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Wyniki wyszukiwania dla: skin barrier dysfunction
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Opioid Growth Factor and its Derivatives as Potential Non-toxic Multifunctional Anticancer and Analgesic Compounds
PublikacjaIn this paper, we review the structure-activity relationship of OGF and its analogues. We highlight also OGF derivatives with analgesic, immunomodulatory activity and the ability to penetrate the blood-brain barrier and may be used as safe agents enhancing chemotherapy efficacy and improving quality of life in cancer patients. The reviewed papers indicate that Met-enkephalin and its analogues are interesting candidates for the...
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Multi-DBD actuator with floating interelectrode for aerodynamic control
PublikacjaIn this paper the use of a floating inter-electrode in a multi-DBD (dielectric barrier discharge) plasma actuator is described. The multi-DBD plasma actuators with floating inter-electrodes were investigated to get a longer DBD on a dielectric surface and to maximise generated net airflow. Our actuator was used to control the boundary layer flow separation around NACA0012 airfoil model. The results of our investigations suggests...
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Wyzwania i problemy aktywizacji peryferyjnych niskorozwiniętych obszarów Unii Europejskiej
PublikacjaSą duże dysproporcje w poziomie rozwoju między obszarami metropolitalnymi a pozostałymi, zwanymi tu peryferyjnymi. Dysproporcje dotyczą też badań – wiele z nich dotyczy obszarów metropolitalnych. Dlatego autor podjął w 2009 r. badania dotyczące problemów aktywizacji obszarów peryferyjnych. Głównym problemem jest w nich niedostatek endogenicznych czynników stanowiący barierę samodzielnego zainicjowania wzrostu. Potrzeba rozwoju...
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Active dynamic thermography method for TRAM flap blood perfusion mapping in breast reconstruction
PublikacjaThis paper presents the new method of the transverse rectus abdominis musculocutaneous flap blood perfusion mapping based on the active dynamic thermography. The method is aimed at aiding a surgeon during breast reconstruction procedure. A pair of dTnorm and t90_10 parameters were used as parametric image descriptors of the flap blood perfusion. The method was tested on 38 patients that were subjected to breast reconstruction procedure....
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Long-Term Measurement of Physiological Parameters – Child Dataset
PublikacjaThe dataset titled “Long-term measurement of physiological parameters – child is one dataset” of the bigger series named Long-term measurement of physiological parameters. The dataset contains physiological parameter measurements such as skin temperature and resistance, blood pulse, as well as the stress detection marker, which can have a value of 0 when there is no stress detected or 1 when stress appeared. Additionally, the dataset...
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The Synergistic Microbiological Effects of Industrial Produced Packaging Polyethylene Films Incorporated with Zinc Nanoparticles
PublikacjaZinc compounds in polyolefin films regulate the transmission of UV-VIS radiation, affect mechanical properties and antimicrobial activity. According to hypothesis, the use of zinc- containing masterbatches in polyethylene films (PE) with different chemical nature—hydrophilic zinc oxide (ZO) and hydrophobic zinc stearate (ZS)—can cause a synergistic effect, especially due to their antimicrobial properties. PE films obtained on an...
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Enhanced gas sensing by graphene-silicon Schottky diodes under UV irradiation
PublikacjaThe effect of ultraviolet (UV) or blue irradiation on graphene/n-doped silicon Schottky junctions toward gas sensing was investigated. Schottky diodes were subjected to oxidizing nitrogen dioxide (NO2, 1–3 ppm) and reducing tetrahydrofuran (THF, 50–200 ppm), showing significantly different responses observed on the currentvoltage (I-V) characteristics, especially under UV light (275 nm). NO2 affected the resistive part of the forward region...
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On the influence of shell element properties on the response of car model in crash test
PublikacjaIt goes without saying that numerical simulations play important role in the modern engineering practice. Contemporary CAD environments combined with FEM solvers, along with computer power of modern processors, give the engineer fast and efficient tool. Ultimately, however it is the user alone who is responsible for the correctness of the results. As long as the FEM calculations remain in the sphere of academic exercise, the inevitable...
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Applications of Raman spectroscopy for detection of selected substances in tissues
PublikacjaThis dissertation explores the applications of Raman spectroscopy for biological tissue analysis. Basics of Raman and surface-enhanced Raman spectroscopy (SERS) are described, along with an analysis of the literature on biodetection and non-invasive blood analysis with emphasis on glucose detection. Instrumentation for Raman measurements is described. The sources of noise and interferences occurring in biological tissue measurements...
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CHEMOTHERAPY-MEDIATED COMPLICATIONS OF WOUND HEALING. AN UNDERSTUDIED SIDE EFFECT
PublikacjaSignificance: Chemotherapy is a primary method to treat cancer, but while cytotoxic drugs are designed to target rapidly dividing cancer cells, they can also affect other cell types, including dermal cells and macrophages involved in wound healing, which often leads to the development of chronic wounds. The situation becomes even more severe when chemotherapy is combined with surgical tumor excision. Recent advances: Despite its...
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On the influence of the acceleration recording time on the calculation of impact severity indexes
PublikacjaThe paper concerns with the analysis of normative requirements pertaining to experimental setup of a crash test and its numerical modelling. An overview of parameters describing the collision of a vehicle with a road restraining system is presented. A short description of a concrete road safety barrier is presented. A brief description of numerical modelling procedures for crash tests is given as well. The parametric influence...
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Receptor for advanced glycation end‐products: Biological significance and imaging applications
PublikacjaThe receptor for advanced glycation end-products (RAGE or AGER) is a transmembrane, immunoglobulin-like receptor that, due to its multiple isoform structures, binds to a diverse range of endo- and exogenous ligands. RAGE activation caused by the ligand binding initiates a cascade of complex pathways associated with producing free radicals, such as reactive nitric oxide and oxygen species, cell proliferation, and immunoinflammatory...
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DEEP CONVOLUTIONAL NEURAL NETWORKS AS A DECISION SUPPORT TOOL IN MEDICAL PROBLEMS – MALIGNANT MELANOMA CASE STUDY
PublikacjaThe paper presents utilization of one of the latest tool from the group of Machine learning techniques, namely Deep Convolutional Neural Networks (CNN), in process of decision making in selected medical problems. After the survey of the most successful applications of CNN in solving medical problems, the paper focuses on the very difficult problem of automatic analyses of the skin lesions. The authors propose the CNN structure...
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The Mechanism of a Retro-Diels–Alder Fragmentation of Luteolin: Theoretical Studies Supported by Electrospray Ionization Tandem Mass Spectrometry Results
PublikacjaThe mechanisms of retro-Diels–Alder fragmentation of luteolin are studied theoretically using the Density Functional Theory method (B3LYP hybrid functional) together with the 6-311++G(d,p) basis set and supported by electrospray ionization tandem mass spectrometry (ESI-MS) results. The reaction paths leading to the formation of 1,3A and 1,3B fragment ions observed as the main spectral features in the ESI-MS spectrum are described...
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Effect of the Road Environment on Road Safety in Poland
PublikacjaRun-off-road accidents tend to be very severe because when a vehicle leaves the road, it will often crash into a solid obstacle (tree, pole, supports, front wall of a culvert, barrier). A statistical analysis of the data shows that Poland's main roadside hazard is trees and the severity of vehicles striking a tree in a run-off-road crash. The risks are particularly high in north-west Poland with many of the roads lined up with...
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Regulation of Cellular Redox Homeostasis by (–)-Epicatechin and Cocoa Extracts—A Pilot Study
PublikacjaCocoa polyphenols play an important role in protection against diseases in which oxidative stress is implicated as a causal or contributing factor. The main aim of this study was to elucidate the influence of different cocoa extracts and main cocoa bioactive compound (–)-epicatechin on cell growth and support of antioxidant cellular barrier in colon adenocarcinoma cell line model (HT29). Results show that the tested cocoa bioactivity...
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REGULATION OF CELLULAR REDOX HOMEOSTASIS BY (-)-EPICATECHIN AND COCOA EXTRACTS – PILOT STUDY
PublikacjaCocoa polyphenols play an important role in protection against diseases in which oxidative stress is implicated as a causal or contributing factor. The main aim of this study was to elucidate the influence of different cocoa extracts and main cocoa bioactive compound (–)-epicatechin on cell growth and support of antioxidant cellular barrier in colon adenocarcinoma cell line model (HT29). Results show that the tested cocoa bioactivity...
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Gold nanoparticles and their coatings, their effect on cells and their interaction with radiation
PublikacjaTwo nanometre gold nanoparticles (AuNPs), bearing sugar moieties and/or polyethylene glycolamine (PEG-amine), were synthesised and evaluated for their in vitro toxicity and ability to radiosensitise cells with 220 kV and 6 MV X-rays, using four cell lines representing normal and cancerous skin and breast tissues. In addition to the observed intrinsic cancer-selective chemotoxicity, these AuNPs acted as radiosensitisers in combination with...
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From tryptophan to novel mitochondria-disruptive agent, synthesis and biological evaluation of 1,2,3,6-tetrasubstituted carbazoles
PublikacjaMitochondrial targeting plays an important role in anticancer therapy. The Mn(III)-promoted cyclization of 5- (1H-indol-3-yl)-3-oxopentanoic acid allow to obtain novel substituted carbazole derivatives that can act as mitochondria-disruptive agents. The starting materials used for the synthesis of these new aminocarbazoles are oxopentanoate derivatives of tryptophan. The scope and limitation of this method of synthesis are determined...
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Transcriptional activity of epigenetic remodeling genes declines in keratinocytes after in vitro expansion
PublikacjaPURPOSE: In vitro expansion is an invaluable method to obtain keratinocytes in amounts necessary for effective transplantation therapies. In vitro cell culturing provokes questions concerning potential epigenetic alterations occurring in expanded cells in the context of usefulness for transplantation and safety. The purpose of this study was to investigate as to whether keratinocyte expansion is associated with changes in the activity...
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Modeling and simulation of blood flow under the influence of radioactive materials having slip with MHD and nonlinear mixed convection
PublikacjaRadioactive materials are widely in industry, nuclear plants and medical treatments. Scientists and workers in these fields are mostly exposed to such materials, and adverse effects on blood and temperature profiles are observed. In this regard, objective of the current study is to model and simulate blood based nanofluid with three very important radioactive materials, named as Uranium dioxide (UO2), Thorium dioxide (ThO2) and...
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The field–dependent interface recombination velocity for organic–inorganic heterojunction
PublikacjaWe have derived an analytical formula which describes the field–dependent interface recombination velocity for the boundary of two materials characterized by different permittivities. The interface recombination of charge carriers has been considered in the presence of image force Schottky barrier. We suggest that this effect may play an important role in the loss of current for organic–inorganic hybrid heterojunctions. It has...
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Improved performance of LaNi0.6Fe0.4O3 solid oxide fuel cell cathode by application of a thin interface cathode functional layer
PublikacjaIn this work, novel functional layers were prepared by a low temperature spray pyrolysis method on the oxygen side of the solid oxide cells. Thin layers of Ce0.8Gd0.2O2 and LaNi0.6Fe0.4O3 are prepared between the electrolyte and the porous oxygen electrode. Additionally the influence of the sprayed ceria barrier layer on the zirconia based electrolyte with the new layers is evaluated. Impedance spectroscopy results show improvement...
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Real-time PCR approach in dermatophyte detection and Trichophyton rubrum identification
PublikacjaDermatophytes are keratinophilic molds that infect human hair, nails and skin. Diagnosis of dermatophytosis is based on morphological, serological and biochemical features. However, identification is difficult and laborious due to similarities between microorganisms. Thus, there is considerable interest to develop mycological diagnostic procedures based on molecular biology methods. In this study, fast, two-step DNA extraction...
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Deep neural network architecture search using network morphism
PublikacjaThe paper presents the results of the research on neural architecture search (NAS) algorithm. We utilized the hill climbing algorithm to search for well-performing structures of deep convolutional neural network. Moreover, we used the function preserving transformations which enabled the effective operation of the algorithm in a short period of time. The network obtained with the advantage of NAS was validated on skin lesion classification...
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Functionality of road safety devices - identification and analysis of factors
PublikacjaRoad safety devices are designed to protect road users from the risk of injury or death. The principal type of restraint is the safety barrier. Deployed on sites with the highest risk of run-off-road accidents, safety barriers are mostly found on bridges, flyovers, central reservations, and on road edges which have fixed obstacles next to them. If properly designed and installed, safety barriers just as other road safety devices,...
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Methods of estimating the cost of traffic safety equipment’s life cycle
Publikacjan the article, the authors discuss the preliminary information necessary to determine the scope and direction of further research conducted within the project called “The influence of time and operating conditions on the durability and functionality of road safety elements”. The main objective of the project is to develop the concept of a method for optimizing the life cycle costs of road safety devices. The authors draw attention...
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Cavitation erosion degradation of Belzona® coatings
PublikacjaIn hydrocarbon and maritime industry there is a constant need of materials and coatings withstanding severe conditions. One of adverse phenomena present there is cavitation erosion. The paper presents evaluation of cavitation resistance of three different steel coatings. Belzona 2141 (ACR-Fluid Elastormer), 1321 (Ceramic S-Steal) and 5831 (ST-Barrier) were deployed on P110 steel and subjected to ultrasound cavitation in distilled...
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The Influence of Titania Electrode Modification with Lanthanide Ions Containing Thin Layer on the Performance of Dye-Sensitized Solar Cells
PublikacjaThe lanthanide and scandium groups ions (except Pm and Ac) have been used as dopants of TiO2 film in dye-sensitized solar cells. The X-ray diffraction spectra show that the modification has no influence on the structure of the electrode; however, the diffuse reflectance UV-Vis measurements exhibit significant changes in the electronic properties of modified electrodes. The appearance of energy barrier preventing photoexcited electron...
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Assessment of Road Restraint Systems in Polish Conditions
PublikacjaKey to understanding the needs and tools of road infrastructure management is identifying the hazards and their sources involved in having no or faulty road restraint systems. Clarity is also needed on why the systems are wrongly designed, constructed, built and operated. To ensure that the problem is adequately understood, research and site observations were conducted and...
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Experimental tests and numerical simulations of full scale composite sandwich segment of a foot- and cycle- bridge
PublikacjaIn the paper experimental tests and numerical simulations of a full cross-section segment of ultimately designed foot-and cycle-bridge are presented. The experimental tests were conducted on element with length reduced to 3 m and unchanged (target) cross-section dimensions. The external skin of structure is GFRP laminate while internal core is PET foam. Several quasi-static tests were performed using hydraulic cylinder to generate...
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Emotion Monitor - Concept, Construction and Lessons Learned
PublikacjaThis paper concerns the design and physical construction of an emotion monitor stand for tracking human emotions in Human-Computer Interaction using multi-modal approach. The concept of the stand using cameras, behavioral analysis tools and a set of physiological sensors such as galvanic skin response, blood-volume pulse, temperature, breath and electromyography is presented and followed...
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An inclination in Thermal Energy Using Nanoparticles with Casson Liquid Past an Expanding Porous Surface
PublikacjaPhysical aspects of inclined MHD nanofluid towards a stretching sheet embedded in a porous medium are visualized. Two types of nanoparticles are used named as copper and alumna dioxide with water as base fluid. Similarity transformations are used to convert the partial differential equations into the set of ordinary differential equation. Closed solutions are found to examine the velocity and the temperature profiles. It is examined...
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TOWARDS EXPLAINABLE CLASSIFIERS USING THE COUNTERFACTUAL APPROACH - GLOBAL EXPLANATIONS FOR DISCOVERING BIAS IN DATA
PublikacjaThe paper proposes summarized attribution-based post-hoc explanations for the detection and identification of bias in data. A global explanation is proposed, and a step-by-step framework on how to detect and test bias is introduced. Since removing unwanted bias is often a complicated and tremendous task, it is automatically inserted, instead. Then, the bias is evaluated with the proposed counterfactual approach. The obtained results...
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Fluorescence Imaging Using Methylene Blue Sentinel Lymph Node Biopsy in Melanoma
PublikacjaIntroduction: Fluorescence imaging of sentinel node biopsy in melanoma is a novel method. Both indocyanine green (ICG) and methylene blue (MB) have fl uorescent properties. The aim of this study was to present, for the fi rst time in a clinical series of patients, the possible usage of MB as a fl uorescent dye for sentinel node biopsy during surgery for melanoma. Material and methods: Twenty patients with...
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Theoretical Organic Rankine Cycle efficiency depending on different thermodynamic work variables.
PublikacjaOne of promising technologies of utilizing low- temperature waste heat is through ORC (Organic Rankine Cycle) system implementation. A primary objective in designing in-stallations based on such systems is to maximize the installation's work efficiency. On the other hand, ecological factors are commonly considered a natural barrier in introducing new, often very expensive technologies. Ecological effect of a potential modernization...
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IMPACT OF THE FINANCING STRUCTURE ON EFFICIENCY OF HEALTHCARE SYSTEMS IN THE FORMER EASTERN BLOC COUNTRIES
PublikacjaOut-of-pocket expenditures are a significant barrier in accessing health services. This paper aims to analyse the structure of financing system in the context of the performance indicators of healthcare systems. The study was conducted for the 28 countries of the former Eastern bloc in the years 2000 and 2013, based on data from the World Health Organization. In the DEA-CCR input-oriented model, inputs are the percentage share...
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Visual Lip Contour Detection for the Purpose of Speech Recognition
PublikacjaA method for visual detection of lip contours in frontal recordings of speakers is described and evaluated. The purpose of the method is to facilitate speech recognition with visual features extracted from a mouth region. Different Active Appearance Models are employed for finding lips in video frames and for lip shape and texture statistical description. Search initialization procedure is proposed and error measure values are...
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Maximum transportation growth in energy and solute particles in Prandtl martial across a vertical 3D-heated surface: Simulations achieved using by finite element approach
PublikacjaThe goal of this study is to determine the maximum energy and solute particles' transportation growth in a 3D-heated region of Prandtl martial through a dynamic magnetic field. The effects of this field on the properties of solvent molecules and heat conduction are studied. A correctly stated functional method and a finite element approach are comparable to a certain type of differential equations. In order demonstrate the effects...
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The effect of road restraint systems on the level of road safety - Polish experience
PublikacjaRoadside accidents happen when a vehicle runs off the road. The majority of these accidents are very severe because leaving the road is usually followed by hitting a solid obstacle (tree, pole, support, culvert front wall, barrier). Roadsides are some of the most important issues of road safety. They have been studied for years to identify roadside hazards and the effectiveness of road safety measures such as restraint systems....
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Rainwater chemistry composition in Bellsund: Sources of elements and deposition discrepancies in the coastal area (SW Spitsbergen, Svalbard)
PublikacjaDiscrepancies in rainfall chemistry in Bellsund were found to be influenced by the orographic barrier and related to the variability in the inflow of air masses as well as to the distance of sampling sites from the sea and thus the extent of sea spray impact. This study covers measurements of rainfall (P) and air temperature (T), physicochemical parameters (pH, specific electrolytic conductivity (SEC), major ions (Cl , NO3 , SO4...
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Insight into heart regeneration
PublikacjaThe mammalian heart is thought to be incapable of regeneration because of the limited ability of cardiomyocytes. to proliferate. However, it has been recently shown that the neonatal murine heart is able to restore its normal function after coronary artery ligation or even partial resection. Unfortunately, this feature is lost in a few days after birth, although lower vertebrates as zebrafish or newt, retain this ability until adulthood. Therefore,...
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Current Status, Barriers and Development Perspectives for Circular Bioeconomy in Polish South Baltic Area
PublikacjaThe following article presents the current legal situation in Poland as well as in the European Union. Data on biomass production in the Polish South Baltic area were analyzed, along with an indication of the key sectors for the development of bioeconomy. Presentation of the current state of biomass management was made and areas necessary for development were indicated to facilitate the sustainable management of biomass and waste...
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Active Dynamic Thermography in Medical Diagnostics
PublikacjaThis is an overview of active thermal imaging methods in medical diagnostics using external thermal stimulation. In this chapter, several clinical cases diagnosed using the active dynamic thermography method, ADT, are presented. Features of this technology are discussed and main advantages underlined. Applications in skin burn diagnostics and quantitative evaluation leading to modern classification of burned patients for further...
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Numerical modeling and experimental validation of full-scale segment to support design of novel GFRP footbridge
PublikacjaThe paper contains analysis of full-scaled three meters long segment of a novel composite footbridge. Both numerical modeling and experimental validation were performed. Analyzed object is a shell type sandwich channel-like structure made of composite sandwich with GFRP laminates as a skin and PET foam as a core. Several static load schemes were performed including vertical and horizontal forces. In FEM analysis multilayered laminate...
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Solid road environment and its hazards
PublikacjaAccidents that involve vehicles departing the road tend to have very high severity, as they often result in the vehicle hitting a permanent obstacle (which can be a ree, a pole, facility pillar, front wall of a culvert or a barrier). In recent years, this type of accident caused approx. 19% of all road deaths in Poland. A particularly high risk can be observed on roads located in northern and western...
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Safety Assessment of the Regional Warmia and Mazury Road Network Using Time-Series Analysis
PublikacjaWarmia and Mazury still belongs to the areas with the smallest transport accessibility in Europe. Unsatisfactory state of road infrastructure is a major barrier to the development of the regional economy, impacting negatively on the life conditions of the population. Also in terms of road safety Warmia and Mazury is one of the most endangered regions in Poland. The Police statistics show that beside a high pedestrian risk observed...
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Comparison of the exponential thermal transient parameterization methods with the SMTP method in the unipedicled DIEP flap computer modelling and simulation
PublikacjaThe aim of this paper is to compare the spatial contrast of the image descriptors obtained via three different thermal transient parameterization methods in Active Dynamic Thermography. The thermal constants and amplitude values of the one- and two- exponential parametrization are compared to the Simplified Magnitude-Temporal Parametrization method (SMTP). The comparison is performed using the data obtained by simulating the cold...
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Composite GFRP U-shaped footbridge
PublikacjaThe paper presents proposals for the use of glass fiber reinforced polymer composites for the construction of engineering objects, known and commonly used in the shipbuilding industry. An example of a pedestrian footbridge was used in this case, which, despite the considerable thickness of the structural material, was made using infusion technology in one production cycle. The designed and produced footbridge span is durable, dynamically...
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Full scattering profile of circular optical phantoms mimicking biological tissue
PublikacjaHuman tissue is one of the most complex optical media since it is turbid and nonhomogeneous. In our poster, we suggest a new type of skin phantom and an optical method for sensing physiological tissue condition, basing on the collection of the ejected light at all exit angles, to receive the full scattering profile. Conducted experiments were carried out on an unique set-up for noninvasive encircled measurement. Set-up consisted...