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Wyniki wyszukiwania dla: drug delivery systems
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Pharmaceutical and forensic drug applications of chiral supercritical fluid chromatography
PublikacjaTHE SUPERCRITICAL FLUID IS AN EXCELLENT CHOICE AS THE CHROMATOGRAPHIC MOBILE PHASE BECAUSE IT ALLOWS RAPID SEPARATION WITH HIGH EFFICIENCY AND APPLICATIONS INVOLVING ENANTIORESOLUTION ARE COMMON. SUPERCRITICAL FLUID CHROMATOGRAPHY (SFC) IS INCREASINGLY USED FOR ANALYTICAL, SEMI-PREPARATIVE AND PREPARATIVE PURIFICATION OF CHIRAL COMPOUNDS, INCLUDING PRODUCTION OF ENANTIOMERS THAT ARE MAINLY ENCOUNTERED DURING DRUG DEVELOPMENT. SFC...
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Methods for Elucidation of DNA-Anticancer Drug Interactions and Their Applications in the Development of New Drugs
PublikacjaDNA damaging agents including anthracyclines, camptothecins and platinum drugs are among most frequently used drugs in the chemotherapeutic routine. Due to their relatively low selectivity for cancer cells, administration is associated with adverse side effects, whereas the inherent genotoxicity of these drugs is associated with risk of developing secondary cancers. Development of new drugs, which could be spared of these drawbacks...
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Disposition of Drugs of Abuse and Their Metabolites in Wastewater as a Method of the Estimation of Drug Consumption
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Determination of the chemical structure of potencial organic impurities occuring in the drug substance opopramol
PublikacjaThe tricyclic antipsychotic and antidepressant drug opipramol was examined with regard to the chemical structure of its organic impurities. Impurities were isolated from the technical product by chromatographic methods and their chemical structures were estabilished by HMNR, MS and FTIR.
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Rafał Leszczyna dr hab. inż.
OsobyDr hab. inż. Rafał Leszczyna jest profesorem uczelni na Wydziale Zarządzania i Ekonomii Politechniki Gdańskiej. W lipcu 2020 r., na podstawie osiągnięcia naukowego w obszarze zarządzania cyberbezpieczeństwem infrastruktur krytycznych w sektorze elektroenergetycznym, uzyskał stopień doktora habilitowanego w dziedzinie nauk inżynieryjno-technicznych, dyscyplina informatyka techniczna i telekomunikacja. W latach 2004–2008 pracował...
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Synthetic strategies in construction of organic low molecular-weight carrier-drug conjugates
PublikacjaInefficient transportation of polar metabolic inhibitors through cell membranes of eukaryotic and prokaryotic cells precludes their direct use as drug candidates in chemotherapy. One of the possible solutions to this problem is application of the ‘Trojan horse’ strategy, i.e. conjugation of an active substance with a molecular carrier of organic or inorganic nature, facilitating membrane penetration. In this work, the synthetic...
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Chemical Biology & Drug Design
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Tomasz Zubowicz dr inż.
OsobyTomasz Zubowicz has received his M.Sc. Eng. degree in Control Engineering from the Faculty of Electrical and Control Engineering at the Gda{\'n}sk University of Technology (GUT) in $2008$. He received his Ph.D. Eng. (Hons.) in the field of Control Engineering from the same faculty in $2019$. In $2012$ he became a permanent staff member at the Department of Intelligent Control and Decision Support Systems at GUT and a member of...
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Current state of a dual behaviour of antimicrobial peptides-Therapeutic agents and promising delivery vectors
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Longitudinal drug synergy assessment using convolutional neural network image-decoding of glioblastoma single-spheroid cultures
PublikacjaAbstract Background In recent years, drug combinations have become increasingly popular to improve therapeutic outcomes in various diseases, including difficult to cure cancers such as the brain cancer glioblastoma. Assessing the interaction between drugs over time is critical for predicting drug combination effectiveness and minimizing the risk of therapy resistance. However, as viability readouts of drug combination experiments...
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Ahmer Bin Hafeez
OsobyI have experience in Computational Biology, particularly bioinformatics, homology modeling, phylogenetics, structural biology, and drug discovery. Furthermore, I have hands-on experience with Bioinformatics software. Currently, my interest lies in translatable omics studies and drug discovery against novel protein targets involved in cancer and infectious diseases and Host-Pathogen PPIs. My aim involves the use of computational...
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Information Discovery and Delivery
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Accidents, victims and risk levels on regional roads in pomorskie voivodeship, 2017-2019 - Alcohol and drug accidents
Dane BadawczeData contain risk classification on regional roads (voivodeship roads) in pomorskie voivodeship in 2017-2019, risk group: Offenders under influence of alcohol or drug - driver or pedestrian. Measures used to assess the level of risk are (5 classes low, low to medium, medium, medium to high, high):
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Magdalena Gajewska prof. dr hab. inż.
OsobyMagdalena Gajewska (ur. 1.06.1968 r. w Gdańsku) ukończyła studia w 1993 roku na Wydziale Hydrotechniki Politechniki Gdańskiej. Jest adiunktem w Katedrze Technologii Wody i Ścieków na Wydziale Inżynierii Lądowej i Środowiska Politechniki Gdańskiej. Doktorat (2001) i habilitacja (2013) w dyscyplinie inżynierii środowiska. W kadencji 2016–2020 pełni funkcję prodziekana ds. nauki. Specjalizuję się w technologiach związanych z ekoinżynierią:...
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The Imidazoacridinone Antitumor Drug, C-1311, Is Metabolized by Flavin Monooxygenases but Not by Cytochrome P450s.
PublikacjaPrezentowane w publikacji wyniki badań mają na celu wyjaśnienie roli enzymów wątrobowych w metabolizmie przeciwnowotworowych pochodnych C-1311 oraz C-1330. Oba związki inkubowane były z frakcją mikrosomalną oraz enzymami rekombinantowymi należącymi do grypy cytochromu P450, FMO oraz UGT. Badania wykazały, że oba związki są metabolizowane przez enzymy frakcji mikrosomalnej, ale nie przez enzymy cytochromu P450. Aktywność enzymatyczna...
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Determination of the chemical structure of potential organic impurities occurring in drug substance opipramol
PublikacjaThe tricyclic antipsychotic and antidepressant drug opipramol (opipramole) was examined with regard to the chemical structure of its organic impurities. Impurities were isolated from the technical product by chromatographic methods and their chemical structures were established by 1H NMR, MS and FTIR and further confirmed by comparison with commercially available products or with products obtained by independent synthesis, and...
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Adam Dąbrowski dr inż.
OsobyAdam Dąbrowski uzyskał stopień doktora nauk inżynieryjno-technicznych w dyscyplinie inżynieria mechaniczna na Politechnice Gdańskiej oraz ukończył studia II stopnia na kierunku mechatronika na Technische Universität Hamburg a także double degree Engineering and Management of Space Systems na Hochschule Bremen. Posiada doświadczenie przemysłowe (Instytut Lotnictwa w Warszawie, SICK AG w Hamburgu, Blue Dot Solutions w Gdańsku, Niemieckie...
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The influence of small amount of substances present in tissue on the optical spectrum of immunosuppressive drug
PublikacjaIn this paper, we describe how commonly present in tissue substances - sodium chloride and glucose - affect the optical spectrum of an immunosuppressive drug (Cyclaid® by Apotex). Prepared samples were investigated using the spectrophotometer in the spectrum range from 250 nm to 1100 nm. The maximum wavelength shift calculated on the basis of measurement results is not bigger than the measurement wavelength step. So, it can be...
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Spontaneous unilateral exophthalmos after a vaginal delivery
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Emerging anticancer activity of candidal glucoseamine-6-phosphate synthase inhibitors upon nanoparticle-mediated delivery
PublikacjaNumerous glutamine analogues have been reported as irreversible inhibitors of the glucosamine-6-phosphate (GlcN-6-P) synthase in pathogenic Candida albicans in the last 3.5 decades. Among the reported inhibitors, the most effective N3-(4-methoxyfumaroyl)-L-2,3- diaminopropanoic acid (FMDP) has been extensively studied in order to develop its more active analogues. Several peptide−FMDP conjugates were tested to deliver FMDP to its...
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The Influence of the Co-Dopant Dexamethasone Phosphate on the Electrodeposition Process and Drug-Release Properties of Polypyrrole-Salicylate on Iron
PublikacjaIn this work, the influence of incorporation of two anti-inflammatory drugs dexamethasone phosphate and sodium salicylate on the electrodeposition process of polypyrrole (PPy) film on iron has been studied. The incorporation of the agents into PPy has been carried out in a one-step electropolymerization process on oxidizable iron. The role of each drug agent during the deposition process has been discussed. The morphological and...
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Information Systems Security 2023
Kursy OnlineThe e-learning course for the Information Systems Security, in the field of Electronics and Telecommunications in the II degree studies (2nd year of studies, 3rd semester).
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Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: implications for drug resistance and in vitro drug screening models
PublikacjaBadania z użyciem modelu komórek nowotworu płuc A549 wykazały, że komórki te po traktowaniu lekami uszkadzającymi DNA zatrzymują proliferację i wchodzą w stan starzenia komórkowego. Jednak post-inkubacja tych komórek prowadzi do powrotu do stanu proliferacji małej frakcji komórek. Wykazaliśy, że frakcja ta związana jest z obecnością komórek pierwotnych nowotworu w populacji komórek A549. Powrót do stanu proliferacji komóek A549...
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Nanosize effect of clay mineral nanoparticles on the drug diffusion processes in polyurethane nanocomposite hydrogels
PublikacjaStudies of swelling and release of naproxen sodium (NAP) solution by polyurethane nanocomposite hydrogels containing Cloisite® 30B (organically modified montmorillonite (OMMT)) have been performed. Polyurethane nanocomposite hydrogels are hybrid, nontoxic biomaterials with unique swelling and release properties in comparison with unmodified hydrogels. These features enable to use nanocomposite hydrogels as a modern wound dressing....
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Operational Research - Queuing Systems 2022
Kursy OnlineComponents, characteristics, classification, analysis, and applications of queuing systems.
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Information systems management - autumn 2023
Kursy OnlineInformation Systems in Management for International Management students. Autumn 2023
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Piotr Rajchowski dr inż.
OsobyPiotr Rajchowski (Member, IEEE) was born in Poland, in 1989. He received the E.Eng., M.Sc., and Ph.D. degrees in radio communication from the Gdańsk University of Technology (Gdańsk Tech), Poland, in 2012, 2013, and 2017, respectively. Since 2013, he has been working at the Department of Radiocommunication Systems and Networks, Faculty of Electronics, Telecommunications and Informatics, Gdańsk University of Technology, as a IT...
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Exposure to non-opioid analgesics during pregnancy and the risk of adverse drug reactions
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Construction of a simulation model of goods delivery in international road transportation taking into account the functioning efficiency of logistics supply chain
PublikacjaThe object of this study is the process of goods delivery in international road transport using various types of logistics chains. The problem being solved is due to the need to develop recommendations for exporters of goods to reformat or design new supply chains during wartime. The expediency of organizing foreign trade operations by the cargo owners' own forces or with the involvement of enterprises providing logistics consulting...
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Operational Research - Queuing Systems 2024
Kursy OnlineCourse discusses components, characteristics, classification, analysis, and applications of queuing systems.
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Operational Research - Queuing Systems 2024
Kursy OnlineCourse discusses components, characteristics, classification, analysis, and applications of queuing systems.
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Low-Barrier Hydrogen Bond Determines Target-Binding Affinity and Specificity of the Antitubercular Drug Bedaquiline
PublikacjaThe role of short strong hydrogen bonds (SSHB) in ligand-target binding remains largely unexplored, thereby hin- dering a potentially important avenue in the rational drug de- sign. Here, we investigate the interaction between bedaquiline (Bq), a potent anti-tuberculosis drug, and the mycobacterial ATP synthase, to unravel the role of a specific hydrogen bond to a conserved acidic residue in the target affinity and specificity....
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Large-scale multimedia content delivery over optical networks for interactive TV services
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Internet as a new platform for delivery of microwave CAD services.
PublikacjaZaprezentowano aplikację przeznaczoną do syntezy filtrów rezonatorowych, która jest realizacją nowego sposobu myślenia związanego z rewolucją usług internetowych, które charakteryzują się niskim kosztem tworzenia oraz szybką i bezpieczną dystrybucją. Opisano stworzoną wielowarstwową aplikację, która gwarantuje łatwy, bezpieczny oraz ograniczony dostęp do aplikacji dla szerokiego kręgu osób. Zawarto w niej algorytm szybkiej syntezy...
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Solutions of inverter systems in Shore-to-Ship Power supply systems
PublikacjaThe article presents a clearly formulated need for installing S2SP (Shore to Ship Power) systems, in particular Medium Voltage (MV) systems, along with certain solutions of modern inverter systems used in those systems. Requirements and basic configurations of S2SP systems are discussed, focusing in particular on capabilities of the S2SP system with DC distribution busbar. Moreover, on the background of the executing assumptions...
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Systems Software Design 1
Kursy OnlineSystems Software Design
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Future research directions in design of reliable communication systems
PublikacjaIn this position paper on reliable networks, we discuss new trends in the design of reliable communication systems. We focus on a wide range of research directions including protection against software failures as well as failures of communication systems equipment. In particular, we outline future research trends in software failure mitigation, reliability of wireless communications, robust optimization and network design, multilevel...
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Drug-resistant and hospital-associated Enterococcus faecium from wastewater, riverine estuary and anthropogenically impacted marine catchment basin.
PublikacjaEnterococci, ubiquitous colonizers of humans and other animals, play an increasingly important role in health-care associated infections (HAIs). Acquisition of resistance determinants not only seriously limits available therapeutic options but also increases available gene pool for other species. It is believed that the recent evolution of two clinically relevant species, Enterococcus faecalis and Enterococcus faecium occurred...
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Smart Knowledge Engineering for Cognitive Systems: A Brief Overview
PublikacjaCognition in computer sciences refers to the ability of a system to learn at scale, reason with purpose, and naturally interact with humans and other smart systems, such as humans do. To enhance intelligence, as well as to introduce cognitive functions into machines, recent studies have brought humans into the loop, turning the system into a human–AI hybrid. To effectively integrate and manipulate hybrid knowledge, suitable technologies...
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Drug-Eluting Biopsy Needle as a Novel Strategy for Antimicrobial Prophylaxis in Transrectal Prostate Biopsy
PublikacjaOBJECTIVES: To preclinically evaluate drug-eluting biopsy needles (patent pending WO2016118026) as a new potential way of antimicrobial prophylaxis for transrectal prostate biopsy. METHODS: Twenty steel biopsy needles have been coated with polyvinyl alcohol, ciprofloxacin, and amikacin. Modified biopsy needles have been randomly divided into 3 groups (1:2:1 ratio). Needles from group I were immersed for 30 minutes in dedicated...
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Adapting new tools of urban freight management based on Gdynia’s dedicated delivery bays example – an analysis of the process
PublikacjaThe article presents an analysis of a process which ultimately helped Gdynia to designate pilot delivery sites in its downtown area using international experience. A verification was conducted of policy transfer theory and its practical implementation based on an URBACT Freight Tails project. While the choice of the solution was based on critical analysis of existing practical examples, it needed to be adapted to the local conditions...
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Computer controlled systems - 2022/2023
Kursy Onlinemateriały wspierające wykład na studiach II stopnia na kierunku ACR pod tytułem komputerowe systemy automatyki 1. Computer system – controlled plant interfacing technique; simple interfacing and with both side acknowledgement; ideas, algorithms, acknowledge passing. 2. Methods of acknowledgement passing: software checking and passing, using interrupt techniques, using readiness checking (ready – wait lines). The best solution...
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Information Systems Security 2023/2024
Kursy OnlineThe e-learning course for the Information Systems Security, in the field of Electronics and Telecommunications in the II degree studies (2nd year of studies, 3rd semester).
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ENCAPSULATION OF ROXITHROMYCIN INTO GELLAN GUM MATRICES AND THE IMPACT OF OTHER NATURAL POLYMERS ON DRUG RELEASE
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A five-year retrospective study shows increasing rates of antimicrobial drug resistance in Cabo Verde for both Staphylococcus aureus and Escherichia coli
PublikacjaObjectives Data on baseline drug resistance is important in informing future antimicrobial stewardship programs. So far, no data on the antimicrobial drug resistance of clinical isolates was available for the African archipelago of Cabo Verde. Methods We have performed a retrospective analysis over five-years (2013-17) of the antimicrombial drug susceptibility profiles of clinical isolates in the two main hospitals of Cabo Verde....
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Cognitive Systems, Concepts, Processes, and Techniques for the Age of Industry 4.0
PublikacjaThe aim of this Guest Edition of Cybernetics and Systems is to present a wide-ranging scale of concepts and processes being currently researched, developed, and evaluated in real life settings in anticipation of incoming Industry 4.0 era. With the fourth industrial revolution expectation, the broad spectrum of cognitive approaches have emerged as an attempt to mimic and augment, in some way, human intelligence. Intelligence, in...
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Subharmonic solutions for a class of Lagrangian systems
PublikacjaWe prove that second order Hamiltonian systems with a potential of class C1, periodic in time and superquadratic at infinity with respect to the space variable have subharmonic solutions. Our intention is to generalise a result on subharmonics for Hamiltonian systems with a potential satisfying the global Ambrosetti-Rabinowitz condition from [P. H. Rabinowitz, Proc. Roy. Soc. Edinburgh Sect. A, 114 (1990), 33-38]. Indeed, we weaken...
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Safety-Critical Systems 2023
Kursy OnlineSafety-Critical Systems / Bezpieczeństwo systemówKierunek Informatyka, studia II stopniaProwadzący: Andrzej WardzińskiWykład: Poniedziałek 15:15 EA 07 (od 27 lutego 2023)Projekt w drugiej połowie semestruKod dostępu do przedmiotu w eNauczanie będzie przekazany podczas pierwszego wykładu
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Safety-Critical Systems 2023
Kursy OnlineSafety-Critical Systems / Bezpieczeństwo systemówKierunek Informatyka, studia II stopnia Prowadzący: Andrzej Wardziński Wykład: Poniedziałek 15:15 EA 07 (od 27 lutego 2023) Projekt w drugiej połowie semestru Kod dostępu do przedmiotu w eNauczanie będzie przekazany podczas pierwszego wykładu
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The modelling method of discrete-continuous systems
PublikacjaThe paper introduces a method of discrete-continuous systems modelling. In the proposed method a three-dimensional system is divided into finite elements in only two directions, with the third direction remaining continuous. The thus obtained discrete-continuous model is described by a set of partial differential equations. General difference equations of discrete system are obtained using the rigid finite element method. The limit...