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Wyniki wyszukiwania dla: PHANTOMS MIMICKING TISSUE
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Development of polyurethanes for bone repair
PublikacjaThe purpose of this paper is to review recent developments on polyurethanes aimed at the design, synthesis, modifications, and biological properties in the field of bone tissue engineering. Different polyurethane systems are presented and discussed in terms of biodegradation, biocompatibility and bioactivity. A comprehensive discussion is provided of the influence of hard to soft segments ratio, catalysts, stiffness and hydrophilicity...
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Cellulose Nanomaterials in Biomedical, Food, and Nutraceutical Applications: A Review
PublikacjaNanotechnology with bionanomaterials have tremendous potential to enhance and utilize for nutrient and bioactive absorption, drug delivery systems, pharmaceutical, and nutraceutical field through various applications. Cellulose nanomaterials are green materials that are obtained from renewable sources and possess exceptional mechanical strength and biocompatibility. The associated unique physical and chemical properties have made...
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A new finite element with variable Young's modulus
PublikacjaThe Finite Element Method (FEM) is a numerical technique that is well-established in the field of engineering. However, in biological sciences, it is justtaking its first steps. Bone tissue is an example of biological material which isexposed to high loads in its natural environment. Practically every movementof the body results in changing stress levels in the bone. Nature copes with thisvery well but when human intervention is...
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Behavioral state classification in epileptic brain using intracranial electrophysiology
PublikacjaOBJECTIVE: Automated behavioral state classification can benefit next generation implantable epilepsy devices. In this study we explored the feasibility of automated awake (AW) and slow wave sleep (SWS) classification using wide bandwidth intracranial EEG (iEEG) in patients undergoing evaluation for epilepsy surgery. APPROACH: Data from seven patients (age [Formula: see text], 4 women) who underwent intracranial depth electrode...
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Polyurethanes Crosslinked with Poly(vinyl alcohol) as a Slowly-Degradable and Hydrophilic Materials of Potential Use in Regenerative Medicine
PublikacjaNovel, slowly-degradable and hydrophilic materials with proper mechanical properties and surface characteristics are in great demand within the biomedical field. In this paper, the design, synthesis, and characterization of polyurethanes (PUR) crosslinked with poly(vinyl alcohol) (PVA) as a new proposition for regenerative medicine is described. PVA-crosslinked PURs were synthesized by a two-step polymerization performed in a solvent...
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Olfactory receptor-based biosensors as potential future tools in medical diagnosis
PublikacjaThe detection of biomarkers is the future of non-invasive medical diagnosis and screening. Discovery and identification of reliable disease specific volatile organic compounds is dependent on repeatable, accurate analysis of trace level gaseous analytes mainly in breath samples. Natural variety of the olfactory systems and the compounds capable of gas molecules binding creates wide possibilities of acquisition and implementation...
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Emerging strategies for enhancing detection of explosives by artificial olfaction
PublikacjaExplosives detection systems need to be able to reliably detect a wide range of explosive materials and their vapours. The continued development and improvement of artificial olfaction techniques, including electronic nose (EN), remains important to overcome existing challenges and meet requirements posed by new improvements in the field of explosives. There is an increasingly popular trend aimed at improvement of fundamental metrological...
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Polysaccharides-Based Hybrid Materials for Bio- and Non-Bio Sectors. Edytorial
PublikacjaThis special edition spotlights the recent research in the design, development, and emerging applications of polysaccharides-based hybrid materials for biotechnological and biomedical purposes. All the articles published in this issue underscore the significance of materials derived from cellulose, alginate, chitosan, starch, and carrageenan for various applications, including enzyme production, encapsulation, targeted drug delivery,...
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A Fast Method of Separation of the Noisy Background from the Head-Cross Section in the Sequence of MRI Scans
PublikacjaThe paper presents a new method of removing the noisy background from the sequence of magnetic resonance imaging (MRl) scans. The sequence of scans is required in order to monitor a passage of a contrast agent through the brain tissue. The scans contain the noisy head-cross data and also the noisy background data. The latter has to be removed and excluded from a further analysis. It is achieved by applying some basic morphological...
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The influence of image masks definition onsegmentation results of histopathological imagesusing convolutional neural network
PublikacjaAbstract—In the era of collecting large amounts of tissue materials, assisting the work of histopathologists with various electronic and information IT tools is an undeniable fact. The traditional interaction between a human pathologist and the glass slide is changing to interaction between an AI pathologist with a whole slide images. One of the important tasks is the segmentation of objects (e.g. cells) in such images. In this...
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Isogeometric Shell FE Analysis of the Human Abdominal Wall
PublikacjaIn this paper a nonlinear isogeometric Kirchhoff-Love shell model of the human abdominal wall is proposed. Its geometry is based on in vivo measurements obtained from a polygon mesh that is transformed into a NURBS surface, and then used directly for the finite element analysis. The passive response of the abdominal wall model under uniform pressure is considered. A hyperelastic membrane model based on the Gasser-Ogden-Holzapfel...
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Wpływ stopowania laserowego z użyciem nanorurek węglowych stopu Ti13Nb13Zr do zastosowań biomedycznych na jego wybrane własności mechaniczne
PublikacjaDo eksperymentu użyto stopu tytanu Ti13Nb13Zr, który ze względu na swój skład chemiczny i właściwości mechaniczne stanowi materiał do zastosowań w inżynierii medycznej. Celem pracy była ocena wpływu stopowania laserowego stopu Ti13Nb13Zr z powłoką z wielościennych nanorurek węglowych na jego właściwości mechaniczne (chropowatość, nanotwardość, moduł Younga). Do wytworzenia powłoki węglowej wykorzystano metodę osadzania elektroforetycznego (EDP)....
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IN VIVO DEGRADATION OF BIOMATERIALS
PublikacjaThe material designed to be introduced into the human tissue should be biocompatible and biofunctional. Unless it is so, the body may respond to the implant in different ways. An inflammation reaction may appear such as: parting of items of the implant surface resulting from fraction or pressure. The condition of the surface has an important influence on the usefulness of the implant. The required values depend on the implant function...
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Evaluation of the use of reindeer droppings for monitoring essential and non-essential elements in the polar terrestrial environment
PublikacjaExcess or toxic metals, non-metals and metalloids can be eliminated from the organism by deposition in inert tissue (e.g. fur) or excretion with body secretions, urine and faeces. Droppings are one of the main routes for the elimination of multiple elements and they can be collected without direct contact with the animal. Contaminant concentration has been examined in non-lethally collected tissues of several species (especially...
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Activation of endogenous regenerative potential in mammals using epigenetic inhibitor zebularine
PublikacjaIn this work, a nucleoside inhibitor of DNA methyltransferases, zebularine, was investigated as a wound healing and regeneration promoting agent. It was found that a high dose of intraperitoneally delivered zebularine improved punch wound closure in the ear pinna in mice. Both cytidine, a zebularine analogue, and uridine, a zebularine metabolite, did not promote ear pinna hole closure. The effect of zebularine on ear pinna healing...
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Parametric versus nonparametric modelling of dynamic susceptibility contrast enhanced MRI based data
PublikacjaDynamic tracking of a bolus of a paramagnetic agent (dynamic susceptibility contract - DSC) in MRI (magnetic resonance imaging) measurements is successfully used for assessment of the tissue perfusion and the other features and functions of the brain (i.e. cerebral blood flow - CBF, cerebral blood volume - CBV, mean transit time - MTT). The parametric and nonparametric approaches to the identification of MRI models are presented...
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Graphene Production and Biomedical Applications: A Review
PublikacjaGraphene is a two-dimensional nanomaterial composed of carbon atoms with sp2 hybrid orbitals. Both graphene and graphene-based composite have gained broad interest among researchers because of their outstanding physiochemical, mechanical, and biological properties. Graphene production techniques are divided into top-down and bottom-up synthesis methods, of which chemical vapor deposition (CVD) is the most popular. The biomedical...
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LCT, PIV and IR Imaging Detection in Selected Technical and Biomedical Applications
PublikacjaThermochromic liquid crystals (TLC), Particle Image Velocimetry (PIV) and Infrared Imaging Themography (IR) have been successfully used in non-intrusive technical, industrial and biomedical studies and applications. These four tools (based on the desktop computers) have come together during the past two decades to produce a powerful advanced experimental technique as a judgment of quality of information that cannot be obtained...
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Thermal and mechanical properties of polyurethanes modified with L-ascorbic acid
PublikacjaIn this study we report the thermal and mechanical properties of polyurethanes modified with ascorbic acid (AA). Ascorbic acid was used as a modifier at concentration of 1 or 2 mass%. The antioxidative properties of AA may improve the biocompatibility of the obtained materials, which were designed for biomedical applications. In this paper we describe characterization of obtained unmodified and ascorbic acid modified polyurethanes...
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Three-Dimensional Printing of Bone Models
PublikacjaThe trabecular bone occurs, for example, in the femoral heads. Understanding the phenomenon of bone tissue degeneration can be the basis for the possibility of looking for alternative methods of surgical treatment of bone loss. The paper presents the results of the trabecular bone model, which was produced in additive manufacturing method with fused filament fabrication technology. The verification of the mechanical behavior of...
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Carnivorous plants used for green synthesis of silver nanoparticles with broad-spectrum antimicrobial activity
PublikacjaIn this study, we exploit the anti-oxidative potential of four carnivorous plants to produce uniform and biologically active silver nanoparticles. The use of polyvinylpyrrolidone promoted syn-thesis of quasi-spherical nanoparticles characterized by stability and high uniformity. Their activity was tested against three human pathogens and three species of plant pathogenic bacteria. The study demonstrates the influence of synthesis...
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Liquid Crystals, PIV and IR-Photography in Selected Technical and Biomedical Applications
PublikacjaThermochromic liquid crystals (TLC), Particle Image Velocimetry (PIV), Infrared Imaging Themography (IR) and True-Colour Digital Image Processing (TDIP) have been successfully used in non-intrusive technical, industrial and biomedical studies and applications. These four tools (based on the desktop computers) have come together during the past two decades to produce a powerful advanced...
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Structural and Material Determinants Influencing the Behavior of Porous Ti and Its Alloys Made by Additive Manufacturing Techniques for Biomedical Applications
PublikacjaOne of the biggest challenges in tissue engineering is the manufacturing of porous structures that are customized in size and shape and that mimic natural bone structure. Additive manufacturing is known as a sufficient method to produce 3D porous structures used as bone substitutes in large segmental bone defects. The literature indicates that the mechanical and biological properties of scaffolds highly depend on geometrical features...
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The effective elastic properties of human trabecular bone may be approximated using micro-finite element analyses of embedded volume elements.
PublikacjaBoundary conditions (BCs) and sample size affect the measured elastic properties of cancellous bone. Samples too small to be representative appear stiffer under kinematic uniform BCs (KUBCs) than under periodicity-compatible mixed uniform BCs (PMUBCs). To avoid those effects, we propose to determine the effective properties of trabecular bone using an embedded configuration. Cubic samples of various sizes (2.63, 5.29, 7.96, 10.58...
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The selective salinity and hydrazine parameters for the start-up of non-anammox-specific biomass SBR
PublikacjaThe presence of ammonium (NH 4+ ) in wastewater above the permissible limits leads to undesirable ecological impact and public health concerns. In this study, the anaerobic ammonium oxidizing (anammox) bacteria-mediated nitrogen removal was investigated using a sequential batch reactor (SBR). Effects of different salinity levels were evaluated on the bacterial activity at: mild (below 0.2 g NaCl/L), elevated (18.2 g NaCl/L) and...
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Visual Content Representation for Cognitive Systems: Towards Augmented Intelligence
PublikacjaCognitive Vision Systems have gained significant attention from academia and industry during the past few decades. One of the main reasons behind this interest is the potential of such technologies to revolutionize human life since they intend to work robustly under complex visual scenes (which environmental conditions may vary), adapting to a comprehensive range of unforeseen changes, and exhibiting prospective behavior. The combination...
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Transcriptomic responses to wounding: meta-analysis of gene expression microarray data
PublikacjaBackground A vast amount of microarray data on transcriptomic response to injury has been collected so far. We designed the analysis in order to identify the genes displaying significant changes in expression after wounding in different organisms and tissues. This meta-analysis is the first study to compare gene expression profiles in response to wounding in as different tissues as heart, liver, skin, bones, and spinal cord, and...
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Chronic Rhinosinusitis—Microbiological Etiology, Potential Genetic Markers, and Diagnosis
PublikacjaChronic rhinosinusitis (CRS) is a significant public health problem. Bacterial colonization and impaired mucociliary clearance play a significant role in the inflammatory process. Several inflammatory pathways and host defense elements are altered in CRS, which may contribute to observed differences in the microbiome. To date, researching CRS has been difficult due to limited access to the studied tissue and a lack of available...
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The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma-Recent Findings and Review
PublikacjaThe inflammatory process plays a significant role in the development of colon cancer (CRC). Intestinal cytokine networks are critical mediators of tissue homeostasis and inflammation but also impact carcinogenesis at all stages of the disease. Recent studies suggest that inflammation is of greater importance in the serrated pathway than in the adenoma-carcinoma pathway. Interleukins have gained the most attention due to their...
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PERFORMANCE OF ENDOSCOPIC IMAGE ANALYSIS ALGORITHMS IN LARGE BOWEL VIDEOS PROCESSING
PublikacjaComputer-assisted endoscopy is a rapidly developing eld of study. Many image anal- ysis algorithms exist, achieving very high rates of eciency at processing single endoscopic images. However, most of them were never tested in processing real-life endoscopic videos. In the article such tests of 16 endoscopy image analysis algorithms are presented and dis- cussed. Tests were performed on two real-life endoscopic videos of a human...
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Bacterial cellulose in the field of wound healing and regenerative medicine of skin: recent trends and future prospectives
PublikacjaIn this overview, we focused on the bacterial cellulose (BC) applications, described in recently published scientific papers, in the field of skin regenerative medicine and wound care industry. Bacterial cellulose was proven to be biocompatible with living tissues. Moreover, its mechanical properties and porous structure are considered to be suitable for biomedical applications. It is due to the fact that porous structure of bacterial...
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Rating mathematical models for first-pass of tracer in pCT lung studies
PublikacjaThis paper presents a comparison of model based on the Gauss function and the most commonly used Gamma-variate model in perfusion computed tomography (pCT) lung studies. It also verifies whether used model affects value of blood volume parameter. Three mean concentration-time curves were created from actual pCT measurements: arterial input function, blood vessels in lungs and lung parenchyma. On the basis of these mean curves we...
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Impact of surface skin temperature change on blood flow characteristics in palm
PublikacjaHeating a human palm during 3 minutes period causes changes in superficial skin temperature and leads to thermoregulation system response. The response time and level of flow characteristics change depend on the subject hand size and health of his vascular tree. A solution of Pennes bioheat propagation model was analyzed in order to see how much heat has to be transferred into the tissue to extort the observable reaction. The reflective...
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Obtaining a Well-Trained Artificial Intelligence Algorithm from Cross-Validation in Endoscopy
PublikacjaThe article shortly discusses endoscopic video analysis problems and artificial intelligence algorithms supporting it. The most common method of efficiency testing of these algorithms is to perform intensive cross-validation. This allows for accurately evaluate their performance of generalization. One of the main problems of this procedure is that there is no simple and universal way of obtaining a specific instance of a well-trained...
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Bioactive core material for porous load-bearing implants
PublikacjaSo far state of knowledge on biodegradable materials is reviewed. Among a variety of investigated materials, those composed of polymers and ceramics may be considered as only candidates for a core material in porous titanium alloy. The collagen and chitosan among natural polymers, polyhydroxy acids among synthetic polymers, and hydroxyapatite and tricalcium phosphate among ceramics are proposed for further research. Three essential...
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Determination of isoprostanes in exhaled breath condensate samples by liquid chromatography coupled with tandem mass spectrometry
PublikacjaOxidative stress (OS) is a state of imbalance between continuously generating reactive oxygen species (ROS) during normal cell metabolism and mechanism of detoxifying oxygen radicals through a network of antioxidative enzymes. Isoprostanes are prostaglandin -like substances that are produced in vivo primarily by free radical-induced peroxidation of arachidonic acid. The measurement of isoprostanes in biological fluids and/or tissue...
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3D porous graphene-based structures- synthesis and applications
PublikacjaPorous carbon-based materials are of the great industrial and academic interest due to their high surface area, low density, good electrical conductivity, chemical inertness and low cost of fabrication. Up to now, the main approach to obtain porous carbon structures has involved the pyrolysis of carbonaceous natural or synthetic precursors. After the isolation of graphene, the interest in 3D porous graphene-based structures (called...
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A PRELIMINARY STUDY ON THE OPTIMAL CHOICE OF AN IMPLANT AND ITS ORIENTATION IN VENTRAL HERNIA REPAIR
PublikacjaThis paper addresses the problem of ventral hernia repair. The main goals are to find an optimal surgical mesh for hernia repair and to define its optimal orientation in the abdominal wall to minimise the maximum force at the tissue-implant juncture. The optimal mesh is chosen from a set of orthotropic meshes with different stiffness ratios for typical hernia placement in the abdominal area. The implant is subjected to an anisotropic...
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Enzymatic activities behind degradation of glucosinolates
PublikacjaMyrosinase (thioglucosidase, EC 3.2.1.147) is the enzyme responsible for the hydrolysis of glucosinolates (GLs). In plant tissue, myrosinase and GLs are sequestered in separate cellular compartments. As a result of cell disruption, e.g., after pathogen attack or on chopping or grinding during food preparation, the myrosinase comes into contact with GLs and catalyzes the hydrolysis of thioglucosidic bond in GL structure. Consequently,...
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REVIEW OF CURRENT RESEARCH ON CHITOSAN AS A RAW MATERIAL IN THREE-DIMENSIONAL PRINTING TECHNOLOGY IN BIOMEDICAL APPLICATIONS
PublikacjaThree-dimensional (3D) biomaterial manufacturing strategies show an extraordinary driving force for the development of innovative solutions in the biomedical sector, including drug delivery systems, disease modelling and tissue and organ engineering. Due to its remarkable and promising biological and structural properties, chitosan has been widely studied for decades in several potential applications in the biomedical field. However,...
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Polysaccharide-based electroconductive hydrogels: Structure, properties and biomedical applications
PublikacjaArchitecting an appropriate platform for biomedical applications requires setting a balance between simplicity and complexity. Polysaccharides (PSAs) play essential roles in our life in food resources, structural materials, and energy storage capacitors. Moreover, the diversity and abundance of PSAs have made them an indispensable part of food ingredients and cosmetics. PSA-based hydrogels have been extensively reviewed in biomedical...
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Ciprofloxacin-modified degradable hybrid polyurethane-polylactide porous scaffolds developed for potential use as an antibacterial scaffold for regeneration of skin
PublikacjaThe aim of the performed study was to fabricate an antibacterial and degradable scaffold that may be used in the field of skin regeneration. To reach the degradation criterion for the biocompatible polyurethane (PUR), obtained by using amorphous α,ω-dihydroxy(ethylene-butylene adipate) macrodiol (PEBA), was used and processed with so-called “fast-degradable” polymer polylactide (PLA) (5 or 10 wt %). To meet the antibacterial requirement...
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Marine and Cosmic Inspirations for AI Algorithms
PublikacjaArtificial Intelligence (AI) is a scientific area that currently sees an enormous growth. Various new algorithms and methods are developed and many of them meets practical, successful applications. Authors of new algorithms draw different inspirations. Probably the most common one is the nature. For example, Artificial Neural Networks were inspired by the structure of human brain and nervous system while the classic Genetic Algorithm...
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Identification of the mechanical properties of the skin by electromechanical impedance analysis of resonant piezoelectric actuator
PublikacjaThis paper is devoted to the analysis and verification of developed piezoelectric sensor/actuator for measuring the mechanical properties of soft tissues, especially human skin. The key element of the measurement structure is an electromechanical system that uses both the reverse piezoelectric effect (vibration generation – stimulation of the tissues in the appropriate frequency range) and direct piezoelectric effect (system response...
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Tools for Automatic Wound Healing Evaluation
PublikacjaFinal results of the research project devoted to development of a new objective and quantitative method of post cardiosurgery wound healing diagnostics, already preliminary discussed at the QIRT 2014 Conference, is presented. We assumed that thermal processes should be effective in subtle description of temporal changes of tissue thermal properties after surgical interventions. To prove this assumption more than 400 patients after...
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Antioxidant Interactions between Major Phenolic Compounds Found in 'Ataulfo' Mango Pulp: Chlorogenic, Gallic, Protocatechuic and Vanillic Acids
PublikacjaPhenolic compounds are known to have antioxidant capacity; however, there is little information about molecular interactions between particular phenolics found in fruits at different developmental stages. Therefore, the total antioxidant capacity of the phenolic compounds of a fruit may not correspond to the sum of individual antioxidant capacity given by antioxidants from that tissue. In this study, individual antioxidant capacity...
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Various cases of preservation and adaptive reuse Heritage Buildings in the Port of Gdynia
PublikacjaThe port of Gdynia contains a diverse range of heritage assets, starting with its spatial layout which is an urban concept designed in the first half of the 1920s. It is important to point out, this historically-shaped harbor space is preserved in its general idea and still functioning in port activities. Another significant element is the structural, technological solution which was the basis for constructing the entire port area...
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Recent advances in electrochemically surface treated titanium and its alloys for biomedical applications: A review of anodic and plasma electrolytic oxidation methods
PublikacjaNowadays, titanium and its alloys are widely used materials in implantology. Nevertheless, the greatest challenge is still its appropriate surface treatment in order to induce optimal properties, which facilitates formation of a permanent bond between the implant and human tissue. The use of electrochemical treatment such as anodic oxidation or plasma electrolytic oxidation allows for the production of porous coating that mimics...
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Nanotubular oxide layers and hydroxyapatite coatings on porous titanium alloy Ti13Nb13Zr
PublikacjaThe surface condition of an implant has a significant impact on response occurring at the implant-biosystem border. The knowledge of physical-chemical and biological processes allows for targeted modification of biomaterials to induce a specified response of a tissue. The present research was aimed at development of technology composing of obtaining the nanotube oxide layers on a porous titanium alloy Ti13Nb13Zr, followed by the...
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Wpływ wysokiej osteotomii piszczelowej na mechanikę stawu kolanowego
PublikacjaW rozprawie podjęto próbę weryfikacji wpływu zabiegu chirurgicznego wysokiej osteotomii piszczelowej na mechanikę stawu kolanowego. Po wykonanym przeglądzie literatury, postawiono trzy hipotezy, które poddano weryfikacji na drodze badań numerycznych. Otrzymane wyniki zwalidowano poprzez badania nacisków powierzchniowych występujących w stawach kolanowych świni domowej, prowadzonych na maszynie do jednoosiowego ściskania. Praca...