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Wyniki wyszukiwania dla: mean value
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Higher Responsiveness to Rosuvastatin in Polygenic versus Monogenic Hypercholesterolemia: A Propensity Score Analysis
PublikacjaBackground: The monogenic defect in familial hypercholesterolemia (FH) is detected in ∼40% of cases. The majority of mutation-negative patients have a polygenic cause of high LDL-cholesterol (LDL-C). We sought to investigate whether the underlying monogenic or polygenic defect is associated with the response to rosuvastatin. Methods: FH Individuals were tested for mutations in LDLR and APOB genes. A previously established LDL-C-specific...
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Hyperbranched polyethylenimine functionalized silica/polysulfone nanocomposite membranes for water purification
PublikacjaHyperbranched polyethyleneimine functionalized silica (PEI-SiO2) nanoparticles with considerable hydrophilicity were synthesized and incorporated into a polysulfone (PSF)/dimethylacetamide (DMA)/polyvinylpyrrolidone (PVP) membrane casting solution in five different ratios to fabricate PEI-SiO2/PSF nanocomposite membranes using nonsolvent-induced phase separation. The hydrophilic PEI-SiO2 nanoparticles were characterized by TEM,...
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Field Evaluation of High Modulus Asphalt Concrete Resistance to Low-Temperature Cracking
PublikacjaHigh-modulus asphalt concrete has numerous advantages in comparison to conventional asphalt concrete, including increased resistance to permanent deformations and increased pavement fatigue life. However, previous studies have shown that the construction of road pavements with High Modulus Asphalt Concrete (HMAC) may significantly increase the risk of low-temperature cracking. Those observations were the motivation for the research...
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Spatial variability of the hydrochemistry of shallow groundwaters and surface waters of the Rensdyrbekken: A case study of a permafrost catchment in Bellsund (SW Spitsbergen, Svalbard)
PublikacjaProgressive climate change may have unpredictable consequences for the Arctic environment. Permafrost catchments off the west coast of Svalbard, described as “thin” and “warm,” are particularly sensitive to climate change. The interdisciplinary research on the hydrochemical response of surface and underground water functioning within a small permafrost catchment area focused on the determination of the impact of meteorological...
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Variable Data Structures and Customized Deep Learning Surrogates for Computationally Efficient and Reliable Characterization of Buried Objects
PublikacjaIn this study, in order to characterize the buried object via deep-learning-based surrogate modeling approach, 3-D full-wave electromagnetic simulations of a GPR model has been used. The task is to predict simultaneously and independent of each characteristic parameters of a buried object of several radii at different positions (depth and lateral position) in various dispersive subsurface media. This study has analyzed variable...
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Seasonal and spatial differences in metal and metalloid concentrations in the snow cover of Hansbreen, Svalbard
PublikacjaMetals and metalloids in snow on glaciers, depending on the season of deposition, may come from various sources: local rock dust (erosion of the geological substratum), marine aerosol, local human activity (e.g. fuel combustion, waste incineration) and long-range atmospheric transport. Hansbreen glacier, located close to the Polish Polar Station in Svalbard, is a perfect site to study metals and metalloids: it has complex geological...
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Globalized Parametric Optimization of Microwave Passive Components Using Simplex-Based Surrogates
PublikacjaOptimization-based parameter adjustment involving full-wave electromagnetic (EM) simulation models is a crucial stage of present-day microwave design process. In fact, rigorous optimization is the only reliable mean permitting to simultaneously handle multiple geometry/material parameters, objectives, and constraints. Unfortunately, EM-driven design is a computationally intensive endeavor. While local tuning is usually manageable,...
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Characterization of Bioactivity of Selective Molecules in Fruit Wines by FTIR and NMR Spectroscopies, Fluorescence and Docking Calculations
PublikacjaFourier transform infrared (FTIR) and proton nuclear magnetic resonance (1H NMR) spectroscopies were applied to characterize and compare the chemical shifts in the polyphenols’ regions of some fruit wines. The obtained results showed that FTIR spectra (1800–900 cm−1) and 1H NMR (δ 6.5–9.3 ppm) of different fruit wines can be used as main indices of the year of vintage and quality of fruit wines. In addition to the classical determination...
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RMS-based damage identification in adhesive joint between concrete beam and steel plate using ultrasonic guided waves
PublikacjaAdhesive joints have numerous applications in many branches of industry, such as civil engineering, automotive, aerospace and shipbuilding. As with most structural elements, adhesive joints can experience any damage mechanism, which induces the need for diagnostic testing. Ultrasonic waves are widely used for non-destructive inspection of many structures and their elements, including adhesive joints. Guided wave propagation method...
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Role of the Solvation Water in Remote Interactions of Hyperactive Antifreeze Proteins with the Surface of Ice
PublikacjaMost protein molecules do not adsorb onto ice, one of the exceptions being so-called antifreeze proteins. In this paper, we describe that there is a force pushing an antifreeze protein molecule away from the ice surface when it is not oriented with its ice-binding plane toward the ice and that this pushing force may be also present even when the protein is oriented with its ice-binding plane toward the ice. This force is absent...
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Determination of Odor Air Quality Index (OAQII) Using Gas Sensor Matrix
PublikacjaThis article presents a new way to determine odor nuisance based on the proposed odor air quality index (OAQII), using an instrumental method. This indicator relates the most important odor features, such as intensity, hedonic tone and odor concentration. The research was conducted at the compost screening yard of the municipal treatment plant in Central Poland, on which a self-constructed gas sensor array was placed. It consisted...
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Analysis of energy efficiency of suburban railway transport network
PublikacjaRising numbers of agglomeration residents cause increased need for people movement on daily basis. Because of congestion of local roads, air pollution and limited parking space, providing mass transit based on electric traction is reasonable. While the electric rail vehicles are considered highly efficient in themselves, they need to be analyzed as a part of a transport network, because energy consumption depends on operating conditions...
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Arctic catchment as a sensitive indicator of the environmental changes: distribution and migration of metals (Svalbard)
PublikacjaArctic regions experience metal pollution, despite their remote location, and the distribution and migration of those metals determine their potential impact on the local environment. Here, a High-Arctic catchment (Revelva, Svalbard) located remotely from human-induced pollution sources is studied with respect to the distribution and migration of chosen trace elements (Ag, Al, As, B, Ba, Bi, Ca, Cd, Co, Cr, Cu, Cs, Mo, Ni, Pb,...
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Invasive Assessment of the Myocardial Microcirculation during Beating Heart Coronary Artery Bypass Grafting
PublikacjaCoronary artery bypass grafting may be associated with several cardiac complications, including ischemia, acute myocardial infarction, arrhythmias, or hemodynamic instability. Accumulating evidence suggests that well-developed coronary collateral circulation may protect against adverse effects, including myocardial ischemia. Assessment of myocardial microvascular perfusion is, therefore, of great clinical interest in beating heart...
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Assessment of the Relationship between the Shape of the Lateral Meniscus and the Risk of Extrusion Based on MRI Examination of the Knee Joint
PublikacjaBackground Meniscus extrusion is a serious and relatively frequent clinical problem. For this reason the role of different risk factors for this pathology is still the subject of debate. The goal of this study was to verify the results of previous theoretical work, based on the mathematical models, regarding a relationship between the cross-section shape of the meniscus and the risk of its extrusion. Materials and Methods Knee...
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The importance of individual spray properties in performance improvement of a urea-SCR system employing flash-boiling injection
PublikacjaThe appropriate mixing of a urea–water solution (UWS) with exhaust gases in a selective catalytic reduction system is crucial to efficiently reduce nitrogen oxides and diminish the deposition of liquid wall film. One of the methods to enhance the mixing of the UWS with the exhaust gases is a flash-boiling injection. Its positive effect has been linked with a reduced Sauter mean diameter (SMD) and improved evaporation, but the...
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Ischemic stroke in general practice - risk factors, prognosis - prospective single center study
PublikacjaBackground. Ischemic stroke is one of the leading causes of death and disability in Poland, in the European Union and in the United States. Awareness related to the risk factors, particularly the modifiable ones, is of crucial importance in general practice and may improve early and long-term prognoses. Objectives. The aim of this study was to assess the risk factors and half-year survival rate in patients with ischemic stroke...
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Spatio-Temporal Validation of GNSS-Derived Global Ionosphere Maps Using 16 Years of Jason Satellites Observations
PublikacjaExisting ionospheric models perform very well in mapping the calm state of the ionosphere. However, the problem is accurately determining the total electron content (TEC) for disturbed days. Knowledge of the exact electron density is essential for single−frequency receivers, which cannot eliminate the ionospheric delay. This study aims to investigate temporal and spatial variability in the distribution of TEC based on differences...
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Defected Ag/Cu-MOF as a modifier of polyethersulfone membranes for enhancing permeability, antifouling properties and heavy metal and dye pollutant removal
PublikacjaIn this study, a novel bimetallic metal-organic framework (MOF) i.e. Ag/Cu-MOF was synthesized using a solvothermal method and later incorporated at different concentrations (0.1–2 wt%) using a phase inversion method for modification and antifouling property improvement of polyethersulfone (PES) membranes. The resulting Ag/Cu-MOF characteristics were investigated using different techniques, such as FTIR, XRD, FE-SEM and EDX. The...
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Damage detection in 3D printed plates using ultrasonic wave propagation supported with weighted root mean square calculation and wavefield curvature imaging
Publikacja3D printing (additive manufacturing, AM) is a promising approach to producing light and strong structures with many successful applications, e.g., in dentistry and orthopaedics. Many types of filaments differing in mechanical properties can be used to produce 3D printed structures, including polymers, metals or ceramics. Due to the simplicity of the manufacturing process, biodegradable polymers are widely used, e.g., polylactide (polylactide...
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Application of a Gas Sensor Array to Effectiveness Monitoring of Air Contaminated with Toluene Vapors Absorption Process
PublikacjaThis article demonstrates the application of a gas sensor array to monitor the effectiveness of the absorption process of air stream purification from odorous compounds (toluene vapors). A self-constructed matrix consisting of five commercially available gas sensors was used. Multiple linear regression (MLR) was selected as the statistical technique used to calibrate the matrice. Gas chromatography coupled with a flame ionization...
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Predicting seismic response of SMRFs founded on different soil types using machine learning techniques
PublikacjaPredicting the Maximum Interstory Drift Ratio (M-IDR) of Steel Moment-Resisting Frames (SMRFs) is a useful tool for designers to approximately evaluate the vulnerability of SMRFs. This study aims to explore supervised Machine Learning (ML) algorithms to build a surrogate prediction model for SMRFs to reduce the need for complex modeling. For this purpose, twenty well-known ML algorithms implemented in Python software are trained...
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Can bottom sediments be a prospective fertilizing material? A chemical composition analysis for potential reuse in agriculture.
PublikacjaEvery year huge amounts of bottom sediments are extracted worldwide, which need to be dis-posed. The recycling of bottom sediments for soil fertilization is in line with the long-promoted circular economy policy and enables the use of micro and macronutrients accumulated in sedi-ments for soil fertilization. When considering potential agricultural reuse of the dredge sediments, the first necessary step should be to analyze whether...
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Highly antifouling polymer-nanoparticle-nanoparticle/polymer hybrid membranes
PublikacjaWe introduce highly antifouling Polymer-Nanoparticle-Nanoparticle/Polymer (PNNP) hybrid membranes as multi-functional materials for versatile purification of wastewater. Nitrogen-rich polyethylenimine (PEI)-functionalized halloysite nanotube (HNT-SiO2-PEI) nanoparticles were developed and embedded in polyvinyl chloride (PVC) membranes for protein and dye filtration. Bulk and surface characteristics of the resulting HNT-SiO2-PEI...
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Cascade Object Detection and Remote Sensing Object Detection Method Based on Trainable Activation Function
PublikacjaObject detection is an important process in surveillance system to locate objects and it is considered as major application in computer vision. The Convolution Neural Network (CNN) based models have been developed by many researchers for object detection to achieve higher performance. However, existing models have some limitations such as overfitting problem and lower efficiency in small object detection. Object detection in remote...
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Effect of MgSO4 nutrition on Theobroma cacao L. susceptibility to Phytophthora megakarya infection
PublikacjaA new strategy to reduce the severity of black pod disease (BPD) in T. cacao plants using MgSO4 nutrition was investigated. The dynamics of the tolerance to BPD of 18 susceptible T. cacao plantlets coming from the cross (♀SNK64 × ♂UPA14) was monitored during weekly (8 weeks) supply of MgSO4 into the soil. Prior to MgSO4 application, disease scores of the 18 plantlets (in six sets of three plantlets per set) were varying between...
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Comparison of hydrochemistry and organic compound transport in two non-glaciated high Arctic catchments with a permafrost regime (Bellsund Fjord, Spitsbergen)
PublikacjaAn increase in air temperature related to climate change results in the retreat of glaciers, the degradation of permafrost, and the expansion of glacier-free areas in the polar regions. All these processes lead to changes in the Arctic landscape. They influence the hydrochemistry of streams and rivers fed by glaciers and thawing permafrost. In this study, we examine eighty two water samples from two non-glaciated catchments with...
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From the pills to environment – Prediction and tracking of non-steroidal anti-inflammatory drug concentrations in wastewater
PublikacjaThe extend of environment pollution by pharmaceuticals is in a stage that required more automatic and integrated solutions. The non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most popular pharmaceutical in the world and emerging pollutants of natural waters. The aim of the paper was to check the correlation of the sales data of selected NSAIDs (ibuprofen, naproxen, diclofenac) and their concentration in the WWTP...
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No Evidence for Sex-specificity in Vitamin C, E and Fatty Acid Content of Human Milk from Healthy Polish Mothers
PublikacjaHuman milk (HM) is a complex fluid that meets the nutritional needs of infants. Its composition idrfs associated with environmental, maternal, and foetal variables. It provides nutrients and bioactive substances, including cytokines, immunoglobulins, and constituents with antioxidative properties. Boys are reportedly more susceptible to oxidative stress. This study aimed to determine the relationship between infant sex and the...
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A Simple Neural Network for Collision Detection of Collaborative Robots
PublikacjaDue to the epidemic threat, more and more companies decide to automate their production lines. Given the lack of adequate security or space, in most cases, such companies cannot use classic production robots. The solution to this problem is the use of collaborative robots (cobots). However, the required equipment (force sensors) or alternative methods of detecting a threat to humans are usually quite expensive. The article presents...
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Integrate-and-fire models with an almost periodic input function
PublikacjaWe investigate leaky integrate-and-fire models (LIF models for short) driven by Stepanov and μ-almost periodic functions. Special attention is paid to the properties of the firing map and its displacement, which give information about the spiking behavior of the considered system. We provide conditions under which such maps are well-defined and are uniformly continuous. We show that the LIF models with Stepanov almost periodic...
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CPLFD-GDPT5: High-resolution gridded daily precipitation and temperature data set for two largest Polish river basins
PublikacjaThe CHASE-PL (Climate change impact assessment for selected sectors in Poland) Forcing Data–Gridded Daily Precipitation & Temperature Dataset–5 km (CPLFD-GDPT5) consists of 1951–2013 daily minimum and maximum air temperatures and precipitation totals interpolated onto a 5 km grid based on daily meteorological observations from the Institute of Meteorology and Water Management (IMGW-PIB; Polish stations), Deutscher Wetterdienst...
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A neural network based system for soft fault diagnosis in electronic circuits
PublikacjaW artykule przedstawiono system do diagnostyki uszkodzeń parametrycznych w układach elektronicznych. W systemie zaimplementowano słownikową metodę lokalizacji uszkodzeń, bazującą na pomiarach w dziedzinie częstotliwości przeprowadzanych za pomocą analizatora transmitancji HP4192A. Rozważono główne etapy projektowania systemu: definiowanie modelu uszkodzeń, wybór optymalnych częstotliwosci pomiarowych, ekstrakcję cech diagnostycznych,...
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Knowledge Management for Managing Crisis in Tourism: Theoretical insights
PublikacjaCOVID-19 has caused an unprecedented crisis affecting the entire tourism industry. Accommodation, food, and travel sectors have been affected by the decreased number of visitors, which had a ripple effect on the financial situation of the whole industry. The purpose of this work is a better understanding of the role of knowledge management in terms of mitigating the crisis in the tourism sector, as well as a development of the...
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Global defensive secure structures
PublikacjaLet S ⊂ V (G) for a given simple non-empty graph G. We define for any nonempty subset X of S the predicate SECG,S(X) = true iff |NG[X]∩S| ≥ |NG[X]\S|. Let H be a non-empty family of graphs such that for each vertex v ∈ V (G) there is a subgraph H of G containing v and isomorphic to a member of H. We introduce the concept of H-alliance extending the concept of global defensive secure structures. By an H-alliance in a graph G we...
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Opracowanie deskryptora nawierzchni drogowej do oceny oporu toczenia opon samochodowych
PublikacjaNa początku niniejszej pracy pt. „Opracowanie deskryptora nawierzchni drogowej do oceny oporu toczenia opon samochodowych” przedstawiono zagadnienia dotyczące oporów ruchu pojazdu. Omówiono metody zarówno drogowe, jak i laboratoryjne badań oporu toczenia opon samochodowych. Zaprezentowano przykładowe wartości współczynników oporu toczenia opon na różnych rodzajach nawierzchni. Kolejno omówiono metody pomiaru tekstury nawierzchni....
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Late Aortic Remodeling after Endovascular Repair of Complicated Type B Aortic Dissection—TEVAR Protects Only the Covered Segment of Thoracic Aorta
PublikacjaIntroduction: TEVAR is the preferred way of treatment of complicated type B aortic dissection. The purpose of the study was to assess the impact of TEVAR on aortic remodelling in the thoracic and abdominal segment in long-term follow-up. Methods: 23 patients with complicated type B aortic dissection were treated by TEVAR in years 2004-2012 in our Department. Aortic remodelling was rated based on preoperative and final follow-up...
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City and Urbanity in the Social Discourse
PublikacjaThe aim of our article is an attempt to present the concept of urbanity that has been shaped throughout centuries along with the development of European civilisation and now entered a new phase of social production of space based on cultural dimensions. The future of the majority of World’s population is connected currently with the urban life with the assumption that qualitative characteristics of life in the 21st century define...
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Spatial distribution of pharmaceuticals in conventional wastewater treatment plant with Sludge Treatment Reed Beds technology
PublikacjaPharmaceutical residues are an emerging environmental problem. It is strongly confirmed that pharmaceuticals are present in soils and environmental waters (surface, marine and even groundwater), and that wastewater treatment plant (WWTP) effluents are the main source of pharmaceuticals in the watershed. The aim of this studywas to recognize the spatial distribution and seasonal changes of selected pharmaceuticals in conventional WWTP...
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Multispectral Imaging Using Fluorescent Properties of Indocyanine Green and Methylene Blue in Colorectal Surgery—Initial Experience
PublikacjaIntroduction: Image-guided surgery is becoming a new tool in colorectal surgery. Intraoperative visualisation of different structures using fluorophores helps during various steps of operations. In our report, we used two fluorophores—indocyanine green (ICG), and methylene blue (MB)— during different steps of colorectal surgery, using one camera system for two separate near-infrared wavelengths. Material and methods: Twelve patients...
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Valorization of waste cabbage leaves by postharvest photochemical treatments monitored with a non-destructive fluorescence-based sensor
PublikacjaThe biosynthesis of polyphenolic compounds in cabbage waste, outer green leaves of white head cabbage (Brassica oleracea L. var. capitata subvar. alba), was stimulated by postharvest irradiation with UVB lamps or sunlight. Both treatments boosted the content of kaempferol and quercetin glycosides, especially in the basal leaf zone, as determined by the HPLC analysis of leaf extracts and by a non-destructive optical sensor. The...
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Interval Edge Coloring of Bipartite Graphs with Small Vertex Degrees
PublikacjaAn edge coloring of a graph G is called interval edge coloring if for each v ∈ V(G) the set of colors on edges incident to v forms an interval of integers. A graph G is interval colorable if there is an interval coloring of G. For an interval colorable graph G, by the interval chromatic index of G, denoted by χ'_i(G), we mean the smallest number k such that G is interval colorable with k colors. A bipartite graph G is called (α,β)-biregular...
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Application of the neural networks for developing new parametrization of the Tersoff potential for carbon
PublikacjaPenta-graphene (PG) is a 2D carbon allotrope composed of a layer of pentagons having sp2- and sp3-bonded carbon atoms. A study carried out in 2018 has shown that the parameterization of the Tersoff potential proposed in 2005 by Ehrhart and Able (T05 potential) performs better than other potentials available for carbon, being able to reproduce structural and mechanical properties of the PG. In this work, we tried to improve the...
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Comparing the permeability of human and porcine small intestinal mucus for particle transport studies
PublikacjaThe gastrointestinal mucus layer represents the last barrier between ingested food or orally administered pharmaceuticals and the mucosal epithelium. This complex gel structure plays an important role in the process of small intestinal absorption. It provides protection against hazardous particles such as bacteria but allows the passage of nutrients and drug molecules towards the intestinal epithelium. In scientific research, mucus...
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Determination of benzodiazepines and Z-hypnotic drugs in whole blood samples by GC–MS/MS: Method development, validation and application
PublikacjaBenzodiazepines (BZDs) and Z-drugs are widely used as anxiolytics, sedative hypnotics, anticonvulsants and muscle relaxants. “Designer benzodiazepines” (DBZDs) are a new psychoactive substance class consisting of benzodiazepine derivatives that are not allowed for medical use and are known for being used recreationally. From a toxicologist standpoint, the huge number of such substances implicate a necessity for developing fast...
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Practical Approach to Large-Scale Electronic Structure Calculations in Electrolyte Solutions via Continuum-Embedded Linear-Scaling Density Functional Theory
PublikacjaWe present the implementation of a hybrid continuum-atomistic model for including the effects of a surrounding electrolyte in large-scale density functional theory (DFT) calculations within the Order-N Electronic Total Energy Package (ONETEP) linear-scaling DFT code, which allows the simulation of large complex systems such as electrochemical interfaces. The model represents the electrolyte ions as a scalar field and the solvent...
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The hydrogen bond network structure within the hydration shell around simple osmolytes: Urea, tetramethylurea, and trimethylamine-N-oxide, investigated using both a fixed charge and a polarizable water model
PublikacjaDespite numerous experimental and computer simulation studies, a controversy still exists regarding the effect of osmolytes on the structure of surrounding water. There is a question, to what extent some of the contradictory results may arise from differences in potential models used to simulate the system or parameters employed to describe physical properties of the mixture and interpretation of the results. Bearing this in mind,...
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The hydrogen bond network structure within the hydration shell around simple osmolytes: Urea, tetramethylurea, and trimethylamine-N-oxide, investigated using both a fixed charge and a polarizable water model
PublikacjaDespite numerous experimental and computer simulation studies, a controversy still exists regarding the effect of osmolytes on the structure of surrounding water. There is a question, to what extent some of the contradictory results may arise from differences in potential models used to simulate the system or parameters employed to describe physical properties of the mixture and interpretation of the results. Bearing this in mind,...
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Effect of Maximal Apnoea Easy-Going and Struggle Phases on Subarachnoid Width and Pial Artery Pulsation in Elite Breath-Hold Divers
PublikacjaPurpose: The aim of the study was to assess changes in subarachnoid space width (sas-TQ), the marker of intracranial pressure (ICP), pial artery pulsation (cc-TQ) and cardiac contribution to blood pressure (BP), cerebral blood flow velocity (CBFV) and cc-TQ oscillations throughout the maximal breath hold in elite apnoea divers. Non-invasive assessment of sas-TQ and cc-TQ became possible due to recently developed method based on...
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Higher responsiveness to rosuvastatin in polygenic versus monogenic hypercholesterolaemia: a propensity score analysis
PublikacjaBackground The underlying monogenic defect in familial hypercholesterolemia (FH) can be detected in ∼40% of cases. The majority of mutation-negative patients have a polygenic cause of high LDL-cholesterol (LDL-C) due to having inherited a greater than average number of common LDL-C raising single nucleotide polymorphisms (SNPs). Purpose We sought to investigate, whether the monogenic or polygenic defect in FH is associated with...