Filters
total: 8128
-
Catalog
- Publications 6164 available results
- Journals 66 available results
- Conferences 4 available results
- Publishing Houses 2 available results
- People 118 available results
- Inventions 7 available results
- Projects 15 available results
- Laboratories 2 available results
- Research Teams 2 available results
- Research Equipment 1 available results
- e-Learning Courses 981 available results
- Events 15 available results
- Open Research Data 751 available results
displaying 1000 best results Help
Search results for: IBUPROFEN AND ITS METABOLITES
-
CTS-Clinical and Translational Science
Journals -
ETS Research Report Series
Journals -
Phase I and phase II metabolism simulation of antitumor-active 2-hydroxyacridinone with electrochemistry coupled on-line with mass spectrometry.
PublicationHere, we report the metabolic profile and the results of associated metabolic studies of 2-hydroxyacridinone (2-OH-AC), the reference compound for antitumor-active imidazo- and triazoloacridinones. Electrochemistry coupled with mass spectrometry was applied to simulate the general oxidative metabolism of 2-OH-AC for the first time. The reactivity of 2-OH-AC products to biomolecules was also examined. The usefulness of the electrochemistry...
-
Acridinone antitumor agents, C-1305 and C-1299 are metabolized rather by flavin-containing monooxygenases and UDP-glucuronosyltransferases than cytochromes P450
PublicationStwierdzono, że to monooksygenazy flawinowe, a nie enzymy cytochromu P450, są głównymi enzymami frakcji mikrosomalnej, odpowiedzialnymi za detoksyfikacyjny metabolizm dwóch badanych pochodnych triazoloakrydonu. Dodatkowo C-1305 ulega sprzęganiu w czasie drugiej fazy metabolizmu z kwasem glukuronowym do postaci O-glukuronidu
-
Topographic AFM imaging of the leaf surface with magnification of details of its morphological structure
Open Research DataTopographic imaging of the leaf surface with magnification of details of its morphological structure. Measurements in semi-contact mode. NTEGRA Prima (NT-MDT) device. NSG 01 probe.
-
Marek Kubale prof. dr hab. inż.
PeopleDetails concerning: Qualifications, Experiences, Editorial boards, Ph.D. theses supervised, Books, and Recent articles can be found at http://eti.pg.edu.pl/katedra-algorytmow-i-modelowania-systemow/Marek_KubaleGoogle ScholarSylwetka prof. Marka Kubalego Prof. Marek Kubale pracuje na Wydziale ETI Politechniki Gdańskiej nieprzerwanie od roku 1969. W tym czasie napisał ponad 150 prac naukowych, w tym ponad 40 z listy JCR. Ponadto...
-
The potential of historical railway infrastructure, possibilities of its adaptation on the examples of railway water towers
Publication...
-
Sparse vector autoregressive modeling of audio signals and its application to the elimination of impulsive disturbances
PublicationArchive audio files are often corrupted by impulsive disturbances, such as clicks, pops and record scratches. This paper presents a new method for elimination of impulsive disturbances from stereo audio signals. The proposed approach is based on a sparse vector autoregressive signal model, made up of two components: one taking care of short-term signal correlations, and the other one taking care of long-term correlations. The method...
-
Forced Degradation Studies of Ivabradine and In Silico Toxicology Predictions for Its New Designated Impurities
PublicationAll activities should aim to eliminate genotoxic impurities and/or protect the API against degradation. There is a necessity to monitor impurities from all classification groups, hence ivabradine forced degradation studies were performed. Ivabradine was proved to be quite durable active substance, but still new and with insufficient stability data. Increased temperature, acid, base, oxidation reagents and light were found to cause...
-
Composition of the Essential Oil of Bidens tripartita L. Roots and Its Antibacterial and Antifungal Activities
Publication -
Chemometric analysis of UV-Vis spektra of associated forms of Amphotericin B and its derivatives
PublicationPrzedmiotem badań był proces agregacji nowych pochodnych antybiotyku polienowego Amfoterycyny B. Do śledzenia procesu agregacji wykorzystano spektroskopię absorpcyjną w zakresie widzialnym i bliskiego nadfioletu. Zastosowanie zaawansowanych technik chemometrycznych pozwoliło na dogłębną analizę agregacji tych pochodnych, co pozwoliło na wyciągniecie następujacych wniosków: i) w przypadku wszystkich pochodnych przy stężeniach poniżej...
-
A method of supporting client-provider cooperation in software acquisition processes and its evaluation criteria
PublicationArtykuł przedstawia metodę Wspomagania Interakcji KLienta i Dostawcy Oprogramowania (WIKLIDO). Metoda ta została zpowodzeniem zastosowana w dwóch studiach przypadków w komercyjnych projektach pozyskiwania oprogramowania. Artykuł wyjaśnia w jaki sposób metoda wykorzystuje środki modelowania do usystematyzowania interakcji pomiędzy klientem i dostawcą oprogramowania. Przedstawia również w jaki sposób wykorzystano podejście GQM (ang....
-
Effect of Chitosan Deacetylation on Its Affinity to Type III Collagen: A Molecular Dynamics Study
PublicationThe ability to form strong intermolecular interactions by linear glucosamine polysaccharides with collagen is strictly related to their nonlinear dynamic behavior and hence bio-lubricating features. Type III collagen plays a crucial role in tissue regeneration, and its presence in the articular cartilage affects its bio-technical features. In this study, the molecular dynamics methodology was applied to evaluate the effect of...
-
Empirical Analysis of Forest Penalizing Attribute and Its Enhanced Variations for Android Malware Detection
Publication -
Coexpression of human chorionic gonadotropin beta subunit and its receptor in nontrophoblastic gynecological cancer
Publication -
Antimicrobial and antioxidant activities of Cinnamomum cassia essential oil and its application in food preservation
Publication -
BIODIVERSITY OF YEASTS ISOLATED FROM CAVES OF THE POLISH TATRA MOUNTAINS, AND ITS BIOTECHNOLOGICAL POTENTIAL
PublicationMost of the Earth’s biosphere is permanently or periodically exposed to temperatures below 5°C. Cold habitats harbor a wide diversity of psychrophiles. For many years Antarctica has been the geographic area preferred for studying the diversity and properties of cold-adapted microorganisms. However, the non-Antarctic habitats like Himalayas or Alps are also extensively explored. The Tatra Mountains are Europe’s second-highest massif...
-
Impact of Euro 2012 on the Pomeranian Region and Its Small and Medium Enterprises in Terms of Competitiveness
Publication..
-
Eveningness and its possibility of predicting burnout symptoms among physicians and nurses – preliminary results
Publication -
Issue of changes in technical states of a diesel engiene as the result of wear of its tribological systems
PublicationWskazano na konieczność rozpatrywania procesów obciążeń i zużywania układów tribologicznych silników o zapłonie samoczynnym (a zatem również zmiany ich stanów) w warunkach rzeczywistych jako procesów losowych. Oznacza to, że matematycznymi modelami tych procesów mogą być funkcje losowe o argumencie, którym jest czas (t) i o wartościach, którymi są zmienne losowe takie jak obciążenia i zużycia poszczególnych układów tribologicznych....
-
Expression of goose parvovirus whole VP3 protein and its epitopes in Escherichia coli cells
PublicationThe aim of this study was the expression of goose parvovirus capsid protein (VP3) and its epitopes in Escherichia coli cells. Expression of the whole VP3 protein provided an insufficient amount of protein. In contrast, the expression of two VP3 epitopes (VP3ep4, VP3ep6) in E. coli, resulted in very high expression levels. This may suggest that smaller parts of the GPV antigenic determinants are more efficiently expressed than the...
-
Associations of ESR1 and ESR2 gene polymorphisms with metabolic syndrome and its components in postmenopausal women
Publication -
Solvent effects on fluorescence properties of protochlorophyll and its derivatives with various porphyrin side chains
Publication -
Potential pitfalls of propofol target controlled infusion delivery related to its pharmacokinetics and pharmacodynamics
Publication -
An analysis and evaluation of the WeFold collaborative for protein structure prediction and its pipelines in CASP11 and CASP12
Publication -
The effect of the type of substrate and its surface treatment on the pull-off strength of gypsum plasters
Publication -
Role of Myeloid-derived suppressor cell (MDSC) in autoimmunity and its potential as a therapeutic target
Publication -
The critical rotational speed of circular saw: simple measurement method and its practical implementations.
PublicationProducenci pił tarczowych są zobligowani do podawania ich dopuszczalnych prędkości obrotowych. Jednakże, umieszczane przez nich prędkości na piłach są często bliskie prędkościom krytycznym lub je przewyższają. Przecinanie takimi narzędziami może być więc niebezpieczne dla obsługującego. Praca przedstawia prostą metodologię wyznaczania prędkości obrotowych krytycznych pił tarczowych. Badania były prowadzone z wykorzystaniem technik...
-
Adaptive Method of Raster Images Compression and Examples of Its Applications in the Transport Telematic Systems
PublicationThe paper presents a concept and exemplary application of an adaptive method of compression of raster images which may be applied, i.a. in ITS systems. The described method allows to improve the efficiency of systems belonging to ITS category, which require transmission of large volumes of image data through telecommunications networks. The concept of the adaptive method of compression of raster images described in the paper uses...
-
Dielectric properties of modified graphene oxide filled polyurethane nanocomposites and its correlation with rheology
PublicationThis study aims at investigating the dynamic mechanical, dielectric and rheological properties of reinforced polyurethane (PU) nanocomposites containing hydrophilic graphene oxide (GO) and/or hydrophobic modified graphene oxide (mGO) sheets. The organic modification of GO was performed with 4,4′-methylenebis (phenyl isocyanate) (MDI) and the samples were prepared by solvent mixing. We found that addition of mGO provides a more...
-
User-generated images and its impact on consumer-based brand equity and on purchase intention
PublicationResearchers and brand managers have limited knowledge of the effects that different types of user-generated content (UGC) have on consumers’ perception of brands and behavior. In this study we investigated 301 authors of a specific category of UGC, i.e., user-generated images (UGI) on a social networking site to confirm the relationships of four drivers reported in literature (co-creation, empowerment, community, and self-concept)...
-
Analysis of positioning error and its impact on high frequency properties of differential signal coupler
PublicationThis paper presents the analysis of the effect of differential signal coupler positioning accuracy on its high frequency performance parameters for contact-less high speed chip-to-chip data transmission on PCB application. Our considerations are continuation of the previous works on differential signal coupler concept, design methodology and analysis for high speed data transmission monitoring. The theoretical analysis of possible...
-
Implication of the disulfide bridge in trypsin inhibitor SFTI-1 in its interaction with serine proteinases
PublicationFourteen monocyclic analogues of trypsin inhibitor SFTI-1 isolated from sunflower seeds were synthesized by the solid-phase method. The purpose of this work was to establish the role of a disulfide bridge present in inhibitor's side chains of Cys3 and Cys11 in association with serine proteinases. This cyclic fragment was replaced by the disulfide bridges formed by L-pencillamine (Pen), homo-L-cysteine (Hcy), N-sulfanylethylglycine...
-
Territorial Extrapolation of Basic Data as a Solution of the Problem of Its Deficiency during Mass Appraisal
Publication -
The role of the LB structural loop and its interactions with the PDZ domain of the human HtrA3 protease
Publication -
Atmospheric emission of nitric oxide and processes involved in its biogeochemical transformation in terrestrial environment
Publication -
Seasonal differences in the content of phenols and pigments in thalli of freshwater Cladophora glomerata and its habitat
Publication -
Revelations About Carotid Body Function Through its Pathological Role in Resistant Hypertension
Publication -
Health Risk Assessment of Exposure to Nitrates in Drinking Water Depending on the Source of Its Origin
Publication -
Cadmium in edible plants from Silesia, Poland, and its implications for health risk in populations
Publication -
Plants of the Genus Terminalia: An Insight on Its Biological Potentials, Pre-Clinical and Clinical Studies
Publication -
Forced degradation studies of ivabradine and in silico toxicology predictions for its new designated impurities
PublicationAll activities should aim to eliminate genotoxic impurities and/or protect the API againstdegradation. There is a necessity to monitor impurities from all classification groups,hence ivabradine forced degradation studies were performed. Ivabradine was provedto be quite durable active substance, but still new and with insufficient stability data.Increased temperature, acid, base, oxidation reagents and...
-
Precise regulation of defect concentration in MOF and its influence on photocatalytic overall water splitting
Publication -
Nanosized zinc, epigenetic changes and its relationship with DMBA induced breast cancer in rats
Publication -
The Role and Importance of a Footbridge Suspended over a Highway in the Opinion of Its Users—Trabzon (Turkey)
Publication -
Locally Adaptive Cooperative Kalman Smoothing and Its Application to Identification of Nonstationary Stochastic Systems
PublicationOne of the central problems of the stochastic approximation theory is the proper adjustment of the smoothing algorithm to the unknown, and possibly time-varying, rate and mode of variation of the estimated signals/parameters. In this paper we propose a novel locally adaptive parallel estimation scheme which can be used to solve the problem of fixed-interval Kalman smoothing in the presence of model uncertainty. The proposed solution...
-
Expression of Deinococcus geothermalis Trehalose Synthase Gene in Escherichia coli and Its Enzymatic Properties
PublicationA novel trehalose synthase gene from Deinococcus geothermalis (DSMZ 11300) containing 1,692 bp reading-frame encoding 564 amino acids was amplified using PCR. The gene was ligated into pET30Ek/LIC vector and expressed after isopropyl alfa-D-thiogalactopyranoside induction in Escherichia coli BL21(DE3)pLysS. The recombinant trehalose synthase (DgeoTreS) containing a His6 tag at the C-terminus was purified by metal affinity chromatography...
-
Investigation of Noise-Induced Instabilities in Quantitative BiologicalSpectroscopy and Its Implications for Noninvasive Glucose Monitoring
PublicationPrzedstawiono sposób oceny błędów jakie pojawiają się przy estymacji poziomu glukozy we krwi za pomocą pomiarów widm Ramana. Zastosowano nieliniowy algorytm regresji według maszyny wektorów nośnych. Określono jak na wyznaczenie stężenia glukozy we krwi wpływają błędy pomiarów widmach Ramana oraz błędów pomiaru referencyjnego stężenia glukozy podczas etapu kalibracji modelu (etapu uczenia algorytmu maszyny wektorów nośnych). Określono...
-
Thermal Imaging Aided Assessment of a State of Equipment Under Test and its Protecting Elements
PublicationIn the paper the investigation results using thermal imaging methods are presented. The examined is a state of equipment under test and its protecting components. The estimations are done for the chosen protecting elements during surge immunity testing. The results show that the thermal imaging methods are useful for early detection of possible damage of a device being tested
-
Synthesis and antimicrobial activity of 6-sulfo-6-deoxy-D-glucosamine and its derivatives
Publication6-Sulfo-6-deoxy-D-glucosamine (GlcN6S), 6-sulfo-6-deoxy-D-glucosaminitol (ADGS) and their N-acetyl and methyl ester derivatives have been synthesized and tested as inhibitors of enzymes catalyzing reactions of the UDP-GlcNAc pathway in bacteria and yeasts. GlcN6S and ADGS at micromolar concentrations inhibited glucosamine-6-phosphate (GlcN6P) synthase of microbial origin. The former was also inhibitory towards fungal GlcN6P N-acetyl...