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Wyniki wyszukiwania dla: dawid hume
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Acid-triggered release from sterically stabilized fusogenic liposomes via ahydrolytic DePEGylation strategy
PublikacjaOpracowano nowe, labilne w stosunku do kwasów, pochodne diplasmenylo-cholinysprzężone z glikolem polietylenowym (PEG) i zbadano ich wpływ na lipozomy.Opisano szybkość hydrolizy oraz szybkość uwalniania oraz kinetykę tworzenialipozomów DOPE stabilizowanych BVEP stosunków molowych BCEP/DOPE wynoszących1:99, 3:97 oraz 5:95. Zbadano widma 31P NMR, także dla układów z jonami Mn2+dla różnych wartości pH.
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Sub-national structures matter when evaluating physical activity promotion: Lessons from Germany
PublikacjaBackground Public policies are increasingly acknowledged as important part of promoting physical activity (PA). However, especially in states with sub-national administrative structures such as Germany, national and sub-national approaches differ considerably. In Germany, sport for all (SfA) promotion is mostly organized at sub-national level, which is usually not covered in national evaluations. Knowledge of these structures helps...
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Redesigning Informal Beirut: Shaping the Sustainable Transformation Strategies
PublikacjaLebanon is distinguished by its strategic geographical location among the Arab countries. Beirut, as the capital city and the major commercial and cultural centre of the country, is a point of interest for migrants. The region has witnessed many changes since the end of World War II, which have resulted in internal and external conflicts, migrations, the centralization of the country’s economy, etc. Furthermore, the city has witnessed...
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Evaluation of the use of reindeer droppings for monitoring essential and non-essential elements in the polar terrestrial environment
PublikacjaExcess or toxic metals, non-metals and metalloids can be eliminated from the organism by deposition in inert tissue (e.g. fur) or excretion with body secretions, urine and faeces. Droppings are one of the main routes for the elimination of multiple elements and they can be collected without direct contact with the animal. Contaminant concentration has been examined in non-lethally collected tissues of several species (especially...
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Shooting Gas Cylinders to Prevent Their Explosion in Fire
PublikacjaGas cylinders in general, and particularly cylinders containing acetylene, constitute a great potential danger to fire and rescue services involved in salvage operations. Experiments show that gas cylinders with acetylene, oxygen, hydrogen, CNG, LPG or CO2 may blow after short exposition to heat with very destructive effect as fragments of blown cylinder may fly even several hundred meters. In the case of acetylene the explosion...
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Real-Time Facial Features Detection from Low Resolution Thermal Images with Deep Classification Models
PublikacjaDeep networks have already shown a spectacular success for object classification and detection for various applications from everyday use cases to advanced medical problems. The main advantage of the classification models over the detection models is less time and effort needed for dataset preparation, because classification networks do not require bounding box annotations, but labels at the image level only. Yet, after passing...
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Electron-scattering cross sections for selected alkyne molecules: Measurements and calculations
PublikacjaWe report cross-section results from experimental and theoretical studies on electron collisions with 1-butyne (HC≡C–CH2CH3) and acetylene (HC≡CH) molecules and from computations for a propyne (HC≡C–CH3) molecule. Absolute grand -total electron-scattering cross sections (TCSs) were measured at impact energies ranging from about 0.5 to 300 eV using the linear electron-transmission method. The TCS energy curve for 1-butyne has a...
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US not bright but right method of thyroid volume estimation even in large and substernal extended goitres. Comparison of US and three methods of CT thyroid evaluation - prospective study.ON LINE
PublikacjaBackground Ultrasound is nowadays a method of choice for thyroid volume assessment. However, its disadvantage is some inaccuracy, which is said to be higher in huge, especially substernally extended goitres. Aims The aim of the study was to compare the US and CT thyroid volumetric measurements: multi-observers (CT MO) and one-observer (CT OO) to CT planimetry results (CT Pl) in patients with large goitres. Materials & Methods The...
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Nowe rozwiązania metodyczne i techniczne w zakresie techniki mikroekstrakcji do fazy stracjonarnej
PublikacjaSample preparation has been recognized as a critical step of the analytical process, being even considered as the bottleneck of the overall process. Enrichment of target compounds, transfer of the analytes into a solvent compatible with the analytical instrumentation, minimization of potential interferences, and efficient sample clean-up, are among the main aims of sample preparation techniques. In this regard, liquid-liquid extraction...
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Differential Response of MDA-MB-231 and MCF-7 Breast Cancer Cells to In Vitro Inhibition with CTLA-4 and PD-1 through Cancer-Immune Cells Modified Interactions
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Szybkie wykrywanie wirusa grypy we wczesnej fazie rozwoju za pomocą sensorów nanodiamentowych domieszkowanych borem
PublikacjaPrzedstawiono konstrukcję i wyniki wstępnych badań szybkiego elektrochemicznego sensora wykonanego na bazie cienkich warstw nanokrystalicznego diamentu domieszkowanego borem, który umożliwia wykrywanie śladowych ilości wirusa grypy we wczesnej fazie rozwoju. Zapewnia to identyfikację ognisk pandemii.
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Truncation of Huia versabilis Bowman-Birk inhibitor increases its selectivity, matriptase-1 inhibitory activity and proteolytic stability
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The Effect of Varying the Light Spectrum of a Scene on the Localisation of Photogrammetric Features
PublikacjaIn modern digital photogrammetry, an image is usually registered via a digital matrix with an array of colour filters. From the registration of the image until feature points are detected on the image, the image is subjected to a series of calculations, i.e., demosaicing and conversion to greyscale, among others. These algorithms respond differently to the varying light spectrum of the scene, which consequently results in the feature...
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Modelowanie systemów energetycznych wytwarzania energii elektrycznej i ciepła do celów planowania rozwoju - wybrane zagadnienia
PublikacjaSystemy energetyczne wymagają przemian technologicznych w kierunku neutralności klimatycznej. W Polsce, w której systemie elektroenergetycznym i systemach ciepłowniczych dominują przestarzałe elektrownie i ciepłownie węglowe, dążenie do minimalizacji wpływu na środowisko wiąże się z wysokimi kosztami. Dlatego należy szukać optymalnych ścieżek roz-woju energetyki, aby osiągnąć ambitne długoterminowe cele strategiczne, przy minimalizacji...
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Lack of magnetoacoustic emission in iron with 6.5% silicon
PublikacjaZjawisko emisji magnetoakustycznej (EMA) na ogół tłumaczy się dwoma przyczynami: ruchem nie 180-cio stopniowych granic domenowych (1) lub kreacją i anihilacją domen magnetycznych. Artykuł prezentuje silne dowody na poparcie faktu, że to właśnie ruch granic nie 180-cio stopniowych odpowiada za powstawanie efektu EMA. Wynika to z wyników pomiarów dających zerowe natężenie efektu EMA przeprowadzonych dla szerokiego zakresu naprężeń...
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The supramolecular organization of self-assembling chlorosomal bacteriochlorophyll c, d, or e mimics
PublikacjaBacteriochlorophylls (BChls) c, d, and e are the main light-harvesting pigments of green photosynthetic bacteria that self-assemble into nanostructures within the chlorosomes forming the most efficient antennas of photosynthetic organisms. All previous models of the chlorosomal antennae, which are quite controversially discussed because no single crystals could be grown so far from these organelles, involve a strong hydrogen-bonding...
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Properties of Composite Modified with Limestone Powder for 3D Concrete Printing
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Folding kinetics of WW domains with the united residue force field for bridging microscopic motions and experimental measurements
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Pea Protein for Hempseed Oil Nanoemulsion Stabilization
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RECODIS: Resilient Communication Services Protecting End-user Applications from Disaster-based Failures
PublikacjaDisaster-based failures can seriously disrupt any communication network, making its services unavailable. Such disruptions may be caused by natural disasters, technology-related failures, or malicious attacks, and they are observably increasing in number, intensity and scale. When network services that are a part of critical infrastructure become unavailable, commercial and/or societal problems are inevitable. The issue of limiting...
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Morphology control via dual solvent crystallization for high-mobility functionalized pentacene-blend thin film transistors
PublikacjaWe present an approach to improving the performance of solution processed organic semiconductor transistors based on a dual solvent system. We here apply this to a blend containing the π-conjugated small molecule 6,13 bis(triisopropylsilylethynyl) pentacene (TIPS-pentacene) and polystyrene, which acts as an inert binder. Using a semiconductor-binder solution of two solvents, where the main solvent is a better solvent of the small...
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In Search of Panacea—Review of Recent Studies Concerning Nature-Derived Anticancer Agents
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Low-volume label-free SARS-CoV-2 detection with the microcavity-based optical fiber sensor
PublikacjaAccurate and fast detection of viruses is crucial for controlling outbreaks of many diseases; therefore, to date, numerous sensing systems for their detection have been studied. On top of the performance of these sensing systems, the availability of biorecognition elements specific to especially the new etiological agents is an additional fundamental challenge. Therefore, besides high sensitivity and selectivity, such advantages...
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Lactoferrin B Combined with Antibiotics Exhibits Leukemic Selectivity and Antimicrobial Activity
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Lactoferricin B Combined with Antibiotics Exhibits Leukemic Selectivity and Antimicrobial Activity
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Lactoferricin B Combined with Antibiotics Exhibits Leukemic Selectivity and Antimicrobial Activity
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Peptide conjugates of lactoferricin analogues and antimicrobials—Design, chemical synthesis, evaluation of antimicrobial activity and mammalian cytotoxicity
PublikacjaEight new peptide conjugates composed of modified bovine lactoferricin truncated analogues (LFcinB) and oneof the three antimicrobials — ciprofloxacin (CIP), levofloxacin (LVX), and fluconazole (FLC) — were synthesized. Four different linkers were applied to connect a peptide and an antimicrobial agent. The FLC-containing peptidic conjugates were synthesized using the “click chemistry” method. This novel approach is reported here...
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A rapid-response ultrasensitive biosensor for influenza virus detection using antibody modified boron-doped diamond
PublikacjaAccording to the World Health Organization (WHO), almost 2 billion people each year are infected worldwide with flu-like pathogens including influenza. This is a contagious disease caused by viruses belonging to the family Orthomyxoviridae. Employee absenteeism caused by flu infection costs hundreds of millions of dollars every year. To successfully treat influenza virus infections, detection of the virus during the initial development...
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THE METHOD OF MEASURING THE MEMBRANE COVER GEOMETRY USING LASER SCANNING AND SYNCHRONOUS PHOTOGRAMMETRY
PublikacjaThe authors present the experience and results of field studies carried out at the technical acceptance of Forest Opera (name in Polish: Opera Leśna) in Sopot (Poland). An unusual design of covering made in the form of “Sheerfill I” technical fabric membrane required spanned in the form of sails, required the use of terrestrial laser scanning. Such approach allowed for the fast and accurate record of the surface of individual panels...
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Determination of benzodiazepines and Z-hypnotic drugs in whole blood samples by GC–MS/MS: Method development, validation and application
PublikacjaBenzodiazepines (BZDs) and Z-drugs are widely used as anxiolytics, sedative hypnotics, anticonvulsants and muscle relaxants. “Designer benzodiazepines” (DBZDs) are a new psychoactive substance class consisting of benzodiazepine derivatives that are not allowed for medical use and are known for being used recreationally. From a toxicologist standpoint, the huge number of such substances implicate a necessity for developing fast...
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Historic railway stations, documentation and revitalization of the railway infrastructure facilities - protection of cultural and social heritage
PublikacjaThe article presents problems of documentation and adaptation of buildings which constitute the cultural heritage of the railway infrastructure facilities in Pomerania in Poland. Shows the potential and possibilityto be adopted for various purposes. This problem affects many sites and buildings, railway stations, railway warehouses, residential buildings, technical buildings, water towers, trackman shelters, bridges, viaducts,...
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Health System Efficiency in European Countries: Network Data Envelopment Analysis Approach
PublikacjaPurpose: The article's main aim is to investigate the effectiveness of health systems in European countries based on EUROSTAT data. A comparative analysis of the health systems' effectiveness in different countries is based on their improvement (reform), using the best practices approach. Design/Methodology/Approach: The network DEA model and a slack-based model (NDEA – SBM) are used. A non-oriented model is used. The research...
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Should we seek further improvement of fluid film bearings - what for and how?
PublikacjaFluid film bearings have been extensively used in the industry because of their unbeatable durability and extremely low friction coefficient. Large bearings supporting shafts of huge and important rotating machines constitute a special group of fluid film bearings since the reliability of crucial systems, like for example electro-energetic system, rely on their trouble-free operation. Large thrust bearings, apart from enormous...
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Serum miRNA-based signature indicates radiation exposure and dose in humans: A multicenter diagnostic biomarker study
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Soil pH effects on the comparative toxicity of dissolved zinc, non-nano and nano ZnO to the earthwormEisenia fetida
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Serum miRNA-based signature indicates radiation exposure and dose in humans: a multicenter diagnostic biomarker study
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CRI board for CBM experiment: preliminary studies
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Disaster-resilient communication networks: Principles and best practices
PublikacjaCommunication network failures that are caused by disasters, such as hurricanes, arthquakes and cyber-attacks, can have significant economic and societal impact. To address this problem, the research community has been investigating approaches to network resilience for several years. However, aside from well-established techniques, many of these solutions have not found their way into operational...
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Water uptake analysis of acceptor-doped lanthanum orthoniobates
PublikacjaIn this work, lanthanum orthoniobates doped with either antimony, calcium, or both have been synthesized and studied. The water uptake of the investigated materials has been analyzed by means of thermogravimetric studies. The results show the difference between the thermodynamics of hydration between the lanthanum orthoniobate system and other proton conducting ceramics. The relation between the water uptake and effective acceptor...
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Conjugates of Ciprofloxacin and Levofloxacin with Cell-Penetrating Peptide Exhibit Antifungal Activity and Mammalian Cytotoxicity
PublikacjaSeven conjugates composed of well-known fluoroquinolone antibacterial agents, ciprofloxacin (CIP) or levofloxacin (LVX), and a cell-penetrating peptide transportan 10 (TP10-NH2) were synthesised. The drugs were covalently bound to the peptide via an amide bond, methylenecarbonyl moiety, or a disulfide bridge. Conjugation of fluoroquinolones to TP10-NH2 resulted in congeners demonstrating antifungal in vitro activity against human...
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Highly selective impedimetric determination of Haemophilus influenzae protein D using maze-like boron-doped carbon nanowall electrodes
PublikacjaThis study reports a novel impedimetric immunosensor for protein D detection in purified and bacterial (Haemophilus influenzae, Hi) samples. The detection was based on antigen recognition by anti-protein D antibodies (apD) immobilised at the maze-like boron-doped carbon nanowall electrodes (B:CNW). The B:CNW electrodes were synthesised, and their surface was characterised by scanning electron microscopy (SEM) and X-ray photoelectron...
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Acute impact of blood flow restriction on strength-endurance performance during the bench press exercise
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Photodynamic therapy with 5-aminolevulinic acid and diamino acid derivatives of protoporphyrin IX reduces papillomas in mice without eliminating transformation into squamous cell carcinoma of the skin
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Antimicrobial Activity of Chimera Peptides Composed of Human Neutrophil Peptide 1 (HNP-1) Truncated Analogues and Bovine Lactoferrampin
PublikacjaThree chimera peptides composed of bovine lactoferrampin and the analogue of truncated human neutrophil peptide 1 were synthesized by the solid-phase method. In two compounds peptide chains were connected via isopeptide bond, whereas in the third one disulfide bridge served as a linker. All three chimeras displayed significantly higher antimicrobial activity than the constituent peptides as well as their equimolar mixtures. The...
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Stardust - Investigation of Microbes in the Stratosphere
PublikacjaThe stratospheric microbiome has been investigated several times using the methods of classical microbiology. In this experiment, we have combined them with some novel approaches including whole- metagenome amplification, Maldi TOF mass spectrometry and Sanger DNA sequencing. The results of the experiment may provide the scientists with knowledge about the mechanisms of survivability of microorganisms in stratospheric conditions...
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Specialist Committee V.3 "Fabrication Technology"
PublikacjaTreścią raportu jest analiza rozwoju zaawansowanych technologii produkcyjnych w przemyśle stoczniowym oraz analiza opracowania nowych stali konstrukcyjnych do stosowania w zaawansowanych konstrukcjach obiektów oceanotechnicznych, ze szczególnym uwzględnieniem ich odporności na wysokie temperatury, odporności korozyjnej i odporności na zmęczenie. Przeanalizowany został postęp w zakresie rozwoju metod oceny stanu naprężeń i odkształceń...
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The hypoxia‐induced changes in miRNA‐mRNA in RNA ‐induced silencing complexes and HIF ‐2 induced miRNAs in human endothelial cells
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Integration Data Model of the Bathymetric Monitoring System for Shallow Waterbodies Using UAV and USV Platforms
PublikacjaChanges in the seafloor relief are particularly noticeable in shallow waterbodies (at depths up to several metres), where they are of significance for human safety and environmental protection, as well as for which the highest measurement accuracy is required. The aim of this publication is to present the integration data model of the bathymetric monitoring system for shallow waterbodies using Unmanned Aerial Vehicles (UAV) and...
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The literature review on boundary conditions of use for non-residential buildings. Educational buildings.
PublikacjaThis paper describes the results of qualitative and quantitative literature reviews on boundary conditions within educational buildings, emphasising the users' perspective. The studies were performed before and during the COVID-19 pandemic using Scopus, Taylor& Francis, and Web of Science databases. The boundary conditions are understood as special characteristics for use and or precondition, determining specific features of...
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Electronic Voting: 8th International Joint Conference, E-Vote-ID 2023, Luxembourg City, Luxembourg, October 3–6, 2023, Proceedings
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