnetic field is assessed which contains magnetic effects along the circumferential, radial and axial coordinates system. Based on the results of the nonlocal model of strain gradient small-scale approach and the first-order...
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Badania systemów powstrzymujących pojazd przed wypadnięciem z drogi - cz. II
PublicationW artykule zaprezentowana została tematyka systemów powstrzymujących pojazd przed wypadnięciem z drogi. Podczas codziennego użytkowania dróg występuje szereg zagrożeń, które wpływają na bezpieczeństwo. Badanie, identyfikacja i klasyfikacja zagrożeń stanowią istotny element utrzymania dróg. Artykuł stanowi drugą część podjętej problematyki. Pierwsza została opublikowana w magazynie Mosty nr 3-4/19 str. 66-68.
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Badania systemów powstrzymujących pojazd przed wypadnięciem z drogi - cz. I
PublicationTransportation systems are designed and used so as to effectively and safely relocate people, goods and services. Despite this there are numerous hazards that disrupt or damage these systems. Risks such as extreme weather conditions, terrorist threats, landsliders or earthquakes are difficult to predict, manage and mitigate. One of the hazards for transportation systems are accidents, and their impact on the transport functioning...
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Stable and degradable microgels linked with cystine for storing and environmentally triggered release of drugs
PublicationEnvironmentally sensitive, degradable microgels based on poly(N-isopropylacrylamide) (pNIPA) crosslinked with the diacryloyl derivative of cystine (BISS) were synthesized by applying surfactant-free emulsion polymerization. pNIPA contributed the sensitivity to temperature to the microgels and the cross-linker made them degradable and sensitive to pH. The morphology of the microgels was investigated by using scanning and transmission...
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Impact of selected drugs and their binary mixtures on the germination of Sorghum bicolor (sorgo) seeds
PublicationThe aim of this study was to assess the toxicological potential of binary drug mixtures and individual drugs under different pH conditions with different inorganic ion additions on the germination of Sorghum bicolor (sorgo) seeds. To assess whether the given drug mixtures were more phytotoxic than the individual compounds, concentration addition (CA) and independent action (IA) approaches were applied to estimate the predicted...
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Studies of human and veterinary drugs' fate in environmental solid samples- analytical problems.
PublicationW różnych ośrodkach naukowych na całym świecie trwają prace nad poznaniem losu środowiskowego zanieczyszczeń z grupy farmaceutyków. Obecność pozostałości farmaceutycznych w poszczególnych elementach środowiska stanowi nowe wyzwanie zarówno z punktu widzenia technologii oczyszczania wód i ścieków jak i analityków, których zadaniem jest opracowanie nowych metodyk analitycznych. W publikacji przedstawiono problemy z jakimi stykają...
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European Society of Hypertension Working Group on Obesity: obesity drugs and cardiovascular outcomes
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Detrimental effects of chemotherapeutics and other drugs on the endothelium: A call for endothelial toxicity profiling
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Interaction of selected drugs with food in the group of patients over 60 years of age
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The Comparison Between the Calculated and HPLC-Predicted Lipophilicity Parameters for Selected Groups of Drugs
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Activity evaluation of some psychoactive drugs with the application of QSAR/QSPR modeling methods
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Wyznaczanie drogi tarcia w warunkach ślizgania oscylacyjnego o małej amplitudzie.
PublicationW pracy omówiono sposób wyznaczania drogi tarcia w warunkach ruchu oscylacyjnego o małej amplitudzie, która jak wykazały badania, w takim przypadku dla niemetalowych materiałów łożyskowych różni się znacząco od nominalnej drogi ślizgania. Jest to spowodowane postaciowymi odkształceniami materiału umożliwiającymi ruch względny czopa i panwi bez poślizgu na powierzchni styku. Zaproponowana metoda umożliwia uwzględnienie tego zjawiska....
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Damped forced vibration analysis of single-walled carbon nanotubes resting on viscoelastic foundation in thermal environment using nonlocal strain gradient theory
PublicationIn this paper, the damped forced vibration of single-walled carbon nanotubes (SWCNTs) is analyzed using a new shear deformation beam theory. The SWCNTs are modeled as a flexible beam on the viscoelastic foundation embedded in the thermal environment and subjected to a transverse dynamic load. The equilibrium equations are formulated by the new shear deformation beam theory which is accompanied with higher-order nonlocal strain...
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HYGRO-MAGNETIC VIBRATION OF THE SINGLE-WALLED CARBON NANOTUBE WITH NONLINEAR TEMPERATURE DISTRIBUTION BASED ON A MODIFIED BEAM THEORY AND NONLOCAL STRAIN GRADIENT MODEL
PublicationIn this study, vibration analysis of single-walled carbon nanotube (SWCNT) has been carried out by using a refined beam theory, namely one variable shear deformation beam theory. This approach has one variable lesser than a contractual shear deformation theory such as first-order shear deformation theory (FSDT) and acts like classical beam approach but with considering shear deformations. The SWCNT has been placed in an axial or...
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Detection ofHelicobacterspecies in liver and stomach tissues of patients with chronic liver diseases using polymerase chain reaction-denaturing gradient gel electrophoresis and immunohistochemistry
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Simultaneous determination of hydrophobicity and dissociation constant for a large set of compounds by gradient reverse phase high performance liquid chromatography–mass spectrometry technique
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