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Rat cathepsin K: Enzymatic specificity and regulation of its collagenolytic activity
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Quiet Quitting and its Link With Knowledge Risks in Organizations – Theoretical Insights
PublikacjaPurpose: Quiet quitting has become a widely publicized concept, driven by social mediain the United States and other countries in 2022. It is a term used to describe thephenomenon by which employees do the least amount of their work, just enough tomeet the requirements of one’s job description (Mahand and Caldwell, 2023). The trendis spreading quickly among young workers. It can potentially harm individuals,...
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European Society of Hypertension Working Group on Obesity: background, aims and perspectives
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Nitrogen Cycling Dynamics: Investigating Volatilization and its Interplay with N2 Fixation
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Association between Gut Dysbiosis and the Occurrence of SIBO, LIBO, SIFO and IMO
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Banking Sector’s Profitability and Its Transformation in the Selected Western Balkan Countries
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The control of the mass of an aggregates deliveries and its impact on the effectiveness of earthworks execution
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Baseline chromogranin A and its dynamics are prognostic markers in gastroenteropancreatic neuroendocrine tumors
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Influence of TiO2 structure on its photocatalytic activity towards acetaldehyde decomposition
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H2AX phosphorylation, its role in DNA damage response and cancer therapy
PublikacjaDouble-strand breaks (DSBs) are the most deleterious DNA lesions, which, if left unrepaired, may have severe consequences for cell survival, as they lead to chromosome aberrations, genomic instability, or cell death. Various physical, chemical, and biological factors are involved in DSB induction. Cells respond to DNA damage by activating the so-called DNA damage response (DDR), a complex molecular mechanism developed to detect...
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Stress analysis in the steel tank shell at its connection with product pipeline
PublikacjaPrzeanalizowano zaburzenia stanu błonowego w powłoce zbiornika walcowego pionowego w strefie przyłączenia do płaszcza rurociągu produktowego
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Combretastatin A-4 (CA-4) and its analogues. Synthesis and biological activity
PublikacjaSpośród wielu związków przeciwnowotworowych otrzymanych w ostatnich dwóch dekadach, na szczególną uwagę zasługują te, które powodują reorganizację mikrotubul. Jedną z takich substancji jest opisana w artykule kombretastatyna A-4 (CA-4), związek który indukuje apoptozęproliferujących komórek śródbłonka naczyń guza nowotworowego. Hamuje on polimeryzację tubuliny, prowadząc do rozpadu mikrotubul. CA-4 wyizolowana została z kory wierzby...
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Novel approaches in the synthesis of batracylin and its analogs: rebirth of an old player?
PublikacjaW pracy opisano batracylinę (BAT), jej syntezę i aktywność biologiczną oraz otrzymane analogi. BAT została wyselekcjonowana przez NCI (Bethesda, USA) w programie poszukiwań nowych potencjalnych leków przeciwnowotworowych. Związek ten w badaniach in vivo na myszach okazał się bardzo aktywny przeciw nowotworowi okrężnicy 38 (Colon 38), trudnemu do wyleczenia przez dotychczas znane leki przeciwnowotworowe. Jest ona skuteczna również...
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System numerycznej prognozy pogody oparty na pakiecie WRF EMS
PublikacjaW artykule przedstawiono zagadnienia dotyczące wykorzystania systemów numerycznego prognozowania pogody przy pomocy oprogramowania wchodzącego w skład pakietu WRF EMS (ang. Weather Research and Forecast Environmental Modeling System). Artykuł opisuje podstawowe równania modelujące procesy w atmosferze oraz architekturę systemu numerycznego prognozowania pogody WRF EMS. Przedstawiono także architekturę prototypu systemu informacji...
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THE PANTOGRAPH AND ITS GEOMETRIC TRANSFORMATIONS - A FORMER POPULAR TOOL FOR COPYING AND SCALING
PublikacjaDevelopment of digital technology has resulted in significant transformations of designer workshops. Computer applications replaced the previously existing tools and methods for drawing up of projects. Professional, sophisticated drawing instruments and tools for manual plotting, as well as basic drawing aids, have gradually fallen into oblivion and become relicts of a bygone era - the objects of collectors' interest. Gdansk University...
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Realizacja elementu LMS wspomagającego proces oceny wiedzy uczestników kursu
PublikacjaW rozdziale monografii omówiono mechanizmy realizacji testowania wiedzy studentów w systemach LMS. Przedstawiono opracowany na Wydziale Elektroniki, Telekomunikacji i Informatyki Politechniki Gdańskiej element systemu LMS oceny wiedzy uczestników zajęć laboratoryjnych. Wyróżniającą cechą tego systemu jest jego modułowa, rozproszona i hierarchiczna architektura oraz niezależność od jakości pracy sieci komputerowej.
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The conditions of the business services sector in Poland and its competitiveness in the global market
PublikacjaThe following article presents the conditions of the business services sector (BSS) in Poland and the assessment of its competitiveness in the global market. The first section discusses the BSS sector and the categories of the provided services, in the division of business process outsourcing, shared services center, information technology outsourcing, research and development. Next the authors presents the status of the business...
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Modelling of Thyroid Peroxidase Reveals Insights into Its Enzyme Function and Autoantigenicity
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Artemisia dracunculus (Tarragon): A Review of Its Traditional Uses, Phytochemistry and Pharmacology
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Recent Trends in the Application of Chromatographic Techniques in the Analysis of Luteolin and Its Derivatives
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Finding the protection of lighting grounding with estimating its impulse impedance componets
PublikacjaOmówiono metodę rozdzielania składowych impedancji udarowej uziemień. Podano wskazania dotyczące oceny jakości ochrony odgromowej na podstawie wartości składowych impedancji udarowej.
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Bow-Tie cylindrical posts in a rectangular waveguide and its filter applications
PublikacjaRozwinięcie teorii rozpraszania fali elektromagnetycznej w mikrofalowych złączach falowodowych na dwuwymiarowych, cylindrycznych obiektach typu ''Bow-Tie'' przy użyciu zmodyfikowanej procedury iteracyjnej i metody dopasowania rodzajów. Wynikiem analizy są odpowiedzi częstotliwościowe współczynników odbicia i transmisji w prostokątnych złączach falowodowych zawierających opisywane obiekty. Struktura typu ''Bow-Tie'' składa się z...
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Technika spektrometrii mas rozcieńczenia izotopowego (IDMS) w analityce chemicznej.
PublikacjaOpisano podstawy teoretyczne techniki spektrometrii mas rozcieńczenia izotopowego. Przedstawiono zalety i wady techniki oraz obszar jej zastosowań.
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Continuous-time active-RC filters: general model and its applications.
PublikacjaW pracy przedstawiono ogólny model filtru aktywnego RC opartego na wzmacniaczach odwracających fazę. Model analizowany jest przy użyciu równań macierzowych. Podano jawną formułę określającą funkcję przenoszenia filtru w ogólnym przypadku. Przedstawiono rozszerzenia modelu pozwalające uwzględniać nieidealności wzmacniaczy operacyjnych, w tym skończone wzmocnienie i pasmo przenoszenia oraz niezerową rezystancję wyjściową. Zastosowanie...
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Employee Well-Being and its Potential Link With Human Knowledge Risks
PublikacjaEmployee well-being is an essential component of any organisation organisation. Conscious companies make every effort to create a healthy work environment. The well-being of employees and their overall emotional, physical and economic health is affected by various internal and external factors. When employees feel well, they tend to perform better. Therefore, the impact of employee well-being on the organisation is a fact and has...
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Quiet Quitting and its Link With Knowledge Risks in Organizations – Theoretical Insights
PublikacjaPurpose: Quiet quitting has become a widely publicized concept, driven by social media in the United States and other countries in 2022. It is a term used to describe the phenomenon by which employees do the least amount of their work, just enough to meet the requirements of one’s job description (Mahand and Caldwell, 2023). The trend is spreading quickly among young workers. It can potentially harm individuals, job performance,...
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Preparatory Railway Track Geometry Estimation Based on GNSS and IMU Systems
PublikacjaThe article discusses an important issue of railway line construction and maintenance, which fundamentally is the verification of geometric parameters of the railway track. For this purpose, mobile measurements have been performed using a measuring platform with two properly arranged GNSS receivers, which made it possible to determine the base vector of the platform. The measuring functionality of the system was extended by IMU....
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Investigation of energy deposition and its optical imaging in polymer gel dosimeters
PublikacjaThis following chapter describes methods for verifying the absorbed dose during radiotherapy. Special attention is paid to the method using polymer-gel dosimeters, the dose reading of which is performed by means of Laser Computed Tomography. The chapter also includes considerations on alternative solutions for dosimetric measurements and various types of radiotherapy and their pros and cons. In addition, both the methods of structural...
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Checkpoints that regulate balanced biosynthesis of lipopolysaccharide and its essentiality in Escherichia coli
PublikacjaThe outer membrane (OM) of Gram-negative bacteria, such as Escherichia coli, is essential for their viability. Lipopolysaccharide (LPS) constitutes the major component of OM, providing the permeability barrier, and a tight balance exists between LPS and phospholipids amounts as both of these essential components use a common metabolic precursor. Hence, checkpoints are in place, right from the regulation of the first committed step...
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Mangiferin: A comprehensive review on its extraction, purification and uses in food systems
PublikacjaWith the target of fabricating healthier products, food manufacturing companies look for natural-based nutraceuticals that can potentially improve the physicochemical properties of food systems while being nutritive to the consumer and providing additional health benefits (biological activities). In this regard, Mangiferin joins all these requirements as a potential nutraceutical, which is typically contained in Mangifera indica...
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Palladium nanoparticles deposited on graphene and its electrochemical performance for glucose sensing
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Snow cover and its variability in the Polish Sudetes Mts. and the Sudetic Foreland
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Sources of Market Information, Its Quality and New Product Financial Performance
PublikacjaWhile we observe a growing interest in the role of market information in new product development (NPD), existing research has still largely ignored the quality of market information that is a crucial issue in the era of the information society. What does affect the quality of market information in new product development projects, and how does this quality influence the financial performance of new products? In this paper, we address...
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Wdrażanie systemów ITS na przykładzie miasta Łodzi i Bydgoszczy
PublikacjaW niniejszym artykule opisano zalety funkcjonowania, przyczyny wdrażania i wskazano ścieżkę rozwoju Inteligentnych Systemów Transportowych w miastach. Przedstawiono krótką analizę podstaw prawnych wdrażania systemów ITS. Opisano dwa praktyczne przykłady wdrażania systemów ITS w Polsce, na przykładzie wdrożenia zintegrowanego systemu zarządzania ruchem w mieście Łodzi i mieście Bydgoszczy. Cechą charakterystyczną obu projektów był...
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Histaminol and Its Complexes with Copper(II) - Studies in Solid State and Solution
PublikacjaHistaminol [4(5)-(B-hydroxyethyl)imidazole, 4-(1H-imidazol-2-yl)ethanol, L] is an analogue of histamine and its minor metabolite. So far its properties have not been studied in detail due to the synthetic difficulties. Here, the structure and acid-base properties of histaminol, as well as the results of studies on its copper(II) complexes in solid state and aqueous solution are reported. Stability constants of the histaminol–CuII...
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Pantographic metamaterials: an example of mathematically driven design and of its technological challenges
PublikacjaIn this paper, we account for the research efforts that have been started, for some among us, already since 2003, and aimed to the design of a class of exotic architectured, optimized (meta) materials. At the first stage of these efforts, as it often happens, the research was based on the results of mathematical investigations. The problem to be solved was stated as follows: determine the material (micro)structure governed by those...
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Stability analysis of a road scarp in the Carpathian Mountains and methods of its protection
PublikacjaThe purpose of the study was to analyse the stability of a road scarp endangered by a landslide and to consider some measures for its stabilization. The potential landslide could unfavourably alter the shape of the slope, thus a religious sanctuary situated above the slope. The present research has resulted in suggestions of possible protection methods, namely, drainage, soil nailing, installation of piles, supporting the scarp...
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The influence of position of the post or its absence on the performance of the cable barrier system
PublikacjaRoad safety barriers are used to increase safety in potentially dangerous places on the roads. They are designed and installed on the roads to prevent any vehicle from getting outside the travelled way or from entering the opposite lane of the road. Barriers, which are used on European roads, have to undergo full scale crash tests according to the EN 1317 standards. Nowadays as a supplement to real crash tests, numerical simulations...
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Concept of 'Good Urban Governance' and Its Application in Sustainable Urban Planning
PublikacjaContemporary urban theory and practice in the post-industrial era is increasingly often turning towards an approach based on sustainable development. That concept bearing the traits of a paradigm has grown on the ground of broad quest for an alternative to the existing development model of the industrial civilisation. It has gained wide social acceptance and is the basis for many development and environmental programmes at the...
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Next generation ITS implementation aspects in 5G wireless communication network
PublikacjaIn the paper the study of Intelligent Transportation systems implementation in the 5G wireless communication network is presented. Firstly, small-cell concept in Ultra Dense Heterogeneous network was analyzed. Secondly, the 5G network requirements were presented which are important from the point of view of transportation systems development. Next, the study on the 5G network architectures proposals dedicated to the ITS systems...
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QRS Morphology-Based EDR Signal—Factors Determining its Properties
PublikacjaRespiration-induced signals contain a clinically significant information. It could be obtained utilizing both direct and indirect methods. ECG-Derived Respiration (EDR) method is the latter one. However, in this case, two approaches could be distinguished. First one is based on determining changes in the morphology of QRS complexes while the second one is based on the Respiratory Sinus Arrhythmia (RSA) mechanism. The former approach...
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Representing and Managing Experiential Knowledge with Decisional DNA and its Drimos® Extension
PublikacjaThe Semantic Web concept is proposing a future concept of the WorldWideWeb (WWW) where both humans and man-made systems are able to interconnect and exchange knowledge. One of the challenges of Semantic Web is smart and trusted accommodation of knowledge in artificial systems so it can be unified, enhanced, reused, shared, communicated and distributed with added aptitude. Our research represents an important component of addressing...
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THE ART OF VIRTUAL INFORMATION EXCHANGE AND ITS INFLUENCE ON REAL CITY SPACE
PublikacjaThe paper investigates the impact of the new genres of contemporary public art based on the virtual information exchange in real spaces of the cities. On the basis of theoretical approaches, trans-disciplinary surveys and case studies, the paper focuses on the art that not only relies on the technological support but also refers to the new public sphere, where people are co-creators of the art object giving their personal input...
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RMS-based damage detection in reinforced concrete beams: numerical simulations
PublikacjaImage-based damage detection methods using guided waves are well known and widely applied approaches in structural diagnostics. They are usually utilized in detection of surface damages or defects of plate-like structures. The article presents results of the study of applicability of imaging wave-based methods in detection in miniscule internal damage in the form of debonding. The investigations were carried out on numerical models...
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Effects of the Origin and Deacetylation Degree of Chitosan on Properties of Its Coatings on Titanium
PublikacjaThe properties of chitosan coatings on titanium surfaces may be influenced by a variety of factors, including their chemical characteristics and the deposition method. The aim of this research was to determine the influence of a chitosan’s origin (a type of shrimp) and deacetylation degree (DD), when deposited on a very smooth titanium surface, on adhesion and biological behavior. The tests were performed using chitosan of a degree...
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Identification of the Agile Mindset and Its Comparison to the Competencies of Selected Agile Roles
PublikacjaIn this paper we present the results of the identification and evalua-tion of the elements of an agile mindset as well as its comparison to the compe-tence models for the roles of Scrum Master, Product Owner and agile analyst. We have identified 70 unique agile mindset elements from literature and 5 in-terviews with experts. Based on an opinion survey among 52 agile practitioners we evaluated the importance of 26 selected elements...
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Relation between steel microstructure and its properties in inert and aggressive environments
PublikacjaBadano stale 26H2MF i 34HNM poddane różnej obróbce cieplnej. Mikrostruktury stali zmieniały sie od martenzytu i bainitu do odpuszczonego martenzytu i sorbitu. Obserwowano spadek energii zniszczenia, wydłużenia i przewżenia w próbie rozciągania z małą prędkością i równoczesnej polaryzacji katodowej do 100 mA/cm2. Degradacji towarzyszyła zmiana przełomu z ciągliwego na kruchy łupliwy i quasiłupliwy.
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Dopants and gas modifiers in ion mobility spectrometry
PublikacjaThe ion mobility techniques, including the most commonly used drift-tube ion mobility spectrometry (IMS) and differential mobility spectrometry (DMS), are used successfully for the detection of a wide range of organic compounds in the gas phase. In order to improve detection quality, admixtures are added to gas streams flowing through the detector. Dopants mostly prevent the ionization of interfering chemicals however, better detection...
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Development and validation of GC–MS/MS method useful in diagnosing intestinal dysbiosis
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PTR-MS and GC-MS as complementary techniques for analysis of volatiles: A tutorial review
PublikacjaThis tutorial review is a critical commentary on the combined use of two instrumental analytical techniques, namely GC-MS and PTR-MS. The first mention of such an analytical approach likely appeared after the year 2000 and despite many advantages, it has not been applied very often. Therefore, the aim of this article is to elaborate on the concept of their combined use and to provide a curse tutorial for those considering taking...