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Wyniki wyszukiwania dla: cyp51a sequence
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Examination of cyp51A and cyp51B expression level of the first Polish azole resistant clinical Aspergillus fumigatus isolate
PublikacjaAspergillus fumigatus is one of the most prevalent airborne fungal pathogens causing infections worldwide. Most A. fumigatus strains are susceptible to azoles, which are administered as the first line therapeutics. However, during last decade the acquired resistance to triazoles by these species has been described. There is a number of publications concerning the examination of clinical A. fumigatus strains from different countries,...
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Relation of the polymorphism of cyp51A sequence and the susceptibility of Aspergillus fumigatus isolates to triazoles determined by commercial gradient test (Etest) and by reference methods
PublikacjaThe aim of this study was to evaluate the accuracy of commercial gradient test (Etest) in the detection of triazole resistant Aspergillus fumigatus isolates using reference microdilution methods and the analysis of sequences of the cyp 51A gene. The study was performed on twenty clinical isolates which were identified as Aspergillus fumigatus based on the DNA sequences of the ITS1-2 fragment of ribosomal DNA and the β-tubulin gene,...
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Modulation of CYP1A1, CYP1A2 and CYP1B1 expression by cabbage juices and indoles in human breast cell lines
PublikacjaEpidemiological studies have shown that consumption of cab- bage and sauerkraut is connected with significant reduction of breast cancer incidences. Estrogens are considered a major breast cancer risk factor and their metabolism by P450 enzymes substan- tially contributes to carcinogenic activity. The aim of this study was to investigate the effect of cabbage and sauerkraut juices of differ- ent origin on the expression profile...
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The Boltzmann sequence-structure channel
PublikacjaWe rigorously study a channel that maps binary sequences to self-avoiding walks in the two-dimensional grid, inspired by a model of protein statistics. This channel, which we also call the Boltzmann sequence-structure channel, is characterized by a Boltzmann/Gibbs distribution with a free parameter corresponding to temperature. In our previous work, we verified experimentally that the channel capacity has a phase transition for...
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Phase Transition in a Sequence-Structure Channel
PublikacjaWe study an interesting channel which maps binary sequences to self-avoiding walks in the two-dimensional grid, inspired by a model of protein folding from statistical physics. The channel is characterized by a Boltzmann/Gibbs distribution with a free parameter corresponding to temperature. We estimate the conditional entropy between the input sequence and the output fold, giving an upper bound which exhibits an unusual phase transition...
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Role of bead sequence in underwater welding
PublikacjaThis paper presents examinations of the role of the bead sequence in underwater welding. Two specimens of wet welded layers made by covered electrodes with the use of normalized S355G10+N steel were welded by a reasonable bead sequence. For each specimen, metallographic macro- and micro-scopic tests were done. Then, Vickers HV10 hardness measurements were conducted for each pad weld in the welded layer. The results show that welding...
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On sequences of the white noises
PublikacjaPodano dowód mocnego prawa wielkich liczb dla funkcjonałów gaussowskich.
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Application of Maximum Lenght Sequence in Silent Sonar
PublikacjaSilent sonars are designed to reduce the distance over which their sounding pulses can be detected by intercept sonars. In order to meet this objective, we can use periodical sounding signals that have low power, a very long duration and wide spectrum. If used in the silent sonar's receiver, matched filtration ensures very good detection of motionless or slow moving targets. However, it is more difficult to detect echo signals...
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Frequent Sequence Mining in Web Log Data
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Frequent Sequence Mining in Web Log Data
PublikacjaThe amount of information available even on a single web server can be huge. On the other hand, the amount of visitors (users) can often reach a number of at least six digits. Users vary in gender, age and education, and in consequence their information needs are different. Moreover, they subconsciously expect to get more adequate content after visiting the first few pages. The scope of this kind of problem relates to the domain...
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The Conley index and spectral sequences
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Analysis of the complete genome sequence of the lactococcal bacteriophage bIBB29
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Periodicity of a sequence of local fixed point indices of iterations
PublikacjaPraca uogólnia klasyczne twierdzenie Shuba i Sullivana o periodyczności ciągu indeksów punktu stałego iteracji odwzorowań gładkich na szerszą klasę przekształeń.
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Distribution of the displacement sequence of an orientation preserving circle homeomorphism
PublikacjaIn some applications not only the knowledge of the behaviour of trajectories of a map is important, but also their displacements. We describe in detail the distribution of elements of the displacement sequence along a trajectory of an orientation preserving circle homeomorphism ϕ with irrational rotation number ϱ(ϕ). The values of displacement are dense in a set which depends on the map γ (semi-)conjugating ϕ with the rotation...
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On the regularity of the displacement sequence of an orientation preserving circle homeomorphism
PublikacjaWe investigate the regularity properties of the displacemnet sequence of an orientation preserving circle homeomorphism. is rational, then ηn(z) is asymptotically periodic with semi-period q. This
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A method to determine the tightening sequence for standing rigging of a mast
PublikacjaThe article proposes an alternative method to determine the sequence of generation of pre-tension forces in standing rigging of a mast. The proposed approach has been verified on both a virtual simulation experiment and laboratory tests. In this method, the desired tension values are obtained using the influence matrix which allows to calculate the effect of tension change in an individual rope on the tension distribution in the...
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Spectral sequences and detailed connection matrices
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Generating sequences of Lefschetz numbers of iterates
PublikacjaDu, Huang and Li showed in 2003 that the class of Dold–Fermat sequences coincides with the class of Newton sequences, which are defined in terms of socalled generating sequences. The sequences of Lefschetz numbers of iterates form an important subclass of Dold–Fermat (thus also Newton) sequences. In this paper we characterize generating sequences of Lefschetz numbers of iterates.
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Dold sequences, periodic points, and dynamics
PublikacjaIn this survey we describe how the so-called Dold congruence arises in topology, and how it relates to periodic point counting in dynamical systems.
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Detection of the Direct Sequence Spread Spectrum Signals with BPSK Modulation
PublikacjaThis paper presents a method of the DS CDMA signals with BPSK modulation detection through the examination of the enhanced signal spectrum density. On the base of experiments carried out on the real radio communication signals the impact of a narrowband emission occurring in the examined frequency band on the detection process effectiveness was shown. The results of the experiment aimed at the detection of the satellite navigation...
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Ancient DNA sequence quality is independent of fish bone weight
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The accuracy of pulse rate estimation from the sequence of face images
PublikacjaThe goal of this paper is to analyze the accuracy of pulse rate estimation from the sequence of face images. Simulated and real signals were used to evaluate two pulse rate estimators; one for frequency domain and the second one for time domain using the autocorrelation function. The results show that the mean difference between the reference measurements and estimated pulse rate values are about 2bpm. In the analysis of short...
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Generalized Dold sequences on partially-ordered sets
PublikacjaDold sequences constitute an important class of integer sequences that play an important role in combinatorics, number theory, topology and dynamical systems. We generalize the notion of Dold sequence for the case of partially ordered sets and describe their properties. In particular we give two alternative descriptions of generalized Dold sequences: by some class of elementary sequences as well as by different...
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IEEE 802.15.4a Impulse Radio Spectrum Shaping by Changes in Pulse Sequence
PublikacjaThis paper presents one of possible techniques of IEEE 802.15.4a ultra-wideband signal spectrum control, based on changes in sequences of transmitted pulses with very short duration time. This technique can reduce probability of mutual interferences between new ultra-wideband and existing narrowband devices, which may be helpful in further studies on allowing UWB transmission in wider range of spectrum in theEuropean Union.
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Tracts of high or low sequence divergence in the mouse major histocompatibility complex.
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Maps with bounded sequence of indices of interations and finitaly many periodic points
PublikacjaW pracy badane są związki pomiędzy globalną topologiczną strukturą przestrzeni wyrażoną w terminach charakterystyki Eulera-Poincar odwzorowań na niej określonych, a spełniających założenia z tytułu, a lokalnymi własnościami przestrzeni zdeterminowanymi przez zachowanie się tych odwzorowań w punkatach periodycznych.
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Simulation model for evaluation of packet sequence changed order of stream in DiffServ network
PublikacjaCurrent packet networks use a large variety of mechanisms which should support QoS (Quality of Service). One of those mechanisms is routing (calculating connection paths for incoming service requests). The most effective mechanism in QoS context is dynamic routing, which is based on the current network state described by the offered traffic matrix and link states. After switching between calculated available paths, connection...
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Genome Sequence of the Probiotic Strain Lactobacillus rhamnosus (Formerly Lactobacillus casei) LOCK900
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Genome Sequence of the Probiotic Strain Lactobacillus rhamnosus (Formerly Lactobacillus casei) LOCK908
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Probabilistic Sequence Mining – Evaluation and Extension of ProMFS Algorithm for Real-Time Problems
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Butyrylcholinesterase signal sequence self-aggregates and enhances amyloid fibril formation in vitro
PublikacjaAlzheimer’s disease (AD) pathogenesis has been attributed to extracellular aggregates of amyloid β (Aβ) plaques and neurofibrillary tangles in the human brain. It has been reported that butyrylcholinesterase (BChE) also accumulates in the brain Aβ plaques in AD. We have previously found that the BChE substitution in 5′UTR caused an in-frame N-terminal extension of 41 amino acids of the BChE signal peptide. The resultant variant...
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An accurate assignment test for extremely low‐coverage whole‐genome sequence data
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An accurate assignment test for extremely low-coverage whole-genome sequence data
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Continuous wave sonar with hyperbolic frequency modulation keyed by pseudo-random sequence
PublikacjaA CW FM type sounding signal is used in the classical solution of silent sonar. While the signal provides a relatively simple implementation of digital signal processing, and ensures good detection conditions, unfortunately, in the presence of the Doppler effect, distance measurement results tend to be wrong. This is due to the fact that the received signal’s instantaneous frequency value is dependent both on the distance to the...
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Study of the Performance of DSSS UAC System Depending on the System Bandwidth and the Spreading Sequence
PublikacjaA signal transmitted in an Underwater Acoustic Communication (UAC) system operating in a shallow-water channel suffers from strong time dispersion due to multipath propagation. This causes the Inter-Symbol Interference (ISI) observed in the received signal, which significantly limits the communication system’s reliability and transmission rate. In such propagation conditions, the Direct-Sequence Spread Spectrum (DSSS) method is...
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Constructing a map of an anonymous graph: applications of universal sequences
PublikacjaWe study the problem of mapping an unknown environmentrepresented as an unlabelled undirected graph. A robot (or automaton)starting at a single vertex of the graph G has to traverse the graph and return to its starting point building a map of the graph in the process. We are interested in the cost of achieving this task (whenever possible) in terms of the number of edge traversal made by the robot. Another optimization criteria...
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Sequences of fixed point indices of iterations in dimension 2.
PublikacjaW pracy dowodzi się, że każdy ciąg liczb całkowitych spełniający relacje Dolda może zostać zrealizowany jako ciąg indeksów punktu stałego iteracji ciągłego odwzorowania dwuwymiarowego dysku w siebie.
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Complete Genome Sequence of the Probiotic Strain Lactobacillus casei (Formerly Lactobacillus paracasei) LOCK919
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Primary role identification in e-mail networks using pattern subgraphs and sequence diagrams
PublikacjaSocial networks often forms very complex structures that additionally change over time. Description of actors' roles in such structures requires to take into account this dynamics reflecting behavioral characteristics of the actors. A role can be defined as a sequence of different types of activities. Various types of activities are modeled by pattern subgraphs, whereas sequences of these activities are modeled by sequence diagrams....
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INFLUENCE OF TACK WELDS DISTRIBUTION AND WELDING SEQUENCE ON THE ANGULAR DISTORTION OF TIG WELDED JOINT
PublikacjaIn this paper the influence of tack welds distribution and welding sequence on angular distortion of the Tungsten Inert Gas (TIG) welded joint was tested. Additionally, the effect of welding current on angular distortion was assessed. For research X2CrTiNb18 (AISI 441) stainless steel (2.5 mm thick) was chosen. During research specimens were prepared with different distributionsof tack...
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Interactions of telomeric proteins with nucleic acids: sequence recognition on intact and oxidatively damaged telomeres
PublikacjaTelomeres are complex nucleoprotein assemblies that play a vital role in the maintenance of functional ends of linear chromosomes. Telomeric DNA, composed of tandem repeats of the 5'-TTAGGG-3' motif, solves the so-called end replication problem: as chromosomes shorten with each cell division, no information is lost, and the telomere can be re-extended. In the cell, many protein factors regulate telomere length, nuclear positioning...
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Introducing a Computational Method to Retrofit Damaged Buildings under Seismic Mainshock-Aftershock Sequence
PublikacjaRetrofitting damaged buildings is a challenge for engineers, since commercial software does not have the ability to consider the local damages and deformed shape of a building resulting from the mainshock record of an earthquake before applying the aftershock record. In this research, a computational method for retrofitting of damaged buildings under seismic mainshock-aftershock sequences is proposed, and proposed computational...
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Mining e-mail message sequences from log data
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Normal-form preemption sequences for an open problem in scheduling theory
PublikacjaStructural properties of optimal preemptive schedules have been studied in a number of recent papers with a primary focus on two structural parameters: the minimum number of preemptions necessary, and a tight lower bound on shifts, i.e., the sizes of intervals bounded by the times created by preemptions, job starts, or completions. These two parameters have been investigated for a large class of preemptive scheduling problems,...
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Face detection in image sequences using a portable thermal camera
PublikacjaFace detection is often a first step in quantitative analysis of face images. It is an important research area for visible images and recently also for thermography. Due to technological developments thermal cameras may be embedded into wearable devices to provide remote healthcare. In this paper, we compared three algorithms for face detection in thermal images by testing execution time, accuracy, symmetry ratio and false-positives....
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MP3vec: A Reusable Machine-Constructed Feature Representation for Protein Sequences
Publikacja—Machine Learning (ML) methods have been used with varying degrees of success on protein prediction tasks, with two inherent limitations. First, prediction performance often depends upon the features extracted from the proteins. Second, experimental data may be insufficient to construct reliable ML models. Here we introduce MP3vec, a transferable representation for protein sequences that is designed to be used specifically for sequence-to-sequence...
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Thermal sequences database of the skin flaps in breast reconstruction and burns
PublikacjaThis paper presents a database of Active Dynamic Thermography (ADT) thermal sequences gathered throughout 6 year study on ADT application in skin flap blood perfusion monitoring and burn wounds diagnosis. For skin flap monitoring the database comprises of data collected during three different breast reconstruction procedures. The patients were monitored pre, intra and post surgically within 90 days period. The sequences were used...
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Thermal sequences database of the skin flaps in breast reconstruction and burns
PublikacjaThis paper presents a database of Active Dynamic Thermography (ADT) thermal sequences gathered throughout 6 year study on ADT application in skin flap blood perfusion monitoring and burn wounds diagnosis. For skin flap monitoring the database comprises of data collected during three different breast reconstruction procedures. The patients were monitored pre, intra and post surgically within 90 days period. The sequences were used...
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Fiber Optic Pulse Sequencers/Desequencers
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Metabolic transformation of antitumor agent C1311 with various fractions of rat liver.
PublikacjaWykazano, że enzymatyczna aktywacja jest konieczna dla aktywności bilogicznej pochodnej C-1311. Zbadano przemiany związku w obecności różnych frakcji enzymatycznych mikrosomalnych komórek wątroby szczura.Badania te wykazały, że związek C-1311 jest bardziej podatny na transformację pod wpływem frakcji aktywowanych enzymów mikrosomalnych (CYP1A, CYP2B, CYP3A i CYP4A) niż frakcji S9, cytozolowej czy mikrosomów nieaktywowanych. Związek...