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The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part III: Polymorphisms of genes involved in Tregs’ activation and function
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Disruption of homocitrate synthase genes in Candida albicans affects growth but not virulence
PublicationDwa geny, LYS21 i LYS22, kodujące izoformy syntazy homocytrynianowej, enzymu katalizującego pierwszy wyjątkowy etap w szlaku biosyntezy lizyny, zostały rozbite z komórkach Candida albicans z wykorzystaniem strategii ''SAT flipper''. Podwójny mutant lys21delta/lys22delta nie wykazywał aktywności syntazy homocytrynianowej, natomiast charakteryzował się auksotrofią wzrostową wobec lizyny w podłożach minimalnych, co można było odwrócić...
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The Role of Dopaminergic Genes in Probabilistic Reinforcement Learning in Schizophrenia Spectrum Disorders
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Microarray analysis of differentially expressed genes in cells resistant to HIV-1
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Selected mitochondrial genes as species markers of the Arctic Contracaecum osculatum complex
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Amplification of the PDGFRA, KIT and KDR genes in glioblastoma: a population-based study
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Activities of genes controlling sphingolipid metabolism in human fibroblasts treated with flavonoids
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Modulation of expression of genes involved in glycosaminoglycan metabolism and lysosome biogenesis by flavonoids
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Typology and comparative analysis of black tents built in tradition of iranian tribes
PublicationThis study focused on the habits and way of life of nomads in the Iranian Highlands, but their homes, called Black Tents, were of the main interest. The research explored the construction of the Black Tents and the way of shaping the space in which family life takes place. It concerned the architectural forms of tents, structures and materials from which they are erected, as well as interior furnishings and objects that determine...
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Chitosan/poly(4-vinylpyridine) coatings formed on AgNPs-decorated titanium
PublicationElectrophoretic deposition (EPD) of chitosan/poly(4-vinylpyridine) (chit/P4VP) coatings on titanium substrates previously decorated with silver nanoparticles (AgNPs) was performed at different content of P4VP in the suspension and different voltage values. The results revealed that the composite coatings were formed, well-adjacent to the titanium substrate, of suitable roughness, hydrophilicity, and corrosion resistance. The voltage...
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Genes of cellular components of morphogenesis in porcine oocytes before and after IVM
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Genes involved in glucocorticoid receptor signalling affect susceptibility to mood disorders
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Defect in Mitochondrial NADH-Dehydrogenase Genes in Canine Mast Cell Tumours
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A universal method for the identification of genes encoding amatoxins and phallotoxins in poisonous mushrooms
PublicationABSTRACT Background. As the currently known diagnostic DNA targets amplified in the PCR assays for detection of poisonous mushrooms have their counterparts in edible species, there is a need to design PCR primers specific to the genes encoding amanitins and phallotoxins, which occur only in poisonous mushrooms. Objective. The aim of the study was testing of PCR-based method for detection of all genes encoding hepatotoxic cyclic...
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Epigenetic regulation and regeneration: the search for differentially methylated genes in the MRL mouse
PublicationThe MRL mouse is an inbred laboratory strain, which was developed in the 60’s of the 20th century and has been extensively used as a model of lupus erythematosus. The regenerative abilities of the strain were discovered in the 90' when the MRL mouse was shown to close 2 mm hole punches made in the ear pinnae four weeks after injury without scarring. The phenomenon has not been observed in other mouse strains, where the holes...
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Direct cloning of heavy metal resistance genes from metagenomic DNA
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Lichenochora tertia (Phyllachorales): the third species of the genus growing on Xanthoria elegans
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Palicella, a new genus of lichenized fungi and its phylogenetic position withinLecanoraceae
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Influence of Escherichia coli on Expression of Selected Human Drug Addiction Genes
PublicationThe impact of enteric microflora on the expression of genes associated with cocaine and amphetamine addiction was described. Human genome-wide experiments on RNA transcripts expressed in response to three selected Escherichia coli strains allowed for significant alteration (p > 0.05) of the linear regression model between HT-29 RNA transcripts associated with the KEGG pathway:hsa05030:Cocaine addiction after 3 h stimulation with...
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Algorithms and Tools for Intelligent Control of Critical Infrastructure Systems
PublicationCritical Infrastructure Systems (CIS) are spatially distributed and of a network structure. The dynamics are nonlinear, uncertain and with several time scales. There is a variety of different objectives to be reliably met under a wide range of operational conditions. The operational conditions are influenced by the disturbance inputs, operating ranges of the CIS, faults in the sensors and actuators and abnormalities occurring in...
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Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice
PublicationThe ear pinna is a complex tissue consisting of the dermis, cartilage, muscles, vessels, and nerves. Ear pinna healing is a model of regeneration in mammals. In some mammals, including rabbits, punch wounds in the ear pinna close spontaneously; in common-use laboratory mice, they remain for life. Agents inducing ear pinna healing are potential regenerative drugs. We tested the effects of selected bioactive agents on 2 mm ear pinna...
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Międzynarodowe Agendy Badawcze MAB - spotkanie informacyjne ON-LINE
Eventstransmisja on-line w jęz. angielskim na kanale Fundacji na Rzecz Nauki Polskiej na portalu YouTube; w trakcie spotkania istnieje możliwość zadawania pytań drogą elektroniczną - e-mail: infodaymab@fnp.org.pl; zapis transmisji będzie dostępny na portalu YT natychmiast po zakończeniu spotkania. Agenda spotkania: kwestie dotyczące programu, możliwości i...
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CYP3A4 overexpression enhances apoptosis induced by anticancer agent imidazoacridinone C-1311, but does not change the metabolism of C-1311 in CHO cells
PublicationWe examine whether CYP3A4 overexpression influences the rate and pattern of antitumor imidazoacridinone C-1311 metabolism, in relation to the impact of this overexpression on cell cycle progression and final cellular response of CHO cells following C-1311 treatment. Methods: Three CHO cell lines: CHO-WT, wild type, CHO-HR, overexpressing cytochrome P450 reductase (CPR) and CHO-HR-3A4, coexpressing CPR and CYP3A4 were applied....
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Drug-drug interaction potential of antitumor acridine agent C-1748: The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7
PublicationBackground The compound 9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine (C-1748), the promising antitumor agent developed in our laboratory was determined to undergo phase I metabolic pathways. The present studies aimed to know its biotransformation with phase II enzymes – UDP-glucuronosyltransferases (UGTs) and its potential to be engaged in drug-drug interactions arising from the modulation of UGT activity. Methods UGT-mediated...
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Prospective study of brentuximab vedotin in relapsed/refractory Hodgkin lymphoma patients who are not suitable for stem cell transplant or multi-agent chemotherapy
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Recent Patents on Endocrine Metabolic & Immune Drug Discovery
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The organophosphorus sulfenyl bromides as versatile reagents for cysteine derivatives functionalization by unsymmetrical disulfide bond formation
PublicationWe have developed a convenient method for the synthesis of L-cysteine unsymmetrical disulfides under mild conditions with good to excellent yields. Described method is based on the straightforward preparation of the organophosphorus sulfenyl bromide readily available from bis-(5,5-dimethyl-2-thiono-1,3,2-dioxaphosphorinanyl) disulfide. The unsymmetrical disulfides can be obtained for L-cysteine derivatives and thiols bearing neutral...
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Model of identification of events and accident scenarios for a method of risk and safety assessment of ships in damaged conditions
PublicationW pracy opisano podstawowe problemy związane z identyfikacją zdarzeń i scenariuszy wypadku oraz modelowaniem ryzyka dla alternatywnej metody oceny bezpieczeństwa statków w stanie uszkodzonym. Zastosowano podejście do bezpieczeństwa statków oparte na ocenie zachowania się statku i ocenie ryzyka wypadku. Wskazano możliwości zastosowania modelowania do analizy bezpieczeństwa statków na etapie projektowania, w czasie eksploatacji i...
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Professional activity, gender and disease-related emotions: The impact on parents' experiences in caring for children with phenylketonuria
PublicationIntroduction: Clinical management of rare diseases often fails to acknowledge the challenges faced by caregivers.Whilst management of phenylketonuria (PKU) may not be considered as dire as other conditions, most studiesprimarily concentrate on clinical issues, dietary adherence, or the quality of life of the PKU patients, leavingcaregivers in the background. The aim of the study was to evaluate the psychosocial...
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Telomere Length and Risk of Major Adverse Cardiac Events and Cancer in Obstructive Sleep Apnea Patients
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Trinuclear Complexes Derived from R/S Schiff Bases – Chiral Single‐Molecule Magnets
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Trinuclear Complexes Derived from R/S Schiff Bases – Chiral Single‐Molecule Magnets
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The determinants of the Region's and its SMEs' Competitive Position in the Context of Mega Events - the Case of the Euro 2012
PublicationIn this paper a modified Preuss model was used to assess the factors to enhance the competitiveness of the region and the SMEs located in the region. To accomplish the above, six types of event-structure were applied: infrastructure, knowledge, networks, culture, image and emotions. They were described in detail in reference to the case of Euro 2012 in Poland in general and Pomeranian region in particular. Finally the Authors take...
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Evaluating the challenges and needs of parents caring for children with Williams syndrome: A preliminary study from Poland
PublicationBackground: Although physical, cognitive and behavioural manifestations of Williams syndrome(WS) affect every dimension of caregivers lives, no studies on the parental experiences of caringfor a WS child have to date been carried out in Poland.Methods: In order to identify the challenges and needs of Polish carers of WS children a survey wasconducted...
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Application of a commercially available derivatization instrument and commonly used reagents to HPLC on-line determination of antioxidants
PublicationThis study demonstrates the potential of a commercially available derivatization instrument coupled with HPLC for separation and on-line determination of antioxidants detected with widely used screening reagents - DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) or FCR (Folin-Ciocalteu's phenol reagent ). As the result of optimization, key parameters of the analytical procedure,...
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Detection, classification and localization of acoustic events in the presence of background noise for acoustic surveillance of hazardous situations
PublicationEvaluation of sound event detection, classification and localization of hazardous acoustic events in the presence of background noise of different types and changing intensities is presented. The methods for discerning between the events being in focus and the acoustic background are introduced. The classifier, based on a Support Vector Machine algorithm, is described. The set of features and samples used for the training of the...
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An investigation on the chemistry of the R2P=P ligand: reactions of a phosphanylphosphinidene complex of tungsten(VI) with electrophilic reagents
PublicationThe nucleophilic properties of the title compound [(2,6-i-Pr2C6H3N)2(Cl)W(η2-t-Bu2PvP)]Li·3DME (1) were investigated in reactions with selected electrophilic reagents such as MeI, M(CO)5THF (M = Cr, Mo, W), AlCl3, and GaCl3. Methylation of 1 by MeI yields phosphanylphosphido complexes [(2,6-i-Pr2C6H3N)2W(X)(1,2-η-t-Bu2PvP–CH3)] (X = Cl, I) (2-Cl/2-I) with the formation of a new P–C bond. Moreover, 1 reacts with electrophilic compounds...
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The central server of the Border Guard's distributed multimedia system for monitoring and visualisation of ongoing and archival events
PublicationThe paper presents the architecture and functionalities of the central server (CENTER) of the distributed system for the Polish Border Guard (BG) for monitoring maritime areas. The overall system has been extended to incorporate, apart from map data, also different multimedia elements such as video from cameras or audio from telephone connections operated by BG units. This requires new system elements: Archive Servers for storing...
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The use of innovative application in creating new marketing space for cultural and entertainment events in the local market
PublicationThe following article describes the problems concerning marketing of mass events in the local market and potential solutions. In the first part the barriers that occur in communication between the organizers and the articipants are defined. In the process of identifying problems the results of research conducted for the needs article were used. In following sections the solution with use of Smartphone app is shown. The features that...
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Why set of experience knowledge structure can be considered a knowledge representattion for formal decision events?
PublicationOmówiono zasady reprezentacji wiedzy przy pomocy zbioru dośwadczeń. Uzasadniono wybór takiej reprezentacji na tle badańliteraturowych.
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Professional activity, gender and disease-related emotions: The impact on parents' experiences in caring for children with phenylketonuria
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Activity of Patents in Fuel Cells and Hydrogen Production in the Context of Passenger Car Fleet in the V4 Countries
PublicationThe hydrogen market in the world today is capable ovule and em-pirical evidence on activity of patents in fuel cells and hydrogen production islimited so far. Patent applications in zero-emission mobility in the aspect of fuelcells include: DAFC/DMFC&DMFC, PEMFC, SOFC, AFC, PAFC. As for thepatents relating to the hydrogen production, they concern low carbon, electrol-ysis and inorganic. The purpose of the study was to investigate...
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NADPH Oxidase Gene Polymorphism is Associated with Mortality and Cardiovascular Events in 7-Year Follow-Up
PublicationThe CYBA gene encodes the regulatory subunit of NADPH oxidase, which maintains the redox state within cells and in the blood vessels. That led us to investigate the course of coronary artery disease (CAD) with regards to CYBA polymorphisms. Thus, we recruited 1197 subjects with coronary atherosclerosis and observed them during 7-year follow-up. Three CYBA polymorphisms: c.214C>T (rs4673), c.-932G>A (rs9932581), and c.*24G>A (1049255)...
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A framework of open government data (OGD) e-service quality dimensions with future research agenda
PublicationPurpose This research paper aims to present a framework of open government data (OGD) relating to e-service quality dimensions. In addition, it provides a research agenda for the e-service delivery of OGD. Design/methodology/approach A literature review pertaining to e-service quality with special reference to e-government was delivered to deduce the key dimensions of e-service quality for OGD. Findings Five e-service quality dimensions...
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The most important elements of the social package that guide students of Wrocław University of Science and Technology when choosing their first job
Open Research DataThis dataset contains the results of research that were carried out by the Wrocław University of Science and Technology in March and April 2016, using an anonymous "on-line" questionnaire. 1,320 people took part in the study entitled "My ideal employer" - students and doctoral students of all faculties of the university (including those fields of study...
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Other specified bacterial agents as the cause of diseases classified to other chapters - Female, 55 - Tissue image [5050730010502011]
Open Research DataThis is the histopathological image of STOMACH tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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International Workshop on Intelligent Agents
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IEEE Symposium on Intelligent Agents
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Study of Bioreductive Anticancer Agent RH-1-Induced Signals Leading the Wild-Type p53-Bearing Lung Cancer A549 Cells to Apoptosis
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Altered circadian genes expression in breast cancer tissue according to the clinical characteristics
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