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- Publikacje 1313 wyników po odfiltrowaniu
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Wyniki wyszukiwania dla: LYSINE BIOSYNTHESIS
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GNSS INVENTORY OF HISTORIC NARROW-GAUGE RAILWAY LINE IN KOSZALIN UNDER EXTREMELY UNFAVORABLE MEASUREMENTS CONDITIONS FROM THE POINT OF VIEW OF SATELLITE SIGNALS AVAILABILITY
PublikacjaA team of academic researchers from the Gdańsk University of Technology, Gdynia Maritime University and the Polish Naval Academy have been working since 2009 on the methodology of using active GNSS geodetic networks for geodetic inventory of railways and on adapting this measurement technique for designing geometric layouts of railway and tram lines. Over the years, the team tested a variety of configurations of receivers and settings...
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Modelling of mutual coupling in microstrip antenna arrays fed by microstrip line. Modelowanie sprzężenia w szykach anten mikropaskowych zasilanych przez linie mikropaskowe.
PublikacjaPrzedstawiono wyniki modelowania sprzężenia pomiędzy prostokątnymi radiatorami mikropaskowymi w szyku liniowym anten zasilanych przez linie mikropaskowe. Zaproponowano schemat zastępczy sprzężenia w postaci kombinacji linii transmisyjnych wraz z sękami zwartymi i rozwartymi. Pokazano, że schemat taki dobrze modeluje sprzężenie w wąskim pasmie częstotliwości ok. 4%. Wyniki modelowania sprawdzono eksperymentalnie poprzez pomiary...
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Leszek Osiecki dr hab. inż.
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The Effect of Mechanical Vibration during Transport under Model Conditions on the Shelf-Life, Quality and Physico-Chemical Parameters of Four Apple Cultivars
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Raman spectra for pyrolized natural compounds
Dane BadawczeThe presented data showcases the results of Raman spectroscopy analysis conducted on pyrolyzed natural compounds both with and without the inclusion of graphene. The study delved into four specific compounds: methylcellulose with lysine (ML), methylcellulose with lysine-graphene composite (MLG), algae (A), and algae-graphene composite (AG). Raman spectra...
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Automated Analysis of Images from Confocal Laser Scanning Microscopy Applied to Observation of Calcium Channel Subunits in Nerve Cell Model Line Subjected Electroporation and Calcium
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Amino Acid Based Antimicrobial Agents – Synthesis and Properties
PublikacjaStructures of several dozen of known antibacterial, antifungal or antiprotozoal agents are based on the amino acid scaffold. In most of them, the amino acid skeleton is of a crucial importance for their antimicrobial activity, since very often they are structural analogs of amino acid intermediates of different microbial biosynthetic pathways. Particularly, some aminophosphonate or aminoboronate analogs of protein amino acids are...
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The methodology of design of satellite working mechanism of positive displacement machine
PublikacjaIn this paper is described a methodology of design of satellite mechanism consisting of two noncircular gears (externally toothed rotor and internally toothed curvature) and circular gears (satellites). In the presented methodology is assumed that the rotor pitch line is known, and the curvature pitch line is necessary to designate. The presented methodology applies to mechanisms for which the number of the curvature humps is at...
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Physicochemical properties of whole fruit plum powders obtained using different drying technologies
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Effect of different drying techniques on physical properties, total polyphenols and antioxidant capacity of blackcurrant pomace powders
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Functional relationships between phytochemicals and drying conditions during the processing of blackcurrant pomace into powders
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N-doped carbon nanospheres as selective fluorescent probes for mercury detection in contaminated aqueous media: chemistry, fluorescence probing, cell line patterning, and liver tissue interaction
PublikacjaA precise nano-scale biosensor was developed here to detect Hg2+ in aqueous media. Nitrogen-doped carbon nanospheres (NCS) created from the pyrolysis of melamine–formaldehyde resin were characterized by FESEM, XRD, Raman spectra, EDS, PL, UV–vis spectra, and N2 adsorption–desorption, and were used as a highly selective and sensitive probe for detecting Hg2+ in aqueous media. The sensitivity of NCS to Hg2+ was evaluated by photoluminescence...
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Enhanced supercapacitor materials from pyrolyzed algae and graphene composites
PublikacjaThis study focuses on the synthesis and characterization of supercapacitor materials derived from pyrolyzed natural compounds. Four compounds were investigated: methylcellulose with lysine (ML), methylcellulose with lysine-graphene composite (MLG), algae (A), and algae-graphene composite (AG). The pyrolysis process was utilized to convert these natural compounds into carbon-based materials suitable for supercapacitor applications....
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The Content of Selected Minerals, Bioactive Compounds, and the Antioxidant Properties of the Flowers and Fruit of Selected Cultivars and Wildly Growing Plants of Sambucus nigra L.
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Marcin Jaskólski dr inż.
OsobyStudiował na kierunku Elektrotechnika na Wydziale Elektrotechniki i Automatyki Politechniki Gdańskiej. W roku 2002 obronił pracę magisterską pt. "Analiza zastosowań technologii ogniw paliwowych w energetyce", realizowaną pod opieką dr. inż. Andrzeja Augusiaka z Katedry Elektroenergetyki. W tym samym rozpoczął realizację pracy doktorskiej z zakresu modelowania rozwoju regionalnych systemów energetycznych w programie MARKAL i wykorzystania...
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US not bright but right method of thyroid volume estimation even in large and substernal extended goitres. Comparison of US and three methods of CT thyroid evaluation - prospective study.ON LINE
PublikacjaBackground Ultrasound is nowadays a method of choice for thyroid volume assessment. However, its disadvantage is some inaccuracy, which is said to be higher in huge, especially substernally extended goitres. Aims The aim of the study was to compare the US and CT thyroid volumetric measurements: multi-observers (CT MO) and one-observer (CT OO) to CT planimetry results (CT Pl) in patients with large goitres. Materials & Methods The...
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In silico modelling for predicting the cationic hydrophobicity and cytotoxicity of ionic liquids towards the Leukemia rat cell line, Vibrio fischeri and Scenedesmus vacuolatus based on molecular interaction potentials of ions
PublikacjaIn this study we present prediction models for estimating in silico the cationic hydrophobicity and the cytotoxicity (log [1/EC50]) of ionic liquids (ILs) towards the Leukemia rat cell line (IPC-81), the marine bacterium Vibrio fischeri and the limnic green algae Scenedesmus vacuolatus using linear free energy relationship (LFER) descriptors computed by COSMO calculations. The LFER descriptors used for the prediction model (i.e....
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Comparative analysis of mRNA transcripts of HT-29 cell line expressed in identical quantities for pathogenic E. coli strains UM146 and UM147 with control Escherichia coli Nissle 1917
PublikacjaAim of study was comparative analysis of mRNA transcripts of HT-29 cell line, expressed in identical quantities for the combination of pathogenic and non-pathogenic Escherichia coli strains. HT-29 confluent monolayers infection with two pathogenic E. coli strains UM146 and UM147 resulted in two sets of mRNA transcripts that were identical with RNA transcripts obtained for non-pathogenic one strain E. coli Nissle 1917. In this study...
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Determination of flow properties of a pneumatic hose from changes in air pressure in a tank being emptied or filled by a differently configured pneumatic line
Dane BadawczeThe aim of the study was to determine the flow properties of various pneumatic hoses. The experiments were to measure the pressure changes in a being filled or emptied tank for a differently configured pneumatic line, including pneumatic hoses of different length and diameter. Three test configurations were used: (1) pressure source -> pneumatic...
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Correction: Bocheńska, K. et al. Lysosome Alterations in the Human Epithelial Cell Line HaCaT and Skin Specimens: Relevance to Psoriasis. Int. J. Mol. Sci. 2019, 20, 2255
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Panax quinquefolium L. Ginsenosides from Hairy Root Cultures and Their Clones Exert Cytotoxic, Genotoxic and Pro-Apoptotic Activity towards Human Colon Adenocarcinoma Cell Line Caco-2
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Synthesis and biological evaluation of 2,7-Dihydro-3H-dibenzo[de,h]cinnoli- ne-3,7-done derivatives a novel group of anticancer agents active on a multidrug resistance cell line.
PublikacjaZsyntezowano serię pochodnych pirydazonu z jednym lub dwoma łańcuchami bocznymi w różnych pozycjach chromoforu tetracyklicznego. Związki wykazały aktywność cytoksyczną na mysią białaczkę L1210 i ludzką k562 oraz na linii komórkowej oporności krzyżowej MDR (k562/DX). Dwa najbardziej aktywne związki przetestowano in vivo na mysiej białaczce P388. Wykazały one aktywność przeciwnowotworową porównywalną z aktywnością Mitoxantronu.
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Paweł Śliwiński dr hab. inż.
OsobyStopnie naukowe marzec 2017 – nadanie stopnia doktora habilitowanego;2006 – doktor nauk technicznych (praca doktorska obroniona na Wydziale Mechanicznym PG z wyróżnieniem);2001–2006 – studia doktoranckie „Nowoczesne Technologie i Konwersja Energii” przy Wydziale Mechanicznym Politechniki Gdańskiej; Informacje o dotychczasowym zatrudnieniu: od 01.07.2018 - profesor uczelni, Wydział Mechanicznyod 01.05.2017 – adiunkt, Wydział Mechaniczny...
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David Duenas Cid dr hab.
OsobyHe is an Associate Professor at Kozminski University and the director of the Pub-Tech (Public Sector Data-Driven Technologies) Research Center. Previously, he served as an H2020 Marie Skłodowska-Curie Widening Fellow at Gdansk University of Technology, as a Researcher at the Johan Skytte Institute of Political Studies of the University of Tartu, as a Postdoctoral Researcher at the Ragnar Nurkse Department of Innovation and Governance...
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Maciej Sienkiewicz dr inż.
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Dicyclohexylammonium benzenethiolate. Acta Cryst. Sect. E Struct. Rep. [on-line]**2003 vol. 59 s. o765-o766, 2 rys. 2 tab. bibliogr. 11 poz. tiofenolan dicykloheksyloamoniowy.
PublikacjaZwiązek o wzorze C12H24N+ x C6H5S- został otrzymany poprzez reakcję tiofeno-lu z dicykloheksyloaminą. Oba fragmenty jonowe powiązane są w długie łańcu-chy poprzez wiązania N-H...S. Strukturę cząsteczkową i krystaliczną wyzna-czono posługując się rentgenowską analizą strukturalną.
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Effects of Post-Harvest Elicitor Treatments with Ultrasound, UV- and Photosynthetic Active Radiation on Polyphenols, Glucosinolates and Antioxidant Activity in a Waste Fraction of White Cabbage (Brassica oleracea var. capitata)
PublikacjaBiosynthesis of phytochemicals in leaves of Brassica can be initiated by abiotic factors. The aim of the study was to investigate elicitor treatments to add value to waste of cabbage. A leaf waste fraction from industrial trimming of head cabbage was exposed to UV radiation (250–400 nm, 59 and 99 kJ m-2, respectively), photosynthetic active radiation (PAR, 400–700 nm, 497 kJ m-2), and ultrasound in water bath (35 kHz, at 15, 30...
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Molecular Strategy for Survival at a Critical High Temperature in Eschierichia coli
PublikacjaThe molecular mechanism supporting survival at a critical high temperature (CHT) in Escherichia coli was investigated. Genome-wide screening with a single-gene knockout library provided a list of genes indispensable for growth at 47°C, called thermotolerant genes. Genes for which expression was affected by exposure to CHT were identified by DNA chip analysis. Unexpectedly, the former contents did not overlap with the latter except...
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A new factor LapD is required for the regulation of LpxC amounts and lipopolysaccharide trafficking
PublikacjaLipopolysaccharide (LPS) constitutes the major component of the outer membrane and is essential for bacteria, such as Escherichia coli. Recent work has revealed the essential roles of LapB and LapC proteins in regulating LPS amounts; although, if any additional partners are involved is unknown. Examination of proteins co-purifying with LapB identified LapD as a new partner. The purification of LapD reveals that it forms a complex...
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Molecular basis of essentiality of early critical steps in the lipopolysaccharide biogenesis in Escherichia coli K-12: requirement of MsbA, cardiolipin, LpxL, LpxM and GcvB
PublikacjaTo identify the physiological factors that limit the growth of Escherichia coli K-12 strains synthesizing minimal lipopolysaccharide (LPS), we describe the first construction of strains devoid of the entire waa locus and concomitantly lacking all three acyltransferases (LpxL/LpxM/LpxP), synthesizing minimal lipid IVA derivatives with a restricted ability to grow at around 21 °C. Suppressors restoring growth up to 37 °C of Δ(gmhD-waaA)...
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In vitro enzyme kinetics and NMR-based product elucidation for glutathione S-conjugation of the anticancer unsymmetrical bisacridine C-2028 in liver microsomes and cytosol: major role of glutathione S-transferase M1-1 isoenzyme
PublikacjaThis work is the next step in studying the interplay between C-2028 (anticancer-active unsymmetrical bisacridine developed in our group) and the glutathione S-transferase/glutathione (GST/GSH) system. Here, we analyzed the concentration- and pH-dependent GSH conjugation of C-2028 in rat liver microsomes and cytosol. We also applied three recombinant human GST isoenzymes, which altered expression was found in various tumors. The...
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Krzysztof Druet dr inż.
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The compositional space of exhaled breath condensate and its link to the human breath volatilome
PublikacjaBreath analysis is commonly understood to target gaseous or volatile organic compounds (VOCs) for the characterization of different pathologies. Targeted analysis is most effective if a working hypothesis can be based on a plethora of data. The recently published volatilome builds an optimal basis for organizing powerful target sets. However, the origin and pathways of biosynthesis of many VOCs are not known, which complicates...
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Measurement and visualization of sound intensity vector distribution in proximity of acoustic diffusers
PublikacjaIn this work, we would like to present analyses and visualizations of sound intensity distribution measured in proximity of an acoustic diffuser. Such distribution may be used for estimation of basic acoustic parameters of a diffuser. Measurement is performed with the use of a logarithmic sine sweep which allows for the analysis of waves scattered by the diffuser and rejecting the direct sound signal component. Pressure and sound...
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SU‐E‐T‐472: Characterization of the Very High Energy Electrons, ISO ‐ 250 MeV (VHEE) Beam Generated by ALPHA‐X Laser Wakefield Accelerator Beam Line for Utilization in Monte Carlo Simulation for Biomedical Experiment Planning
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Targeting yeast topoisomerase II by imidazo and triazoloacridinone derivatives resulting in their antifungal activity
PublikacjaFungal pathogens are considered as serious factors for deadly diseases and are a case of medical concern. Invasive fungal infections also complicate the clinical course of COVID-19, leading to a significant increase in mortality. Furthermore, fungal strains' multidrug resistance has increased the demand for antifungals with a different mechanism of action. The present study aimed to identify antifungal compounds targeting yeast...
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Marek Olesz dr hab. inż.
OsobyWydział Elektrotechniki i Automatyki, Prodziekan ds. rozwoju dr hab. inż. Marek Olesz, prof. PG data urodzenia 1966 wykształcenie Politechnika Gdańska, Wydział Elektryczny (1990) stopień / tytuł naukowy doktor habilitowany – Politechnika Gdańska, Wydział Elektrotechniki i Automatyki (2017), doktor – Politechnika Gdańska, Wydział Elektrotechniki i Automatyki (1998) zatrudnienie Politechnika Gdańska: asystent stażysta (1989 –...
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Investigation of interaction between xanthene dye rhodamine B and metagenomic-derivated methylthioadenosine phosphorylase RSFP
PublikacjaIn the previous study we found that the expression of the metagenomic - derived methylthioadenosine phosphorylase gene (rsfp) in E. coli cells and the presence of rhodamine B in the growth medium were crucial for the pink fluorescence of one E. coli colony from Antarctic soil metagenomic library (Cieśliński et al., 2009). In this study, rsfp gene expression was induced by an arabinose promoter in an LMG194 E. coli strain and the...
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Human UDP-Glucuronosyltransferases: Effects of altered expression in breast and pancreatic cancer cell lines.
PublikacjaIncreased aerobic glycolysis and de novo lipid biosynthesis are common characteristics of invasive cancers. UDP-glucuronosyltransferases (UGTs) are phase II drug metabolizing enzymes that in normal cells possess the ability to glucuronidate these lipids and speed their excretion; however, de-regulation of these enzymes in cancer cells can lead to an accumulation of bioactive lipids, which further fuels cancer progression. We hypothesize...
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Valorization of waste cabbage leaves by postharvest photochemical treatments monitored with a non-destructive fluorescence-based sensor
PublikacjaThe biosynthesis of polyphenolic compounds in cabbage waste, outer green leaves of white head cabbage (Brassica oleracea L. var. capitata subvar. alba), was stimulated by postharvest irradiation with UVB lamps or sunlight. Both treatments boosted the content of kaempferol and quercetin glycosides, especially in the basal leaf zone, as determined by the HPLC analysis of leaf extracts and by a non-destructive optical sensor. The...
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Glyceraldehyde - 3 - phosphate dehydrogenase gen from Amanita citrina. Ac-cession AJ532582, 2002 GenBank NCBI [on line].**2002 [cytowany 07.01.03]. Dostępny: http://www.ncbi.nml.nih.gov Sekwencja genu kodującego dehydrogenzę aldehydu - 3 - fsfoglicerynowego dla muchomora cytrynowego (Amanita citrina).
PublikacjaPo raz pierwszy ustalono sekwencję nukleotydową fragmentu genu gpd (dehydro-genazy aldehydu - 3 - fosfoglicerynowego) dla muchomora cytrynowego (Amanitacitrina), pozwoli to na ustalenie sekwencji starterów umożliwiających wykry-wanie grzybów tego gatunku za pomocą techniki PCR.
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Glyceraldehyde - 3 - phosphate dehydrogenase gene from Coprinus atramenta-rius. Accession AJ532581, 2002 GenBank NCBI [on line].**2002 [cytowany 07.01.03]. Dostępny: http://www.ncbi.nlm.nih.gov Sekwencja genu kodujacego dehydrogenazę aldehydu - 3 - fosfoglicerynowego dla czernidłaka pospolitego (Coprinus atramentarius).
PublikacjaPo raz pierwszy ustalono sekwencję nukleotydową fragmentu genu gpd (dehydro-genazy aldehydu - 3 - fosfoglicerynowego)dla gatunku Coprinus atramentarius,pozwoli to na zaprojektowanie pary starterów umożliwiających wykrywaniegrzybów tego gatunku za pomocą reakcji PCR.
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Impedimetric sensing of α-amino acids driven by micro-patterned 1,8-Diazafluoren-9-one into titania- boron- doped maze-like nanocarbons
PublikacjaThe development of impedimetric, non-faradaic label-free sensors for the detection of α-amino acids constitutes a trailblazing technology for the fast and inexpensive quantification of such biomarkers. Since α-amino acids, such as glycine and sarcosine, are basic constituents in biological processes, a variation in their concentration may be an indicator of cardiovascular diseases and metabolic disorders or neurological conditions....
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CSR (on line)
Kursy Online -
International Conference on Heterogeneous Networking for Quality, Reliability, Security and Robustness (International Conference on Quality of Service in Heterogeneous Wired/Wireless Networks[Qsine])
Konferencje -
Piotr Grudowski dr hab. inż.
OsobyDr hab. inż. Piotr Grudowski, profesor w Politechnice Gdańskiej karierę naukową rozpoczynał na Wydziale Mechanicznym Technologicznym Politechniki Gdańskiej w zespole „Inżynierii Jakości i Metrologii”. Stopień doktora nauk technicznych w dyscyplinie budowa i eksploatacja maszyn uzyskał w roku 1993 na Wydziale Mechanicznym PG a stopień doktora habilitowanego nauk ekonomicznych, w dyscyplinie nauk o zarządzaniu, w 2008 roku na Wydziale...
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Antifungal Effect of Penicillamine Due to the Selective Targeting of L-Homoserine O-Acetyltransferase
PublikacjaDue to the apparent similarity of fungal and mammalian metabolic pathways, the number of established antifungal targets is low, and the identification of novel ones is highly desirable. The results of our studies, presented in this work, indicate that the fungal biosynthetic pathway of L-methionine, an amino acid essential for humans, seems to be an attractive perspective. The MET2 gene from Candida albicans encoding L-homoserine...
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Phenotypic consequences of LYS4 gene disruption in Candida albicans
PublikacjaA BLAST search of the Candida Genome Database with the Saccharomyces cerevisiae LYS4 sequence known to encode homoaconitase (HA) revealed ORFs 19.3846 and 19.11327. Both alleles of the LYS4 gene were sequentially disrupted in Candida albicans BWP17 cells using PCR-based methodology. The null lys4Δ mutant exhibited lysine auxotrophy in minimal medium but was able to grow in the presence of L-Lys and α-aminoadipate, an intermediate...
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Novel DNA-binding protein from Nanoarchaeum equitans Kin4-M binds all kinds of nucleic acids
PublikacjaNanoarchaeum equitans is the only known representative of Archaea phylum Nanoarchaeota and stands out as one of the tiniest known living organism. What is more it has smallest genome, which is only 490.885 base pairs long. It is also one of the most compact genomes. According to predictions about 95% of the DNA encodes proteins or stable RNA. Nanoarchaeum equitans lacks genes for most vital metabolic pathways including lipid, cofactor,...
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Statystyka Społeczna (on-line)
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