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Wyniki wyszukiwania dla: LIPIDOME STABILITY
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Effects of plant extract antioxidative phenolic compounds on energetic status and viability of Saccharomyces cerevisiae cells undergoing oxidative stress
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Synthesis, physical properties and preliminary investigation of hemocompa-tibility of polyurethanes from aliphatic resources with castor oil participation
PublikacjaWykonano syntezy PUR z oligoeterodiolu, dioli małocząsteczkowych, oleju rycynowego i 4,4´diizocyjanianudicykloheksylometanu. Oznaczono właściwości mechaniczne PUR, kąty zwilżania i napięcie powierzchniowe. Opisano wstępne badania zgodności PUR z ludzką krwią oraz kalcyfikacji powierzchni PUR w warunkach statycznych in vitro. Napięcie powierzchniowe otrzymanych PUR jest zbliżone do napięcia powierzchniowego naturalnych powierzchni...
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The ability to overcome multidrug resistance of tumor cell lines by novel acridine cytostatics with condensed heterocyclic rings
PublikacjaZbadano aktywność cytotoksyczną, in vitzo dwóch nowych grup cytostatyków akrydynowych zawierających skondensowane pierścienie heterocykliczne w stosunku do komórek nowotworowych linii wrażliwych i opornych. Otrzymane wyniki potwierdziły naszą wcześniejszą hipotezę o istotnej roli pierścieni hetero-cyklicznych w pokonywaniu krzyżowej oporności wielolekowej.
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The ability of selected plant essential oils to enhance the action of recommended antibiotics against pathogenic wound bacteria
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Ability of paramedics to perform intraosseous access. A randomized cadaver study comparing EZ-IO® and NIO® devices
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Characteristics of the Properties of Absodan Plus Sorbent and Its Ability to Remove Phosphates and Chromates from Aqueous Solutions
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Sulfonamides with hydroxyphenyl moiety: Synthesis, structure, physicochemical properties, and ability to form complexes with Rh(III) ion
PublikacjaSulfonamides are the first successfully synthesized antimicrobial drugs. The mechanism of sulfonamides’ antimicrobial action involves competitive inhibition of folic acid synthesis and prevention of the growth and reproduction of bacteria. Even though they have been applied in therapy for more than 75 years, sulfonamides are still the drugs of choice for the treatment of various diseases. The aim of this work was to synthesize...
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The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability
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Analysis and assessment of the acoustic emission suitability for determination of the energy states of a tribological system in the form of a four-ball tester friction node
PublikacjaThe present operating safety and cost reduction requirements of the compression ignition engines make it necessary to search for new methods of detecting their defects, e.g. by the analysis of acoustic emission signals coming from the slide bearings. The paper presents non-destructive measurements of acoustic emission (AE) in order to obtain information on the processes taking place in a tribological system under the continuously...
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Thermal Instability of Choline Chloride-Based Deep Eutectic Solvents and Its Influence on Their Toxicity─Important Limitations of DESs as Sustainable Materials
PublikacjaDeep eutectic solvents (DESs) have become a hot topic in many branches of science due to their remarkable properties. They have been studied in a wide variety of applications. In particular, choline chloride (ChCl)-based DESs are one of the most commonly used representatives of these fluids. Nevertheless, in order to apply DESs in some fields, it is essential to guarantee their stability, reusability, and biocompatibility. In this...
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Novel 5-Substituted 2-(Aylmethylthio)-4-chloro-N-(5-aryl-1,2,4-triazin-3-yl)benzenesulfonamides: Synthesis, Molecular Structure, Anticancer Activity, Apoptosis-Inducing Activity and Metabolic Stability
PublikacjaA series of novel 5-substituted 2-(arylmethylthio)-4-chloro-N-(5-aryl-1,2,4-triazin-3-yl) benzenesulfonamide derivatives 27–60 have been synthesized by the reaction of aminoguanidines with an appropriate phenylglyoxal hydrate in glacial acetic acid. A majority of the compounds showed cytotoxic activity toward the human cancer cell lines HCT-116, HeLa and MCF-7, with IC50 values below 100 M. It was found that for the analogues 36–38...
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Investigation on domestic fruits seed oils in personal care emulsion systems
PublikacjaThe use of fruit seed oils in personal care products is of significance to both their function and image. Poland is an important processor of fruit products within the EU, and thus has a large availability of seeds from domestic fruits, which are normally considered to be a waste material. Unfortunately, current literature is scarce of the suitability of these oils for topical use in the form of cosmetic emulsions. Published data...
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Non-Adaptive Speed and Position Observer of Doubly-Fed Induction Generator
PublikacjaThe non-adaptive speed and position estimation of a doubly-fed induction generator (DFIG) is presented in this paper. The speed observer is based on the mathematical model of DFIG and to stabilize the structure the Lyapunov method is used. The classic stator field-oriented control to active and reactive power control is used in the sensorless control system. The performance of the proposed algorithm of a speed observer is validated...
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Running performance of an aerodynamic journal bearing with squeeze film effect
PublikacjaResults of theoretical and experimental studies concerning the performance of an aerodynamic journal bearing of which running is assisted by squeeze film ultrasonic levitation (SFUL) are presented in this paper. The SFUL mechanism not only can separate journal from the bearing at the start and stop phases of operation but also can significantly contribute to the dynamic stability of the bearing when it runs at speed. Computer calculations...
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Viability and intracellular nitric oxide generation in the umbilical cord blood CD34+CD133– and CD34+CD133+ cell populations exposed to local anaesthetics
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Assessment of the Suitability of Aromatic and High-Bitter Hop Varieties (Humulus lupulus L.) for Beer Production in the Conditions of the Małopolska Vistula Gorge Region
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Preliminary study on the influence of UV-C irradiation on microorganism viability and polyphenol compounds content during winemaking of ‘Regent’ red grape cultivar
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Wykorzystaniem metody elementów skończonych w obliczaniu stateczności silosu z blachy falistej = Finite element method in determining stability of with corrugated walls strengthened by vertical columns of thin walled open cross section
PublikacjaGwałtowny rozwój zastosowania MES w działalności inżynierskiej nastąpił w połowie lat osiemdziesiątych w związku z pojawieniem się komputerów osobistych (PC), na które przeniesione zostały programy z dużych jednostek obliczeniowych. W ten sposób efektywne narzędzie rozwiązywania problemów analiz i projektowania jakim jest MES, stało się powszechnie dostępne. W artykule przedstawiono zastosowanie MES w analizie stateczności stalowego...
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On the possibility of using liquid or lipid - polymer membrane systems as taste sensors
PublikacjaMembrany ciekłe z anionowym surfaktanetem mogą być użyte do rozpoznawania molekularnego substancji smakowych ale nie mogą stanowić podstawy sensora smaku głównie z powodu chaotycznych zachowań. Przeciwnie membrany polimerowo-lipidowe mogą być zastosowane w sensorze smaku do badania jakości pewnych napojów handlowych.
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New sample preparation strategies for comprehensive lipidomics of human breast milk
PublikacjaGLOBAL PROFILING ANALYSIS OF HUMAN BREAST MILK (HBM) LIPIDS IS HINDERED BY COMPLEX COMPOSITION OF HBM. THIS PROBLEM IS HUGE FROM ANALYTICAL POINT OF VIEW, SINCE DUE TO THAT DETECTION OF ALL HBM LIPIDS DURING ONE ANALYTICAL RUN IS LIMITED. THUS, SAMPLE PREPARATION STEP CONSTITUTES A CRUCIAL STEP IN UNTARGETED LIPIDOMIC ANALYSIS OF HBM, ESPECIALLY WHEN SEMI-QUANTITATIVE ANALYSIS IS ASSUMED. HEREIN, WE PRESENT A COMPARISON OF PUBLISHED...
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Mechanical Design, Construction and Control of a Lower Extremity Exoskeleton Robot Prototype with a new structure in the form of three-wheeled Mobile robot
PublikacjaIn this paper, mechanical design, dynamic modeling, construction and Fuzzy computed torque control of a lab prototype of lower extremity exoskeleton robot with a new structure in the form of three-wheeled Mobile robot is presented. One of the most important applications of next generation of lower extremity exoskeleton robot is usability as smart vehicle. In order to autonomously moving of this robot which is the foundation...
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Cold plasma treatment of tannic acid as a green technology for the fabrication of advanced cross-linkers for bioactive collagen/gelatin hydrogels
PublikacjaTannic acid (TA) is a natural compound studied as the cross-linker for biopolymers due to its ability to form hydrogen bonds. There are different methods to improve its reactivity and effectiveness to be used as a modifier for biopolymeric materials. This work employed plasma to modify tannic acid TA, which was then used as a cross-linker for fabricating collagen/gelatin scaffolds. Plasma treatment did not cause any significant...
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Space Vector Pulsewidth Modulation Strategy for Multilevel Cascaded H-Bridge Inverter With DC-Link Voltage Balancing Ability
PublikacjaSpace vector pulsewidth modulation (SVPWM) algorithms for cascaded H-bridge multilevel (CHB ML) inverter usually provide the possibility of using several combinations of active voltage vectors to generate the same output voltage vector. For preselected H-bridges, some of them may generate output voltages opposite to the assumed direction. This results in the change of the dc-link voltages of these H-bridges in the opposite direction...
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Synthesis, molecular structure, and metabolic stability of new series of N' -(2-alkylthio-4-chloro-5-methylbenzenesulfonyl)-1-(5-phenyl-1 H -pyrazol-1-yl)amidine as potential anti-cancer agents
PublikacjaA series of new N'-(2-alkylthio-4-chloro-5-methylbenzenesulfonyl)-1-(5-phenyl-1H-pyrazol-1-yl)amidine derivatives have been synthesized and evaluated in vitro by MTT assays for their antiproliferative activity against cell lines of colon cancer HCT-116, cervical cancer HeLa and breast cancer MCF-7. The studied compounds display selective activity mainly against HCT-116 and HeLa cells. Thus, five compounds show selective cytotoxic...
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Thermodynamic, Anticoagulant, and Antiproliferative Properties of Thrombin Binding Aptamer Containing Novel UNA Derivative
PublikacjaThrombin is a serine protease that plays a crucial role in hemostasis, fibrinolysis, cell proliferation, and migration. Thrombin binding aptamer (TBA) is able to inhibit the activity of thrombin molecule via binding to its exosite I. This 15-nt DNA oligonucleotide forms an intramolecular, antiparallel G-quadruplex structure with a chair-like conformation. In this paper, we report on our investigations on the influence of certain...
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Searching for in vitro biomarkers of susceptibility to prostate and cervical cancers by analysis of chromosomal instability, γ-H2AX foci, polymorphisms in DNA repair genes and apoptosis
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Viral infection-oxidative stress/DNA damage-aberrant DNA methylation: separate or interrelated events responsible for genetic instability and childhood ALL development?
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The extended version of restriction analysis approach for the examination of the ability of low-molecular-weight compounds to modify DNA in a cell-free system
PublikacjaOne of the primary requirements in toxicology is the assessment of ability of chemicals to induce DNA covalent modification. There are several well-established methods used for this purpose such as 32P-Postlabeling or HPLC-MS. However, all of these approaches have difficult to overcome limitations, which prevents their use in genotoxin screening. Here, we describe the simple protocol exploiting specificity of restriction enzymes...
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Suitability of biomass from waste wood composites for liquid biofuel production Możliwość wykorzystania biomasy poużytkowych tworzyw drzewnych w technologii ciekłych biopaliw
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Estimation of the Chelating Ability of an Extract from Aronia melanocarpa L. Berries and Its Main Polyphenolic Ingredients Towards Ions of Zinc and Copper
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Design and Optimization of Metamaterial-based Highly-isolated MIMO Antenna with High Gain and Beam Tilting Ability for 5G Millimeter Wave Applications
PublikacjaThis paper presents a wideband multiple-input multiple-output (MIMO) antenna with high gain and isolation, as well as beam tilting capability, for 5G millimeter wave (MMW) applications. A single bow-tie antenna fed by a substrate-integrated waveguide (SIW) is proposed to cover the 28 GHz band (26.5–29.5 GHz) with a maximum gain of 6.35 dB. To enhance the gain, H-shaped metamaterial (MM)-based components are incorporated into the...
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Ability of paramedics to perform endotracheal intubation during continuous chest compressions: a randomized cadaver study comparing Pentax AWS and Macintosh laryngoscopes
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The ability of children aged 6 and 9 years, respectively, to detect errors in a narrative based on incorrect information about evaporation in the water cycle
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Experimental Investigation of the Thermal Performance of a Wickless Heat Pipe Operating with Different Fluids: Water, Ethanol, and SES36. Analysis of Influences of Instability Processes at Working Operation Parameters
PublikacjaIn this study, the influences of different parameters on performance of a wickless heat pipe have been presented. Experiments have been carried out for an input power range from 50 W to 300 W, constant cooling water mass flow rate of 0.01 kg/s, and constant temperature at the inlet to condenser of 10 C. Three working fluids have been tested: water, ethanol, and SES36 (1,1,1,3,3-Pentafluorobutane) with different filling ratios (0.32,...
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Evaluation of the suitability of low hazard surfactants for the separation of phenols and carotenoids from red-flesh orange juice and olive mill wastewater using cloud point extraction
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Conformational latitude – activity relationship of KPPR tetrapeptide analogues toward their ability to inhibit binding of vascular endothelial growth factor 165 to neuropilin‐1
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Addressing challenges of BiVO4 light-harvesting ability through vanadium precursor engineering and sub-nanoclusters deposition for peroxymonosulfate-assisted photocatalytic pharmaceuticals removal
PublikacjaIn this study, we present a complex approach for increasing light utilisation and peroxymonosulfate (PMS) activation in BiVO4-based photocatalyst. This involves two key considerations: the design of the precursor for BiVO4 synthesis and interface engineering through CuOx sub-nanoclusters deposition. The designed precursor of ammonium methavanadate (NH4VO3, NHV) leads to reduction in particle size, better dispersion and improved light...
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Relationship between copper(ii) complexes with FomA adhesin fragments ofF. nucleatumand colorectal cancer. Coordination pattern and ability to promote ROS production
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Introduction to MIP synthesis, characteristics and analytical application
PublikacjaOne of the trends in analytical chemistry is associated with designing and developing new types of sample preparation techniques, which might significantly increase the efficiency and selectivity of the analytes isolation or/and preconcentration process. One of the most widely employed solutions are selective sorption materials, defined as molecularly imprinted polymers (MIPs), as well as the sorbents with the molecular fingerprint....
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Dynamika molekularna oddziaływań przeciwgrzybowych heptaenów aromatycznych i ich izomerów all-trans ze sterolami w błonach lipidowych
PublikacjaAromatyczne heptaeny (AH) należą do grupy makrolidów polienowych o działaniu przeciwgrzybowym. Antybiotyki z tej grupy były pierwszymi, które zostały wykorzystane w terapii układowych infekcji grzybiczych. Amfoterycyna B (AmB) oraz nystatyna, czyli niearomatyczni przedstawiciele makrolidów heptaenowych, mają istotne znaczenie kliniczne w leczeniu, odpowiednio, grzybic wewnętrznych i zewnętrznych. Molekularne podstawy mechanizmu...
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Molecular modelling of membrane activity of amphotericin B, a polyene macrolide antifungal antibiotic
PublikacjaPraca dotyczy różnego typu modelowań molekularnych cząsteczki przeciwgrzybowego antybiotyku (amfoterycyny B). Praca przeglądowa obejmuje opis badań nad właściwościami molekularnymi samej cząsteczki antybiotyku, jej oddziaływań z powierzchnią błony oraz struktur kanałowych jakie tworzą cząsteczki amfoterycyny wewnątrz błony lipidowej.
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Differential ability of cytostatics from anthraquinone group to generatefree radicals in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xantine oxidase.
PublikacjaZbadano szereg cytostatyków z grupy antrachinonu pod względem ich zdolności do pośredniczenia w przeniesieniu jednoelektronowym i generowaniu wolnych rodników tlenowych pod wpływem trzech oksydoreduktaz. Zdefiniowano czynniki strukturalne związków odpowiedzialne za ten proces katalizowany przez poszczególne enzymy.
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Application of Taguchi L16 design method for comparative study of ability of 3A zeolite in removal of Rhodamine B and Malachite green from environmental water samples
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Versatile method employing basic techniques of genetic engineering to study the ability of low molecular weight compounds to bind covalently with DNA in cell free systems.
PublikacjaMechanizm działania większości leków przeciwnowotworowych oraz związków rakotwórczych polega na ich kowalencyjnym wiązaniu z DNA. Poziom tego wiązania jest zazwyczaj bardzo niski, co powoduje, że potrzebne są niezwykle czułe metody aby kowalencyjna modyfikacja mogła być w ogóle wykryta. My podjęliśmy próbę zastosowania w tym celu prostych, szybkich i sprawdzonych technik inżynierii genetycznej: metody PCR do uzyskania fragmentu...
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Burnout Investigation of Small Diameter Tubes Immersed in Nanofluids
PublikacjaThis paper deals with research into pool boiling critical heat flux (CHF) of water–Al2O3, water–TiO2 and water–Cu nanofluids on horizontal stainless steel tubes. The experiments were conducted under atmospheric pressure. Nanoparticles were tested at concentrations of 0.001%, 0.01%, 0.1% and 1% by weight. Ultrasonic vibration was used in order to stabilize the dispersion of the nanoparticles. Although dispersants were not used to...
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Surface active fatty acid ILs: Influence of the hydrophobic tail and/or theimidazolium hydroxyl functionalization on aggregates formation
PublikacjaNine structurally-related fatty acid ionic liquids have been prepared and their thermal behavior as well as their ability to self-assemble in water has been investigated. The thermal properties were studied by thermal gravimetric analysis (TGA) and differential scanning calorimetry (DSC), while the aggregation behavior was analyzed by tensiometry, isothermal titration calorimetry (ITC), conductometry, dynamic light scattering (DLS),...
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Relationship among the Change of Direction Ability, Sprinting, Jumping Performance, Aerobic Power and Anaerobic Speed Reserve: A Cross-Sectional Study in Elite 3x3 Basketball Players
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Solvothermal growth of {0 0 1} exposed anatase nanosheets and their ability to mineralize organic pollutants. The effect of alcohol type and content on the nucleation and growth of TiO2 nanostructures
PublikacjaHerein, the series of {0 0 1} exposed anatase nanosheets from HF-assisted solvothermal growth synthesis were obtained. The two-dimensional TiO2 were characterized, including both bulk (XRD, DR-UV–Vis, Mott-Schottky) and surface characteristics (N2 sorption, XPS, SEM) with experimental results compiled with Density Functional Theory (DFT) calculations. The effect of alcohol amount and type was studied, demonstrating the crucial...
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Comparative in vitro studies on liposomal formulations of amphotericin Band its derivative, N-methyl-N-D-fructosyl amphotericin B methyl ester (MFAME)
PublikacjaMFAME, ester metylowy N-metylo-N-D-fruktozylo amfoterycyny B jest półsyntetyczną pochodną antybiotyku przeciwgrzybowego amfoterycyny B (AMB). W przeciwieństwie do wyjściowego antybiotyku pochodna ta jest nietoksyczna dla komórek zwierzęcych oraz tworzy rozpuszczalne sole rozpuszczalne w wodzie. Przeprowadzono badania porównawcze aktywności biologicznej wolnego antybiotyku i wolnej pochodnej oraz ich preparatów liposomalnych. Stosowano...
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Ho2Pd1.3Ge2.7 – a ternary AlB2-type cluster glass system
PublikacjaWe report a successful synthesis of a ternary AlB2-type intermetallic compound. The phase purity was obtained by fine-tuning the Pd-Ge ratio out of the idealized 1-3. Attempts to synthesize an Er analogue were not successful. We discuss the instability of the Er analogue based on the atomic size ratio and also suggest that the increased stability of Ho2Pd1+xGe3−x in the Pd-rich range likely stems from a combination of atomic size...