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Search results for: GLYCOLYSIS AGENT
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Deterministic rendezvous of asynchronous bounded-memory agents in polygonal terrains
PublicationTwo mobile agents, modeled as points starting at differentlocations of an unknown terrain, have to meet. The terrain is a polygon with polygonal holes. We consider two versions of this rendezvous problem: exact RV, when the points representing the agents have to coincide at some time, and epsilon-RV, when these points have to get at distance less than epsilon in the terrain. In any terrain, each agent chooses its trajectory, but...
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Concept of the mobile monitoring system for chemical agents control in the air
PublicationW artykule przedstawiono koncepcję mobilnego systemu monitoringu związków chemicznych zanieczyszczających powietrze. Nowością w przedstawionej koncepcji monitoringu jest pomiar zanieczyszczeń powietrza wzdłuż ciągów komunikacyjnych, co do tej pory nie jest realizowane. W tym celu przedstawiono propozycję rozwiązania stosunkowo małego, bezobsługowego modułu do pomiarów związków chemicznych, który z łatwością będzie montowany na...
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Quantum strategies for rendezvous and domination tasks on graphs with mobile agents
PublicationThis paper explores the application of quantum nonlocality, a renowned and unique phenomenon acknowledged as a valuable resource. Focusing on an alternative application, we demonstrate its quantum advantage for mobile agents engaged in specific distributed tasks without communication. The research addresses the significant challenge of rendezvous on graphs and introduces a distributed task for mobile agents grounded in the graph...
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A Review of Traffic Analysis Attacks and Countermeasures in Mobile Agents' Networks
PublicationFor traditional, message-based communication, traffic analysis has been already studied for over three decades and during that time various attacks have been recognised. As far as mobile agents’ networks are concerned only a few, specific-scope studies have been conducted. This leaves a gap that needs to be addressed as nowadays, in the era of Big Data, the Internet of Things, Smart Infrastructures and growing concerns for privacy,...
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Selection of derivatisation agents for chlorophenols determination with multicriteria decision analysis
PublicationThe paper shows very systematic method of selection of derivatisation agents for a given group of analytes. In this study 8 derivatisation agents are assessed for their capability to derivatise 8 chlorophenols. Multicriteria decision analysis is used to combine many objectives of derivatisation agents selection into single, easy to be interpreted numerical value. Three basic analyses were performed to obtain rankings with the aims...
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Constructing autonomous agents using the cognitive-emotional architecture of the mind
PublicationThe article discusses an important issue regarding the humanoid aspects of modern science related to the autonomy of systems and robotization. Particular attention is paid to the basic aspects of cognitive architecture. After a short introduction, the Intelligent Decision Making System, developed at the ETI Faculty of the Gdańsk University of Technology, is described.
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An Approach to Data Reduction for Learning from Big Datasets: Integrating Stacking, Rotation, and Agent Population Learning Techniques
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Long-term follow-up of MCL patients treated with single-agent ibrutinib: updated safety and efficacy results
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Interactive information and decision support system for urban and industrial air quality management based on multi-agent system
PublicationThis article presents conception of interactive information and decision support system for urban and industrial air quality management. The emphasis of the project is on real-time analysis and multi-media information, and the support of distributed and mobile clients through the Internet. The approach integrates meteorological data and forecasts, air quality and emission monitoring, dynamic 3D simulation modelling and forecasting,...
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Dimethyl(3,3,3-trifluoropropyl)silyldiethylamine—A new silylating agent for the derivatization of β-blockers and β-agonists in environmental samples
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Imidazoacridinone antitumor agent, c-1311, as a selective mechanism-based inactivator of human recombinant cytochrome P450 1A2
PublicationPrzedmiotem badań była przeciwnowotworowa pochodna imidazoakrydonu, C-1311, która pod nazwą Symadex R, znajduje się aktualnie w II fazie badań klinicznych. Wcześniejsze wyniki pozwoliły stwierdzić, że związek ten jest selektywnym inhibitorem niektórych enzymów cytochromowych. Podjęto zatem próbę wyjaśnienia mechanizmu inhibicji izoenzymów cytochromu P450 przez C-1311. Wykazano, że utrata aktywności katalitycznej obu izoenzymów...
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Trustworthiness and Subversion in Large Service- Oriented Multi-Agent Systems under Virtual Anonymity and Blind Provider Selection
PublicationTo promote honest service provision in multi-agent systems, a Computational Trustworthiness and Rating scheme collects service ratings and computes agents' trustworthiness levels (TLs). Studies of existing schemes fail to reflect closed-loop dynamics of TLs arising from the mutual influence of agents' behavior and TLs, and to capture relevant properties. Recent simulative and analytical models produce results tied to a particular...
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Ireneusz Czarnowski Prof.
PeopleIRENEUSZ CZARNOWSKI is a graduate of the Faculty of Electrical Engineering at Gdynia Maritime University. He gained a doctoral degree in the field of computer science at Poznan University of Technology and a postdoctoral degree in the field of computer science at Wroclaw University of Science and Technology. Since 1998 is associated with Gdynia Maritime University, currently is a professor of computer science in the Department...
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Performance analysis of untraceability protocols for mobile agents using an adaptable framework
PublicationArtykuł przedstawia środowisko oceny wydajności protokołów ochrony przed tropieniem agentów mobilnych oraz wyniki analiz przeprowadzonych za jego pomocą. Chociaż środowisko projektowano i implementowano z myślą o ewaluacji zaproponowanych przez nas protokołów ochrony przed tropieniem, w trakcie badań okazało się, że może ono zostać również wykorzystane do badań całej klasy protokołów bezpieczeństwa dla agentów mobilnych. Chodzi...
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Synthesis of conjugates of Combretastatin A-4 with tuftsin derivatives as potential anticancer agents
PublicationZaprezentowano syntezę nowych koniugatów Combretastatyny A-4 z pochodnymi tuftsyny i retro-tuftsyny, jako potencjalnych związków przeciwnowotworowych.
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Exposure status of sea-dumped chemical warfare agents in the Baltic Sea
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The Baltic Sea as a dumping site of chemical munitions and chemical warfare agents
PublicationW pracy przedstawiono problem składowania w Morzu Bałtyckim aminucji chemicznej i bojowych środków trujących. Przedstawiono typy oraz charakterystykę BST składowanych na dnie Morza Bałtyckiego. Omówiono potencjalne zagrożenia dla środowiska abiotytcznego oraz dla organizmów żywych związanych z tego typu składowiskami. Przedstawiono również podstawowe informacje o procedurach analitycznych, które mogą być wykorzystane do wykrywania...
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Synthesis of conjugates of amino-combretastatin with tuftsin derivatives as potential anticancer agents
PublicationOpisano syntezę nowych koniugatów 3'-N-(tuftsyno lub retro-tuftsyno)-amino-kombretastatyny jako potencjalnych związków przeciw-nowotworowych. Do syntezy amino-kombretastatyny (amino-CA-4) wykorzystano reakację Wittiga a koniugatów metodę DPPA. Mamy nadzieję, że połączenie pochodnych tuftsyny z amino-CA-4 wpłynie na polepszenie właściwości terapeutycznych CA-4.
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Biological fluids as a source of information on the exposure of man to envinonmental chemical agents.
PublicationWiele związków (min. lotne związki chlorowcoorganiczne, metale) ma szkodliwy wpływ na tkanki i narządy organizmu ludzkiego, wywołując nieodwracalne zmiany chorobowe. W celu określenia zagrożenia zawodowego coraz częściej wykonuje się pomiar stężeń substancji chemicznych i ich metabolitów w płynach biologicznych - moczu, krwi, rzadziej w mleku matki, żółci, ślinie, czy też spermie. Aby oznaczyć poziomy tych stężeń, pobrane próbki...
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Synthesis and Biological Evaluation of Acridine/Acridone Analogs as Potential Anticancer Agents
PublicationAcridine and acridone analogues were prepared by Ullmann condensation and then cyclization reaction. As a result of nucleophilic substitution reaction 1-nitro-9-phenoxyacridine or 1-chloro-4-nitro-9(10H)-acridone with the corresponding peptides, the planned acridine derivatives (10a-c, 12, 17-a-d, 19) have been obtained. The cytotoxic activity of the newly obtained analogs were evaluated against melanotic (Ma) and amelanotic (Ab)...
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Bilateral multi-issue negotiation of execution contexts by proactive document agents
PublicationA proactive document can react to its actual environment by autonomously selecting and performing actions integrated into its body and interact with its user. When migrating over a network of execution devices it may encounter diverse execution contexts, each one set up according to temporal characteristics of a receiving device and preferences of its owner. A concept to augment proactive documents with negotiation capability is...
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Novel amides of mycophenolic acid and some heterocyclic derivatives as immunosuppressive agents
PublicationThe group of new amide derivatives of mycophenolic acid (MPA) and selected heterocyclic amines was synthesised as potential immunosuppressive agents functioning as inosine-5'-monophosphate dehydrogenase (IMPDH) uncompetitive inhibitors. The synthesis employed uronium-type activating system (TBTU/HOBt/DIPEA) while or phosphonic acid anhydride method (T3P/Py) facilitating amides to be obtained in moderate to excellent yields without...
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Formation of chlorinated breakdown products during degradation of sunscreen agent, 2-ethylhexyl-4-methoxycinnamate in the presence of sodium hypochlorite
PublicationIn this study, a new degradation path of sunscreen active ingredient, 2-ethylhexyl-4-methoxycinnamate (EHMC) and 4-methoxycinnamic acid (MCA) in the presence of sodium hypochlorite (NaOCl), was discussed. The reaction products were detected using gas chromatography–mass spectrometry (GC-MS). Since HOCl treatment leads to more polar products than EHMC, application of polar extracting agents, dichloromethane and ethyl acetate/n-hexane...
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Imidazoacridinone antitumor agent C-1311 as a selective mechanism- based inactivator of human cytochrome P450 1A2 and 3A4 isoenzymes.
Publication5-Diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311), a promising antitumor agent that is also active against autoimmune diseases, was determined to be a selective inhibitor of the cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Therefore, C-1311 might modulate the effectiveness of other drugs used in multidrug therapy. The present work aimed to identify the mechanism of the observed C-1311-mediated inactivation of CYP1A2...
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Phytotoxic Activity of Metabolites Isolated from Rutstroemia sp.n., the Causal Agent of Bleach Blonde Syndrome on Cheatgrass (Bromus tectorum)
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Enhanced Activity and Sustained Release of Protocatechuic Acid, a Natural Antibacterial Agent, from Hybrid Nanoformulations with Zinc Oxide Nanoparticles
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Pre-clinical evaluation of 1-nitroacridine derived chemotherapeutic agent that has preferential cytotoxic activity towards prostate cancer
PublicationPraca zawiera wyniki badań przedklinicznych pochodnej 1-nitroakrydyny C-1748 wobec komórek ludzkiego raka prostaty CaP in vitro, jak i przeszczepialnego na zwierzęta. W oparciu o fosforylację histonu H2AX jako markera podwójnych cięć DNA wykazano, że C-1748 jest bardziej aktywny w komórkach CaP niż HL60. Zidentyfikowano poza tym receptor androgenny (AR) jako cel molekularny badanego związku. W doświadczeniach na zwierzętach stwierdzono...
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The influence of the choice of the cross linking agent on the electrical properties of polyethyleneimine based humidity sensors. Optoelectronic and Electronic Sensors V.
PublicationW pracy przedstawiono wyniki badań impedancyjnych polimerowych czujników wilgotności.Czujniki zostały wykonane z chemicznie modyfikowane polietylenoiminy. Przedstawiono wpływ środków sieciujących na właściwości czujników.
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A facile structural manipulation strategy to prepare ultra-strong, super-tough, and thermally stable polylactide/nucleating agent composites
PublicationPolylactide (PLA) is a biodegradable thermoplastic widely used in diferent felds, but it should be adequately modifed considering high-performance applications. However, the current processes for developing PLA materials achieve high strength at the expense of toughness or ductility of the materials. Therefore, there is need to develop new strategies for generation of PLA materials with high strength, great toughness, good ductility,...
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Central Nervous System Agents in Medicinal Chemistry
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Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry
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Anti-Cancer Agents in Medicinal Chemistry
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Practical Application of Intelligent Agents and Multi-Agent Technology Conference
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European Workshop on Modelling Autonomous Agents in a Multi-Agent World
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Collision-free network exploration
PublicationMobile agents start at different nodes of an n-node network. The agents synchronously move along the network edges in a collision-free way, i.e., in no round two agents may occupy the same node. An agent has no knowledge of the number and initial positions of other agents. We are looking for the shortest time required to reach a configuration in which each agent has visited all nodes and returned to its starting location. In...
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Ts2631 Endolysin from the Extremophilic Thermus scotoductus Bacteriophage vB_Tsc2631 as an Antimicrobial Agent against Gram-Negative Multidrug-Resistant Bacteria
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Efficacy and safety of idelalisib in patients with relapsed, rituximab- and alkylating agent-refractory follicular lymphoma: a subgroup analysis of a phase 2 study
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Single-agent MOR208 salvage and maintenance therapy in a patient with refractory/relapsing diffuse large B-cell lymphoma: a case report
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Capping Agent-Dependent Toxicity and Antimicrobial Activity of Silver Nanoparticles: An In Vitro Study. Concerns about Potential Application in Dental Practice
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Ts2631 Endolysin from the Extremophilic Thermus scotoductus Bacteriophage vB_Tsc2631 as an Antimicrobial Agent against Gram-Negative Multidrug-Resistant Bacteria
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Resistance of Escherichia coli and Enterococcus spp. to selected antimicrobial agents present in municipal
PublicationIn this study, the susceptibility to erythromycin (E) and to trimethoprim/sulfamethoxazole (SXT) among isolates of Enterococcus spp. and Escherichia coli was tested, respectively. Both fecal indicators were detected and isolated from raw(RW) and treated wastewater (TW) as well as from samples of activated sludge (AS) collected in a local wastewater treatment plant (WWTP). Biodiversity of bacterial community in AS was also monitored...
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Selected anionic and cationic surface active agents: case study on the Kłodnica sediments
PublicationSurface active agents (surfactants) are a group of chemical compounds, which are used as ingredients of detergents, cleaning products, cosmetics and functional products. After use, wastes containing surfactants or their degradation products are discharged to wastewater treatment plants or directly into surface waters. Due to their specific properties of SAAs, compounds are able to migrate between different environmental compartments...
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Natural Deep Eutectic Solvents as Agents for Improving Solubility, Stability and Delivery of Curcumin
PublicationPurpose Study on curcumin dissolved in natural deep eutectic solvents (NADES) was aimed at exploiting their beneficial properties as drug carriers. Methods The concentration of dissolved curcumin in NADES was measured. Simulated gastrointestinal fluids were used to determine the concentration of curcumin and quantum chemistry computations were performed for clarifying the origin of curcumin solubility enhancement in NADES. Results NADES...
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Learning and memory processes in autonomous agents using an intelligent system of decision-making
PublicationThis paper analyzes functions and structures of the memory that is an indispensable part of an Intelligent System of Decision-making (ISD), developed as a universal engine for autonomous robotics. A simplified way of processing and coding information in human cognitive processes is modelled and adopted for the use in autonomous systems. Based on such a knowledge structure, an artificial model of reality representation and a model...
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Exploring ontological approach for user requirements elicitation in design of online virtual agents
PublicationEffective user requirements elicitation is a key factor for the success of software development projects. There are many qualitative and quantitative research studies that promulgate particular methods and show the application of user requirements elicitation in particular domains. However, few try to eliminate the burden of ambiguity in gathered data, naturally occurring in different groups of stakeholders. This paper deals with...
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Overcome the tumor immunotherapy resistance by combination of the HDAC6 inhibitors with antitumor Immunomodulatory agents.
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Natural and synthetic acridines/acridones as antitumor agents: their biological activities and methods of synthesis.
PublicationPraca stanowi przegląd opisanych w literaturze chemicznej modyfikacji struktur naturalnych i syntetycznych pochodnych akrydyny i akrydonu. Artykuł obejmuje swym zakresem metody syntezy, a także wpływ budowy cząsteczek tych związków na ich aktywność przeciwnowotworową oraz mechanizm działania.
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In Search of Panacea—Review of Recent Studies Concerning Nature-Derived Anticancer Agents
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Exploring an Ontological Approach for User Requirements Elicitation in the Design of Online Virtual Agents
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Isothiocyanates as effective agents against enterohemorrhagic Escherichia coli: insight to the mode of action
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