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Źródła, otrzymywanie i przydatność niektórych termostabilnych enzymów w przetwórstwie skrobi i mleka
PublikacjaPrezentowane wyniki wskazują na możliwość usprawnienia produkcji syropów skrobiowych przez zastosowanie rekombinantowej alfa-amylazy z Pyrococcus woesei i termostabilnej alfa-glukozydazy z Thermus thermophilus. Wykazano także przydatność rekombinantowej, termosta-bilnej beta-galaktozydazy z Pyrococcus woesei do wytwarzania bez-laktozowego mleka i serwatki. Enzym ten wykazuje dużą termostabil-ność i znaczną aktywność w szerokim...
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Comparative analysis of mRNA transcripts of HT-29 cell line expressed in identical quantities for pathogenic E. coli strains UM146 and UM147 with control Escherichia coli Nissle 1917
PublikacjaAim of study was comparative analysis of mRNA transcripts of HT-29 cell line, expressed in identical quantities for the combination of pathogenic and non-pathogenic Escherichia coli strains. HT-29 confluent monolayers infection with two pathogenic E. coli strains UM146 and UM147 resulted in two sets of mRNA transcripts that were identical with RNA transcripts obtained for non-pathogenic one strain E. coli Nissle 1917. In this study...
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Influence of Different Nanometals Implemented in PMMA Bone Cement on Biological and Mechanical Properties
PublikacjaCemented arthroplasty is a common process to fix prostheses when a patient becomes older and his/her bone quality deteriorates. The applied cements are biocompatible, can transfer loads, and dampen vibrations, but do not provide antibacterial protection. The present work is aimed at the development of cement with antibacterial effectivity achieved with the implementation of nanoparticles of different metals. The powders of Ag,...
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Recent progress in ultra-low formaldehyde emitting adhesive systems and formaldehyde scavengers in wood-based panels: a review
PublikacjaTraditional wood-based panels are produced with synthetic, formaldehyde-based adhesives, commonly made from fossil-derived constituents, such as urea, phenol, melamine, etc. Along with their numerous advantages, such as chemical versatility, high reactivity and excellent adhesive performance, these adhesives are characterized by certain problems, connected with the hazardous volatile organic compounds (VOCs), mostly free formaldehyde...
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In vivoevaluation of the CB1allosteric modulator LDK1258 reveals CB1-receptor independent behavioral effects
PublikacjaIn the present study, we examined whether LDK1258, which produces strong CB1receptor allosteric effects ininvitroassays, would elicitin vivoeffects consistent with allosteric activity. In initial studies, LDK1258 reducedfood consumption and elicited delayed antinociceptive effects in the chronic constrictive injury of the sciaticnerve (CCI) model of neuropathic pain, which unexpectedly emerged 4 h post-injection. UPLC-MS/MS analysisquantified...
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On Inadequacy of Sequential Design of Experiments for Performance-Driven Surrogate Modeling of Antenna Input Characteristics
PublikacjaDesign of contemporary antennas necessarily involves electromagnetic (EM) simulation tools. Their employment is imperative to ensure evaluation reliability but also to carry out the design process itself, especially, the adjustment of antenna dimensions. For the latter, traditionally used parameter sweeping is more and more often replaced by rigorous numerical optimization, which entails considerable computational expenses, sometimes...
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Measurements of Activity Coefficients at Infinite Dilution for Organic Solutes in the Ionic Liquids N-Ethyl- and N-Octyl-N-methylmorpholinium Bis(trifluoromethanesulfonyl)imide. A Useful Tool for Solvent Selection
PublikacjaIn recent years, many papers describing ionic liquids (IL) as promising solvents in separation techniques have been published. The conscious choice of appropriate ionic liquid as absorption media in effective extraction of selected types of analytes requires deeper understanding of the analyte−IL interactions. Therefore, intensive research is conducted to determine the values of activity coefficient at infinite dilution, which...
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Design-Oriented Two-Stage Surrogate Modeling of Miniaturized Microstrip Circuits with Dimensionality Reduction
PublikacjaContemporary microwave design heavily relies on full-wave electromagnetic (EM) simulation tools. This is especially the case for miniaturized devices where EM cross-coupling effects cannot be adequately accounted for using equivalent network models. Unfortunately, EM analysis incurs considerable computational expenses, which becomes a bottleneck whenever multiple evaluations are required. Common simulation-based design tasks include...
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Effective Air Quality Prediction Using Reinforced Swarm Optimization and Bi-Directional Gated Recurrent Unit
PublikacjaIn the present scenario, air quality prediction (AQP) is a complex task due to high variability, volatility, and dynamic nature in space and time of particulates and pollutants. Recently, several nations have had poor air quality due to the high emission of particulate matter (PM2.5) that affects human health conditions, especially in urban areas. In this research, a new optimization-based regression model was implemented for effective...
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How to make membrane distillation greener? A review on environmentally friendly and sustainable aspects
PublikacjaThere is an urgent need for the development of new water resources in order to solve the problem of the world’s growing demand for clean water. Membrane distillation (MD) is a promising alternative to conventional seawater desalination. Although MD itself is often defined as sustainable desalination technology, there are many aspects within the membrane manufacture and process operation that make it far from being green. For instance,...
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Exploring the landscape of automatic cerebral microbleed detection: A comprehensive review of algorithms, current trends, and future challenges
PublikacjaThis paper provides the first review to date which gathers, describes, and assesses, to the best of our knowledge, all available publications on automating cerebral microbleed (CMB) detection. It provides insights into the current state of the art and highlights the challenges and opportunities in this topic. By incorporating the best practices identified in this review, we established guidelines for the development of CMB detection...
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Interpretable deep learning approach for classification of breast cancer - a comparative analysis of multiple instance learning models
PublikacjaBreast cancer is the most frequent female cancer. Its early diagnosis increases the chances of a complete cure for the patient. Suitably designed deep learning algorithms can be an excellent tool for quick screening analysis and support radiologists and oncologists in diagnosing breast cancer.The design of a deep learning-based system for automated breast cancer diagnosis is not easy due to the lack of annotated data, especially...
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Remote Work Support Needs of Employees with Autism Spectrum Disorder in Poland: Perspectives of Individuals with Autism and Their Coworkers
PublikacjaBackground and Aims: With remote work becoming more common across industries, employees with autism may experience different work support needs from neurotypical peers. However, the specific remote work needs of this group of employees are underexplored in the literature. We aim to propose ways to assess workplace digital adaptation needs for individuals with autism and a framework for communicating these needs to employers. Methods:...
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Robust and Efficient Machine Learning Algorithms for Visual Recognition
PublikacjaIn visual recognition, the task is to identify and localize all objects of interest in the input image. With the ubiquitous presence of visual data in modern days, the role of object recognition algorithms is becoming more significant than ever and ranges from autonomous driving to computer-aided diagnosis in medicine. Current models for visual recognition are dominated by models based on Convolutional Neural Networks (CNNs), which...
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Proximity and the Cluster Organization
PublikacjaIncluding the category of proximity in theoretical considerations and empirical analyzes in cluster organizations is an attempt to integrate existing approaches to understand and explain the specificity of inter-organizational cooperation developed in geographical proximity. The importance of geographical proximity to create a competitive advantage is emphasized in all theories on the establishment and development of industrial...
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Multidirectional Characterization of Phytochemical Profile and Health-Promoting Effects of Ziziphora bungeana Juz. Extracts
PublikacjaZiziphora species (Lamiaceae) have been used in traditional medicine as sedatives, anti-septics, carminatives, or expectorants. Despite their common applications in phytotherapy, there is still lack of evidence about the composition of their extracts and its impact on biological properties of the plants. The aim of this study was to evaluate the content of Ziziphora bungeana, a less studied species growing in Kazakhstan, using...
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A new index for statistical analyses and prediction of travelling ionospheric disturbances
PublikacjaTravelling Ionospheric Disturbances (TIDs) are signatures of atmospheric gravity waves (AGWs) observed in changes in the electron density. The analysis of TIDs is relevant for studying coupling processes in the thermosphere–ionosphere system. A new TID index is introduced, which is based on an easy extension of the commonly used approach for TID detection. This TID activity index, which can be applied for individual Global Navigation...
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Balanced Spider Monkey Optimization with Bi-LSTM for Sustainable Air Quality Prediction
PublikacjaA reliable air quality prediction model is required for pollution control, human health monitoring, and sustainability. The existing air quality prediction models lack efficiency due to overfitting in prediction model and local optima trap in feature selection. This study proposes the Balanced Spider Monkey Optimization (BSMO) technique for effective feature selection to overcome the local optima trap and overfitting problems....
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Two-Rate Based Low-Complexity Variable Fractional-Delay FIR Filter Structures
PublikacjaThis paper considers two-rate based structures for variable fractional-delay (VFD) finite-length impulse response (FIR) filters. They are single-rate structures but derived through a two-rate approach. The basic structure considered hitherto utilizes a regular half-band (HB) linear-phase filter and the Farrow structure with linear-phase subfilters. Especially for wide-band specifications, this structure is computationally efficient...
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Reliability of Corroded Stiffened Plate Subjected to Uniaxial Compressive Loading
PublikacjaThe work is focused on the reliability of corroded stiffened plates subjected to compressive uniaxial load based on the progressive collapse approach as stipulated by the Common Structural Rules for Bulk Carriers and Oil Tankers, employing the limit state design. Two different cases have been investigated. In the first model, the corrosion degradation led to uniform thickness loss, whereas the mechanical properties were unchanged,...
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Bortezomib induces methylation changes in neuroblastoma cells that appear to play a significant role in resistance development to this compound
PublikacjaThe anticancer activity of bortezomib (BTZ) has been increasingly studied in a number of indications and promising results for the use of this treatment have been shown in neuroblastoma. As BTZ treatment is usually administered in cycles, the development of resistance and side effects in patients undergoing therapy with BTZ remains a major challenge for the clinical usage of this compound. Common resistance development also means...
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Improved Modeling of Microwave Structures Using Performance-Driven Fully-Connected Regression Surrogate
PublikacjaFast replacement models (or surrogates) have been widely applied in the recent years to accelerate simulation-driven design procedures in microwave engineering. The fundamental reason is a considerable—and often prohibitive—CPU cost of massive full-wave electromagnetic (EM) analyses related to solving common tasks such as parametric optimization or uncertainty quantification. The most popular class of surrogates are data-driven...
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Expedited Acquisition of Database Designs for Reduced-Cost Performance-Driven Modeling and Rapid Dimension Scaling of Antenna Structures
PublikacjaFast replacement models have been playing an increasing role in high-frequency electronics, including the design of antenna structures. Their role is to improve computational efficiency of the procedures that normally entail large numbers of expensive full-wave electromagnetic (EM) simulations, e.g., parametric optimization or uncertainty quantification. Recently introduced performance-driven modeling methods, such as the nested...
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Development of cooperation in localized cooperation networks: A comparative study of cluster organizations and technology parks
PublikacjaThe main aim of the paper is to analyze the level of development of cooperative relationships in localized cooperation networks – among enterprises associated in cluster organizations and park tenants. The author reports the findings from the quantitative study carried out in the selected cluster organizations and technology parks functioning in Poland. The basic method of data collection was a survey questionnaire. The research...
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The atlas of inequality aversion: theory and empirical evidence on 55 countries from the Luxembourg Income Study database
PublikacjaResearch background: In the distributive analysis, the constant relative inequality aversion utility function is a standard tool for ethical judgements of income distributions. The sole parameter ε of this function expresses a society’s aversion to inequality. However, the profession has not committed to the range of ε. When assessing inequality and other welfare characteristics, analysts assume an arbitrary level of ε, common...
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Low-Cost Yield-Driven Design of Antenna Structures Using Response-Variability Essential Directions and Parameter Space Reduction
PublikacjaQuantifying the effects of fabrication tolerances and uncertainties of other types is fundamental to improve antenna design immunity to limited accuracy of manufacturing procedures and technological spread of material parameters. This is of paramount importance especially for antenna design in the industrial context. Degradation of electrical and field properties due to geometry parameter deviations often manifests itself as, e.g.,...
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Characterization of diatomaceous earth coated with nitrated asphaltenes as superior adsorbent for removal of VOCs from gas phase in fixed bed column
PublikacjaAsphaltenes isolated from bitumen possess unusual adsorption characteristics that can be further enhanced by chemical modifications to promote interactions with VOCs’. Herein, nitrated asphaltenes are used as an active layer coated on a surface of a diatomaceous earth, in order to prepare an efficient adsorbent (AsfNitro). Breakthrough experiments with benzene, pyridine, and 1-nitropropane revealed significant increase in adsorption...
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Highly Dissipative Materials for Damage Protection against Earthquake-Induced Structural Pounding
PublikacjaIt is a common situation that seismic excitations may lead to collisions between adjacent civil engineering structures. This phenomenon, called earthquake-induced structural pounding, may result in serious damage or even the total collapse of the colliding structures. Filling the gap between two buildings erected close to one another by using visco-elastic materials can be considered to be one of the most effective methods to avoid...
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Investigation of Weigh-in-Motion Measurement Accuracy on the Basis of Steering Axle Load Spectra
PublikacjaWeigh-in-motion systems are installed in pavements or on bridges to identify and reduce the number of overloaded vehicles and minimise their adverse eect on road infrastructure. Moreover, the collected trac data are used to obtain axle load characteristics, which are very useful in road infrastructure design. Practical application of data from weigh-in-motion has become more common recently, which calls for adequate attention to...
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Identification of antigen Ag43 in uropathogenic Escherichia coli Dr+ strains and defining its role in the pathogenesis of urinary tract infections
PublikacjaUrinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are among the most common bacterial infectious diseases in the developed world. The urovirulence of UPEC is mainly associated with the surface-exposed fimbrial adhesins and adhesins of the autotransporter (AT) family. The best studied of theses proteins is antigen 43 (Ag43) mediating cell aggregation, adhesion and biofilm development as the causes of...
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Mechanisms of azole resistance among clinical isolates of Candida glabrata in Poland
PublikacjaCandida glabrata is currently ranked as the second most frequently isolated aetiological agent of human fungal infections, next only to Candida albicans. In comparison with C. albicans, C. glabrata shows lower susceptibility to azoles, the most common agents used in treatment of fungal infections. Interestingly, the mechanisms of resistance to azole agents in C. albicans have been much better investigated than those in C. glabrata....
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Value of Age Diversity – Declarations and Practice in Polish Organizations
PublikacjaThe present article relates to management of age diverse teams in organisations and enterprises located in Poland. Managing diversity is an active and conscious process leading not only to a lack of discriminatory conduct but above all to making full use of the potential of the team. The potential resulting from the diversity of knowledge, skills and experience. The diversity of the age of the team members is in fact a differentiation...
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Museums of Gdansk - Tourism Products or Signs of Remembrance?
PublikacjaMuseum buildings constitute a significant element in the composition and functionality of contemporary cities. They are both their attractions and landmarks. The article presents a case study illustrating the relation between museum buildings and their location, as well as the showcased exhibition. The article aims at demonstrating the way in which those elements form a harmonious whole - a cultural tourism product affecting the...
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The Bridge of Knowledge – defining and implementing national Open Access policy by Polish universities. Gdansk University of Technology perspective
PublikacjaThe European Commission states that Open Access to scientific resources funded by the European Union shall facilitate the use of research results financed from the public funds. Moreover, it will cause an increase in the innovative capacity of Europe. The Open Access landscape is determined by several factors such as mandates. The open mandate may be voluntary or mandatory and implemented at the institutional, national or international...
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Study on a polish peat bog “Rucianka” as a source of yeast strains capable of effective phenol biodegradation
PublikacjaPhenol is one of the most widely distributed environmental pollutants which can be found in wastewaters and industrial effluents. Due to its toxicity and resistance to self-degradation, it could become even lethal for humans and animals. The treatment of this toxic compound is focused on psychical–chemical methods, although biological treatment of phenol is preferable for economic aspects related to relatively...
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Computationally Efficient Design Optimization of Compact Microwave and Antenna Structures
PublikacjaMiniaturization is one of the important concerns of contemporary wireless communication systems, especially regarding their passive microwave components, such as filters, couplers, power dividers, etc., as well as antennas. It is also very challenging, because adequate performance evaluation of such components requires full-wave electromagnetic (EM) simulation, which is computationally expensive. Although high-fidelity EM analysis...
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Social convergence in Nordic countries at regional level
PublikacjaResearch background: Geographical proximity, common historical roots and collaboration within the Nordic Council cause the Nordic countries to be often wrongly treated as monoliths. However, in reality, Nordic regions differ in terms of broadly defined social and economic development. Issues concerning the standard of living are one of the priorities of the Helsinki Treaty signed by Nordic countries. Purpose of the article: The...
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Ontological Modeling for Contextual Data Describing Signals Obtained from Electrodermal Activity for Emotion Recognition and Analysis
PublikacjaMost of the research in the field of emotion recognition is based on datasets that contain data obtained during affective computing experiments. However, each dataset is described by different metadata, stored in various structures and formats. This research can be counted among those whose aim is to provide a structural and semantic pattern for affective computing datasets, which is an important step to solve the problem of data...
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Enhancing Renal Tumor Detection: Leveraging Artificial Neural Networks in Computed Tomography Analysis
PublikacjaRenal cell carcinoma is one of the most common cancers in Europe, with a total incidence rate of 18.4 cases per 100 000 population. There is currently significant overdiagnosis (11% to 30.9%) at times of planned surgery based on radiological studies. The purpose of this study was to create an artificial neural network (ANN) solution based on computed tomography (CT) images as an additional tool to improve the differentiation of...
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Accelerated Parameter Tuning of Antenna Structures by Means of Response Features and Principal Directions
PublikacjaPopularity of numerical optimization has been steadily on the rise in the design of modern antenna systems. Resorting to mathematically rigorous parameter tuning methods is a matter of practical necessity as interactive techniques (e.g., parameter sweeping) are no longer adequate when handling several performance figures over multi-dimensional parameter spaces. The most common design scenarios involve local tuning since decent...
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The effects of the IM1-12Br ionic liquid and the oxytetracycline mixture on selected marine and brackish microorganisms
PublikacjaThe number of applications and commercialized processes utilizing ionic liquids has been increasing, and it is anticipated that this trend will persist and even intensify in the future. Ionic liquids possess desirable characteristics, such as low vapor pressure, good water solubility, amphiphilicity, and stability. Nevertheless, these properties can influence their environmental behavior, resulting in resistance to biotic and abiotic...
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Enhanced Activity of P4503A4 and UGT1A10 Induced by Acridinone Derivatives C-1305 and C-1311 in MCF-7 and HCT116 Cancer Cells: Consequences for the Drugs’ Cytotoxicity, Metabolism and Cellular Response
PublikacjaActivity modulation of drug metabolism enzymes can change the biotransformation of chemotherapeutics and cellular responses induced by them. As a result, drug-drug interactions can be modified. Acridinone derivatives, represented here by C-1305 and C-1311, are potent anticancer drugs. Previous studies in non-cellular systems showed that they are mechanism-based inhibitors of cytochrome P4503A4 and undergo glucuronidation via UDP-glucuronosyltranspherase...
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Wpływ rodzaju zanieczyszczenia powierzchni odlewu ze staliwa LH14 na jakość napoin wykonanych elektrodą otuloną
PublikacjaNapawanie jest szeroko stosowaną metodą naprawiania powierzchni. Pozwala między innymi na uzupełnienie miejsc, w których uprzednio wystąpiły wżery korozyjne. Techniki napawania wykorzystywane są również do przywracania pierwotnego kształtu zużytych części. W pracy wykonano badania napoin wykonanych elektrodami otulonymi na czołowych powierzchniach cylindrycznych próbek ze staliwa LH14. Proces wykonywano dwoma rodzajami elektrod:...
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Rewitalizacja dróg wodnych delty Wisły jako podstawa nowej perspektywy osiedleńczej
PublikacjaW artykule opisano badania dotyczące rewitalizacji dróg wodnych Delty Wisły. Problematyka badawcza dotyczy rozwoju obszaru na styku lądu i wody. Wpływ lokalizacji nadmorskiej, i związana z nią problematyka wynikająca z położenia poniżej poziomu morza są dostrzegalne nawet do stu kilometrów od wybrzeża. Dodatkowym aspektem, który ujemnie wpływa na rozwój obszaru delty po II wojnie światowej jest utrata tożsamości regionalnej. Dlatego...
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The influence of selenium addition during seeds' germination on the biological properties of obtained sprouts
PublikacjaSelenium plays a vital role in human body, because in the form of aminoacids (Se-methionine, Se-cysteine) it is found in the active centres of over 25 enzymes, including those regarded as 'cytoprotective'. Unfortunatelly, its daily intake in Poland and other European countries is lower than predicted by dietary recommendations. The consequences of selenium deficiency in diet might be severe, including higher susceptibility to cardio-vascular...
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Novel molecules containing structural features of NSAIDs and 1,2,3-triazole ring: Design, synthesis and evaluation as potential cytotoxic agents
PublikacjaFor the first time the template containing structural features of more than one NSAIDs and the 1,2,3-triazole ring was explored for the identification of potential cytotoxic agents. These new and complex molecules were predicted to be effective inhibitors of PDE4B by molecular modelling studies in silico. The multi-step synthesis of these compounds were carried out starting from the well-known drug nimesulide and involved the use...
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A vector-enzymatic DNA fragment amplification-expression technology for construction of artificial, concatemeric DNA, RNA and proteins for novel biomaterials, biomedical and industrial applications
PublikacjaA DNA fragment amplification/expression technology for the production of new generation biomaterials for scientific, industrial and biomedical applications is described. The technology enables the formation of artificial Open Reading Frames (ORFs) encoding concatemeric RNAs and proteins. It recruits the Type IIS SapI restriction endonuclease (REase) for an assembling of DNA fragments in an ordered head-to-tail-orientation. The...
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Transcriptomic landscape of blood platelets in healthy donors
PublikacjaBlood platelet RNA-sequencing is increasingly used among the scientific community. Aberrant platelet transcriptome is common in cancer or cardiovascular disease, but reference data on platelet RNA content in healthy individuals are scarce and merit complex investigation. We sought to explore the dynamics of platelet transcriptome. Datasets from 204 healthy donors were used for the analysis of splice variants, particularly with...
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The transfer of names in various translations of brothers Grimm’s "Rumpelstilzchen"
PublikacjaVarious scholars point out the transfer of proper nouns as a difficulty. This paper examines the transfer of names in twenty‑one translations of the Grimm Brothers’ fairy tale originally titled Rumpelstilzchen. The article analyses English,Brazilian Portuguese, Polish, Turkish, and Japanese editions of this originally German story. The analysis focuses on the true name of a title dwarf and other names provided by the Queen....
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Metodyka pracy tachimetrem na potrzeby pomiaru i inwentaryzacji cyfrowej muzealiów
PublikacjaOpracowanie metodyki pracy tachimetrem na potrzeby pomiaru i inwentaryzacji cyfrowej muzealiów stanowi kontynuację prac, prowadzonych w latach 2011–2012, w zakresie przygotowania Narodowego Muzeum Morskiego w Gdańsku (NMM) do efektywnej digitalizacji zbiorów. W trakcie realizacji projektu, poświęconego skanowaniu za pomocą ramienia pomiarowego Faro ScanArm, pojawiło się szereg problemów i wniosków dotyczących alternatywnych metod...