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Electrochemical simulation of metabolism for antitumor-active imidazoacridinone C-1311 and in silico prediction of drug metabolic reactions
PublikacjaThe metabolism of antitumor-active 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) has been investigated widely over the last decade but some aspects of molecular mechanisms of its metabolic transformation are still not explained. In the current work, we have reported a direct and rapid analytical tool for better prediction of C-1311 metabolism which is based on electrochemistry (EC) coupled on-line with electrospray...
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The Influence of the Co-Dopant Dexamethasone Phosphate on the Electrodeposition Process and Drug-Release Properties of Polypyrrole-Salicylate on Iron
PublikacjaIn this work, the influence of incorporation of two anti-inflammatory drugs dexamethasone phosphate and sodium salicylate on the electrodeposition process of polypyrrole (PPy) film on iron has been studied. The incorporation of the agents into PPy has been carried out in a one-step electropolymerization process on oxidizable iron. The role of each drug agent during the deposition process has been discussed. The morphological and...
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Application of bioassays in studies on the impact of pharmaceuticals on the environment
PublikacjaDrug interactions are often desirable particularly in medicine, when treatment of a patient requires using a mixture of drugs in specific doses to produce the adequate therapeutic effect. Unfortunately, interactions between drugs in the environment are not as desirable, despite the fact that drugs are present in the environment at low concentration levels [1]. Pharmaceuticals are present in the environment in a mixture of compounds,...
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Spectral Finite Element Method in Condition Monitoring and Damage Detection
PublikacjaIt is well known that the dynamic behaviour of engineering structures may carry very important and crucial information that can be further used for the assessment of their condition as well as detection of any damage induced. The current interest in monitoring techniques based on the propagation of guided elastic waves requires that numerical techniques used for modelling the phenomena associated must shift into the realm of high...
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The Effectiveness of Polymer Damper in Damage Reduction of Temporary Steel Grandstand
PublikacjaA large number of accidents involving damage of temporary grandstands during different types of events were observed in the past. The aim of the paper is to analyse numerically the effectiveness of a polymer damper in damage reduction of a temporary steel scaffolding grandstand exposed to dynamic load due to jumping. The element has been installed as a diagonal one at the back part of the structure. The method has been compared...
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SIGNIFICANT GUIDELINE FOR THE DAMAGE INDICES APPLIED TO REINFORCED CONCRETE STRUCTURES
PublikacjaIn this paper, based on a deep overview and literature study, the different formulas proposed for damage indices (DIs) applied to reinforced concrete structures under monotonic or cyclic loading are classified and presented. The DIs are applied to quantify the damages to structures, ranging from zero to one. Normally, they are applied to make a decision for repairing or demolition of the structures in the post-earthquake phases. Keywords:...
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Scintillation light trapping and radiation damage in CeF/sub 3/
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A role of destructive and non-destructive tests in creep damage Identification
PublikacjaPrzedstawiono wyniki badań mjących zilustrować i określić rolę badań niszczących i nieniszczących w identyfikowaniu degradacji po pełzaniu
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Damage localisation in a stiffened plate structure using a propagating wave
PublikacjaThe paper presents an application of changes in propagating waves for damage detection in a stiffened aluminium plate. The experimental investigation was conducted on an aluminium plate with riveted two L-shape stiffeners. The wave has been excited with a piezoelectric transducer and measured with the Laser Scanning Doppler Vibrometer. Recorded signals were analysed using the special signal processing techniques developed for damage...
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Diagnosis of bearing damage in induction motors by instantaneous power analysis
PublikacjaResearch of the machine with simulated bearing damages has been carried out, where variable load torque, simulating bearing damage, was introduced. The results show that components which can be used for bearings diagnosis appear in the spectrum of the product of current and supply voltage instantaneous values. These components are easier to identify than the components of current spectrum, which have been used so far in diagnostic...
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Experimental bases for the rail track surface damage detection system
PublikacjaA diagnosis of rail surface is generally based on the classical method of direct assessment and track geometry measurements. Identification and qualification of inequality and damage on the surface rails is depend on the skills and experience person who conducting inspection. In times of increasing exploitation of railways, infrastructure managers decide to use systems supporting the assessment of technical condition of the railways....
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Damage detection in turbine wind blades by vibration based methods
PublikacjaThe paper describes results of numerical simulation for damage localization in the composite coat of a wind turbine blade usingmodal parameters and a modern damage detection method (wavelet transform).
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Inelastic damage-involved response of colliding buildings during earthquakes
PublikacjaW artykule poddano analizie nieliniowe zachowanie się kolidujących ze sobą budynków powodujące ich uszkodzenie podczas trzęsień ziemi. Analiza dotyczy zderzeń pomiędzy dwoma sąsiednimi budynkami czterokondygnacyjnymi. Badania pokazują, iż zastosowanie nieliniowego modelu numerycznego zachowania się obu budowli podczas trzęsień ziemi ma duże znaczenia dla dokładności wyników.
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Dynamics of Oxidative Damage at Early Stages of Estrogen-dependant Carcinogenesis
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Effects of basal level of antioxidants on oxidative DNA damage in humans
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Identification and validation of damage parameters for elasto-viscoplastic Chaboche model
PublikacjaArtykuł omawia procedurę identyfikacji parametrów zniszczenia w prawie Chabocha ze zniszczeniem. Proponowane podejście jest zilustrowane przykładami obliczeniowymi w programie MSC.Marc.
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Quantitative risk assessment of new ship designs in damage conditions
PublikacjaThe paper is devoted to safety of ships in damage conditions. The novel contribution of the paper is connected with a new Multi-Task ship (MT-ship) design at the preliminary stage of design. There are a few problems at the preliminary stage that should be considered. One problem is connected with if the quantitative risk-based method is a reliable and formal method for safety assessment of such the new design (MT-ship) in damage...
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Oxidative DNA Damage in Blood of CVD Patients Taking Detralex
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Improvement of damage detection methods based on experimental modal parameters
PublikacjaW pracy przedstwiono sposoby porawy czułości metod detekcji uszkodzeń wykorzystujacych eksperyentalne parametry modalne konstrukcji. Wykazano, że zastosowanie zawansowanych technik obróbki sygnałów pomiarowych pozwala zdecydowanie poprwaić skutecznośc znanych z literatury metod.
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Case study of masts damage of the sail training vessel POGORIA
PublikacjaArtykuł przedstawia opis i analizę przyczyn zdarzenia polegającego na utracie masztów w lipcu 2009 przez barkentynę sts ''POGORIA'' w trakcie regat Tall Ships Race 2009. Przedstawiono podstawowe okoliczności stanowiące tło zdarzenia, dokonano anlizy przyczyn w skali globalnej, zaprezentowano analizę szczegółową utraty nośności konstrukcji stalowej, a na tym tle wypunktowano szczegółowe przyczyny leżące u źródeł wypadku. We wnioskach...
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Assessment of cavitation erosion damage of laser remelted the SUPERSTON alloy
PublikacjaW artykule przedstawiono wpływ obróbki laserowej w warunkach kriogenicznych na mikrostrukturę stopu SUPERSTON po badaniach kawitacyjnych. Badania odporności kawitacyjnej przeprowadzono na stanowisku z wirującą tarczą w IMP PAN Gdańsk. Określono kinetykę ubytku masy próbek podczas testu kawitacyjnego dla stopu odlanego i nadtopionego laserowo.
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Damage detection strategies based on propagation of guided elastic waves
PublikacjaW pracy przedstawiono wyniki symulacji numerycznych oraz badań eksperymentalnych nad wykorzystaniemprowadzonych falsprężystych do wykrywania ilokalizacji uszkodzeń w dwu i trójwymiarowych elementach konstrukcyjnych wykonanych z materiałów izotropowych i kompozytowych.
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Structural analysis of a wheeled tractor oriented towards damage diagnostics
PublikacjaThis study analyses the structure of a wheeled tractor whith the aim of evaluating the available options for diagnosing four types of defects affecting the vehicle's functions, exhaust gas emissions, engine performance and safety.
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Damage-Involved Structural Pounding in Bridges under Seismic Excitation
PublikacjaDuring severe earthquakes, pounding between adjacent superstructure segments of highway elevated bridges was often observed. It is usually caused by the seismic wave propagation effect and may lead to significant damage. The aim of the present paper is to show the results of the numerical analysis focused on damage-involved pounding between neighbouring decks of an elevated bridge under seismic excitation. The analysis was carried...
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Damage detection in composite truss structure by application of elastic waves.
PublikacjaW pracy przedstawiono zastosowanie fal sprężystych do detekcji pęknięć zmęczeniowych w konstrukcjach kompozytowych.
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Fatigue damage evaluation of organic coatings subjected to mechanical stress
PublikacjaZnaczna liczba konstrukcji ulega niszczeniu zmęczeniowemu w wyniku oddziaływania cyklicznych naprężeń mechanicznych. Jednakże w dziedzinie organicznych powłok ochronnych czynnik ten pozostaje niedoceniany. W pracy dokonano porównania wpływu cyklicznych naprężeń mechanicznych na nowe i pre-eksponowane (w podwyższonej temperaturze lub promieniowaniu UV) powłoki epoksydowe.
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Thermodynamically consistent gradient theory of damage coupled with gradient plasticity
PublikacjaPrzedstawiono termodynamicznie zgodną teorię plastycznego zniszczenia w zakresie mechaniki Newtona-Eshelbego. Poza klasycznymi równaniami ruchu w przestrzeni fizycznej sformułowano dynamiczne równania równowagi sił powiązanych z defektami w przestrzeni materialnej oraz pierwsze i drugie prawo termodynamiki w przestrzeni fizycznej i materialnej. Ogólne równania konstytutywne przyjęto jako funkcję gradientu deformacji, jego składników...
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Teloxantron inhibits the processivity of telomerase with preferential DNA damage on telomeres
PublikacjaTelomerase reactivation is one of the hallmarks of cancer, which plays an important role in cellular immortalization and the development and progression of the tumor. Chemical telomerase inhibitors have been shown to trigger replicative senescence and apoptotic cell death both in vitro and in vivo. Due to its upregulation in various cancers, telomerase is considered a potential target in cancer therapy. In this study, we identified...
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Damage of a post-tensioned concrete bridge – Unwanted cracks of the girders
PublikacjaThe cracking of a post-tensioned T-beam superstructure, which was built using the incremental launching method, is analyzed in the paper. The problem is studied in detail, as specific damage was observed in the form of longitudinal cracks, especially in the mid-height zone of the girder at the interface of two assembly sections. The paper is a case study. A detailed inspection is done and non-destructive testing results of the...
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Visual method for detecting critical damage in railway contact strips
PublikacjaEnsuring an uninterrupted supply of power in the electric traction is vital for the safety of this important transport system. For this purpose, monitoring and diagnostics of the technical condition of the vehicle's power supply elements are becoming increasingly common. This paper presents a new visual method for detecting contact strip damage, based on measurement and analysis of the movement of the overhead contact line (OCL)...
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Damage Imaging in Lamb Wave-Based Inspection of Adhesive Joints
PublikacjaAdhesive bonding has become increasingly important in many industries. Non-destructive inspection of adhesive joints is essential for the condition assessment and maintenance of a structure containing such joints. The aim of this paper was the experimental investigation of the damage identification of a single lap adhesive joint of metal plate-like structures. Nine joints with different defects in the form of partial debonding...
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Damage detection in a bolted lap joint using guided waves
PublikacjaThe paper presents the experimental investigation of guided waves application to the condition assessment of prestressed bolted connections and a concept of new quantitative indicator. The main goal of the research was the analysis of the influence of the contact conditions changes to the characteristics of a propagating disturbance. The experimental tests were carried out for a single bolted lap joint. The excitation and acquisition...
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Damage detection in plates based on Lamb wavefront shape reconstruction
PublikacjaMany of the current studies in the area of damage detection using elastic wave propagation are based on deploying sensor networks with a large number of piezoelectric transducers to detect small-size cracks. A major limitation of these studies is that cracks are usually larger and have different shapes in real cases. Moreover, using a large number of sensing nodes for damage detection is both costly and computationally intensive....
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X-ray and UV Radiation Damage of dsDNA/Protein Complexes
PublikacjaRadiation and photodynamic therapies are used for cancer treatment by targeting DNA. However, efficiency is limited due to physico-chemical processes and the insensitivity of native nucleobases to damage. Thus, incorporation of radio- and photosensitizers into these therapies should increase both efficacy and the yield of DNA damage. To date, studies of sensitization processes have been performed on simple model systems, e.g.,...
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Damage Development on the Surface of Nickel Coating in the Initial Period of Erosion
PublikacjaThe common occurrence of the phenomenon of cavitation in many industries and the multitude of factors affecting the resistance to cavitation erosion of used materials contribute to the search for methods and appropriate parameters of coating application that are able to minimize the effects of erosion. To determine the validity of the developed application parameters and the method used, cavitation studies and microscopic observations...
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Evaluating experimental molecular physics studies of radiation damage in DNA*
PublikacjaThe field of Atomic and Molecular Physics (AMP) is a mature field exploring the spectroscopy, excitation, ionisation of atoms and molecules in all three phases. Understanding of the spectroscopy and collisional dynamics of AMP has been fundamental to the development and application of quantum mechanics and is applied across a broad range of disparate disciplines including atmospheric sciences, astrochemistry, combustion and environmental...
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Causes of damage and methods of repairing floor made on polystyrene concrete
PublikacjaThe paper describes damages, tests and repair of the floor made on existing ceiling and expanded polystyrene concrete underlay. The floor was built on a reinforced concrete ceiling with an area of about 1050 m2. Significant damage in the form of cracks, detachments and unevenness was found in the floor. In order to determine the causes of damage, in situ tests and laboratory tests were carried out. It was found that the damage...
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Damage detection in elements of strutures by the elastic wave propagation method.
PublikacjaW pracy przedstawiono wyniki badań dotyczace wykorzystania fal sprężystych do detekcji uszkodzeń i jedno i dwu wymiarowych elementach konstrukcyjnych.
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Modelling of concrete behaviour with a non-local continuum damage approach
PublikacjaW artykule przedstawiono wyniki numerycznej dla różnych problemów brzegowych związanych z powstawaniem rys w betonie. Obliczenia wykonano przy zastosowaniu modelu zniszczeniowego (z uwzględnieniem degradacji sztywności). Do opisu rys, model rozszerzono o nielokalność.
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Rapid and simple multi-analyte LC–MS/MS method for the determination of benzodiazepines and Z-hypnotic drugs in blood samples: Development, validation and application based on three years of toxicological analyses
PublikacjaBenzodiazepines (BZDs) and Z-drugs have been particularly important treatments for sleeping and anxiety disorders for many years. However, recently, a number of new benzodiazepines (named designer benzodiazepines, DBZDs) were synthesised, but some of them have never been used in the clinic; they reached the black drug market as new psychoactive substances and are used for recreational purposes. The abuse of these substances has...
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Potentials of Water Usage in urban Neighbourhood Structures
PublikacjaThis paper will treat about water influence and possibility of its usage in the urban neighborhood structures (e.g. districts, real estate properties, town parts) in the context of actual regional environmental problems and according to directories determined by European targets. It is not rare yet in the basic stage of urban design that water is treated as a threat, not a chance. In result planned structures are often built,...
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Usage of concentrated spectrogram for analysis of acoustical signals
PublikacjaA novel precise method of signal analysis in the time-frequency domain is presented. A signal energy distribution is estimated by discard and displacement of energy parts of the classical spectrogram. A channelized instantaneous frequency and a local group delay are used in order to energy replacement. Additionally, newly introduced representations such as: a channelized instantaneous bandwidth and a local group duration are used...
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Minimization of label usage in (G)MPLS networks
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TECHNOLOGY OF CREATING AND USAGE OF PROECOLOGICAL BLOCK EMPTYSEED
PublikacjaNowadays, finding natural substitutes for mass-produced materials is one of the main tasks faced by scientists and designers. There is an increasing emphasis on the theme of ecology and the need for sustainability. Variants and methods are sought which will create environmentally friendly materials in a fast, relatively inexpensive and ecological way. The aim of this paper is to present different proposals of natural building materials...
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The antitumor derivative, C-1748, affects CYP3A4: crosstalk between drug metabolism, CYP3A4 expression and enzymatic activity
PublikacjaJedną z głównych przeszkód w przewidywaniu wyników terapii u pacjentów z nowotworem jest indywidualny przebieg metabolizmu stosowanych leków wynikający z polimorfizmu genów enzymów metabolizujących, jak również duża zmienność farmakokinetyki leków obserwowana u różnych pacjentów podczas trwania chemioterapii. Z powodu tzw. ''wąskiego okna terapeutycznego'' występującego w przypadku terapii lekami przeciwnowotworowymi, małe zmiany...
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DNA structure and integrity checkpoints in the cell cycle and their role in drug targeting and resistance of tumor cells to anticancer treatment
PublikacjaW artykule dokonaliśmy przeglądu literatury dotyczącej różnych typów uszkodzeń DNA indukowanych przez różne czynniki terapeutyczne w komórkach nowotworowych. Omówiliśmy także w jaki sposób aktywują różne typy punktów kontrolnych w cyklu komórkowym i w jaki sposób punkty te są regulowane przez inne szlaki sygnalizacji wewnątrzkomórkowej takie jak szlaki naprawy uszkodzeń DNA, stresu komórkowego i śmierci-przeżycia. W szczególności...
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Electroporation and lipid nanoparticles with cyanine IR-780 and flavonoids as efficient vectors to enhanced drug delivery in colon cancer
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New diamidequat-type surfactants in fabrication of long-sustained theranostic nanocapsules: Colloidal stability, drug delivery and bioimaging
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Inhibition of ALDH1A1 activity decreases expression of drug transporters and reduces chemotherapy resistance in ovarian cancer cell lines
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Microarray-based detection and expression analysis of new genes associated with drug resistance in ovarian cancer cell lines
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