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Search results for: drug delivery systems
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Environmentally Oriented Models and Methods for the Evaluation of Drug x Drug Interaction Effects
PublicationThis detailed review compares known and widely used methods for drug interaction estimation, some of which now have historical significance. Pharmaceutical application has been noted as far back as several thousand years ago. Relatively late in the 20th century, however, researchers became aware that their fate and metabolism, which still remain a great challenge for environmental analysts and risk assessors. For the patient’s...
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Collaborative Delivery by Energy-Sharing Low-Power Mobile Robots
PublicationWe study two variants of delivery problems for mobile robots sharing energy. Each mobile robot can store at any given moment at most two units of energy, and whenever two robots are at the same location, they can transfer energy between each other, respecting the maximum capacity. The robots operate in a simple graph and initially each robot has two units of energy. A single edge traversal by an robot reduces its energy by one...
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Jarosław Sadowski dr hab. inż.
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Antipsychotic drug prescription sequence analysis in relation to death occurrence and cardiometabolic drug usage: A retrospective longitudinal study
PublicationThe potential role of antipsychotics in increasing cardiovascular risk of mortality is still debated. The aim of this study was to assess the death risk associated with sequences of first-generation antipsychotic (FGA) and second-generation antipsychotic (SGA) prescriptions, including clozapine and lithium, and drugs for cardiometabolic diseases. We conducted a retrospective longitudinal analysis involving 84,881 patients who received...
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Synthetic strategies in construction of organic macromolecular carrier–drug conjugates
PublicationMany metabolic inhibitors, considered potential antimicrobial or anticancer drug candidates, exhibit verylimited ability to cross the biological membranes of target cells. The restricted cellular penetration ofthose molecules is often due to their highhydrophilicity. One of the possible solutions to this problem is aconjugation of an inhibitor with a molecular organic nanocarrier. The conjugate thus formed should beable to penetrate...
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Pharmacokinetics and pharmacodynamics of propofol and fentanyl in patients undergoing abdominal aortic surgery - a study of pharmacodynamic drug-drug interactions
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Drug-drug interaction potential of antitumor acridine agent C-1748: The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7
PublicationBackground The compound 9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine (C-1748), the promising antitumor agent developed in our laboratory was determined to undergo phase I metabolic pathways. The present studies aimed to know its biotransformation with phase II enzymes – UDP-glucuronosyltransferases (UGTs) and its potential to be engaged in drug-drug interactions arising from the modulation of UGT activity. Methods UGT-mediated...
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Piotr Szczuko dr hab. inż.
PeoplePiotr Szczuko received his M.Sc. degree in 2002. His thesis was dedicated to examination of correlation phenomena between perception of sound and vision for surround sound and digital image. He finished Ph.D. studies in 2007 and one year later completed a dissertation "Application of Fuzzy Rules in Computer Character Animation" that received award of Prime Minister of Poland. His interests include: processing of audio and video, computer...
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Investigating Analytics Dashboards’ Support for the Value-based Healthcare Delivery Model
PublicationImproving the value of care is one of the essential aspects of Value-Based Healthcare (VBHC) model today. VBHC is a new HC delivery model which is centered on patient health outcomes and improvements. There is anecdotal evidence that the use of decision aid tools like dashboards can play a significant role in the successful implementation of VBHC models. However, there has been little or no systematic studies and reviews to establish...
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Effective Drug Concentration and Selectivity Depends on Fraction of Primitive Cells
PublicationPoor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has been driving the search for more active and specific compounds. In this work, we show how cell density-dependent stage culture profiles can be used in drug development workflows to achieve more robust drug activity (IC50 and EC50) results. Using flow cytometry and light microscopy, we characterized the cytological stage profiles of the HL-60-,...
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Antimicrobial molecular nanocarrier–drug conjugates
PublicationMany antimicrobial drugs are poorly active against pathogenic microbes causing intracellular infections, such as Mycobacterium tuberculosis or Plasmodium falciparum. On the other hand, several known antimicrobial agents are not effective enough because of their limited cellular penetration. A common feature of both challenges is the inability of an active agent to cross the biological membrane(s). One of the possible approaches...
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Webinarium „Drug Discovery, Development & Commercialization”
EventsCTWT PG zaprasza na webinarium „Drug Discovery, Development & Commercialization”. Spotkanie skierowane jest do osób zajmujących się zawodowo lub planujących swoją karierę w dziedzinie opracowywania i rozwoju leków.
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Novel 1,2,4-Oxadiazole Derivatives in Drug Discovery
PublicationAbstract: Five-membered 1,2,4-oxadiazole heterocyclic ring has received considerable attention because of its unique bioisosteric properties and an unusually wide spectrum of biological activities. Thus, it is a perfect framework for the novel drug development. After a century since the 1,2,4-oxadiazole have been discovered, the uncommon potential attracted medicinal chemists’ attention, leading to the discovery of a few presently...
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Pharmaceutical and forensic drug applications of chiral supercritical fluid chromatography
PublicationTHE SUPERCRITICAL FLUID IS AN EXCELLENT CHOICE AS THE CHROMATOGRAPHIC MOBILE PHASE BECAUSE IT ALLOWS RAPID SEPARATION WITH HIGH EFFICIENCY AND APPLICATIONS INVOLVING ENANTIORESOLUTION ARE COMMON. SUPERCRITICAL FLUID CHROMATOGRAPHY (SFC) IS INCREASINGLY USED FOR ANALYTICAL, SEMI-PREPARATIVE AND PREPARATIVE PURIFICATION OF CHIRAL COMPOUNDS, INCLUDING PRODUCTION OF ENANTIOMERS THAT ARE MAINLY ENCOUNTERED DURING DRUG DEVELOPMENT. SFC...
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Towards Digital Anti-Corruption Typology for Public Service Delivery
PublicationDigital anti-corruption refers to a family of digital technology tools that are used to fight corruption. Many such tools have not performed well in practice due to their non-alignment with forms of corruption they are supposed to fight against and persistence of corruption-enabling conditions. The aim of this paper is to contribute to filling this gap by offering a typology of digital anti-corruption in public service delivery...
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Methods for Elucidation of DNA-Anticancer Drug Interactions and Their Applications in the Development of New Drugs
PublicationDNA damaging agents including anthracyclines, camptothecins and platinum drugs are among most frequently used drugs in the chemotherapeutic routine. Due to their relatively low selectivity for cancer cells, administration is associated with adverse side effects, whereas the inherent genotoxicity of these drugs is associated with risk of developing secondary cancers. Development of new drugs, which could be spared of these drawbacks...
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Rafał Leszczyna dr hab. inż.
PeopleDr hab. Rafal Leszczyna is an associate professor at Gdansk University of Technology, Faculty of Management and Economics. He holds the M.Sc. degrees of Computer Science and Business Management. In December, 2006 he earned a Ph.D. in Computer Science, specialisation - Computer Security at the Faculty of Electronics, Telecommunications and Informatics of Gdansk University of Technology. Between 2004 and 2008 he worked in the European...
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Disposition of Drugs of Abuse and Their Metabolites in Wastewater as a Method of the Estimation of Drug Consumption
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Determination of the chemical structure of potencial organic impurities occuring in the drug substance opopramol
PublicationThe tricyclic antipsychotic and antidepressant drug opipramol was examined with regard to the chemical structure of its organic impurities. Impurities were isolated from the technical product by chromatographic methods and their chemical structures were estabilished by HMNR, MS and FTIR.
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Synthetic strategies in construction of organic low molecular-weight carrier-drug conjugates
PublicationInefficient transportation of polar metabolic inhibitors through cell membranes of eukaryotic and prokaryotic cells precludes their direct use as drug candidates in chemotherapy. One of the possible solutions to this problem is application of the ‘Trojan horse’ strategy, i.e. conjugation of an active substance with a molecular carrier of organic or inorganic nature, facilitating membrane penetration. In this work, the synthetic...
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Chemical Biology & Drug Design
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Magdalena Gajewska prof. dr hab. inż.
PeopleMagdalena Gajewska (born June 1th 1968 in Gdańsk) in 1993 graduated Hydro-Engineering Faculty at Gdańsk University of Technology. At present she is an assistant professor in the Department of Water and Wastewater Technology at the Faculty of Civil and Environmental Engineering GUT. PhD (2001) and habilitation (2013) in the discipline of environmental engineering. In the 2016-2020 term, serves as Vice -dean for science. She...
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Longitudinal drug synergy assessment using convolutional neural network image-decoding of glioblastoma single-spheroid cultures
PublicationAbstract Background In recent years, drug combinations have become increasingly popular to improve therapeutic outcomes in various diseases, including difficult to cure cancers such as the brain cancer glioblastoma. Assessing the interaction between drugs over time is critical for predicting drug combination effectiveness and minimizing the risk of therapy resistance. However, as viability readouts of drug combination experiments...
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Adam Dąbrowski dr inż.
PeopleAdam Dabrowski has obtained a PhD in mechanical engineering from Gdańsk University of Technology and MSc. degree in mechatronics from Technische Universität Hamburg. He has an industry experience in Institute of Aviation Engineering Design Center (Warsaw, Poland) and SICK AG (Hamburg, Germany). Additionally, as an assistant at Gdansk University of Technology he teaught courses on mechanics, space mechanisms and dynamics of space...
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Current state of a dual behaviour of antimicrobial peptides-Therapeutic agents and promising delivery vectors
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Information Discovery and Delivery
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The Imidazoacridinone Antitumor Drug, C-1311, Is Metabolized by Flavin Monooxygenases but Not by Cytochrome P450s.
PublicationPrezentowane w publikacji wyniki badań mają na celu wyjaśnienie roli enzymów wątrobowych w metabolizmie przeciwnowotworowych pochodnych C-1311 oraz C-1330. Oba związki inkubowane były z frakcją mikrosomalną oraz enzymami rekombinantowymi należącymi do grypy cytochromu P450, FMO oraz UGT. Badania wykazały, że oba związki są metabolizowane przez enzymy frakcji mikrosomalnej, ale nie przez enzymy cytochromu P450. Aktywność enzymatyczna...
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Ahmer Bin Hafeez
PeopleI have experience in Microbiology & Computational Biology, particularly bioinformatics, homology modeling, phylogenetics, structural biology, and drug discovery. Currently, my interest lies in translatable omics studies and drug discovery against novel protein targets involved in cancer and infectious diseases and Host-Pathogen PPIs. My aim involves the use of computational methods for the identification of novel targets and to...
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Determination of the chemical structure of potential organic impurities occurring in drug substance opipramol
PublicationThe tricyclic antipsychotic and antidepressant drug opipramol (opipramole) was examined with regard to the chemical structure of its organic impurities. Impurities were isolated from the technical product by chromatographic methods and their chemical structures were established by 1H NMR, MS and FTIR and further confirmed by comparison with commercially available products or with products obtained by independent synthesis, and...
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The influence of small amount of substances present in tissue on the optical spectrum of immunosuppressive drug
PublicationIn this paper, we describe how commonly present in tissue substances - sodium chloride and glucose - affect the optical spectrum of an immunosuppressive drug (Cyclaid® by Apotex). Prepared samples were investigated using the spectrophotometer in the spectrum range from 250 nm to 1100 nm. The maximum wavelength shift calculated on the basis of measurement results is not bigger than the measurement wavelength step. So, it can be...
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The Influence of the Co-Dopant Dexamethasone Phosphate on the Electrodeposition Process and Drug-Release Properties of Polypyrrole-Salicylate on Iron
PublicationIn this work, the influence of incorporation of two anti-inflammatory drugs dexamethasone phosphate and sodium salicylate on the electrodeposition process of polypyrrole (PPy) film on iron has been studied. The incorporation of the agents into PPy has been carried out in a one-step electropolymerization process on oxidizable iron. The role of each drug agent during the deposition process has been discussed. The morphological and...
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Information Systems Security 2023
e-Learning CoursesThe e-learning course for the Information Systems Security, in the field of Electronics and Telecommunications in the II degree studies (2nd year of studies, 3rd semester).
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Emerging anticancer activity of candidal glucoseamine-6-phosphate synthase inhibitors upon nanoparticle-mediated delivery
PublicationNumerous glutamine analogues have been reported as irreversible inhibitors of the glucosamine-6-phosphate (GlcN-6-P) synthase in pathogenic Candida albicans in the last 3.5 decades. Among the reported inhibitors, the most effective N3-(4-methoxyfumaroyl)-L-2,3- diaminopropanoic acid (FMDP) has been extensively studied in order to develop its more active analogues. Several peptide−FMDP conjugates were tested to deliver FMDP to its...
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Spontaneous unilateral exophthalmos after a vaginal delivery
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Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: implications for drug resistance and in vitro drug screening models
PublicationBadania z użyciem modelu komórek nowotworu płuc A549 wykazały, że komórki te po traktowaniu lekami uszkadzającymi DNA zatrzymują proliferację i wchodzą w stan starzenia komórkowego. Jednak post-inkubacja tych komórek prowadzi do powrotu do stanu proliferacji małej frakcji komórek. Wykazaliśy, że frakcja ta związana jest z obecnością komórek pierwotnych nowotworu w populacji komórek A549. Powrót do stanu proliferacji komóek A549...
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Operational Research - Queuing Systems 2022
e-Learning CoursesComponents, characteristics, classification, analysis, and applications of queuing systems.
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Nanosize effect of clay mineral nanoparticles on the drug diffusion processes in polyurethane nanocomposite hydrogels
PublicationStudies of swelling and release of naproxen sodium (NAP) solution by polyurethane nanocomposite hydrogels containing Cloisite® 30B (organically modified montmorillonite (OMMT)) have been performed. Polyurethane nanocomposite hydrogels are hybrid, nontoxic biomaterials with unique swelling and release properties in comparison with unmodified hydrogels. These features enable to use nanocomposite hydrogels as a modern wound dressing....
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Accidents, victims and risk levels on regional roads in pomorskie voivodeship, 2017-2019 - Alcohol and drug accidents
Open Research DataData contain risk classification on regional roads (voivodeship roads) in pomorskie voivodeship in 2017-2019, risk group: Offenders under influence of alcohol or drug - driver or pedestrian. Measures used to assess the level of risk are (5 classes low, low to medium, medium, medium to high, high):
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Information systems management - autumn 2023
e-Learning CoursesInformation Systems in Management for International Management students. Autumn 2023
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Operational Research - Queuing Systems 2024
e-Learning CoursesCourse discusses components, characteristics, classification, analysis, and applications of queuing systems.
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Operational Research - Queuing Systems 2024
e-Learning CoursesCourse discusses components, characteristics, classification, analysis, and applications of queuing systems.
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Exposure to non-opioid analgesics during pregnancy and the risk of adverse drug reactions
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Piotr Rajchowski dr inż.
PeoplePiotr Rajchowski (Member, IEEE) was born in Poland, in 1989. He received the E.Eng., M.Sc., and Ph.D. degrees in radio communication from the Gdańsk University of Technology (Gdańsk Tech), Poland, in 2012, 2013, and 2017, respectively. Since 2013, he has been working at the Department of Radiocommunication Systems and Networks, Faculty of Electronics, Telecommunications and Informatics, Gdańsk University of Technology, as a IT...
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Low-Barrier Hydrogen Bond Determines Target-Binding Affinity and Specificity of the Antitubercular Drug Bedaquiline
PublicationThe role of short strong hydrogen bonds (SSHB) in ligand-target binding remains largely unexplored, thereby hin- dering a potentially important avenue in the rational drug de- sign. Here, we investigate the interaction between bedaquiline (Bq), a potent anti-tuberculosis drug, and the mycobacterial ATP synthase, to unravel the role of a specific hydrogen bond to a conserved acidic residue in the target affinity and specificity....
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Construction of a simulation model of goods delivery in international road transportation taking into account the functioning efficiency of logistics supply chain
PublicationThe object of this study is the process of goods delivery in international road transport using various types of logistics chains. The problem being solved is due to the need to develop recommendations for exporters of goods to reformat or design new supply chains during wartime. The expediency of organizing foreign trade operations by the cargo owners' own forces or with the involvement of enterprises providing logistics consulting...
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Information Systems Security 2024/2025
e-Learning CoursesThe e-learning course for the Information Systems Security, in the field of Electronics and Telecommunications in the II degree studies.
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Large-scale multimedia content delivery over optical networks for interactive TV services
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Systems Software Design 1
e-Learning CoursesSystems Software Design
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Hossein Nejatbakhsh Esfahani Dr.
PeopleMy research interests lie primarily in the area of Learning-based Safety-Critical Control Systems, for which I leverage the following concepts and tools:-Robust/Optimal Control-Reinforcement Learning-Model Predictive Control-Data-Driven Control-Control Barrier Function-Risk-Averse Controland with applications to:-Aerial and Marine robotics (fixed-wing UAVs, autonomous ships and underwater vehicles)-Multi-Robot and Networked Control...
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Solutions of inverter systems in Shore-to-Ship Power supply systems
PublicationThe article presents a clearly formulated need for installing S2SP (Shore to Ship Power) systems, in particular Medium Voltage (MV) systems, along with certain solutions of modern inverter systems used in those systems. Requirements and basic configurations of S2SP systems are discussed, focusing in particular on capabilities of the S2SP system with DC distribution busbar. Moreover, on the background of the executing assumptions...