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Search results for: active appearance models
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Reactive metabolites of acridinone antitumor agents, C-1311 and C-1305, are trapped within the active site of CYP1A2 and CYP3A4, causing irreversible enzymes inactivation
PublicationZwiązki C-1305 i C-1311, zsyntetyzowane w Katedrze Technologii Leków i Biochemii, wykazują najsilniejsze właściwości przeciwnowotworowe wśród pochodnych, odpowiednio, triazolo- i imidazoakrydonu. Obecnie prowadzone są badania mające na celu określenie biochemicznego mechanizmu działania, jak również potencjalnych szlaków biotransformacji C-1305 i C-1311.W bieżącym etapie podjęto próbę określenia mechanizmu obserwowanej inhibicji...
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Pharmacophore models based studies on the affinity and selectivity toward 5-HT1A with reference to α1-adrenergic receptors among arylpiperazine derivatives of phenytoin
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Mutual Expression of ALDH1A1, LOX, and Collagens in Ovarian Cancer Cell Lines as Combined CSCs- and ECM-Related Models of Drug Resistance Development
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Optimization of the UNRES Force Field by Hierarchical Design of the Potential-Energy Landscape. 1. Tests of the Approach Using Simple Lattice Protein Models
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Radial distribution of dose within heavy charged particle tracks – Models and experimental verification using LiF:Mg,Cu,P TL detectors
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A Review of the Monograph by Yu. Bilan, O. Chygryn, S. Kolosok “Environmental and Economic Impacts of Energy Transformation: Concepts Innovation and Business Models”
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P.0253 Two-week lithium treatment modulates translocator protein expression in brain regions in the animal models of acute bipolar episodes
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Hydrochars as a bio-based adsorbent for heavy metals removal: A review of production processes, adsorption mechanisms, kinetic models, regeneration and reusability of hydrochar
PublicationThe spread of heavy metals throughout the ecosystem has extremely endangered human health, animals, plants, and natural resources. Hydrochar has emerged as a promising adsorbent for removing heavy metals from water and wastewater. Hydrochar, obtained from hydrothermal carbonization of biomass, owns unique physical and chemical properties that are highly potent in capturing heavy metals via surface complexation, electrostatic interactions,...
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Contribution of UDP-glucuronosyltransferases (UGTs) in metabolism of acridinone antitumor agents, C-1311, C-1305, and their less active structural analogues, C-1330 and C-1299
PublicationCelem prowadzonych badań było określenie roli UDP-glukuronylotransferaz, uważanych za najważniejsze enzymy detoksykujące, w metabolizmie pochodnych imidazo- i triazoloakrydonu. Wykazano, że najbardziej aktywne przeciwnowotworowo związki z obu grup, tj. C-1311 i C-1305 są transformowane do O-glukuronidów, w przeciwieństwie do ich metoksylowych analogów, odpowiednio związku C-1330 i C-1299. Analiza składu mieszanin reakcyjnych zawierających...
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Extension of the force-matching method to coarse-grained models with axially symmetric sites to produce transferable force fields: Application to the UNRES model of proteins
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The Four-Feature Prognostic Models for Cancer-Specific and Overall Survival after Surgery for Localized Clear Cell Renal Cancer: Is There a Place for Inflammatory Markers?
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Experimental validation and comparison of a SiC MOSFET based 100 kW 1.2 kV 20 kHz three-phase dual active bridge converter using two vector groups
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Corrigendum to “Synthesis and photoelectrochemical behaviour of hydrogenated titania nanotubes modified with conducting polymer infiltrated by redox active network” [Electrochim. Acta 222 (20 December) (2016) 1281–1292]
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2,7-Dihydro-3H-pyridazino[5,4,3-kl]acridin-3-one derivatives, novel type of cytotoxic agents active on multidrug-resistant cell lines. Synthesis and biological evaluation.
PublicationOtrzymano serię pirydazyno akrydyn-3-onów w reakcji 9-okso-9,10-dihydroakrydyno-1-karboksylanu etylu z POCl3, następnie dodanie odpowiedniej alkiloaminoalkilohydrazyny. Badane związki wykazują w porównaniu z referencyjnymi cytostatykami DX, MIT niższe wartości indeksu RI, a także niższe aktywności cytotoksyczne.
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Molecular Simulation Study of the Potentials of Mean Force for the Interactions between Models of Like-Charged and between Charged and Nonpolar Amino Acid Side Chains in Water
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A Hierarchical Multiscale Approach to Protein Structure Prediction: Production of Low‐Resolution Packing Arrangements of Helices and Refinement of the Best Models with a United‐Residue Force Field
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Use of Cytokine Mix-, Imiquimod-, and Serum-Induced Monoculture and Lipopolysaccharide- and Interferon Gamma-Treated Co-Culture to Establish In Vitro Psoriasis-like Inflammation Models
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The Matter of Decision-Making Control Over Operation Processes of Marine Power Plant Systems with the Use of their Models in the form of Semi-Markov Decision-Making Processes
PublicationThe article presents the possibility to control the real operation process of an arbitrary device installed in the marine power plant based on the four-state semi-Markov process, being the model of the process, which describes the transition process of operational states of the device and the transition process of its technical states. All these states are precisely defined for the ship main engine (SG). A hypothesis is proposed...
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An MTA-phosphorylase gene discovered in the metagenomic library derived from Antarctic top soil during screening for lipolytic active clones confers strong pink fluorescence in the presence of rhodamine B.
PublicationIn this work, we present the construction of a metagenomic library in Escherichiacoli using the pUC19 vector and environmental DNA directly isolated fromAntarctic topsoil and screened for lipolytic enzymes. Unexpectedly, the screeningon agar supplemented with olive oil and rhodamine B revealed one unusual pinkfluorescent clone (PINKuv) out of 85 000 clones. This clone harbored a plasmid,pPINKuv, which has an insert of 8317 bp that...
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Synthesis and biological evaluation of 2,7-Dihydro-3H-dibenzo[de,h]cinnoli- ne-3,7-done derivatives a novel group of anticancer agents active on a multidrug resistance cell line.
PublicationZsyntezowano serię pochodnych pirydazonu z jednym lub dwoma łańcuchami bocznymi w różnych pozycjach chromoforu tetracyklicznego. Związki wykazały aktywność cytoksyczną na mysią białaczkę L1210 i ludzką k562 oraz na linii komórkowej oporności krzyżowej MDR (k562/DX). Dwa najbardziej aktywne związki przetestowano in vivo na mysiej białaczce P388. Wykazały one aktywność przeciwnowotworową porównywalną z aktywnością Mitoxantronu.
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Salinity enhances high optically active L-lactate production from co-fermentation of food waste and waste activated sludge: Unveiling the response of microbial community shift and functional profiling
PublicationLactic acid (LA), a versatile platform molecule, can be fermented from organic wastes, such as food waste and waste activated sludge. In this study, an efficient approach using salt, a component of food waste as an additive, was proposed to increase LA production. The LA productivity was increased at 10 g NaCl/L and optical pure L-lactate was obtained at 30 g NaCl/L. The enhancement of LA was in accordance with the increased solubilization...
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Дуальные модели Лотмана и Милоша – в анализах истории России и в автобиографии [Lotman’s and Miłosz’s Dual Models – in Analysis of History of Russia and in Autobiography]
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Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: implications for drug resistance and in vitro drug screening models
PublicationBadania z użyciem modelu komórek nowotworu płuc A549 wykazały, że komórki te po traktowaniu lekami uszkadzającymi DNA zatrzymują proliferację i wchodzą w stan starzenia komórkowego. Jednak post-inkubacja tych komórek prowadzi do powrotu do stanu proliferacji małej frakcji komórek. Wykazaliśy, że frakcja ta związana jest z obecnością komórek pierwotnych nowotworu w populacji komórek A549. Powrót do stanu proliferacji komóek A549...
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Modeling of the alcohol dehydrogenase active site. Two different modes of alcohol binding in crystals of zinc and cadmium tri-tert-butoxysilanethiolates evidenced by X-ray diffraction and solid state vibrational spectroscopy
PublicationOpisano syntezę, struktury cząsteczkowe oraz widma FT-IR, 1H. 13C, 29Si, 113Cd NMR dziesięciu nowych, mieszanoligandowych kompleksów cynku i kadmu z ligandem tri-tert-butoksysilanotiolanowym i pochodnymi imidazolu. Za pomocą rentgenowskiej analizy strukturalnej i spektroskopii w podczerwieni udokumentowano dwa różne sposoby wiązania etanolu i metanolu w kryształach tych związków. Opisane kompleksy stanowią modele miejsca aktywnego...
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Modeling of the Alcohol Dehydrogenase Active Site: Two Different Modes of Alcohol Binding in Crystals of Zinc and Cadmium Tri‐tert‐butoxysilanethiolates Evidenced by X‐ray Diffraction and Solid‐State Vibrational Spectroscopy
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ADT in mammography
PublicationWe discuss limitations of the known methods of IR imaging in diagnostics of breast cancer. In conclusion we show that for practical reasons one requires new approaches because the known methods based on simple observation of external temperature distribution are not fully effective. Even advanced pattern recognition could not help too much for static images. We ask the question: may active dynamic thermography, known in nondestructive...
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Estimating and Forecasting GDP in Poland with Dynamic Factor Model
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Predicting the Purchase of Electricity Prices for Renewable Energy Sources Based on Polish Power Grids Data Using Deep Learning Models for Controlling Small Hybrid PV Microinstallations
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Oznaczanie tlenu – od metody Winklera do czujników enzymatycznych (Determination of oxygen – from Winkler Method to enzymatic sensor)
PublicationMonitoring of dioxygen levels is of utmost importance from the view-point of life processes, medical diagnostics, nutrition and chemical industries. In all these measurements both low and high levels of this element are important. The common methods for the determination of dioxygen are the Winkler method, Clark electrode and pulsoxymeters. A new, already strong field of research can be now recognized – the development of miniaturized...
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THE PHASE SHIFTERS INFLUENCE ON THE POWER SYSTEM STABILITY
PublicationThe paper presents the effect of phase shifters as FACTS devices on the possibility of improving the angle stability. Presented results obtained by the dynamic simulation performed on the mathematical model of the three machine system cooperating with the 400 kV network. The generative blocks models include turbine models with their controllers and models of synchronous generators with their excitation systems and voltage regulation....
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Finite Element Approaches to Model Electromechanical, Periodic Beams
PublicationPeriodic structures have some interesting properties, of which the most evident is the presence of band gaps in their frequency spectra. Nowadays, modern technology allows to design dedicated structures of specific features. From the literature arises that it is possible to construct active periodic structures of desired dynamic properties. It can be considered that this may extend the scope of application of such structures. Therefore,...
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Transport of paracetamol in swellable and relaxing polyurethane nanocomposite hydrogels
PublicationPolyurethane hydrogels are potentially attractive materials for biomedical applications. They are able to absorb large amount of water, biological fluids or active substances, and thus, they have potential to be used as absorbents or wound-healing dressings. They are also used for the controlled release of therapeutics because of their capacity to embed biologically active agents in their water-swollen network. The presence of...
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A two dimensional approach for modelling of pennate muscle behaviour
PublicationThe purpose of this study was to elaborate a two-dimensional approach for unipennate and bipennate striated skeletal muscle modelling. Behavior of chosen flat pennate muscle is modelled as a rheological system composed of serially linked passive and active fragments having different mechanical properties. Each fragment is composed of three elements: mass element, elastic element and viscous element. Each active fragment furthermore...
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Framework for Integration Decentralized and Untrusted Multi-vendor IoMT Environments
PublicationLack of standardization is highly visible while we use historical data sets or compare our model with others that use IoMT devices from different vendors. The problem also concerns the trust in highly decentralized and anonymous environments where sensitive data are transferred through the Internet and then are analyzed by third-party companies. In our research we propose a standard that has been implemented in the form of framework...
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Frequency and time domain characteristics of digital control of electric vehicle in-wheel drives
PublicationIn-wheel electric drives are promising as actuators in active safety systems of electric and hybrid vehicles. This new function requires dedicated control algorithms, making it essential to deliver models that reflect better the wheel-torque control dynamics of electric drives. The timing of digital control events, whose importance is stressed in current research, still lacks an analytical description allowing for modeling its...
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Three dimensional fluid equations from distribution function with discontinuity in velocity space
PublicationUkład równań typu hydrodynamicznego dla rozwarstwionego gazu w polu grawitacyjnym jest wyprowadzony z równania BKG przy użyciu metody kawałków ciągłej funkcji dystrybucji. Otrzymany układ równań uogólnia układ Naviera-Stokesa dla dowolnych liczb Knudsena.
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Wykorzystanie analizy obrazu w rozpoznawaniu mowy
PublicationNiniejszy referat przedstawia metodę rozpoznawania mowy na podstawie analizy ruchu ust. W pracy opisano algorytm wyznaczana i śledzenia położenia ust wykorzystujący modele Active Shape Models oraz zbadano efektywność jego działania. Sztuczna sieć neuronowa została wykorzystana jako klasyfikator rozpoznający sześć wypowiadanych samogłosek w oparciu o wizualne parametry mowy. W pracy umieszczono wyniki klasyfikacji oraz wnioski.
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Audiovisual speech recognition for training hearing impaired patients
PublicationPraca przedstawia system rozpoznawania izolowanych głosek mowy wykorzystujący dane wizualne i akustyczne. Modele Active Shape Models zostały wykorzystane do wyznaczania parametrów wizualnych na podstawie analizy kształtu i ruchu ust w nagraniach wideo. Parametry akustyczne bazują na współczynnikach melcepstralnych. Sieć neuronowa została użyta do rozpoznawania wymawianych głosek na podstawie wektora cech zawierającego oba typy...
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Sensing Direction of Human Motion Using Single-Input-Single-Output (SISO) Channel Model and Neural Networks
PublicationObject detection Through-the-Walls enables localization and identification of hidden objects behind the walls. While numerous studies have exploited Channel State Information of Multiple Input Multiple Output (MIMO) WiFi and radar devices in association with Artificial Intelligence based algorithms (AI) to detect and localize objects behind walls, this study proposes a novel non-invasive Through-the-Walls human motion direction...
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Combining visual and acoustic modalities to ease speech recognition by hearing impaired people
PublicationArtykuł prezentuje system, którego celem działania jest ułatwienie procesu treningu poprawnej wymowy dla osób z poważnymi wadami słuchu. W analizie mowy wykorzystane zostały parametry akutyczne i wizualne. Do wyznaczenia parametrów wizualnych na podstawie kształtu i ruchu ust zostały wykorzystane modele Active Shape Models. Parametry akustyczne bazują na współczynnikach melcepstralnych. Do klasyfikacji wypowiadanych głosek została...
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Face Recognition: Shape versus Texture
PublicationThis paper describes experiments related to the application of well-known techniques of the texture feature extraction (Local Binary Patterns and Gabor filtering) to the problem of automatic face verification. Results of the tests show that simple image normalization strategy based on the eye center detection and a regular grid of fiducial points outperforms the more complicated approach, employing active models that are able to...
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Application 2D Descriptors and Artificial Neural Networks for Beta-Glucosidase Inhibitors Screening
PublicationBeta-glucosidase inhibitors play important medical and biological roles. In this study, simple two-variable artificial neural network (ANN) classification models were developed for beta-glucosidase inhibitors screening. All bioassay data were obtained from the ChEMBL database. The classifiers were generated using 2D molecular descriptors and the data miner tool available in the STATISTICA package (STATISTICA Automated Neural...
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Wear of electroplated diamond tools in lap-grinding of Al2O3 ceramic materials
PublicationCurrent development of modern products, together with ever-increasing demands for their operation and usage, necessitate the search for new processing methods. Abrasive machining is widely used in many industrial areas, especially for processing difficult-to-machine materials such as advanced ceramics. Grinding with lapping kinematics, also called lap-grinding, is still one of the innovative methods of abrasive processing being...
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Speech recognition system for hearing impaired people.
PublicationPraca przedstawia wyniki badań z zakresu rozpoznawania mowy. Tworzony system wykorzystujący dane wizualne i akustyczne będzie ułatwiał trening poprawnego mówienia dla osób po operacji transplantacji ślimaka i innych osób wykazujących poważne uszkodzenia słuchu. Active Shape models zostały wykorzystane do wyznaczania parametrów wizualnych na podstawie analizy kształtu i ruchu ust w nagraniach wideo. Parametry akustyczne bazują na...
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The Role of Electrostatics in Enzymes: Do Biomolecular Force Fields Reflect Protein Electric Fields?
PublicationPreorganization of large, directionally oriented, electric fields inside protein active sites has been proposed as a crucial contributor to catalytic mechanism in many enzymes, and it may be efficiently investigated at the atomistic level with molecular dynamics simulations. Here, we evaluate the ability of the AMOEBA polarizable force field, as well as the additive Amber ff14SB and Charmm C36m models, to describe the electric...
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Wielopoziomowy przekształtnik trakcyjny SiC z izolacją od sieci 3kV DC realizowaną za pomocą transformatorów 30kHz do napędów EZT
PublicationW referacie przedstawiono wielopoziomowy izolowany kaskadowy przekształtnik DC-AC z tranzystorami SiC MOSFET 1,2kV, przeznaczony do napędów elektrycznych zespołów trakcyjnych (EZT). Zaproponowana konstrukcja przekształtnika, przeznaczonego do pracy przy zasilaniu z sieci trakcyjnej 3kV DC, spełnia założenia energoelektronicznego transformatora trakcyjnego (z ang. Power Electronic Traction Transformer). Budowa modułowa z niskonapięciowych...
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Effects of Column Base Flexibility on Seismic Response of Steel Moment-Frame Buildings
PublicationSteel Moment Resisting Frames (SMRFs) are very popular lateral load resisting systems in many seismically active regions. However, their seismic response is strongly dependent on the rotational fixity of column base connections. Despite many studies (both experimental and numerical) in this particular area, available approaches for estimating column base flexibility have been validated only against laboratory test data. In the...
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Vowel recognition based on acoustic and visual features
PublicationW artykule zaprezentowano metodę, która może ułatwić naukę mowy dla osób z wadami słuchu. Opracowany system rozpoznawania samogłosek wykorzystuje łączną analizę parametrów akustycznych i wizualnych sygnału mowy. Parametry akustyczne bazują na współczynnikach mel-cepstralnych. Do wyznaczenia parametrów wizualnych z kształtu i ruchu ust zastosowano Active Shape Models. Jako klasyfikator użyto sztuczną sieć neuronową. Działanie systemu...
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Efficiency of service recovery in scale-free optical networks under multiple node failures
PublicationIn this paper we examine the properties of scale-free networks in case of simultaneous failures of two networknodes. Survivability assumptions are as follows: end-to-end path protection with two node-disjoint backup pathsfor each working path. We investigate three models of scale-free networks generation: IG, PFP and BA.Simulations were to measure the lengths of active and backup paths and the values of service recovery time.We...
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Signal conditioning for examination of shallow-water acoustic noise correlation properties
PublicationThe article describes the process of signal conditioning for examination of acoustic noise correlation properties in shallow water. Knowledge of these properties is very important for the design processes of passive and active hydroacoustic systems. This paper focuses on the above issue from the point of view of passive sonar. In sonar systems, signal processing algorithms operate on both useful acoustic signals, and accompanying...