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Search results for: BACTERIAL CELLULOSE ANTIMICROBIAL ACTIVITY SYNTHETIC POLYMERS WOUND DRESSING SKIN TISSUE SCAFFOLD SKIN SUBSTITUTE INT
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Neuroendocrinology of the skin
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Antioxidant and antimicrobial activity of fermented beverages obtained from fruit pomace
PublicationFruit pomace should not be considered as a waste product but as a by-product as it contains a lot of valuable components such as dietary fiber, bioactive compounds and a source of nutrients. The reasonable way to utilize these by-products, both fresh or dried, could be the fermentation of its extracts, leading to beverages with functional properties. In our research, we checked the possibility of using chokeberry, apple and...
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Investigation of photothermolysis therapy of human skin diseases using optical phantoms
PublicationDermatological diseases, such as neurofibroma (Recklinghausen disease) or hemangiomas can be efficiently treated using photothermolysis from laser irradiation. We have utilized a developed 975 nm fiber diode laser as a low-cost alternative over common Nd:YAG lasers. This paper describes the investigations of interaction of 975 nm diode laser radiation-pulses with optical skin phantoms which were designed and manufactured in our...
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Deep neural networks approach to skin lesions classification — A comparative analysis
PublicationThe paper presents the results of research on the use of Deep Neural Networks (DNN) for automatic classification of the skin lesions. The authors have focused on the most effective kind of DNNs for image processing, namely Convolutional Neural Networks (CNN). In particular, three kinds of CNN were analyzed: VGG19, Residual Networks (ResNet) and the hybrid of VGG19 CNN with the Support Vector Machine (SVM). The research was carried...
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Regulated Proenkephalin Expression in Human Skin and Cultured Skin Cells
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Are the short cationic lipopeptides bacterial membrane disruptors? Structure-Activity Relationship and molecular dynamic evaluation
PublicationShort cationic lipopeptides are amphiphilic molecules that exhibit antimicrobial activity mainly against Grampositives. These compounds bind to bacterial membranes and disrupt their integrity. Here we examine the structure-activity relation (SAR) of lysine-based lipopeptides, with a prospect to rationally design more active compounds. The presented study aims to explain how antimicrobial activity of lipopeptides is affected by...
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Changes of color coordinates of biological tissue with superficial skin damage due to mechanical trauma
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CELLULOSE
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Identification of the mechanical properties of the skin by electromechanical impedance analysis of resonant piezoelectric actuator
PublicationThis paper is devoted to the analysis and verification of developed piezoelectric sensor/actuator for measuring the mechanical properties of soft tissues, especially human skin. The key element of the measurement structure is an electromechanical system that uses both the reverse piezoelectric effect (vibration generation – stimulation of the tissues in the appropriate frequency range) and direct piezoelectric effect (system response...
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Melatonin, mitochondria, and the skin
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Journal of Skin Cancer
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Clinical Skin Cancer
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Skin therapy letter
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Skin Appendage Disorders
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SKIN PHARMACOLOGY AND PHYSIOLOGY
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SKIN RESEARCH AND TECHNOLOGY
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Polyacrylamide‐based phantoms as tissue substitute in experimental radiation physics
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The Influence of PEG on Morphology of Polyurethane Tissue Scaffold
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DIAGNOSIS OF MALIGNANT MELANOMA BY NEURAL NETWORK ENSEMBLE-BASED SYSTEM UTILISING HAND-CRAFTED SKIN LESION FEATURES
PublicationMalignant melanomas are the most deadly type of skin cancer but detected early have high chances for successful treatment. In the last twenty years, the interest of automated melanoma recognition detection and classification dynamically increased partially because of public datasets appearing with dermatoscopic images of skin lesions. Automated computer-aided skin cancer detection in dermatoscopic images is a very challenging task...
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Designing a High-sensitivity Microscale Triple-band Biosensor based on Terahertz MTMs to provide a perfect absorber for Non-Melanoma Skin Cancer diagnostic
PublicationNon-melanoma skin cancer (NMSC) is among the most prevalent forms of cancer originating in the top layer of the skin, with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) being its primary categories. While both types are highly treatable, the success of treatment hinges on early diagnosis. Early-stage NMSC detection can be achieved through clinical examination, typically involving visual inspection. An alternative,...
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Photoprotection and Antiaging Activity of Extracts from Honeybush (Cyclopia sp.)—In Vitro Wound Healing and Inhibition of the Skin Extracellular Matrix Enzymes: Tyrosinase, Collagenase, Elastase and Hyaluronidase
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Self-Supervised Learning to Increase the Performance of Skin Lesion Classification
PublicationTo successfully train a deep neural network, a large amount of human-labeled data is required. Unfortunately, in many areas, collecting and labeling data is a difficult and tedious task. Several ways have been developed to mitigate the problem associated with the shortage of data, the most common of which is transfer learning. However, in many cases, the use of transfer learning as the only remedy is insufficient. In this study,...
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Detection of low- and high-frequency rhythms in the variability of skin sympathetic nerve activity
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Mariusz Kaczmarek dr hab. inż.
PeopleReceived M.Sc., Eng. in Electronics in 1995 from Gdansk University of Technology, Ph.D. in Medical Electronics in 2003 and habilitation in Biocybernetics and Biomedical Engineering in 2017. He was an investigator in about 13 projects receiving a number of awards, including four best papers, practical innovations (7 medals and awards) and also the Andronicos G. Kantsios Award and Siemens Award. Main research activities: the issues...
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Melanoma skin cancer detection using mask-RCNN with modified GRU model
PublicationIntroduction: Melanoma Skin Cancer (MSC) is a type of cancer in the human body; therefore, early disease diagnosis is essential for reducing the mortality rate. However, dermoscopic image analysis poses challenges due to factors such as color illumination, light reflections, and the varying sizes and shapes of lesions. To overcome these challenges, an automated framework is proposed in this manuscript. Methods: Initially, dermoscopic...
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A device for measuring heat flux on a rocket skin surface
PublicationA novel method for measuring heat flux on a surface is presented. It is an extensive upgrade of currently known heat flux sensors used mostly in civil engineering. As the thermal environment of launchers, especially sounding rocket can have an enormous negative effect on payload, careful considerations have to be taken in the process of preparing insulation. Usually, thermal data provided by the launch vehicle manufacturer is limited...
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Corticotropin releasing hormone and the skin
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Ciprofloxacin – Modified Degradable Hybrid Polyurethane-Polylactide Porous Scaffolds Developed for Potential Use as an Antibacterial Scaffold for Regeneration of Skin
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Cellulose Nanomaterials in Biomedical, Food, and Nutraceutical Applications: A Review
PublicationNanotechnology with bionanomaterials have tremendous potential to enhance and utilize for nutrient and bioactive absorption, drug delivery systems, pharmaceutical, and nutraceutical field through various applications. Cellulose nanomaterials are green materials that are obtained from renewable sources and possess exceptional mechanical strength and biocompatibility. The associated unique physical and chemical properties have made...
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Polyurethanes modified with natural polymers for medical application. I. Polyurethanes/ Chitosan and polyurethane/collagen.
PublicationFor over three decades polyurethanes (PUR or PU) have been reported for application in a variety of medical devices. These polymers consist of hard and soft segments, which allow for more subtle control of their structure and properties. By varying the composition of the different segments, properties of PURcan be tuned up for use in many areas of medicine. Recently there is a great interest in modification of biomedical PUR with...
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Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid
PublicationThe series of 16 novel amino acid and peptide mycophenolic acid (MPA) derivatives was obtained as potential antibacterial agents. Coupling of MPA with respective amines was optimized with condensing reagents such as EDCI/DMAP and T3P/TEA. Amino acid analogs were received both as methyl esters and also with the free carboxylic group. The biological activity of the products was tested on five references bacterial strains: Klebsiella...
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Rapid Screening of Antimicrobial Synthetic Peptides
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Melatonin in the skin: synthesis, metabolism and functions
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On the Role of Melatonin in Skin Physiology and Pathology
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Vitamin D in the skin physiology and pathology.
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Non-lipophilic mycobiota of human skin
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Thermal imaging and modelling of burned skin
PublicationW artykule przedstawiono wyniki eksperymentów in-vivo na zwierzętach w diagnostyce oparzeń z wykorzystaniem metod obrazowania termicznego w podczerwieni. Wyniki skorelowano z rezultatami otrzymanymi w symulacjach numerycznych tkanki skóry.
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Support for Employees with ASD in the Workplace Using a Bluetooth Skin Resistance Sensor–A Preliminary Study
PublicationThe application of a Bluetooth skin resistance sensor in assisting people with Autism Spectrum Disorders (ASD), in their day-to-day work, is presented in this paper. The design and construction of the device are discussed. The authors have considered the best placement of the sensor, on the body, to gain the most accurate readings of user stress levels, under various conditions. Trial tests were performed on a group of sixteen...
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Biologically active compounds based on the carbazole scaffold - synthetic and mechanistic aspects
PublicationDoctoral dissertation is divided into three main parts: introduction, results and discussion and experimental. The introduction is divided into four main parts which describe: 5-hydroxytryptamine receptors, the most popular antidepressants, new compounds based on the carbazole structure with affinity for serotonin receptors, telomeres and telomerase with their functions, telomerase inhibition strategies, carbazoles approved in...
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Green and sustainable hydrogels based on quaternized chitosan to enhance wound healing
PublicationHydrogel-based biomaterials applied as wound dressings provide the wound with a moist environment, which facilitates tissue regeneration through granulation and re-epithelialization. The inherent flexibility and adjustable architecture of hydrogels enables incorporation of cells, antimicrobial drugs, growth factors, and bioactive compounds, which leads to expediting wound contraction and enhancing the regeneration process. The...
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SKIN: Journal of Cutaneous Medicine
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Enzymatic and Chemical Cross-Linking of Bacterial Cellulose/Fish Collagen Composites—A Comparative Study
PublicationThis article compares the properties of bacterial cellulose/fish collagen composites (BC/Col) after enzymatic and chemical cross-linking. In our methodology, two transglutaminases are used for enzymatic cross-linking—one recommended for the meat and the other proposed for the fish industry—and pre-oxidated BC (oxBC) is used for chemical cross-linking. The structure of the obtained composites is characterized by scanning electron...
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Evaluation of usefulness of 2DCorr technique in assessing physicochemical properties of bacterial cellulose
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Chitosan-based films with cannabis oil as a base material for wound dressing application
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Biopolymers in designing modern antimicrobial medical materials. Part I. Biopolymer medical materials - collagen, chitosan
PublicationThe article is a review of the literature concerning the possible use of biopolymers for the preparation of dressings with antimicrobial activity. Authors show the potential of biopolymers: collagen and chitosan - which have the ability to immobilize and control the release of various active compounds - for providing the appropriate antibacterial, bacteriostatic and wound healing properties. Types of threats, for which the dressing...
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Results of nanoindentation, XRD and microscopic studies of bacterial cellulose
Open Research DataThe archive contains the results of research on BNC bacterial biocellulose, which was modified in two ways. When BNC was synthesized, it was subjected to in situ modification involving the addition of hyuloronic acid to the bacterial medium. The second way of ex situ modification consisted of soaking the BNC in water and then convectionally drying it...
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Carnivorous plants used for green synthesis of silver nanoparticles with broad-spectrum antimicrobial activity
PublicationIn this study, we exploit the anti-oxidative potential of four carnivorous plants to produce uniform and biologically active silver nanoparticles. The use of polyvinylpyrrolidone promoted syn-thesis of quasi-spherical nanoparticles characterized by stability and high uniformity. Their activity was tested against three human pathogens and three species of plant pathogenic bacteria. The study demonstrates the influence of synthesis...
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Optimal selection of input features and an acompanying neural network structure for the classification purposes - skin lesions case study
PublicationMalignant melanomas are the most deadly type of skin cancers however detected early enough give a high chances for successful treatment. The last years saw the dynamic growth of interest of automatic computer-aided skin cancer diagnosis. Every month brings new research results on new approaches to this problem, new methods of preprocessing, new classifiers, new ideas to follow etc. In particular, the rapid development of dermatoscopy,...
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Structural changes of bacterial cellulose due to incubation in conditions simulating human plasma in the presence of selected pathogens
PublicationBacterial nanocellulose (BNC) is a natural biomaterial with a wide range of medical applications. However, it cannot be used as a biological implant of the circulatory system without checking whether it is biodegradable under human plasma conditions. This work aimed to investigate the BNC biodegradation by selected pathogens under conditions simulating human plasma. The BNC was incubated in simulated biological fluids with or...
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Steroidogenesis in the skin: Implications for local immune functions
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