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Search results for: WOUND HEALING IN VIVO
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Receptor for advanced glycation end‐products: Biological significance and imaging applications
PublicationThe receptor for advanced glycation end-products (RAGE or AGER) is a transmembrane, immunoglobulin-like receptor that, due to its multiple isoform structures, binds to a diverse range of endo- and exogenous ligands. RAGE activation caused by the ligand binding initiates a cascade of complex pathways associated with producing free radicals, such as reactive nitric oxide and oxygen species, cell proliferation, and immunoinflammatory...
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Chitosan, Collagen and Gelatin in the design of novel materials with antimicrobial acticity
PublicationMedical devices containing and releasing antiinfective agents directly on the site of injury are a common group of materials available and widely used in treating difficult to heal wounds. Sustained contact of the active agent to the damaged tissue, needed to inhibit infection and preservation of microbiological purity of the wound, is provided by the immobilization antimicrobial agents on the surface of the matrix material or...
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Synthesis and biological evaluation of 2,7-Dihydro-3H-dibenzo[de,h]cinnoli- ne-3,7-done derivatives a novel group of anticancer agents active on a multidrug resistance cell line.
PublicationZsyntezowano serię pochodnych pirydazonu z jednym lub dwoma łańcuchami bocznymi w różnych pozycjach chromoforu tetracyklicznego. Związki wykazały aktywność cytoksyczną na mysią białaczkę L1210 i ludzką k562 oraz na linii komórkowej oporności krzyżowej MDR (k562/DX). Dwa najbardziej aktywne związki przetestowano in vivo na mysiej białaczce P388. Wykazały one aktywność przeciwnowotworową porównywalną z aktywnością Mitoxantronu.
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The Dynamic Model of Magnetic Hysteresis
PublicationThis paper presents the scalar dynamic magnetic hysteresis model based on the Preisach theory. The important role in this theory played hysteresis operator states. The changes of these operators` states are not immediate in the dynamic model but they are a function of time and parameter k representing the magnetic properties of the material. In this paper the transient state of the hysteresis operator is defined by the nonlinear...
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Solid Phase Microextraction: Apparatus, Sorbent Materials, and Application.
Publicationhe primary objective of this review article is to strategically screen and highlight the advancements in the area of solid phase microextraction (SPME). The plenty of review articles have been written on different aspects of SPME, this review is dedicated to provide the brief but clear overview of the research footprints so produced from SPME. Some of the key advancements in types and designs, coating materials, coating strategies,...
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Biomechanics of the front abdominal wall as a potential factorleading to recurrence with laparoscopic ventral hernia repair
PublicationThis study investigated the front abdominal wallto describe its elasticity in vivo and searched for elongationsthat possibly stretched an implanted mesh, therebycausing fixation failure and subsequent recurrence.To measure front abdominal wall elongations, amodel of fascia movements was created. Eight healthyvolunteers were measured during exercise to determine theextent of elongations in their front abdominal wall. Videoswere...
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Simulation of the Remanence Influence on the Transient States of the Single-Phase Transformer Including Feedback Preisach Model
PublicationThis paper presents the results of the experimental and simulation investigation concerning the influence of remanence in the core of a single-phase transformer at the no-load transient state. Experimental studies consisted of the discharge of the capacitor through the primary winding at several different values of the residual magnetic flux. The paper presents a model of the transformer test system, taking into account the magnetic...
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Quality prediction of foil capacitors by acoustic emission signals
PublicationJakość i trwałość kondensatorów foliowych jest zależna od ich warunków pracy (np. nadmiarowego napięcia pracy, temperatury, wilgotności) oraz od potencjalnych defektów wprowadzonych na różnych etapach wytwarzania kondensatorów. Nieustanny nacisk na wzrost jakości wytwarzanych elementów przy jednoczesnej redukcji kosztów wytwarzania oznacza, że nowe, tanie i szybkie metody predykcji jakości tych elementów są mocno poszukiwane. W...
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Active Dynamic Thermography in Medical Diagnostics
PublicationThis is an overview of active thermal imaging methods in medical diagnostics using external thermal stimulation. In this chapter, several clinical cases diagnosed using the active dynamic thermography method, ADT, are presented. Features of this technology are discussed and main advantages underlined. Applications in skin burn diagnostics and quantitative evaluation leading to modern classification of burned patients for further...
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The immunoregulatory effects of edeine analogues in mice
PublicationZbadano właściwości immunoregulatorowe kilku, otrzymanych na drodze syntezy, uproszczonych analogów peptydowego antybiotyku edeiny w testach in vivo i in vitro z wykorzystaniem modelu mysiego. Jako związek referencyjny zastosowano edeinę B. Otrzymane peptydy wykazywały efekt stymulacyny na proliferację splenocytów z użyciem konkawaliny, podczas gdy zastosowanie mitogenu powodowało hamowanie proliferacji splenocytów. Peptydy hamowały...
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Noninvasive glucose sensing in scattering media using OCT, PAS, and TOF techniques.
PublicationW pracy przedstawiono możliwości wykorzystania optycznej tomografii koherencyjnej (OCT), spektroskopii fotoakustycznej (PAS)i spektroskopii czasu przelotu (TOF) w pomiarach glukozy w ośrodku silnie rozpraszającym. Równolegle opracowano modele propagacji światła w tych ośrodkach wykorzystując metodę Monte Carlo. W pomiarach wykorzystano ''Intralipid'' jako fantom tkanki. W dalszych badaniach wykorzystano mięso wieprzowe i dokonano...
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Accelerated remyelination and immune modulation by the EBI2 agonist 7α,25-dihydroxycholesterol analogue in the cuprizone model
PublicationResearch indicates a role for EBI2 receptor in remyelination, demonstrating that its deficiency or antagonism inhibits this process. However, activation of EBI2 with its endogenous ligand, oxysterol 7α,25-dihydroxycholesterol (7α,25OHC), does not enhance remyelination beyond the levels observed in spontaneously remyelinating tissue. We hypothesized that the short half-life of the natural ligand might explain this lack of beneficial...
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Naturally-derived hydrogels for 3D pancreatic tumor models: A short review
PublicationStatistics suggest a high proportion of mortality rate by pancreatic cancer, which is a solid tumor characterized by high heterogeneity and the presence of a complex extracellular matrix. The very low effectiveness of pancreatic cancer treatment roots in the high metastatic potential and drug resistance of this tumor. Therefore, the quest for efficient cellular models enabling precise mimicking in vivo conditions, and anticancer...
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Nanodiamonds Doped with Manganese for Applications in Magnetic Resonance Imaging
PublicationNanodiamonds (NDs) are emerging with great potential in biomedical applications like biomarking through fluorescence and magnetic resonance imaging (MRI), targeted drug delivery, and cancer therapy. The magnetic and optical properties of NDs could be tuned by selective doping. Therefore, we report multifunctional manganese-incorporated NDs (Mn-NDs) fabricated by Mn ion implantation. The fluorescent properties of Mn-NDs were tuned...
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Healthy financial system of local government on the example of Poland
Publicationhealthy local government financial system lays the foundation for the ability of local government units (LGUs) to carry out public tasks at the current qualitative and quantitative level and to meet their obligations in the short and long term. A healthy financial system of local government is a system that is adequate, stable, unified, consistent, transparent, diversified, counter-cyclical, guarantees the financial independence...
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Batracylina (BAT) - potencjalny lek przeciwnowotworowy. Batracylin (BAT) - potential of anticancer drug
PublicationOpisano działanie potencjalnego leku przeciwnowotworowego - batracyliny(BAT). Batracylina została wyselekcjonowana przez National Cancer Institute (NCI, Bethesda, USA) w 1978 roku jako efekt programu poszukiwań nowych leków chemioterapii.Związek ten w badaniach in vivo u myszy okazał się bardzo aktywny przeciw nowotworowi okrężnicy 38 (colon 38), trudnemu do wyleczenia przez znane leki przeciwnowotworowe. Okazała się ona skuteczna...
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Ciprofloxacin-modified degradable hybrid polyurethane-polylactide porous scaffolds developed for potential use as an antibacterial scaffold for regeneration of skin
PublicationThe aim of the performed study was to fabricate an antibacterial and degradable scaffold that may be used in the field of skin regeneration. To reach the degradation criterion for the biocompatible polyurethane (PUR), obtained by using amorphous α,ω-dihydroxy(ethylene-butylene adipate) macrodiol (PEBA), was used and processed with so-called “fast-degradable” polymer polylactide (PLA) (5 or 10 wt %). To meet the antibacterial requirement...
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EI measurements for OP-CABG monitoring.
PublicationCelem pracy jest analiza możliwości zastosowania pomiarów elektroimpedanycjnych do śródoperacyjnego monitoringu w kardiochirurgii. Omówiono pomiary przeprowadzone in vivo na świniach podczas operacji z użyciem holdera stosowanego w OP-CABG. Holder ten został przystosowany do prowadzenia pomiarów z wykorzystaniem spektroskopii elektroimpedancyjnej podczas operacji. Wykonana na świniach seria operacji obejmujących eksperymentalny...
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Optical properties of the chemotherapy drugs used in the central nervous system lymphoma therapy: monitoring drug delivery
PublicationOur aim is to optically monitor the delivery of the chemotherapy drugs for brain tumours, particularly used in the central nervous system (CNS) lymphoma therapy. In vivo monitoring would help to optimize the treatment and avoiding unnecessary medications. Moreover, it would be beneficial to be able to measure which of the multi-regimen drugs actually do penetrate and how well into the brain tissue. There exist several potential...
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Cell Density-Dependent Cytological Stage Profile and Its Application for a Screen of Cytostatic Agents Active Toward Leukemic Stem Cells
PublicationProliferation and expansion of leukemia is driven by leukemic stem cells (LSCs). Multidrug resistance (MDR) of LSCs is one of the main reasons of failure and relapses in acute myeloid leukemia (AML) treatment. In this study, we show that maintaining HL-60 at low cell culture density or applying a 240-day treatment with anthrapyridazone (BS-121) increased the percentage of primitive cells, which include LSCs determining the overall...
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Biomechanical causes for failure of the Physiomesh/Securestrap system
PublicationThis study investigates the mechanical behavior of the Physiomesh/Securestrap system, a hernia repair system used for IPOM procedures associated with high failure rates. The study involved conducting mechanical experiments and numerical simulations to investigate the mechanical behavior of the Physiomesh/Securestrap system under pressure load. Uniaxial tension tests were conducted to determine the elasticity modulus of the Physiomesh...
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DNAffinity: a machine-learning approach to predict DNA binding affinities of transcription factors
PublicationWe present a physics-based machine learning approach to predict in vitro transcription factor binding affinities from structural and mechanical DNA properties directly derived from atomistic molecular dynamics simulations. The method is able to predict affinities obtained with techniques as different as uPBM, gcPBM and HT-SELEX with an excellent performance, much better than existing algorithms. Due to its nature, the method can...
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The health impact of urban parks along waterways
PublicationWell designed parks along waterways could promote health and well-being of local inhabitants. The way the human settlements meet water bodies can influence the habits of local population. How people spend their time have significant impact on their health. For example, a team of Japanese scientists has proven that a well designed walk-able green spaces are crucial for the longevity of elderly citizens (Takano T. et al, 2002). Nature...
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Biomedical engineering of polysaccharide-based tissue adhesives: Recent advances and future direction
PublicationTissue adhesives have been widely used for preventing wound leaks, sever bleeding, as well as for enhancing drug delivery and biosensing. However, only a few among suggested platforms cover the circumstances required for high-adhesion strength and biocompatibility, without toxicity. Antibacterial properties, controllable degradation, encapsulation capacity, detectability by image-guided procedures and affordable price are also...
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Wyznaczanie względnej i bezwzględnej wartości zmian rezystancji zastępczego krwiobiegu nerki
PublicationZaproponowano sposób wyznaczania bezwzględnych i względnych zmian rezystancji w modelu elektrycznym krwiobiegu nerki. W oparciu o znane analogie między zjawiskami przepływu krwi w naczyniach i organach, a przepływem prądu w obwodach elektrycznych, zastosowano opisaną metodę do wyznaczenia zmian oporu naczyniowego nerki dla rzeczywistych danych medycznych. Przeprowadzono doświadczenie medyczne in vivo, polegające na zarejestrowaniu...
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Inspired by Nature: The Use of Plant-derived Substrate/Enzyme Combinations to Generate Antimicrobial Activity in situ
PublicationThe last decade has witnessed a renewed interest in antimicrobial agents. Plants have received particular attention and frequently rely on the spontaneous enzymatic conversion of an inactive precursor to an active agent. Such two-component substrate/enzyme defence systems can be reconstituted ex vivo. Here, the alliin/alliinase system from garlic seems to be rather effective against Saccharomyces cerevisiae, whilst the glucosinolate/myrosinase...
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Development of polyurethanes for bone repair
PublicationThe purpose of this paper is to review recent developments on polyurethanes aimed at the design, synthesis, modifications, and biological properties in the field of bone tissue engineering. Different polyurethane systems are presented and discussed in terms of biodegradation, biocompatibility and bioactivity. A comprehensive discussion is provided of the influence of hard to soft segments ratio, catalysts, stiffness and hydrophilicity...
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Isogeometric Shell FE Analysis of the Human Abdominal Wall
PublicationIn this paper a nonlinear isogeometric Kirchhoff-Love shell model of the human abdominal wall is proposed. Its geometry is based on in vivo measurements obtained from a polygon mesh that is transformed into a NURBS surface, and then used directly for the finite element analysis. The passive response of the abdominal wall model under uniform pressure is considered. A hyperelastic membrane model based on the Gasser-Ogden-Holzapfel...
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Synthesis and antitumor activity of conjugates of muramyldipeptide or normuramyldipeptide with hydroxyacridine/acridone derivatives
PublicationOpisano syntezę analogów MDP oraz nor-MDP modyfikowanych w części peptydowej pochodnymi hydroksyakrydyny/akrydonu i dwóch analogów modyfikowanych pochodnymi 1-nitro-9-hydroksyetylo(propylo)aminoakrydyny. Tylko związki zawierające pochodne 1-nitro-9-hydroksyetylo(propylo)aminoakrydyny wykazały wysoką aktywność cytotoksyczną badaną na 60 liniach ludzkich komórek nowotworowych, na nowotwór prostaty i AIDS-related lymphoma (ARL). Związek...
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Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects
PublicationSkin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different psoriasis subtypes and the lack of verified biomarkers. Recently, proteomics and metabolomics have been intensively investigated in a broad range of skin diseases with the main purpose...
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Preparation and characterization of genipin cross-linked porous chitosan–collagen–gelatin scaffolds using chitosan–CO2 solution
PublicationNovel porous scaffolds composed of chitosan, collagen and gelatin were prepared by the multistep procedure involving final freeze-drying and characterized. To eliminate the need for residual acid removal from the material after drying, carbon dioxide saturation process was used for chitosan blend formulation. The use of CO2 for chitosan dissolution made the scaffold preparation process more reproducible and economically sustainable....
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Analiza SWOT i analiza 5 sił Portera dla rynku podstawowej opieki medycznej na obszarze miasta Gdańska
PublicationIn recent years we have seen the dynamic development of medical services sector inPoland. Private health centres focus on aggressive development strategy. The role of primaryhealth care facilities, which provide services financed from public funds, declined. The purpose of article is to describe medical services market in Gdańsk, especially in Gdańsk-South district. Itincludes demographics, the number and characteristics...
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Metal-Organic Framework (MOF)/Epoxy Coatings: A Review
PublicationEpoxy coatings are developing fast in order to meet the requirements of advanced materials and systems. Progress in nanomaterial science and technology has opened a new era of engineering for tailoring the bulk and surface properties of organic coatings, e.g., adhesion to the substrate, anti-corrosion, mechanical, flame-retardant, and self-healing characteristics. Metal-organic frameworks (MOFs), a subclass of coordinative polymers...
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Treatment of Odontogenic Maxillary Sinusitis with the Use of Growth Factors in Advanced Platelet-Rich Fibrin for Immediate Closure of Oro-Antral Communication: A Case Report
PublicationChronic odontogenic maxillary sinusitis (COMS), a prolonged inflammation of the maxillary sinus lasting over 12 weeks, is often a result of periapical lesions, marginal periodontitis, and complications like oro-antral communication (OAC) and fistula (OAF). OAC, commonly emerging post-teeth extraction in the lateral maxilla, lacks documented treatments using advanced platelet-rich fibrin (A-PRF). This study evaluates A-PRF’s efficacy...
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Corrosion of titanium biomaterials, mechanisms, effects and modelisation
PublicationBadania in vivo oraz in vitro wskazują na bardzo małą szybkość korozji biostopów tytanu.Najczęstsza przycyną jest korozja ogólna i lokalna oraz korozja frettingowa. Trzy możliwe mechanizmy to: rozpuszczanie warstwy tlenku tytanu, dyfuzja pierwiastków przez warstwę tlenkową oraz reakcje elektrochemiczna w środowisku korozyjnym odsłoniętego metalu. Procesy korozyjne prowadzą do obluzowania implantów i poważnych schorzeń. Standardowe...
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Reactions on the surface of the implant under the influence of biofilm
PublicationThe contact of a biomaterial with the biological environment in in vitro and in vivo tests leads to the production of a particular ecosystem in which the active roles perform both, the material surface and the extracellular matrix protein forming a biofilm. Proteins affect cell and bacteria adhesion processes, biological activity of cells and activation of inflammatory response.The knowledge of the reaction mechanisms active on...
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Termografia w diagnostyce oparzeń.
PublicationW artykule przedstawiono możliwości i ograniczenia zastosowania aktywnej termografii dynamicznej w diagnostyce oparzeń. Prezentowane badania in-vivo poprzedzone były analizami matematycznych modeli skóry zdrowej i oparzonej, w celu optymalizacji procedury diagnostycznej. Szczególną uwagę poświęcono na zgodność wyników otrzymywanych w symulacjach numerycznych i badań doświadczalnych. Otrzymane wyniki wskazują, iż dysponując bezpiecznymi...
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Projektowanie, synteza oraz badanie aktywności biologicznej nowych inhibitorów sulfatazy steroidowej (STS) na bazie amidosiarczanowych pochodnych triazoli i oksadiazoli
PublicationNiniejsza dysertacja dotyczy szeregu badań z wykorzystaniem technik modelowania molekularnego oraz metod syntezy nowych inhibitorów STS opartych o rdzenie pierścieni heterocyklicznych 1,2,3-triazolu oraz 1,2,4-oksadiazolu. Aktywność inhibicyjna otrzymanych pochodnych została oznaczona w testach in vitro z wykorzystaniem enzymu wyizolowanym z łożyska ludzkiego oraz znakowanym radioizotopowo siarczanem estronu, a także w teście komórkowych...
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Progress in ATRP-derived materials for biomedical applications
PublicationThe continuing wave of technological breakthroughs and advances is critical for engineering well- defined materials, particularly biomaterials, with tailored microstructure and properties. Over the last few decades, controlled radical polymerization (CRP) has become a very promising option for the synthesis of precise polymeric materials with an unprecedented degree of control over mo lecular architecture. Atom transfer radical...
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Analiza PCA sekwencji aktywnej termografii dynamicznej w diagnostyce oparzeń
PublicationCelem niniejszej pracy jest analiza metod przetwarzania obrazów opartych na analizie składowychgłównych oraz analizie składowych niezależnych, które pozwola na uzyskanie nowych informacji obadanym obiekcie. W ramach pracy powstało oprogramowanie, które pozwala na analizezarejestrowanych sekwencji termograficznych metoda składowych głównych - Principal ComponentAnalysis - PCA. Została przeprowadzona weryfikacja działania powyższych...
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Phenotypic consequences of LYS4 gene disruption in Candida albicans
PublicationA BLAST search of the Candida Genome Database with the Saccharomyces cerevisiae LYS4 sequence known to encode homoaconitase (HA) revealed ORFs 19.3846 and 19.11327. Both alleles of the LYS4 gene were sequentially disrupted in Candida albicans BWP17 cells using PCR-based methodology. The null lys4Δ mutant exhibited lysine auxotrophy in minimal medium but was able to grow in the presence of L-Lys and α-aminoadipate, an intermediate...
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Biznesplan dla zakładu podstawowej opieki zdrowotnej o rozszerzonej działalności na obszarze dzielnicy Gdańsk-Południe
PublicationIn recent years we have seen the dynamic development of medical services sector in Poland. Private health centres focus on aggressive development strategy. The role of primaryhealth care facilities, which provide services financed from the public funds, declined.The purpose of the article is to present methods of strategic planning which allow toopen new healthcare entity. The next purpose is to make in practice...
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Revitalization of Sopot - The Seaside Spa Town in Poland
PublicationSopot is a Polish seaside resort. In the past - as early as at the beginning of the 20th century - this town was famous for the healing opportunities they created: good conditions for resting and recreation. This town was places where everyone with enough selfesteem was willing to be seen. Since the post-war reconstruction until 1989 (establishment of local governments in Poland), not much has happened in Polish cities in terms...
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Green Therapy w projektowaniu ośrodków medycznych Green Therapy in complex design of health centres
PublicationKoncepcja przestrzenna ogrodu terapeutycznego podporządkowana jest generalnej idei otwierania się projektantów na poszukiwanie nowych możliwości poprawy samopoczucia odbiorcy - poprzez zapewnienie użytkownikom poczucia bezpieczeństwa, komfortu i odprężenia, harmonii. Dotyczy to nie tylko grupy osób chorych, które dręczone są przez niepokoje i napięcia wywołane przez niepełnosprawność czy chorobę, ale także pacjentów w różnym wieku...
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Powikłania po rekonstrukcji piersi: problem zakażeń i strategii prewencyjnej - przegląd literaturowy
PublicationW niniejszej pracy przedstawiono dane dotyczące powikłań po rekonstrukcji piersi. Manuskrypt ma na celu usystematyzowanie wyników badań z ostatnich lat wraz z aspektami, takimi jak: częstotliwość występowania powikłań oraz ich rodzaj, czynniki predysponujące, a także możliwości profilaktyki. Przeanalizowano dane literaturowe z ogólnie dostępnych artykułów z okresu ostatnich pięciu lat, ze szczególnym uwzględnieniem zakażeń. Do...
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New Unsymmetrical Bisacridine Derivatives Noncovalently Attached to Quaternary Quantum Dots Improve Cancer Therapy by Enhancing Cytotoxicity toward Cancer Cells and Protecting Normal Cells
PublicationThe use of nanoparticles for the controlled drug delivery to cells has emerged as a good alternative to traditional systemic delivery. Quantum dots (QDs) offer potentially invaluable societal benefits such as drug targeting and in vivo biomedical imaging. In contrast, QDs may also pose risks to human health and the environment under certain conditions. Here, we demonstrated that unique combination of nanocrystals core components...
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Synergistic Effects of Propolis Combined with 2-Phenoxyethanol and Antipyretics on the Growth of Staphylococcus aureus
PublicationThe present investigation aimed to assess the combinational effect of commonly usedantipyretics and antiseptics with ethanolic extracts of propolis (EEPs) on the growth inhibition ofStaphylococcus aureus. The broth microdilution checkerboard assay revealed synergistic interactionsbetween all investigated antipyretics, namely acetylsalicylic acid, ibuprofen, and acetaminophen,with EEPs samples. The values of the fractional inhibitory...
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Towards large-scale application of nanoporous materials in membranes for separation of energy-relevant gas mixtures
PublicationMembranes containing nanoporous materials (such as zeolites, metal–organic materials and 2D materials such as graphene derivatives) may allow more efficient separation of gas mixtures relevant to emerging energy technologies. For example, such membranes could be applied in the separation of gases containing mixtures of carbon dioxide (CO2) and hydrogen (H2). However, these membranes are currently at a relatively low technology...
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MXenes Antibacterial Properties and Applications: A Review and Perspective
PublicationThe mutations of bacteria due to the excessive use of antibiotics, and generation of antibiotic-resistant bacteria have made the development of new antibacterial compounds a necessity. MXenes have emerged as biocompatible transition metal carbide structures with extensive biomedical applications. This is related to the MXenes’ unique combination of properties, including multifarious elemental compositions, 2D-layered structure,...
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Bioactive core material for porous load-bearing implants
PublicationSo far state of knowledge on biodegradable materials is reviewed. Among a variety of investigated materials, those composed of polymers and ceramics may be considered as only candidates for a core material in porous titanium alloy. The collagen and chitosan among natural polymers, polyhydroxy acids among synthetic polymers, and hydroxyapatite and tricalcium phosphate among ceramics are proposed for further research. Three essential...