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Wyniki wyszukiwania dla: DRUGS RESIDUES
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FPGA realization of the high-speed residue-to-binary converter based on the Chinese Remainder Theorem
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Preparation and characterization of Langmuir-Blodgett films of 16-membered azobenzocrown ether with naphthalene residue
PublikacjaOtrzymano i charakteryzowano filmy Langmuira-Blodgett 16-członowej azobenzokorony z resztą naftalenową. Monowarstwy Langmuira były z sukcesem przenoszone na stałe substraty z utworzeniem filmów LB. Filmy osadzone na elektrodach z ITO zostały również użyte jako elektrody w woltametrii cyklicznej i uzyskano rezultaty wskazujące na to, że filmy te wykazują wyraźną odpowiedź na jony metali.
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Replica Exchange and Multicanonical Algorithms with the Coarse-Grained United-Residue (UNRES) Force Field
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Radix-4 dft butterfly realization with the use of the modified quadratic residue number system
PublikacjaW pracy zaprezentowano projektowanie i realizację obliczenia motylkowego dft dla podstawy 4 z użyciem zespolonego systemu resztowego (CRNS) i zmodyfikowanego kwadratowego systemu resztowego (MQRNS). System MQRNS oprócz własności dekompozycyjnych pozwala na realizację mnożenia zespolonego przy zastosowaniu trzech mnożeń rzeczywistych. Przedstawiono konwertery wejściowy CRNS/MQRNS i wyjściowy MQRNS/CRNS, mnożenie zespolone w MQRNS,...
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Radix-4 dft butterfly realization with the use of the modified quadratic residue number system
PublikacjaW pracy przedstawiono algorytm realizacji mnożenia zespolonego z użyciem zmodyfikowanego kwadratowego zmodyfikowanego systemu liczbowego (mqrns) oraz jego zastosowanie do wykonania obliczenia motylkowego dft dla podstawy 4. pokazano też wstępne rezultaty implementacji w układzie xilinx fpga.
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FPGA realization of the high-speed residue-to-binary converter based on chinese remainder theorem
PublikacjaW pracy przedstawiono architekturę, realizację FPGA oraz symulację numeryczną na poziomie bitowym szybkiego konwertera z systemu resztowego do systemu binarnego dla modułów 5-bitowych opartego na chińskim twierdzeniu o resztach. Algorytm konwertera obejmuje obliczanie projekcji ortogonalnych poprzez odczyt pamięci oraz sumowanie modulo M realizowane dwustopniowo, pierwszy stopień oparty o sumatory CSA umożliwia redukcję do zakresu...
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Sample preparation procedure for the determination of polycyclic aromatic hydrocarbons in petroleum vacuum residue and bitumen
PublikacjaThis paper describes a novel method of samplepreparation for the determination of trace concentrations ofpolycyclic aromatic hydrocarbons (PAHs) in high-boilingpetroleum products. Limits of quantitation of the investigatedPAHs in materials of this type range from tens ofnanograms per kilogram to <20 μg/kg. The studies revealedthat in order to separate most of interferences from theanalytes without a significant loss of PAHs, it...
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Pipelined sceling of signed residue numbers with the mixed-radix conversion in the programmable gate array
PublikacjaIn this work a scaling technique of signed residue numbers is proposed. The method is based on conversion to the Mixed-Radix System (MRS) adapted for the FPGA implementation. The scaling factor is assumed to be a moduli product from the Residue Number System (RNS) base. Scaling is performed by scaling of terms of the mixed-radix expansion, generation of residue reprezentation of scaled terms, binary addition of these representations...
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Production of Biogas from Distillation Residue as a Waste Material from the Distillery Industry in Poland
PublikacjaIn this paper, the possibility to obtain an alternative source of energy from methane fermentation, catalysed by biomass, has been discussed in detail. As a main substrate, the distillation residue from the distillery industry was taken in the case of mono-fermentation and its co-fermentation with sewage sludge. The results showed that higher biogas and methane production can be obtained in a mono-fermentation process. Fermentation...
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Tripping of F-type RCDs for High-Frequency Residual Currents
PublikacjaResidual current devices (RCDs) are apparatus commonly used for protection against electric shock in low-voltage electrical installations. They protect people in the case of an earth fault or even in the case of direct contact with the live parts. However, to be effective protective devices, RCDs have to detect residual currents of various waveform shapes which appear in modern electrical installations. For this purpose, RCDs...
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A Study on the Residual Stress of Seam Pipe Cutting and Girth Welding
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The effect of current delay angle on tripping of residual current devices
PublikacjaPower electronics converters applied in domestic or similar installations may utilize current delay (phase) angle control to change the level of transferred power. Due to application of such types of converters, earth fault current in the installation may be strongly distorted. The current distortion level depends on a value of current delay angle. This delay angle also influences the tripping threshold of residual current devices....
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Application of residual current devices in electrical installations with frequency converters
PublikacjaW instalacjach elektrycznych, w których znajdują się przemienniki częstotliwości mogą pojawić się prądy zwarcia doziemnego o różnej częstotliwości lub stałe. Większość wyłączników różnicowoprądowych nie reaguje na tego typu prądy, co powoduje, że ochrona przeciwporażeniowa jest nieskuteczna. W obwodach z przemiennikami częstotliwości mogą pojawiać się przejściowe i ustalone prądy upływowe o znacznych wartościach. Prądy te znacząco...
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Remarks on the Subject of Back-Up Protection of Residual Current Devices
PublikacjaResidual current devices without integral overcurrent protection (RCCBs) are back-up protected by fuses or miniature circuit-breakers (MCBs). If the latter are used, special attention must be given to the coordination between an RCCB and an MCB. This paper indicates probable cases of the aforementioned devices coordination, in which back-up protection of the RCCB is not adequate. A laboratory test has shown that depending on the...
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Detection of high frequency current components by residual current devices
PublikacjaThe negative impact of current harmonics on the main components of residual current devices is presented. A solution for the improvement of the operation of residual current devices is proposed.
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Behavior of residual current devices at frequencies up to 50 kHz
PublikacjaThe use of residual current devices (RCDs) is obligatory in many types of low-voltage circuits. They are devices that ensure protection against electric shock in the case of indirect contact and may ensure additional protection in the case of direct contact. For the latter purpose of protection, only RCDs of a rated residual operating current not exceeding 30 mA are suitable. Unfortunately, modem current-using equipment supplied...
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Tripping of F-type RCDs for high-frequency residual currents
PublikacjaResidual current devices (RCDs) are apparatus commonly used for protection against electric shock in low-voltage electrical installations. They protect people in the case of an earth fault or even in the case of direct contact with the live parts. However, to be effective protective devices, RCDs have to detect residual currents of various waveform shapes which appear in modern electrical installations. For this purpose, RCDs are...
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Thin layer chromatography in drug discovery process
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Biopolymers and Their Composites for Drug Delivery: A Brief Review
PublikacjaIn recent years, excipient development has become a core area of research in pharmaceutical drug delivery because it influences the formulation development and drug delivery process in various ways. Polymeric drug delivery systems have been of great interest for controlled delivery as they show the great advantage in drug delivery systems because of optimized drug loading and releasing property. Then, the side effects of synthetic...
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Novel 1,2,4-Oxadiazole Derivatives in Drug Discovery
PublikacjaAbstract: Five-membered 1,2,4-oxadiazole heterocyclic ring has received considerable attention because of its unique bioisosteric properties and an unusually wide spectrum of biological activities. Thus, it is a perfect framework for the novel drug development. After a century since the 1,2,4-oxadiazole have been discovered, the uncommon potential attracted medicinal chemists’ attention, leading to the discovery of a few presently...
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Customizing nano-chitosan for sustainable drug delivery
PublikacjaChitosan is a natural polymer with acceptable biocompatibility, biodegradability, and mechanical stability; hence, it has been widely appraised for drug and gene delivery applications. However, there has been no comprehensive assessment to tailor-make chitosan cross-linkers of various types and functionalities as well as complex chitosan-based semi- and full-interpenetrating networks for drug delivery systems (DDSs). Herein, various...
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Analysis of chiral pharmaceutical residues in influent and effluent samples at racemic and enantiomeric level using liquid chromatography-tandem mass spectrometry
PublikacjaIn this work, two different chromatographic methods for seasonal monitoring of pharmaceutical residue in wastewater samples were developed. In the case of enantiomeric separation of selected compounds, LC-MS technique combining with vancomycin based chiral stationary phase was used. The performance of chiral analysis enabled to monitor the pharmaceutical contamination at the enantiomeric level. The d-SPE procedure was developed...
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Simultaneous determination of non-steroidal anti-inflammatory drugs and natural estrogens in the mussels Mytilus edulis trossulus
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Nonsteroidal anti-inflammatory drugs modulate cellular glycosaminoglycan synthesis by affecting EGFR and PI3K signaling pathways
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Study of the chromatographic behavior of selected antipsychotic drugs on RP-TLC based on quantitative structure–retention relationships
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Pharmacomicrobiomics of cell-cycle specific anti-cancer drugs – is it a new perspective for personalized treatment of cancer patients?
PublikacjaIntestinal bacteria are equipped with an enzyme apparatus that is involved in the active biotrans-formation of xenobiotics, including drugs. Pharmacomicrobiomics, a new area of pharmacology, analyses interactions between bacteria and xenobiotics. However, there is another side to the coin. Pharmacotherapeutic agents can significantly modify the microbiota, which consequently affects their efficacy. In this review, we comprehensively...
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Extracting functional groups of ALLINI to design derivatives of FDA‐approved drugs: Inhibition of HIV‐1 integrase
PublikacjaHIV‐1 integrase (IN) is crucial for integration of viral DNA into the host genome and a promising target in development of antiretroviral inhibitors. In this work, six new compounds were designed by linking the structures of two different class of HIV‐1 IN inhibitors (active site binders and allosteric IN inhibitors (ALLINIs)). Among newly designed compounds, INRAT10b was found most potent HIV‐1 IN inhibitor considering different...
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Removal of nonsteroidal anti-inflammatory drugs and analgesics from wastewater by adsorption on cross-linked β-cyclodextrin
PublikacjaWe present a method using the material in the form of cross-linked β-cyclodextrin (CD) showing high efficiency in the simultaneous removal of hazardous pollutants from sewage, such as diclofenac (DIC), ibuprofen (IBU), ketoprofen (KETO), naproxen (NAPR), salicylic acid (SALI) and tramadol (TRAM). The material is stable and particularly easy to regenerate. The sorbent probably remembers the shape of the contaminants, which increases...
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Photocatalytic activity of solvothermal prepared BiOClBr with imidazolium ionic liquids as a halogen sources in cytostatic drugs removal
PublikacjaIn this work, the BiOClBr, as a new family of bismuth based semiconductors, was successfully applied to remove of cytostatic drugs from water under UV-Vis light irradiation. BiOCl, BiOBr and BiOClBr were synthesized using two steps solvothermal method in glycerol. The inorganic salts (KCl and KBr) and 1-butyl-3-metylimidazolium chloride (BmimCl) and 1-butyl-3-metylimidazolium bromide (BmimBr) ionic liquids (ILs) were used as the...
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Using anticipatory and drug-evoked appetitive ultrasonic vocalization for monitoring the rewarding effect of amphetamine in a rat model of drug self-administration
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The Significance of MicroRNAs Expression in Regulation of Extracellular Matrix and Other Drug Resistant Genes in Drug Resistant Ovarian Cancer Cell Lines
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Function and Frustration of Multi-Drug ABC Exporter Protein and Design of Model Proteins for Drug Delivery Using Protein Hydration Thermodynamics
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The effect of a unique halide-stabilizing residue on the catalytic properties of haloalkane dehalogenase DatA fromAgrobacterium tumefaciensC58
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Implementation of a Serial Replica Exchange Method in a Physics-Based United-Residue (UNRES) Force Field
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‘Green’ multi - residue methods for the determination of high importance currently used pesticides in environmental samples
PublikacjaThe purpose of the research has been to develop and apply ‘green’ analytical methodologies to control and monitor the level of currently used pesticides from different chemical groups in aqueous samples. For extraction of analytes solid - phase microextraction (SPME) and dispersive liquid - liquid microextraction (DLLME) have been applied and compared. For SPME, commonly used materials for coating fibers include: polydimethylsiloxane...
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Scaling of signed residue numbers with mixed-radix conversion in FPGA with extended scaling factor selection
PublikacjaA scaling technique of signed residue numbers in FPGA is proposed. The technique is based on conversion of residue numbers to the Mixed-Radix System (MRS). The scaling factor is assumed to be a moduli product from the Residue Number System (RNS) base. Scaling is performed by scaling of MRS terms, the subsequent generation of residue representations of scaled terms, binary addition of these representations and generation of residues...
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High-Speed Binary-to-Residue Converter Design Using 2-Bit Segmentation of the Input Word
PublikacjaIn this paper a new approach to the design of the high-speed binary-to-residue converter is proposed that allows the attaining of high pipelining rates by eliminating memories used in modulo m generators. The converter algorithm uses segmentation of the input binary word into 2-bit segments. The use and effects of the input word segmentation for the synthesis of converters for five-bit moduli are presented. For the number represented...
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The Influence of Low-Temperature Disintegration on the Co-Fermentation Process of Distillation Residue and Waste-Activated Sludge
Publikacja: Innovative low-temperature disintegration (process temperature 55 ◦C and oxygen concentration 0.2 mg/dm3 ) can be an economically rational technology to intensifying energy production from renewable sources. The proposed process can achieve a degree of disintegration—under optimal conditions—of about 50%, which is excellent when compared with other methods of feed pre-treatment. The low-temperature disintegration of distillation...
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Residual K1 and K2 Oscillations in Precise GPS Solutions: Case Study
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The effect of earth fault current harmonics on tripping of residual current devices
PublikacjaSzerokie zastosowanie przekształtników, a w szczególności przemienników częstotliwości sprawia, że wyłączniki różnicowoprądowe znajdują się w obwodach, w których może płynąć odkształcony prąd ziemnozwarciowy. Prąd ziemnozwarciowy w obwodach z przemiennikami częstotliwości zawiera harmoniczne, których rząd głównie zależy od częstotliwości PWM. Odkształcony prąd wpływa na poprawne wyzwalanie wyłączników różnicowoprądowych. W artykule...
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Recent developments in the determination of residual solvents in pharmaceutical products by microextraction methods
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Evolution of post welded residual stress due multilayer circumferentialweld of tube.
PublikacjaOpisano sposób wykorzystania polowego efektu Barkhausena do pomiaru rozkładu naprężeń w spawanych rurach. Przedstawiono procedurę kalibracji oraz wyniki pomiaru naprężeń uzyskanych po stopniowym spawaniu rury.
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Requirements for Residual Current Devices Intended for Electric Vehicle Charging Systems
PublikacjaThe properties of residual current devices have been presented from the point of view of their ability to detect a specific shape of the residual current waveform. Moreover, the standard requirements relating to residual current protection used in electric vehicle charging installations have been pointed out. The operating characteristics of the IC-CPD and RDC-DD protections, which are intended for charging electric vehicles in...
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Separation of the effects of notch and macro residual stress on the MFL signal characteristics
PublikacjaMagnetic flux leakage (MFL) distribution for three configurations of samples has been investigated in order to study the influence of notch and plastic deformation separately as well as together. Samples have been made of S355 steel. The MFL signal measurements were carried out along the longest dimension of the sample over a length of 120 mm. Two components of magnetic field were measured: 1) tangential to the main axis and 2)...
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Behavior of residual current devices at earth fault currents with DC component
PublikacjaLow-voltage electrical installations are increasingly saturated with power electronic converters. Due to very high popularity of photovoltaic (PV) installations and the spread of electric vehicles (EV) as well as their charging installations, DC–AC and AC–DC converters are often found in power systems. The transformerless coupling of AC and DC systems via power electronic converters means that an electrical installation containing...
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Oznaczanie pozostałości pestycydów w próbkach żywności w wykorzystaniem metodyki QuEChERS = QuEChERS approach for the determination of pesticide residues in food matrixes
PublikacjaBez wątpienia, wartym uwagi podejściem do problemu oznaczania pestycydów, ze względu na różnorodność tej grupy związków, jest zastosowanie metodyk oznaczania pozostałości (multi-residue methods - MRMs). Niestety, w literaturze naukowej można znaleźć stosunkowo niewiele informacji na temat takiego podejścia do oznaczania pozostałości pestycydów w próbkach żywności. Stąd próba przybliżenia czytelnikom kilku najistotniejszych, zdaniem...
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Comparison of efficiency of different sorbents used during clean-up of extracts for determination of polychlorinated biphenyls and pesticide residues in low-fat food
PublikacjaOkreślono przydatność i zakres zastosowania kolumienek sorpcyjnych zawierających złoża różnych sorbentów wykorzystywanych do oczyszczania ekstraktów z żywności o zawartości do 20 % tłuszczu z wykorzystaniem techniki ekstrakcji do fazy stałej (SPE). Udowodniono, że zastosowanie kolumienek sorpcyjnych zawierających złoże żelu krzemionkowego modyfikowanego fazą aminopropylową, tlenku glinu bądź krzemianu magnezu do oczyszczania ekstraktów...
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Drug-drug interaction potential of antitumor acridine agent C-1748: The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7
PublikacjaBackground The compound 9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine (C-1748), the promising antitumor agent developed in our laboratory was determined to undergo phase I metabolic pathways. The present studies aimed to know its biotransformation with phase II enzymes – UDP-glucuronosyltransferases (UGTs) and its potential to be engaged in drug-drug interactions arising from the modulation of UGT activity. Methods UGT-mediated...
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Comparison of the Usefulness of SPE Cartridges for the Determination ofβ-Blockers andβ-Agonists (Basic Drugs) in Environmental Aqueous Samples
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Current View on Green Tea Catechins Formulations, Their Interactions with Selected Drugs, and Prospective Applications for Various Health Conditions
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