Filtry
wszystkich: 666
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Wyniki wyszukiwania dla: therapeutic landscapes
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Voltammetric and biological studies of folate-targeted non-lamellar lipid mesophases
PublikacjaFolate-targeted lipid nanostructures are promising strategies for the development of biocompatible drug delivery systems. The objective of this study was to evaluate the efficacy of drug delivery to cancer cells by folate-targeted lipid mesophases, cubosomes (CUB) and hexosomes (HEX), loaded with doxorubicin (DOX). Three cancer-derived cell lines (KB, HeLa, T98G) exhibiting different expressional levels of folate receptor protein...
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Art and Healthcare - Healing Potential of Artistic Interventions in Medical Settings
PublikacjaThe stereotype of a machine for healing seems to be well rooted in common thinking and social perception of hospital buildings. The technological aspect of healthcare architecture has been influenced for several years by three major factors. The first is linked to the necessity of providing safety and security in the environment of elevated epidemiological risk. The second concerns the need for incorporating advanced technology...
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Using creative approaches for discovering biomorphic forms for appropriate human habitation in natural environments. Case study of Kashubian Lake District
PublikacjaThe research process consisted of studies of natural and cultural conditions of the Kashubian Lake District This is an area of exceptional natural conditions. For centuries, it has seen human habitation with respect to landscape values. Given its extensive forest cover and the lack of heterogeneity of natural conditions, the area has become an interesting inspiration for the author’s original project. The project is aimed at searching...
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Machine-Learning-Based Global Optimization of Microwave Passives with Variable-Fidelity EM Models and Response Features
PublikacjaMaximizing microwave passive component performance demands precise parameter tuning, particularly as modern circuits grow increasingly intricate. Yet, achieving this often requires a comprehensive approach due to their complex geometries and miniaturized structures. However, the computational burden of optimizing these components via full-wave electromagnetic (EM) simulations is substantial. EM analysis remains crucial for circuit...
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How to teach architecture? – Remarks on the edge of Polish transformation processes after 1989
PublikacjaThe political changes in Poland after 1989 have resulted in a whole range of dynamic processes including the transformation of space. Until that time the established institutional framework for spatial, urban and architectural planning policy was based on uniform provisions of the so-called planned economy. The same applied to the training of architects, which was based on a unified profile of education provided at the state’s...
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Platform governance for sustainable development: Reshaping citizen-administration relationships in the digital age
PublikacjaChanging governance paradigms has been shaping and reshaping the landscape of citizen-administration relationships, from impartial application of rules and regulations by administration to exercise its authority over citizens (bureaucratic paradigm), through provision of public services by administration to fulfil the needs of citizens (consumerist paradigm), to responsibility-sharing between administration and citizens for policy...
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The Bridge of Knowledge – defining and implementing national Open Access policy by Polish universities. Gdansk University of Technology perspective
PublikacjaThe European Commission states that Open Access to scientific resources funded by the European Union shall facilitate the use of research results financed from the public funds. Moreover, it will cause an increase in the innovative capacity of Europe. The Open Access landscape is determined by several factors such as mandates. The open mandate may be voluntary or mandatory and implemented at the institutional, national or international...
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Improved-Efficacy Optimization of Compact Microwave Passives by Means of Frequency-Related Regularization
PublikacjaElectromagnetic (EM)-driven optimization is an important part of microwave design, especially for miniaturized components where the cross-coupling effects in tightly arranged layouts make traditional (e.g., equivalent network) representations grossly inaccurate. Efficient parameter tuning requires reasonably good initial designs, which are difficult to be rendered for newly developed structures or when re-design for different operating...
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The Changing Nature of In‐Between Spaces in the Transformation Process of Cities
PublikacjaIn the in‐between spaces of cities, there are many problems of various nature and scale: functional, spatial, economic, environmental, visual, and social. There are also some hidden potentials that can be activated. The aim of the article is to explore the possibilities of solving existing problems and to show the possibilities of using the potentials of in‐between spaces with regard to the changing nature of a city. The article,...
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Microbial and chemical quality assessment of the small rivers entering the South Baltic. Part I: Case study on the watercourses in the Baltic Sea catchment area
PublikacjaThe area of the Coastal Landscape Park (CLP) due to its location is extremely attractive touristic area. In the summer season, a significant increase in population density is observed, which influences surface water quality. Large numbers of tourists generate an increased amount of municipal wastewater, being treated in local treatment plants and discharged into rivers and streams. The paper presents preliminary research from summer...
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Accelerated Parameter Tuning of Antenna Structures by Means of Response Features and Principal Directions
PublikacjaPopularity of numerical optimization has been steadily on the rise in the design of modern antenna systems. Resorting to mathematically rigorous parameter tuning methods is a matter of practical necessity as interactive techniques (e.g., parameter sweeping) are no longer adequate when handling several performance figures over multi-dimensional parameter spaces. The most common design scenarios involve local tuning since decent...
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Narratives on cutting down trees on private land. A comparison of urban and rural municipalities in Poland using the Q-deliberation method
PublikacjaIncreased development in rural and urban areas leads to a decrease in tree cover and reduces the ecosystem services that trees provide. Municipal authorities must consider managing trees on private land to ensure that residents have access to trees and green spaces. In doing so, they must frequently confront conflicting stakeholder views, which are driven by diverse public and private interests and impacted by the type of landscape...
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Healthier and Environmentally Responsible Sustainable Cities and Communities. A New Design Framework and Planning Approach for Urban Illumination
PublikacjaAlthough sustainability and sustainable development are both considered necessary practices in various fields today, a recent analysis showed that the Sustainable Development Goal SDG11: Sustainable Cities and Communities established by the United Nations does not address urban illumination and its impact. This oversight is of concern because research carried out in the last 20+ years indicates artificial light at night (ALAN)...
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Methodology for Carrying Out Measurements of the Tombolo Geomorphic Landform Using Unmanned Aerial and Surface Vehicles near Sopot Pier, Poland
PublikacjaThe human impact on the ecosystem has been particularly evident in the last century; it transforms the Earth’s surface on an unprecedented scale and brings about irreversible changes. One example is an oceanographic phenomenon known as a tombolo, i.e., a narrow belt connecting the mainland with an island lying near the shore formed as a result of sand and gravel being deposited by sea currents. The phenomenon contributes to an...
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Analiza wielokryterialna wariantów systemu zaopatrzenia w wodę zespołu padów
PublikacjaJednym z istotnych problemów decyzyjnych na etapie potencjalnej eksploatacji gazu z formacji łupkowych jest wybór sposobu zaopatrzenia w wodę kopalni gazu łupkowego. Z uwagi na duże zapotrzebowanie na wodę do procesu szczelinowania kolejno przekazywanych do eksploatacji odwiertów wydobywczych, należy poszukiwać systemu zaopatrzenia w wodę, który zagwarantuje wymaganą jej ilość, a jednocześnie nie będzie zbyt dużym obciążeniem dla...
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Ocena przekształceń piętrowego, ceglanego domu z dachem półpłaskim z przełomu XIX–XX wieku pod wpływem termomodernizacji na przykładzie gminy Puck, woj. pomorskie.
PublikacjaCeglane budynki mieszkalne z przełomu XIX i XX wieku, które stanowiły charakterystyczny element krajobrazu wsi pomorskiej, obecnie powszechnie poddawane są modernizacji w celu poprawy warunków cieplnych. Przedmiotem badania jest stan zachowania najmłodszego, historycznego typu domuw zagrodzie chłopskiej na Kaszubach – piętrowego, ceglanego domu z dachem półpłaskim. Badanie przeprowadzono na obszarze gminy Puck. Zidentyfikowano...
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Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione: characteristics of non-enzymatic and glutathione S-transferase-mediated reactions
PublikacjaUnsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. A significant route of phase II drug metabolism is conjugation with glutathione (GSH), which can be non-enzymatic and/or catalyzed by GSH-dependent enzymes. The aim of this work was to investigate the GSH-mediated metabolic pathway of a representative UA, C 2028. GSH supplemented incubations of C-2028 with rat, but not with human, liver...
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Attitudes of oncology patients’ towards biospecimen donation for biobank research
PublikacjaBackground Since the biological material that remains after diagnostic and therapeutic procedures plays crucial role in biobank research, this study aims to explore cancer patients’ views on the donation of biospecimens for research purposes. Methods 548 oncology patients from two hospitals with oncology treatment units in Poznan, Poland,...
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Metabolism of antitumour agent 1-nitroacridine derivative, C-1748 in pancreatic cancer cell lines
PublikacjaPancreatic cancer has the highest mortality rate of all major cancers because of limited treatment options. Surgical removal of the tumour is possible only in its early stage, nevertheless the asymptomatic development very often makes unable an accurate diagnose. In the case of metastatic pancreatic cancer only chemotherapy, mainly with gemcitabine, can be offered to patients. However, common resistance towards gemcitabine imposes...
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Prediction of Overall In Vitro Microsomal Stability of Drug Candidates Based on Molecular Modeling and Support Vector Machines. Case Study of Novel Arylpiperazines Derivatives
PublikacjaOther than efficacy of interaction with the molecular target, metabolic stability is the primary factor responsible for the failure or success of a compound in the drug development pipeline. The ideal drug candidate should be stable enough to reach its therapeutic site of action. Despite many recent excellent achievements in the field of computational methods supporting drug metabolism studies, a well-recognized procedure to model...
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Targeting of FLT3-ITD kinase contributes to high selectivity of imidazoacridinone C-1311 against FLT3-activated leukemia cells
PublikacjaDrugs targeting receptor tyrosine kinase FLT3 are of particular interest since activating FLT3-internal tandem duplication (ITD) mutations abundantly occur in fatal acute myeloid leukemias (AMLs). Imidazoacridinone C-1311, a DNA-reactive inhibitor of topoisomerase II, has been previously shown to be a potent and selective inhibitor of recombinant FLT3. Here, we expand those findings by studying its effect on leukemia cells with...
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New Unsymmetrical Bisacridine Derivatives Noncovalently Attached to Quaternary Quantum Dots Improve Cancer Therapy by Enhancing Cytotoxicity toward Cancer Cells and Protecting Normal Cells
PublikacjaThe use of nanoparticles for the controlled drug delivery to cells has emerged as a good alternative to traditional systemic delivery. Quantum dots (QDs) offer potentially invaluable societal benefits such as drug targeting and in vivo biomedical imaging. In contrast, QDs may also pose risks to human health and the environment under certain conditions. Here, we demonstrated that unique combination of nanocrystals core components...
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Glucosinolates from lepidium peruvianum as potential antiamnestic drugs
PublikacjaLepidium peruvianum (maca) (Brassicaceae) is a naturally occurring plant mainly in the high Andes of Peru. In recent years, it has been intensively researched in terms of its influence on various diseases and towards health improvement. Alzheimer’s disease is an incurable disease that most often affects adults over the age of 60. As since 2003 the US Food and Drug Administration (FDA) did not approve any new drug for Alzheimer’s...
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Exploring the cocrystallization potential of urea and benzamide
PublikacjaThe cocrystallization landscape of benzamide and urea interacting with aliphatic and aromatic carboxylic acids was studied both experimentally and theoretically. Ten new cocrystals of benzamide were synthesized using an oriented samples approach via a fast dropped evaporation technique. Information about types of known bi-component cocrystals augmented with knowledge of simple binary eutectic mixtures was used for the analysis...
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Soft skills among academics: Five theoretically informed lessons for current times
PublikacjaRESEARCH OBJECTIVE: The aim of this article is to provide a comprehensive examination of the role of soft skills among academics in the context of the evolving higher-education landscape. THE RESEARCH PROBLEM AND METHODS: We use a scoping review of existing literature to discuss the importance of soft skills in academia. Through critical analysis and synthesis, we identify patterns and gaps in current knowledge and develop five...
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LED Light Sources and Their Complex Set-Up for Visually and Biologically Effective Illumination for Ornamental Indoor Plants
PublikacjaOrnamental plants are often used in indoor environments as part of biophilic design to improve the health and wellbeing of occupants, and to support sustainable, green architecture. Unfortunately, many plants do not thrive and need to be continuously replaced, which is economically unsustainable. The wavelengths and spectrum ratio of commonly used light sources such as light emitting diode (LED), and the lack of an appropriate...
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STORMWATER AS AN ALTERNATIVE WATER SOURCE: QUALITY CHANGES WITH RAINFALL DURATION AND IMPLICATIONS FOR TREATMENT APPROACHES
PublikacjaThe pressure on the world’s water resources is rapidly increasing due to population growth and climatic changes. Valorisation of stormwater as a water resource for non-potable reuse can reduce high-quality water demands and save it for potable uses. In this context, not only roof runoff but also drained stormwater outflow, representing considerably higher pollution levels, should be considered as a potential resource. We analysed...
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Generalized Formulation of Response Features for Reliable Optimization of Antenna Input Characteristics
PublikacjaElectromagnetic (EM)-driven parameter adjustment has become imperative in the design of modern antennas. It is necessary because the initial designs rendered through topology evolution, parameter sweeping, or theoretical models, are often of poor quality and need to be improved to satisfy stringent performance requirements. Given multiple objectives, constraints, and a typically large number of geometry parameters, the design closure...
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Environmental characteristics of a tundra river system in Svalbard. Part 1: Bacterial abundance, community structure and nutrient levels
PublikacjaThe Arctic hosts a set of unique ecosystems, characterised by extreme environmental conditions and undergoing a rapid change resulting from the average temperature rising. We present a study on an aquatic ecosystem of the Revelva catchment (Spitsbergen), based on samples collected from the lake, river and their tributaries, in the summer of 2016. The landscape variety of the study site and the seasonal change in the hydrological...
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Comparison of hydrochemistry and organic compound transport in two non-glaciated high Arctic catchments with a permafrost regime (Bellsund Fjord, Spitsbergen)
PublikacjaAn increase in air temperature related to climate change results in the retreat of glaciers, the degradation of permafrost, and the expansion of glacier-free areas in the polar regions. All these processes lead to changes in the Arctic landscape. They influence the hydrochemistry of streams and rivers fed by glaciers and thawing permafrost. In this study, we examine eighty two water samples from two non-glaciated catchments with...
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Novel Resveratrol-Based Substrates for Human Hepatic, Renal, and Intestinal UDP-Glucuronosyltransferases
PublikacjaTrans-Resveratrol (tRes) has been shown to have powerful antioxidant, anti-inflammatory, anti-carcinogenic, and anti-aging properties; however, its use as a therapeutic agent is limited by its rapid metabolism into its conjugated forms by UDP-Glucuronosyltransferases (UGTs). The aim of the current study was to test the hypothesis that the limited bioavailability of tRes can be improved by modifying its structure to create analogs...
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The antitumor compound triazoloacridinone C-1305 inhibits FLT3 kinase activity and potentiates apoptosis in mutant FLT3-ITD leukemia cells.
PublikacjaAim: FMS-like receptor tyrosine kinase (FLT3) is expressed in some normal hematopoietic cell types and plays an important role in the pathogenesis of acute myeloid leukemia (AML). In this study, we examined the effects of triazoloacridinone C-1305, an antitumor compound, on AML cells with different FLT3 status in vitro. Methods: A panel of human leukemic cell lines with different FLT3 status was used, including FLT3 internal tandem...
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Żuławski dom podcieniowy - przykłady i skala współczesnych działań konserwatorskich
PublikacjaPoczątki zainteresowania architekturą regionalną na terenach Prus Zachodnich sięgają przełomu XIX/XX wieku i związane są z osobą Bernharda Schmida. Koniec II wojny światowej przyniósł na Żuławach zniszczenie ponad 2 744 zagród chłopskich. Ze względu na priorytet ratowania zabytków Gdańska, historyczne obiekty z okolicznych wsi doczekały się szerszej uwagi służb konserwatorskich dopiero w połowie lat pięćdziesiątych. Opracowanie...
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Reemission of inorganic pollution from permafrost? A freshwater hydrochemistry study in the lower Kolyma basin (North-East Siberia)
PublikacjaPermafrost regions are under particular pressure from climate change resulting in widespread landscape changes, which impact also freshwater chemistry. We investi- gated a snapshot of hydrochemistry in various freshwater environments in the lower Kolyma river basin (North-East Siberia, continuous permafrost zone) to explore the mobility of metals, metalloids and non-metals resulting from permafrost thaw. Partic- ular attention...
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Genome-Wide DNA Methylation and Gene Expression in Patients with Indolent Systemic Mastocytosis
PublikacjaMastocytosis is a clinically heterogenous, usually acquired disease of the mast cells with a survival time that depends on the time of onset. It ranges from skin-limited to systemic disease, including indolent and more aggressive variants. The presence of the oncogenic KIT p. D816V gene somatic mutation is a crucial element in the pathogenesis. However, further epigenetic regulation may also affect the expression of genes that...
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Caffeine Inhibits Differentiation Of Lung Cancer Stem Cells By Modulating Their Respiratory Metabolism
PublikacjaIt is ell established that many tumor types contain a fraction of cells, with stem cell-like properties, called cancer stem cells (CSCs), that are resistant to apoptosis induced by therapeutic agents. The presence of CSCs may explain why a standard anticancer treatment, that eliminates only differentiated cancer cells, does not lead to cancer cure.We previously showed the existence of caffeine-sensitive mechanism that controls...
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Direct injection liquid chromatography-mass spectrometry (DI-LC-MS) analysis for rapid lipidomic profiling of extracellular vesicles
PublikacjaExtracellular vesicles (EVs) are small, spherical particles produced by eukaryotic and prokaryotic cells, surrounded by a bilayer membrane and carrying various bioactive molecules, such as proteins, surface receptors, membrane and soluble proteins, lipids, and nucleic acids. EVs are of substantial interest because of their important roles in cell communication, epigenetic regulation and possible application in disease diagnosis...
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Rola przekształceń styku lądu i wody w procesach rewitalizacji
PublikacjaArtykuł poświęcony jest zweryfikowaniu roli, jaką pełnią przekształcenia granic miedzy lądem i wodą w procesach rewitalizacji. Analizując szereg tego typu działań, w szczególności dotyczących transformacji obszarów poprzemysłowych, można zauważyć, że w ostatnim czasie charakterystyczne dla nich stają się modyfikacje planów obszarów wodnych i form ich granic. Jak okazuje się, działania takie mają nie tylko znaczenie kompozycyjne...
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Synagogi dawnej Polski - ich teraźniejszość i przyszłość
PublikacjaTekst stanowi próbę ujęcia w szerszej perspektywie złożonego zjawiska zmiany formy użytkowania ocalałych obiektów kultu religijnego. Postępująca sekularyzacja współczesnych społeczeństw stanowi wyzwanie dla religijnych społeczności różnych wyznań, przynosząc również pytania dotyczące zmiany przeznaczenia pustoszejących świątyń. Biorąc pod uwagę społeczny kontekst zarysowany powyżej, ocalałe budynki synagog można uznać za odrębny,...
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Innovations in Wastewater Treatment: Harnessing Mathematical Modeling and Computer Simulations with Cutting-Edge Technologies and Advanced Control Systems
PublikacjaThe wastewater treatment landscape in Central Europe, particularly in Poland, has undergone a profound transformation due to European Union (EU) integration. Fueled by EU funding and rapid technological advancements, wastewater treatment plants (WWTPs) have adopted cutting-edge control methods to adhere to EU Water Framework Directive mandates. WWTPs contend with complexities such as variable flow rates, temperature fluctuations,...
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On Accelerated Metaheuristic-Based Electromagnetic-Driven Design Optimization of Antenna Structures Using Response Features
PublikacjaDevelopment of present-day antenna systems is an intricate and multi-step process requiring, among others, meticulous tuning of designable (mainly geometry) parameters. Concerning the latter, the most reliable approach is rigorous numerical optimization, which tends to be re-source-intensive in terms of computing due to involving full-wave electromagnetic (EM) simu-lations. The cost-related issues are particularly pronounced whenever...
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Use of Daylight and Aesthetic Image of Glass Facades in Contemporary Buildings
PublikacjaThe paper deals with the architecture of contemporary buildings in respect to their aesthetic image created by the use of natural light. Sustainability is regarded as a principle of contemporary architecture, where daylighting is an important factor as it affects energy consumption and environmental quality of the space inside a building. Environmental awareness of architecture, however, involves a much wider and more holistic...
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Long-Term Impact of Wind Erosion on the Particle Size Distribution of Soils in the Eastern Part of the European Union
PublikacjaWind erosion is the leading cause of soil degradation and air pollution in many regionsof the world. As wind erosion is controlled by climatic factors, research on this phenomenon isurgently needed in soil and land management in order to better adapt to climate change. In thispaper, the impact of wind erosion on the soil surface in relation to particle size distribution wasinvestigated. Changes in percentage of sand, silt and...
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Dietary intervention with beetroot juice during doxorubicin cancer chemotherapy in vivo reduces markers of oxidative stress
PublikacjaCancer chemotherapy with doxorubicin, despite high antitumor activity and broad spectrum of this drug, is on decline due to toxic side effects. The clinical efficacy of anthracyclines have continuously prompted the search for new adjuvants to alleviate undesirable side toxicity incurred by this group of cytostatics. The recent approaches involve the application of synthetic or purified natural antioxidants in combination with doxorubicin...
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Hypericum alpestre extract exhibits in vitro and in vivo anticancer properties by regulating the cellular antioxidant system and metabolic pathway of L‐arginine
PublikacjaConventional treatment methods are not effective enough to fight the rapid increase in cancer cases. The interest is increasing in the investigation of herbal sources for the development of new anticancer therapeutics. This study aims to investigate the antitumor capacity of Hypericum alpestre (H. alpestre) extract in vitro and in vivo, either alone or in combination with the inhibitors of the L‐arginine/polyamine/nitric oxide...
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Green porous benzamide-like nanomembranes for hazardous cations detection, separation, and concentration adjustment
PublikacjaGreen biomaterials play a crucial role in the diagnosis and treatment of diseases as well as health-related problem-solving. Typically, biocompatibility, biodegradability, and mechanical strength are requirements centered on biomaterial engineering. However, in-hospital therapeutics require an elaborated synthesis of hybrid and complex nanomaterials capable of mimicking cellular behavior. Accumulation of hazardous cations like...
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Rewitalizacja dróg wodnych delty Wisły jako podstawa nowej perspektywy osiedleńczej
PublikacjaW artykule opisano badania dotyczące rewitalizacji dróg wodnych Delty Wisły. Problematyka badawcza dotyczy rozwoju obszaru na styku lądu i wody. Wpływ lokalizacji nadmorskiej, i związana z nią problematyka wynikająca z położenia poniżej poziomu morza są dostrzegalne nawet do stu kilometrów od wybrzeża. Dodatkowym aspektem, który ujemnie wpływa na rozwój obszaru delty po II wojnie światowej jest utrata tożsamości regionalnej. Dlatego...
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The Chitosan-Based System with Scutellariae baicalensis radix Extract for the Local Treatment of Vaginal Infections
PublikacjaScutellarie baicalensis radix, as a flavone-rich source, exhibits antibacterial, antifungal, an-tioxidant, and anti-inflammatory activity. It may be used as a therapeutic agent to treat various
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Professional activity, gender and disease-related emotions: The impact on parents' experiences in caring for children with phenylketonuria
PublikacjaIntroduction: Clinical management of rare diseases often fails to acknowledge the challenges faced by caregivers.Whilst management of phenylketonuria (PKU) may not be considered as dire as other conditions, most studiesprimarily concentrate on clinical issues, dietary adherence, or the quality of life of the PKU patients, leavingcaregivers in the background. The aim of the study was to evaluate the psychosocial...
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Changes in Functional and Spatial Layouts of Polish Single-Family Houses
PublikacjaArticle presents the evolution of functional and spatial layouts of single-family houses in Poland, with particular emphasis on the functions of a contemporary house. Singlefamily housing constitutes a significant part of the construction market in Poland. The way of forming functions in single-family buildings in the historical cycle has characteristic features resulting from the culture of the society in a given period. The functional...