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Wyniki wyszukiwania dla: AMIDE RECEPTORS
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Theoretical investigation of the structural insights of the interactions of γ-Fe2O3 nanoparticle with (EMIM TFSI) ionic liquid
PublikacjaOne of the possible applications of ionic liquids is to produce electricity from heat. The iron oxide nanoparticle is a potent electrical particle, which is expected to improve the heat’s efficiency to electricity conversion, however, it is prone to aggregation and sedimentation, which hamper its application. One of the methods to enhance the nanoparticle’s solubility and electrical properties is the use of a stabilizing component...
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Disaster-resilient communication networks: Principles and best practices
PublikacjaCommunication network failures that are caused by disasters, such as hurricanes, arthquakes and cyber-attacks, can have significant economic and societal impact. To address this problem, the research community has been investigating approaches to network resilience for several years. However, aside from well-established techniques, many of these solutions have not found their way into operational...
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Fizyczne podstawy mikrokontrolerowych układów pomiarowych (2022/2023)
Kursy OnlineKurs skierowany dla studentów VI semestru, kierunek Fizyka Techniczna, specjalność Informatyka Stosowana (ale nie tylko). Kurs obejmuje naukę podstawowych metod projektowania i programowania prostych systemów wbudowanych (ang. embedded systems), czyli specjalizowanych systemów informatycznych, odpowiadających za wykonywanie ściśle określonych zadań - głównie związanych z monitorowaniem i sterowaniem. W ramach kursu przedstawiane...
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Fizyczne podstawy mikrokontrolerowych układów pomiarowych (2021/2022)
Kursy OnlineKurs skierowany dla studentów VI semestru, kierunek Fizyka Techniczna, specjalność Informatyka Stosowana (ale nie tylko). Kurs obejmuje naukę podstawowych metod projektowania i programowania prostych systemów wbudowanych (ang. embedded systems), czyli specjalizowanych systemów informatycznych, odpowiadających za wykonywanie ściśle określonych zadań - głównie związanych z monitorowaniem i sterowaniem. W ramach kursu przedstawiane...
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Fizyczne podstawy mikrokontrolerowych układów pomiarowych (2023/2024)
Kursy OnlineKurs skierowany dla studentów VI semestru, kierunek Fizyka Techniczna, specjalność Informatyka Stosowana (ale nie tylko). Kurs obejmuje naukę podstawowych metod projektowania i programowania prostych systemów wbudowanych (ang. embedded systems), czyli specjalizowanych systemów informatycznych, odpowiadających za wykonywanie ściśle określonych zadań - głównie związanych z monitorowaniem i sterowaniem. W ramach kursu przedstawiane...
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Fizyczne podstawy mikrokontrolerowych układów pomiarowych (2024/2025)
Kursy OnlineKurs skierowany dla studentów VI semestru, kierunek Fizyka Techniczna, specjalność Informatyka Stosowana (ale nie tylko). Kurs obejmuje naukę podstawowych metod projektowania i programowania prostych systemów wbudowanych (ang. embedded systems), czyli specjalizowanych systemów informatycznych, odpowiadających za wykonywanie ściśle określonych zadań - głównie związanych z monitorowaniem i sterowaniem. W ramach kursu przedstawiane...
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Study of the effect of Dr fimbria presence on the accumulation of recombinant Escherichia coli strain: AAEC191A/pCC90 cells in polystyrene in a dynamic system
Dane BadawczeThe process of surface colonization, known as biofilm development, begins with bacterial attachment and involves various physicochemical and molecular interactions. Adhesion to neutral surfaces typically involves non-specific interactions, while adhesion to biological surfaces is governed by specific ligand-receptor interactions. In the experiment,...
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Study of the effect of Dr fimbria presence on the accumulation of recombinant Escherichia coli strain: AAEC191A/pCC90 cells in glass in a dynamic system
Dane BadawczeThe process of surface colonization, known as biofilm development, begins with bacterial attachment and involves various physicochemical and molecular interactions. Adhesion to neutral surfaces typically involves non-specific interactions, while adhesion to biological surfaces is governed by specific ligand-receptor interactions. In the experiment,...
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Study of the effect of Dr fimbria presence on the accumulation of recombinant Escherichia coli strain: AAEC191A/pACYCpBAD cells in polystyrene in a dynamic system
Dane BadawczeThe process of surface colonization, known as biofilm development, begins with bacterial attachment and involves various physicochemical and molecular interactions. Adhesion to neutral surfaces typically involves non-specific interactions, while adhesion to biological surfaces is governed by specific ligand-receptor interactions. In the experiment,...
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Study of the effect of Dr fimbria presence on the accumulation of recombinant Escherichia coli strain: AAEC191A/pACYCpBAD cells in glass in a dynamic system
Dane BadawczeThe process of surface colonization, known as biofilm development, begins with bacterial attachment and involves various physicochemical and molecular interactions. Adhesion to neutral surfaces typically involves non-specific interactions, while adhesion to biological surfaces is governed by specific ligand-receptor interactions. In the experiment,...
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Escherichia coli Strains with Virulent Factors Typical for Uropathogens were Isolated from Sinuses from Patients with Chronic Rhinosinusitis—Case Report
PublikacjaEscherichia coli were isolated from three patients with chronic rhinosinusitis (CRS) by intraoperative sinus tissue biopsy. Taking into account the unusual replicative niche and previous treatment failures, it was decided to focus on the virulence and drug resistance of these bacteria. The strains turned out to be multi-sensitive, but the rich virulence factors profile of bacteria typical for phylogenetic group B2 deserved attention....
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Alternative treatment approaches of urinary tract infections caused by uropathogenic Escherichia coli strains
PublikacjaUrinary tract infections (UTIs) are the most widespread and annoying infections affecting millions of people every year annually. The biggest problem of urinary diseases are recurrences, the increasing resistance of uropathogens to commonly used antibiotics, as well as the high health care costs of afflicted persons. Uropathogenic Escherichia coli strains (UPECs) are the most dominant etiologic agent of community-acquired infections...
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Conjugates of Ciprofloxacin and Levofloxacin with Cell-Penetrating Peptide Exhibit Antifungal Activity and Mammalian Cytotoxicity
PublikacjaSeven conjugates composed of well-known fluoroquinolone antibacterial agents, ciprofloxacin (CIP) or levofloxacin (LVX), and a cell-penetrating peptide transportan 10 (TP10-NH2) were synthesised. The drugs were covalently bound to the peptide via an amide bond, methylenecarbonyl moiety, or a disulfide bridge. Conjugation of fluoroquinolones to TP10-NH2 resulted in congeners demonstrating antifungal in vitro activity against human...
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The impact of training and neurotrophins on functional recovery after spinal cord transection: cellular and molecular mechanisms contributing to motor improvement
PublikacjaBeneficial effects of locomotor training on the functional recovery after complete transection of the spinal cord indicate that in chronic spinal animals spontaneous recovery processes are enhanced and shaped by the training. The mechanisms of that use-dependent improvement are still not fully understood. This review tackles three aspects of this issue: (1) neurochemical attributes of functional improvement...
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Mechanism of the reaction of Lawesson's reagent with N-alkylhydroxamic acids
PublikacjaIdentyfikacja fosforowych produktów powstających w reakcji kwasów hydroksamowych z odczynnikiem Lawessona pozwoliła ustalić mechanizm tytułowej reakcji. Wykorzystano w tym celu spektroskopię 31P NMR. Wzorce labilnych produktów otrzymano na niezależnej drodze syntetycznej lub przeprowadzono je w trwałe pochodne, które wyizolowano z mieszanin reakcyjnych. Produktem przejściowym badanej reakcji okazał się odpowiedni O-ditiofosfonylowany...
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Analysis of MArkers of Exposure to Constituents of Environmental Tobacco Smoke (ETS)
PublikacjaTobacco smoke is a complex mixture of more than 4000 chemical compounds, many of which are harmful to human health. These compounds belong to various chemical classes, including amides, imides, lactams, carboxylic acids, aldehydes, ketones, alcohols, phenols, amines, hydrocarbons, ethers, and inorganic compounds. There are three types of tobacco smoke streams: the mainstream, the sidestream, and environmental tobacco smoke (ETS)....
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Transport properties of aqueous ionic liquid microemulsions: influence of the anion type and presence of the cosurfactant
PublikacjaTransport properties, viz. specific conductivity, dynamic viscosity and apparent diffusion coefficients, were measured as a function of water content in aqueous ionic liquid microemulsions containing 1-butyl-3- methylimidazolium hexafluorophosphate, [BMIM][PF6] and bis(trifluoromethanesulphonyl)imide, [BMIM][Tf2N], stabilized by the nonionic surfactant TX-100, or its mixture with a cosurfactant, i.e. butanol. The investigation covered...
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Micellar aggregation of Triton X-100 surfactant in imidazolium ionic liquids
PublikacjaIn this work we investigated aggregation behavior of a nonionic surfactant Triton X-100 in eighteen imidazolium ionic liquids (ILs) with two to eight carbon atoms in cations alkyl chain, namely 1-ethyl-3-methylimidazolium, [EMIM], 1-butyl-3-methylimidazolium, [PrMIM], 3-methyl-1-propylimidazolium, [BMIM], 1-hexyl-3-methylimidazolium, [PMIM], 3-methyl-1-pentyl-imidazolium, [HMIM], and 1-octyl-3-methylimidazolium, [OMIM], and with...
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Experimental and Machine-Learning-Assisted Design of Pharmaceutically Acceptable Deep Eutectic Solvents for the Solubility Improvement of Non-Selective COX Inhibitors Ibuprofen and Ketoprofen
PublikacjaDeep eutectic solvents (DESs) are commonly used in pharmaceutical applications as excellent solubilizers of active substances. This study investigated the tuning of ibuprofen and ketoprofen solubility utilizing DESs containing choline chloride or betaine as hydrogen bond acceptors and various polyols (ethylene glycol, diethylene glycol, triethylene glycol, glycerol, 1,2-propanediol, 1,3-butanediol) as hydrogen bond donors. Experimental...
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Experimental and Machine-Learning-Assisted Design of Pharmaceutically Acceptable Deep Eutectic Solvents for the Solubility Improvement of Non-Selective COX Inhibitors Ibuprofen and Ketoprofen
PublikacjaDeep eutectic solvents (DESs) are commonly used in pharmaceutical applications as excellent solubilizers of active substances. This study investigated the tuning of ibuprofen and ketoprofen solubility utilizing DESs containing choline chloride or betaine as hydrogen bond acceptors and various polyols (ethylene glycol, diethylene glycol, triethylene glycol, glycerol, 1,2-propanediol, 1,3-butanediol) as hydrogen bond donors. Experimental...
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Supramolecular Synthesis Based on a Combination of Se···N Secondary Bonding Interactions with Hydrogen and Halogen Bonds
PublikacjaExamination of the solid state structures of 2,1,3-benzoselenadiazole complexes with hydrogen or halogen bond donors has demonstrated that the 2,1,3-benzoselenadiazole molecules preferably form centrosymmetric dimers with use of [Se–N]2 supramolecular synthon, whereas the two remaining nitrogen atoms not involved in the [Se–N]2 supramolecular interactions can act as acceptors of hydrogen or halogen bonds. Cocrystallization of selenadiazoles...
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Performance of microbial fuel cells operated under anoxic conditions
PublikacjaNowadays, microbial fuel cells (MFC) stand up as a promising renewable energy source. Due to the ability of the MFC to oxidize a wide spectrum of substrates, wastewater seems to be one of the most interesting fuels. Unfortunately, wastewater could contain electron acceptors such as nitrate, which could interfere with the electrical performance of the MFC. In this work, the influence of oxidised nitrogen forms on the electricity...
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Evaluation of the Effect of Four Bioactive Compounds in Combination with Chemical Product against Two Spider Mites Tetranychus urticae and Eutetranychus orientalis(Acari: Tetranychidae)
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Do Phenyl Substituents Affect the Properties of Azobenzocrown Derivatives?
PublikacjaNew products of photo- and thermal rearrangements of 19-membered azoxybenzocrown with phenyl substituents in benzene rings in the para positions to oligooxyethylene fragments are characterized. The yields of photochemical transformations depend on the solvent. Para-hydroxyazocrown is formed with yields over 50% in propan-2-ol. Ortho-hydroxyazobenzocrown is obtained with yields up to 70% in toluene/acetic acid mixture. Macrocyclic...
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Usuwanie lotnych związków organicznych z fazy gazowej z zastosowaniem cieczy jonowych
PublikacjaUżycie cieczy jonowej do usuwania LZO jest limitowane przez rozpuszczalność usuwanych związków. Dane literaturowe sugerują, że ciecze jonowe jako faza membranowa mogą być z powodzeniem stosowane do selektywnej separacji węglowodorów aromatycznych z mieszanin węglowodorów aromatycznych i alifatycznych. Przedmiotem pracy było kompleksowe opisanie procesu separacji LZO z fazy gazowej z uwzględnieniem czynników wpływających na efektywność...
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Actual and reference evapotranspiration for a natural, temperate zone fen wetland – Upper Biebrza case study
PublikacjaEvapotranspiration is the key and predominant component of the water balance in wetlands. Direct evapotranspiration measurements are challenging in wetlands due to their remoteness and high surface water level. This article describes the actual (ETa and reference evapotranspiration (ET0) from a cultivated wet meadow located in the Biebrza National Park – the largest national park in north-east Poland, Central Europe. The data were...
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Durability of Asphalt Concrete Subjected to Deteriorating Effects of Water and Frost
PublikacjaThe paper presents testing of the detrimental effects of water and frost on asphalt pavements. It included laboratory testing of 5 fatigue life of asphalt concrete that was subjected to action of water and frost and field testing of damages caused by water and frost on 6 existing asphalt pavements, such as stripping, raveling, and potholes. Laboratory simulation of water and frost action was based on the 7 original AASHTO T283...
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Synthesis of 5-Substituted 1H-Tetrazoles from Nitriles in the Presence of Heterogeneous Catalyst
PublikacjaTetrazoles are five-membered heterocyclic compounds containing in their rings four nitrogen atoms. They have wide applications as corrosion inhibitors, analytical reagents, high-energy materials and gas generating compositions. Tetrazoles also play important role in coordination chemistry as ligands and in medicinal chemistry as metabolically stable surrogates for carboxylic acids. In recent years, investigation of new method of...
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Micelle formation of Tween 20 nonionic surfactant in imidazolium ionic liquids
PublikacjaAggregation behavior of polyoxyethylene (POE)-type nonionic surfactant Tween 20 in imidazolium ionic liquids with varying chain length and different anions, such as tetrafluoroborate, hexafluorophosphate, bis(trifluoromethanesulfonyl)imide, and trifluoromethanesulfonate, was investigated by means of surface tension, conductivity and dynamic light scattering measurements. The role of the chain length, anion size as well as interactions...
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Opracowanie nowego wyrobu do odzysku ciepła na podstawie ustalenia najefektywniejszego składu absorbentów w systemie grzewczym, wraz z nową technologią dostosowaną do ich produkcji
PublikacjaNiniejszy projekt niewątpliwie wpłynie na podniesienie innowacyjności przedsiębiorstwa poprzez wdrożenie do produkcji nowego oryginalnego produktu o szerokie perspektywie wykorzystania w różnych gałęziach przemysłu lokalnego i krajowego. Firma Klar otrzymała unikatową „recepturę” dotyczącą właściwej do zastosowania, optymalnej substancji roboczej oraz parametrów i sposobu jej napełniania. Rurka ciepła jest elementem znanym nauce...
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Exploring the cocrystallization potential of urea and benzamide
PublikacjaThe cocrystallization landscape of benzamide and urea interacting with aliphatic and aromatic carboxylic acids was studied both experimentally and theoretically. Ten new cocrystals of benzamide were synthesized using an oriented samples approach via a fast dropped evaporation technique. Information about types of known bi-component cocrystals augmented with knowledge of simple binary eutectic mixtures was used for the analysis...
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Antibiotic-Based Conjugates Containing Antimicrobial HLopt2 Peptide: Design, Synthesis, Antimicrobial and Cytotoxic Activities
PublikacjaRecent studies have shown that modified human lactoferrin 20−31 fragment, named HLopt2, possesses antibacterial and antifungal activity. Thus, we decided to synthesize and evaluate the biological activity of a series of conjugates based on this peptide and one of the antimicrobials with proven antibacterial (ciprofloxacin, CIP, and levofloxacin, LVX) or antifungal (fluconazole, FLC) activity. The drugs were covalently connected...
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An Investigation of Polyamides Based on Isoidide-2,5-dimethyleneamine as a Green Rigid Building Block with Enhanced Reactivity
PublikacjaNovel, semicrystalline polyamides and copolyamides were synthesized from a new carbohydrate-based diamine, namely isoidide-2,5-dimethyleneamine (IIDMA). In combination with 1,6-hexamethylene diamine (1,6-HDA) as well as the biobased sebacic acid (SA) or brassylic acid (BrA), the desired copolyamides were obtained via melt polymerization of the nylon salts followed by a solid-state polycondensation (SSPC) process. Depending on the...
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Phosphate tricyclic coumarin analogs as steroid sulfatase inhibitors: synthesis and biological activity.
PublikacjaIn the present work, we report convenient methods for the synthesis and biological evaluation of phosphate tricyclic coumarin derivatives as potential steroid sulfatase inhibitors. The described synthesis includes the straightforward preparation of 7-hydroxy-2,3-dihydro-1H-cyclopenta[c]chromen-4-one, 3-hydroxy-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one and 3-hydroxy-8,9,10,11-tetrahydro-7H-cyclohepta[c]chromen-6-one modified...
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Anticancer Imidazoacridinone C-1311 is Effective in Androgen-Dependent and Androgen-Independent Prostate Cancer Cells
PublikacjaAndrogen receptor (AR) plays a crutial role in prostate cancer (PCa) development and metastasis. Here, we reported potent anti-PCa activity of a small molecule imidazoacridinone C-1311. In AR-positive PCa cells, C-1311 was found to inhibit the transcriptional activity of AR uncovering a novel mechanism that may be relevant for its anticancer effect. Mechanistically, C-1311 decreased AR binding to prostate-specific antigen (PSA)...
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Genetic variations as predictors of dispositional and dyadic empathy - a couple study
PublikacjaBiological drivers of empathy have been explored in an interdisciplinary manner for decades. Research that merges the psychological and genetic perspectives of empathy has recently gained interest, and more complex designs and analyses are needed. Empathy is a multidimensional construct that might be regarded both dispositionally (as a personality trait) and contextually (experienced and/or expressed in a particular relationship/situation)....
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Phytoecdysteroid containing plants – a source of bioactive compounds with potential anticarcinogenic effects
PublikacjaEcdysteroids are a group of steroids synthesized in inver- tebrates as molting hormones and also in some plants as secondary metabolites acting as a defense against parasites. These compounds do not naturally occur in mammals and are not structurally related to mammalian steroid hor- mones, consequently do not activate mammalian hormone receptors. Ecdysteroids exhibit very low toxicity to mam- mals and to date no serious side effects...
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Reverse vaccinology-based prediction of a multi-epitope SARS-CoV-2 vaccine and its tailoring to new coronavirus variants
PublikacjaThe genome feature of SARS-CoV-2 leads the virus to mutate and creates new variants of concern. Tackling viral mutations is also an important challenge for the development of a new vaccine. Accordingly, in the present study, we undertook to identify B- and T-cell epitopes with immunogenic potential for eliciting responses to SARS-CoV-2, using computational approaches and its tailoring to coronavirus variants. A total of 47 novel...
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Natural fish oil improves the differentiation and maturation of oligodendrocyte precursor cells to oligodendrocytes in vitro after interaction with the blood–brain barrier
PublikacjaThe blood–brain barrier (BBB) tightly controls the microenvironment of the central nervous system (CNS) to allow neurons to function properly. Additionally, emerging studies point to the beneficial effect of natural oils affecting a wide variety of physiological and pathological processes in the human body. In this study, using an in vitro model of the BBB, we tested the influence of natural fish oil mixture (FOM) vs. borage oil...
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Phytochemical composition and biological activities of differently pigmented cabbage (Brassica oleracea var. capitata) and cauliflower (Brassica oleracea var. botrytis) varieties
PublikacjaBACKGROUND:Brassica plants contain awide spectrumofbioactive components that are responsible for their health-promoting potential such as vitamins, polyphenols and glucosinolates. This study attempted to relate the composition of bioactive phytochemicals and chosen biological activities (antioxidant, cytotoxic, anti-genotoxic, and influence on enzymatic activities) for extracts from differently pigmented cabbage (white and red)...
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The influence of different glycerine purities on chemical recycling process of polyurethane waste and resulting semi‐products
PublikacjaChemical recycling is the most favourable recycling method due to the possibility of polyol recovery. This work is dedicatedto the utilisation of crude glycerine and polyurethane waste. It aims at determining the impact of the use of glycerine fromthe production of biodiesel with various degrees of purity as a cleavage agent on the decomposition process of polyurethanefoam. The influence of glycerine purit y on the chemical structure...
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Flame retardant epoxy/halloysite nanotubes nanocomposite coatings: Exploring low-concentration threshold for flammability compared to expandable graphite as superior fire retardant
PublikacjaEpoxy nanocomposites containing halloysite nanotubes (HNTs) were developed and their low-concentration thresholds for thermal stability and flame retardancy were compared with that of epoxy system containing expandable graphite (EG), as a reference with superior flame retardancy. The effects of HNTs and EG on the peak of Heat Release Rate (pHRR), Total Heat Release (THR), and Time-To-Ignition (TTI) of the prepared samples were...
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Evaluation of the Impact of Storage Conditions on the Biogenic Amines Profile in Opened Wine Bottles
PublikacjaA survey of biogenic amine (BA) profiles in opened wine bottles has been established to monitor the level of biogenic amines (BAs) in opened bottles against time and other conditions. Bottles of red and white wine were submitted to different temperatures, stopper type (screw cap, cork), and use of vacuum devices. A total of six wines made from a variety of grapes were obtained from vineyards from regions across Poland. Dispersive...
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Selected elements of the methodology and method of designing amphibious flood rescue vehicles
PublikacjaThe methodology of designing amphibious flood rescue vehicles at the preliminary stage of the design process has been presented. The study has been focused on the properties of such vehicles when afloat, with their on-land behaviour and performance characteristics having been left aside. In the study, a general assumption has been made that the amphibious flood rescue vehicles should be designed as, above all, watercraft that additionally...
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Towards sugar-derived polyamides as environmentally friendly materials
PublikacjaAs part of our ongoing study investigating isohexide-based polyamides, we have synthesized isosorbide(bis(propan-1-amine)) (DAPIS) and studied its reactivity in the polymerization towards fully biobased polyamides. Polycondensation of nylon salts with various contributions of DAPIS afforded a family of homo- and copolyamides, which were characterized using complementary spectroscopic techniques. The chemical structure of the materials...
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Comprehensive determination of flavouring additives and nicotine in e-cigarette refill solutions. Part II: Gas-chromatography–mass spectrometry analysis
PublikacjaFlavouring compounds are an essential part of e-liquid products for cigarettes. In general, they are regarded as safe for ingestion, but they may have unrecognized risks when they are inhaled. In some cases, manufactures do not currently abide by the Tobacco Products Directive (2014/40/EU) and do not declare the detailed contents of e-liquids on their labels. To help evaluate the health impact of flavouring substances, there is...
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Application of safirinium N-hydroxysuccinimide esters to derivatization of peptides for high-resolution mass spectrometry, tandem mass spectrometry, and fluorescent labeling of bacterial cells
PublikacjaMass spectrometry methods are commonly used in the identification of peptides and biomarkers. Due to a relatively low abundance of proteins in biological samples, there is a need for the development of novel derivatization methods that would improve MS detection limits. Hence, novel fluorescent N-hydroxysuccinimide esters of dihydro-[1,2,4]triazolo[4,3-a]pyridin-2-ium carboxylates (Safirinium P dyes) have been synthesized. The...
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The Efficiency of Public and Private Higher Education Institutions in Poland
PublikacjaChanges introduced to Poland’s education system in 2011 and 2014 amid efforts to adjust it to the needs of the labour market had an effect on the country’s institutions of higher learning. This paper provides an analysis of the efficiency of public and private Polish universities and examines the impact of selected factors in the years that followed. To estimate this efficiency, a Banker, Charnes and Cooper (BCC) model of the...
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Synthesis of adenosine analogues
PublikacjaAdenozyna jest endogennym nukleozydem purynowym, który nie tylko stanowi prekursor nukleotydów adeninowych, ale jest także neuromodulatorem odgrywającym istotną rolę w funkcjonowaniu wielu komórek. Swoje działanie ujawnia poprzez wiązanie z receptorami dla adenozyny, których zidentyfikowano do tej pory cztery podtypy: A1, A2A, A2B oraz A3. Należą one do rodziny receptorów sprzężonych z białkami G. Adenozyna znalazła zastosowanie...
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Accelerated remyelination and immune modulation by the EBI2 agonist 7α,25-dihydroxycholesterol analogue in the cuprizone model
PublikacjaResearch indicates a role for EBI2 receptor in remyelination, demonstrating that its deficiency or antagonism inhibits this process. However, activation of EBI2 with its endogenous ligand, oxysterol 7α,25-dihydroxycholesterol (7α,25OHC), does not enhance remyelination beyond the levels observed in spontaneously remyelinating tissue. We hypothesized that the short half-life of the natural ligand might explain this lack of beneficial...