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Search results for: EDWARD KAJDAŃSKI
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Actual and reference evapotranspiration for a natural, temperate zone fen wetland – Upper Biebrza case study
PublicationEvapotranspiration is the key and predominant component of the water balance in wetlands. Direct evapotranspiration measurements are challenging in wetlands due to their remoteness and high surface water level. This article describes the actual (ETa and reference evapotranspiration (ET0) from a cultivated wet meadow located in the Biebrza National Park – the largest national park in north-east Poland, Central Europe. The data were...
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Facilitated diffusion of glucosamine-6-phosphate synthase inhibitors enhances their antifungal activity
PublicationKwas N-3(4-metoksyfumaroilo)-L-2,3-diaminopropanowy (FMDP) i 2-amino-2-deo-ksy-D-glucitolo-6-fosforan (ADGP) są silnymi inhibitorami syntazy glukoza-mino-6-fosforanu, istotnego enzymu grzybowego, jednak ich aktywność przeciwgrzybowa jest słaba, ze względu na powolną penetrację tych związków przez błonę cytoplazmatyczną. W tej pracy badaliśmy możliwość poprawy działania przeciwgrzybowego ADGP i FMDP poprzez zwiększenie ich własności...
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Dietary Habits Among Young Triathlonists as a Result of Proecological Style of Life - Preliminary Study
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Does the chemical modification of Nystatin A1 affect the drug's ability to overcome the multidrug resistance of fungi?
PublicationAlthough the contemporary medicine keeps moving forward, disseminated infections caused by fungal pathogens are an emerging challenge. The dramatic rise of fungal diseases, especially the most life-threatening systemic mycoses is associated with a permanently growing number of immunodeficient patients. Undoubted difficulties in the treatment of fungal infections are caused by lack of highly effective and selective antifungal drugs,...
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The mechanism of overcoming multidrug resistance (MDR) of fungi by amphotericin B and its derivatives
PublicationPrzeprowadzono badania porównawcze w celu określenia aktywności i cytotoksyczności amfoterycyny B (AmB) i jej pochodnych wobec standardowego szczepu S. cerevisiae i jego transformantów zawierających geny C. albicans kodujące białka oporności wielolekowej (MDR) typu ABC i MFS. Pochodne AmB: amid 3-dimetyloaminopropylowy amfoterycyny B oraz ester metylowy N-metylo-N-D-fruktopiranozylo-amfoterycyny B wykazały efekt fungistatyczny...
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Chemical Composition of Industrial Wood Waste and the Possibility of its Management
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Experience-Based Cognition for Driving Behavioral Fingerprint Extraction
PublicationABSTRACT With the rapid progress of information technologies, cars have been made increasingly intelligent. This allows cars to act as cognitive agents, i.e., to acquire knowledge and understanding of the driving habits and behavioral characteristics of drivers (i.e., driving behavioral fingerprint) through experience. Such knowledge can be then reused to facilitate the interaction between a car and its driver, and to develop better and...
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Amphotericin B derivatives: novel strategy for the development of non-toxic, broad spectrum, fungicidal and overcoming multidrug resistance antifungal agents.
PublicationZaprezentowano porównawczą charakterystykę działania amfoterycyny B (AmB) oraz jej pochodnych o różnym stopniu selektywnej toksyczności na szczepy grzybów reperezentujących różne mechanizmy oporności. Były to mutanty C. albicans posiadające defekt w szlaku biosyntezy ergosterolu oraz wielolekooporne szczepy S. cerevisiae wyposażone w pompy eksportujące typu ABC i MFS. Badania obejmowały: 1)porównanie aktywności przeciwgrzybowej...
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Yoga for Heart Rate Variability: A Systematic Review and Meta-analysis of Randomized Clinical Trials
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Application of a cellular automaton to simulations of granular flow in silos
PublicationA cellular automaton based on a gas model of hydrodynamics was used to calculate the kinematics of non-cohesive granular materials during confined flow in a mass flow and funnel flow model silo. In the model, collisions of particles were taken into account during granular flow. In addition, a simplified automaton was used wherein granular flow was assumed as an upward propagation of holes through a lattice composed of cells representing...
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Global dynamics in a stage-structured discrete-time population model with harvesting
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CHALK & TALK OR SWIPE & SKYPE?
PublicationTechnology in classroom is a matter of heated discussions in the field of education development, especially when multidisciplinary education goes along with language skills. Engineers’ education requires theoretical and practical knowledge. Moreover, dedicated computer skills become crucial for both young graduates and experienced educators on the labor market. Teaching online with or without using different Learning Management...
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Natural convective heat transfer from isothermalconic
PublicationTheoretical considerations on convective heat transfer from isothermal upward conicalsurfaces have been presented. The physical model of this phenomenon consists of an isothermalcone of inclination angle (φ) between the cone generating line (X) and the radius (R) of the cone base. The angle is a parameter of conical surface which varied from (φ = 0−circular horizontal plate) to (φ = π/2—vertical cylinder) . Onthe basis of Navier–Stokes...
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Opportunities and shortcomings of ionic liquids in single-drop microextraction
PublicationThe synergistic combination of ionic liquids (ILs) and single-drop microextraction (SDME) involves a powerful coupling toward the development of sustainable analytical methodologies. This overview provides a survey of the literature regarding the IL-SDME, including a database on relevant physicochemical properties of ILs for their application in SDME, the strategies implemented to combine IL-based SDME methods efficiently with...
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2,7-Dihydro-3H-pyridazino[5,4,3-kl]acridin-3-one derivatives, novel type of cytotoxic agents active on multidrug-resistant cell lines. Synthesis and biological evaluation.
PublicationOtrzymano serię pirydazyno akrydyn-3-onów w reakcji 9-okso-9,10-dihydroakrydyno-1-karboksylanu etylu z POCl3, następnie dodanie odpowiedniej alkiloaminoalkilohydrazyny. Badane związki wykazują w porównaniu z referencyjnymi cytostatykami DX, MIT niższe wartości indeksu RI, a także niższe aktywności cytotoksyczne.
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Effect of pesticides on microorganisms, enzymatic activity and plant in biochar-amended soil
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Effect of biostimulants and storage on the content of macroelements in storage roots of carrot
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Monosaccharides as Potential Chiral Probes for the Determination of the Absolute Configuration of Secondary Alcohols
PublicationHerein, a new method for the elucidation of the absolute configuration of chiral secondary alcohols is proposed. This method is an alternative for a widely used approach reported by Mosher and Dale and similar methods that are based on the 1H NMR shift (δ) changes of protons that are attached to the substituents of the oxymethine carbon atom. The presented method is not based on tracking the chemical shift changes and utilizes...
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Stream Reasoning to Improve Decision-Making in Cognitive Systems
PublicationABSTRACT Cognitive Vision Systems have gained a lot of interest from industry and academia recently, due to their potential to revolutionize human life as they are designed to work under complex scenes, adapting to a range of unforeseen situations, changing accordingly to new scenarios and exhibiting prospective behavior. The combination of these properties aims to mimic the human capabilities and create more intelligent and efficient...
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Thick - film and LTCC multicontact resistors - preliminary results
PublicationW artykule zaprezentowano i skomentowano wstępne wyniki elektryczxnych i geometrycznych charakterystyk wielokontaktowychstruktur rezystywnych wykonanych w technologiigrubowarstwowej i LTCC ( ceramicznej z niską temperatura wypadaniz). Realizowane struktury miały rozmiary od 200 x 100 μm2 do 1500 x 500 μm2 i 3 lub 6 kontaktów rozmieszczonych e różny sposób na obwodzie warstwy rezystywnej.
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Impedimetric sensing of α-amino acids driven by micro-patterned 1,8-Diazafluoren-9-one into titania- boron- doped maze-like nanocarbons
PublicationThe development of impedimetric, non-faradaic label-free sensors for the detection of α-amino acids constitutes a trailblazing technology for the fast and inexpensive quantification of such biomarkers. Since α-amino acids, such as glycine and sarcosine, are basic constituents in biological processes, a variation in their concentration may be an indicator of cardiovascular diseases and metabolic disorders or neurological conditions....
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Design, synthesis, and molecular docking of new 5-HT reuptake inhibitors based on modified 1,2-dihydrocyclopenta[b] indol-3(4H)-one scaffold
PublicationA new group of serotonin reuptake inhibitors containing 1,2-dihydrocyclopenta[b]indol-3(4H)-one scaffoldwas synthesized, starting from indole 5-((1H-indol-3-yl)(1,3-dioxane-4,6-diones as a key intermediates. Following three transformations including intramolecular cyclization and formation of imines, a series of new ligand for human serotonin transporter was obtained. The ability of these ligands to inhibit human TS3 serotonin transporter...
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Synthesis and biological activity of novel ester derivatives of N3-(4-metoxyfumaroyl)-(S)-2,3-diaminopropanoic acid containing amide and keto function as inhibitors of glucosamine-6-phosphate synthase
PublicationA short series of novel ester derivatives of N3-4-methoxyfumaroyl-(S)-2,3-diaminopropanoic acid (FMDP) containing amido or keto functions have been designed and synthesized. Their antifungal activity and inhibitory properties toward fungal glucosamine-6-phosphate synthase has also been evaluated. The obtained compounds 11-13 and 15-17 demonstrated good antifunga activity against Candida albicans. Compounds 11-13 displayed also...
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Open-Set Speaker Identification Using Closed-Set Pretrained Embeddings
PublicationThe paper proposes an approach for extending deep neural networks-based solutions to closed-set speaker identification toward the open-set problem. The idea is built on the characteristics of deep neural networks trained for the classification tasks, where there is a layer consisting of a set of deep features extracted from the analyzed inputs. By extracting this vector and performing anomaly detection against the set of known...
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Sulfurization of phosphanylphosphinidene ligand: Access to phosphinothioyltrithiophosphonato platinum(II) complexes
PublicationThe reactivity of phosphanylphosphinidene Pt(0) complexes [DppePt(η2-P–PtBu2)] (1) and [(pTol3P)2Pt(η2-P–PtBu2)] (2) toward sulfur was studied. Reactions of 1 and 2 with an excess of sulfur led to the formation of the first transition metal complexes 3 and 4 with phosphinothioyltrithiophosphonato ligands with the formula [tBu2P(=S)–P(=S)S2]2-. In contrast to previous reports on the phosphanylphosphinidene moiety sulfurization,...
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The gyrotron source for the EPR spectroscopy
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Experience based knowledge representation for Internet of Things and Cyber Physical Systems with case studies
PublicationCyber Physical Systems and Internet of Things have grown significant attention from industry and academia during the past decade. The main reason behind this interest is the capabilities of such technologies to revolutionize human life since they appear as seamlessly integrating classical networks, networked objects and people to create more efficient environments. However, enhancing these technologies with intelligent skills becomes...
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The Neural Knowledge DNA Based Smart Internet of Things
PublicationABSTRACT The Internet of Things (IoT) has gained significant attention from industry as well as academia during the past decade. Smartness, however, remains a substantial challenge for IoT applications. Recent advances in networked sensor technologies, computing, and machine learning have made it possible for building new smart IoT applications. In this paper, we propose a novel approach: the Neural Knowledge DNA based Smart Internet...
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Inhibitors of glucosamine-6-phosphate synthase as potential antifungal drugs.
PublicationPrzedstawiono stan obecny i perspektywy zastosowania inhibitorów enzymu syntazy GlcN-6-P jako leków skutecznych w leczeniu grzybic układowych. Używając metod modelowania molekularnego zaprojektowano struktury inhibitorów enzymu należących do dwóch grup strukturalnych: analogów glutaminy oraz analogów stanu przejściowego reakcji katalizowanej przez enzym. Opracowano metody syntezy pochodnych zoptymalizowanych inhibitorów, wykazujących...
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The activity of latent benzoperimidine esters to inhibit P-glycoprotein and multidrug resistance-associated protein 1 dependent efflux of pirarubicin from several lines of multidrug resistant tumor cells.
PublicationZaprezentowano wyniki badań biologicznych przeprowadzonych dla nowej grupy związków: estrów benzoperymidyny z zastosowaniem wybranych linii komórek nowotworowych: wrażliwych i opornych o oporności P-gp-zależnej, MRP1-zależnej i o oporności związanej z nadekspresją białek MRP1/LRP. Metodą spektrofluorymetryczną zbadano zdolność estrów benzoperymidyny do hamowania eksportu aktywnego pirarubicyny z komórek opornych. Estry benzoperymidyny...
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Insights into baby disposable diapers sustainable application
PublicationThe sustainable use of baby disposable diapers is one of the issues currently being discussed to reduce the undesirable impact on the environment and improve the public's understanding of the proper use of diapers. This issue is a step toward promoting a cleaner, greener, and waste-less environment. In this article, the authors discuss options for a viable future for both people and the planet. We believe that it inspire others...
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Initial Considerations
PublicationChemical processes have made use of a wide number of volatile organic solvents due to their efficiency in countless unit operations. The increasing knowledge on the environmental, health, and safety hazards associated to their use has significantly contributed to the search for greener alternatives. The primary purpose of this book is to provide an overview of alternative solvents with reduced issues that have successfully replaced...
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Heat and mass transfer in air-fed pressurised suits
PublicationOpisano konieczność modelowania transportu masy i ciepła w kombinezonach ochronnych. Omówiono różne sposoby modelowania wymiany ciepła, łącznie ze sprzężoną wymianą ciepła. Uwzględniono również ludzki metabolizm i turbulentne mechanizmy wymiany masy i ciepła. Publikacja opisuje również sposób modelowanie turbulentnych przepływów wieloskładnikowych. Pokazano również porównanie obliczeń z eksperymentem.
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Determining heat transfer coefficients using evolutionary alogrithms
PublicationPokazano sposób kalibracji współczynnika wymiany ciepła za pomocą algorytmów ewolucyjnych. Wykorzystano tu minimalizację błędu między pomiarami a obliczeniami. Pokazano dwie metody optymalizacji: wielokryterialną i jednokryterialną.
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Yoga for hypertension: A systematic review of randomized clinical trials
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Modelling of two-component turbulent mass and heat transfer in air-fed pressurised suits
PublicationIn this paper the modelling of an important industrial problem is addressed, which involves the two-component turbulent flow with heat transfer that takes place inside protective clothing. The geometry of the flow boundaries is reconstructed in a CAD system from photogrammetry scan data. The overall model is sufficiently realistic to allow, after validation, design improvements to be tested. Those presented here allow the reduction...
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Nowy Orlean : zrobmy to porządnie
PublicationOpis społecznego projektu odbudowy dzielnicy Lower Ninth Ward, zniszczonej przez huragan Katrina w 2005 roku w Nowym Orleanie, realizowanego przez fundację Make it Right.
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Zaufanie w zespole projektowym a (kobiecy) model przywództwa
PublicationArtykuł prezentuje wyniki badań dotyczące znaczenia czynników kształtujących zaufanie w pracy zespołowej, do których należą: adekwatne nagradzanie, dzielenie się informacjami, ustalone cele i zasady pracy, przejrzystość środowiska i otwarta komunikacja. Wyniki koncentrują się na zachowaniach lidera/ przywódcy, które maja wpływ na kształtowanie zaufanie w zespole i pokazują różnice w zależności od płci.
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Wymiary klimatu pracy zespołowej
PublicationArtykuł prezentuje koncepcje klimatu pracy zespołowej jako determinanty zespołowej efektywności i innowacyjności. Zaprezentowano sześć modeli klimatu pracy zespołowej i przeanalizowano główne wymiary klimatu, opracowując na tej podstawie nowy, 5-wymiarowy model, który obejmuje: wsparcie oparte na zaufaniu, popieranie innowacji,odpowiedzialność, wizja i motywacja. Pokazano również kilka narzędzi do pomiaru klimatu pracy zespołowej.
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Thermo-fluid Transport Phenomena in Air-fed Pressurised Protective Clothing
PublicationPublikacja opisuje sposób modelowania turbulentnych przepływów dwuskładnikowych w ciśnieniowych kombinezonach ochronnych, które używane są w reaktorach fuzyjnych. Rozważane są różne modele turbulencji. Przepływy modelowane są w realistycznych geometriach, które odtwarzane są metodą fotogrametrii. Pokazano również sposób modelowania kondensacji pary wodnej na wewnętrznych powierzchniach kombinezonów.
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Heat and mass transfer in air-fed pressurised suits
PublicationOpisano konieczność modelowania transportu masy i ciepła w kombinezonach ochronnych. Omówiono różne sposoby modelowania wymiany ciepła, łącznie ze sprzężoną wymianą ciepła. Uwzględniono również ludzki metabolizm i turbulentne mechanizmy wymiany masy i ciepła. Publikacja opisuje również sposób modelowanie turbulentnych przepływów wieloskładnikowych. Pokazano również porównanie obliczeń z eksperymentem.
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Synthesis and biological evaluation of 2,7-Dihydro-3H-dibenzo[de,h]cinnoli- ne-3,7-done derivatives a novel group of anticancer agents active on a multidrug resistance cell line.
PublicationZsyntezowano serię pochodnych pirydazonu z jednym lub dwoma łańcuchami bocznymi w różnych pozycjach chromoforu tetracyklicznego. Związki wykazały aktywność cytoksyczną na mysią białaczkę L1210 i ludzką k562 oraz na linii komórkowej oporności krzyżowej MDR (k562/DX). Dwa najbardziej aktywne związki przetestowano in vivo na mysiej białaczce P388. Wykazały one aktywność przeciwnowotworową porównywalną z aktywnością Mitoxantronu.
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Synthesis of 7-oxo-7h-naphto[1,2,3-de]quinoline derivatives as potential anticancer agents active on multidrug resistant cell lines
PublicationOpierając się na naszym wcześniejszym stwierdzeniu, że tetracykliczne analogi antrachinonów z wbudowanym pierścieniem pirydynowym wykazują aktywną cytotoksyczność względem komórek z indukowaną opornością, przeprowadzono syntezę pochodnych 7-oxo-7h-nafto[1,2,3-de]chinoliny (3, 6-8, 10-12, 14,15 i 18) posiadających jeden lub dwa zasadowe łańcuchy boczne i różne podstawniki w pierścieniu pirydynowym, związków o potencjalnym działaniu...
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Wetlands in flux: looking for the drivers in a central European case
PublicationPlanet Earth is undergoing significant changes which are driven by natural and anthropogenic factors. However, it is difficult to identify the drivers and their effect on the environment and ecosystems because there are many interdependencies. In this study we present a multi-parameter approach to assess the effect of changes in human-induced and natural drivers on a wetland ecosystem. The study area is one of the most prominent...
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Methods of Cyclist Training in Europe
PublicationThe following study aims to address the issue of cyclist training methodologies. Recent European bicycle accident statistics reveal a troubling upward trend. A potential solution to mitigate such incidents involves providing cyclists with comprehensive training encompassing traffic regulations and interactions with fellow road users. We conducted a comparative analysis of the cycling education approaches and cyclist training systems...
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Technology adoption review for ageing well: analysis of technical solutions
PublicationWhile several technological solutions are available for older adults to improve their wellbeing and quality of life, little is known about the gaps between the needs, provided solutions, and their adoption from a more pragmatic perspective. This paper reports on reviewing existing technological solutions for older adults, which span the work life, life in the community, and wellbeing at home. We analyzed 50 different solutions...
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The Control System Based on FPGA Technology For Fatigue Test Stand MZGS-100 PL
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Energy-Saving Mechatronic System for Fatigue Tests of Materials under Variable-Amplitude Proportional Bending and Torsion
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Event driven MPC for networked control systems
PublicationBecause of variable delays and stochastic data packets loss networked control systems require suitable algorithms to ensure stability of the control system and guarantee desired control performance. This paper presents the idea of an event driven approach with MPC controller. In opposition to network compensation, where standard regulators are used, the presented solution integrates network with plant. A MPC based controller is...
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Hybrid Approach to Networked Control System
PublicationEffcient control of Networked Control System (NCS) is a challenge, as the control methods need to deal with non-deterministic variable delays and data loss. This paper presents a novel hybrid approach to NCS where Model Predictive Control (MPC) is applied as a main controller and implicit switching MPC is used for data transmission control in event-driven shared communication medium, leading to complex control system with active...