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Search results for: PEPTIDE FIBRILS
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Cyclic Peptidic Furin Inhibitors Developed by Combinatorial Chemistry
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Technical fabrics in costruction of large scale roofs - numerical and experimental aspects
PublicationDesigning and construction of textile hanging roofs is the challenging subject for engineers. This type of structure needs geometrically and very often also physically non-linear calculations. Due to different behaviour of two families of threads (warp and weft), which during deformation can change the angle between their directions, they require special constitutive modelling. Also the loading of hanging roofs is very special....
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Dynamic analysis including special constitutive model for PVC-coated fabrics.
PublicationW pracy przestawiono dynamiczne obliczenia membranowego przekrycia wiszącego w kształcie paraboloidy hiperbolicznej poddanej impulsowemu działaniu wiatru. Do opisu zachowania się powleczonej polichlorkiem winylu tkaniny technicznej zastosowano równania konstytutywne modelu sieci gęstej z uwzględnieniem sprężystych i sprężysto-lepkoplastycznych właściwości wątku i osnowy.
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Review of constitutive models for technical woven fabrics in finite element analysis
PublicationArtykuł opisuje typy modeli konstytutywnych stosowanych do opisu zachowania się tkanin technicznych w analizie MES. Proponowany jest także warstwowy model sieci gęstej.
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Proposal of Objective Assesment of the Phenomenon of Light Passage Through Blackout Fabrics
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Design, synthesis and in vitro biological evaluation of a small cyclic peptide as inhibitor of vascular endothelial growth factor binding to neuropilin-1
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Osteoblast and bacterial cell response on RGD peptide‐functionalized chitosan coatings electrophoretically deposited from different suspensions on Ti13Nb13Zr alloy
PublicationMetallic materials for long-term load-bearing implants still do not provide high antimicrobial activity while maintaining strong compatibility with bone cells. This study aimed to modify the surface of Ti13Nb13Zr alloy by electrophoretic deposition of a chitosan coating with a covalently attached Arg-Gly-Asp (RGD) peptide. The suspensions for coating deposition were prepared in two different ways either using hydroxyacetic acid...
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Inhibition of amyloid fibril formation of hen egg white lysozyme by trimethylamine N-oxide at low pH
PublicationIn vitro inhibition of the formation of fibrous aggregates of proteins (amyloids) has gained increasing attention due to the number of diseases associated with protein misfolding and fibrillation. An interesting group of compounds for which pronounced activity against this phenomenon can be expected consists of low molecular weight substances (osmolytes) which have the ability to change protein stability. Here we investigate the...
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Effect of Marination Time on the Antioxidant Properties of Peptides Extracted from Organic Dry-Fermented Beef
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Retro analog concept: comparative study on physico-chemical and biological properties of selected antimicrobial peptides
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Synergistic action of extracts from carnivorous plants and synthetic peptides against plant pathoghenic bacteria
Publicationw pracy przedstawiono rezultaty badań nad sprawdzeniem aktywności przeciwbakteryjnej ekstraktów z roślin Drosera capensis i Dionaea muscipula w połączeniu z dwoma syntetycznymi peptydami: CAMEL oraz pexiganan. Najwyższą aktywnością przeciwbakteryjną odznaczał się chloroformowy ekstrakt z D. muscipula z peptydem CAMEL.
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Possible mechanisms for protecting NCα bonds in helical peptides from electron-capture (or transfer) dissociation
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Amides as models to study the hydration of proteins and peptides — spectroscopic and theoretical approach on hydration in various temperatures
PublicationInteractions with water are one of the key factors which determine protein stability and activity in aqueous solutions. However, the protein hydration is still insufficiently understood. N-methylacetamide (NMA) is regarded as a minimal part of the peptide backbone and the relative simplicity of its structure makes it a good model for studies on protein–water interactions. In this paper, the influence of NMA and N,N-dimethylacetamide...
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A study on the protection of methionine and the reduction of methionine sulfoxide in methionine-containing analogues of the growth-modeling factor Gly-His-Lys
PublicationThe protection of methionine and the reduction of methionine sulfoxide in methionine-containing analogues of Gly-His-Lys are described. The peptides were synthesized by a solid-phase method using the standard Fmoc procedure. Simultaneous deprotection of the peptide side chain and liberation from the resin were achieved using an appropriate TFA cocktail. The TFA cocktail was selected to minimize oxidation of the methionine residue....
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Technological Sensitizing Of Mosaic Optical Fibres For Sensory And Microoptics Applications
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Evaluation of recycled tyre steel fibres adhesion to cement matrix
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Mode interaction in few-mode optical fibres with Kerr effect
PublicationUogólnioną metodę rzutowania do ortogonalnej bazy funkcji poprzecznej współrzędnej Bessela stosuje się do wyprowadzania układów równań nieliniowych Schrodingera. Teoria jest ważna dla paczek falowych w światłowodach i kilku modelach.
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Prussian Blue Analogues Cubes in the Organic Polymer Electrospun Fibres
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The Application of Fibres from Recycled Postconsumer Tyres for Concrete Reinforcement
PublicationPoland as a Member State is obliged to implement the EU specific environmental legislation focused on the reduction, transport and treatment of waste. The Landfill Directive prohibited the landfilling of whole tyres and their by-products. Although the EU Directive of Waste limits the use of tyres as secondary fuel, Poland is still the EU leader in burning tyres in cement kilns. Post-consumer tyres are utilised in a number of...
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Fibres from recycled post-consumer tyres for concrete reinforcement
PublicationW pracy przedstawiono aktualną sytuację dot. wykorzystania drutu stalowego z recyklingu opon samochodowych. Przedstawiono wyniki badań przeprowadzonych w laboratorium Katedry Konstrukcji Betonowych i Technologii Betonu nad zastosowaniem włókien stalowych z recyklingu do zbrojenia betonu. Otrzymane wyniki porównano z próbkami fibrobetonu uzyskanego na bazie przemysłowo produkowanych włókien stalowych.
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The effect of mercerized sisal fibres on natural rubber composites' properties
PublicationW pracy omówiono wyniki badań fizyko-mechanicznych kompozytów otrzymanych z mieszanek zawierających kauczuk naturalny oraz statystycznie zdyspergowane krótkie włókno sisalowe. Włókno naturalne przed użyciem poddano merceryzacji.Otrzymane wulkanizaty poddano badaniom wytrzymałościowym w warunkach statycznych w celu określenia wpływu parametrów wulkanizacji i ilości dodanego włókna na właściwości otrzymanych produktów. Stwierdzono...
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Effect of polymer fibres reinforcement on selected properties of asphalt mixtures
PublicationThe paper presents selected results of the research program concerning fibre reinforced asphalt concrete. Aramid-polyalphaolefin fibres was used in this study. Selected properties responsible for low temperature cracking and resistance to permanent deformation are presented in this paper. Low temperature cracking susceptibility was evaluated with the results obtained from bending test of rectangular beams with constant rate of...
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The ORBIT bleeding score is associated with lysis and permeability of fibrin clots
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Influence of the ionic strength on the amyloid fibrillogenesis of hen egg white lysozyme
PublicationThe study investigates the role of the electrostatic interactions in the fibrillation of the hen egg white lysozyme (HEWL). In order to achieve this aim the influence of the cations Na+, Mg2+ and Al3+ on the amyloid fibril formation and amorphous aggregation was tested. The amyloids are formed in the solution without added salt but the Thioflavin T fluorescence gives the false-negative result. In these conditions, the HEWL fibrils...
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Synthesis of novel, peptidic kinase inhibitors with cytostatic/cytotoxic activity
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The influence of a synthetic growth hormone‐releasing hormone analogue G11 and opioid peptide biphalin on selected fibroblasts parameters relevant to wound healing
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Probing the binding selected metal ions and biologically active substances to the antimicrobial peptide LL-37 using DSC, ITC measurements and calculations
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Comparison of peptide cancer signatures identified by mass spectrometry in serum of patients with head and neck, lung and colorectal cancers: Association with tumor progression
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Electrochemical detection of bacterial endotoxin lipopolysaccharide (LPS) on gold electrode modified with DAL-PEG-DK5-PEG-OH - Antimicrobial peptide conjugate
PublicationThis work describes fabrication of gold electrodes modified with peptide conjugate DAL-PEG-DK5-PEG-OH that enables ultra-sensitive detection of lipopolysaccharide (LPS) isolated from the reference strain of Escherichia coli O26:B6. The initial step of the established procedure implies immobilization of the fully protected DAL-PEG-DK5-PEG-OH peptide on the surface of the gold electrode previously modified by cysteamine. Then side...
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Layer-by-layer polymer deposited fabrics with superior flame retardancy and electrical conductivity
PublicationSmart and multifunctional textiles and fabrics are progressively developing, such that multifunctional fabrics are becoming more widespread. We elaborated herein multi-layered flax fabrics with superior flame retardancy and conductivity, which revealed fireproof feature while keeping conductivity during burning. The flax fabric was reinforced by layer-by-layer (LbL) deposition of sodium polyacrylate (SPA), polyethylenimine (PEI),...
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Multiple β-sheet molecular dynamics of amyloid formation from two ABl-SH3 domain peptides
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Chicken feather keratin as a source of bioactive peptides useful in prevention of metabolic disorders – in silico and in vitro hydrolysis
PublicationProtein derived bioactive peptides not only serve as nutrients but can also exert drug-like activity, e.g. antidiabetic, antihypertensive, or antimicrobial, to name a few. Most biopeptides have beneficial effects on health that make them attractive for nutraceutical applications. The majority of bioactive peptides have been obtained from food proteins, but protein-rich by-products generated by agriculture...
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Non-ribosomal peptides produced by Planktothrix agardhii from Siemianówka Dam Reservoir SDR (northeast Poland)
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Inhibitory and antimicrobial activities of OGTI and HV-BBI peptides, fragments and analogs derived from amphibian skin
PublicationA series of linear and cyclic fragments and analogs of two peptides (OGTI and HV-BBI) isolated from skin secretions of frogs were synthesized by the solid-phase method. Their inhibitory activity against several serine proteinases: bovine beta-trypsin, bovine alpha-chymotypsin, human leukocyte elastase and cathepsin G from human neutrophils, was investigated together with evaluation of their antimicrobial activities against Gram-negative...
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Peptydy penetrujące – rodzaje i mechanizmy przenikania przez błony komórkowe
PublicationPeptydy penetrujące z pewnością są wyjątkową i ciekawą grupą związków peptydowych. Zostały odkryte ponad dwadzieścia lat temu, ale wiedza na ich temat wciąż jest rozbudowywana. Liczne badania nad mechanizmami ich przenikania do wnętrza komórek pozwalają zrozumieć jakie cechy strukturalne warunkują ich zdolność do penetracji komórek. Wiedza ta pozwala na projektowanie nowych, bardziej efektywnych peptydów penetrujących., które mogą...
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The Arctic mutation alters helix length and type in the 11–28 β-amyloid peptide monomer—CD, NMR and MD studies in an SDS micelle
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Inhibition of inflammatory response in human keratinocytes by magnetic nanoparticles functionalized with PBP10 peptide derived from the PIP2-binding site of human plasma gelsolin
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The Product of Matrix Metalloproteinase Cleavage of Doxorubicin Conjugate for Anticancer Drug Delivery: Calorimetric, Spectroscopic, and Molecular Dynamics Studies on Peptide–Doxorubicin Binding to DNA
PublicationMatrix metalloproteinases (MMPs) are extracellular matrix degradation factors, promoting cancer progression. Hence, they could provide an enzyme-assisted delivery of doxorubicin (DOX) in cancer treatment. In the current study, the intercalation process of DOX and tetrapeptide-DOX, the product of the MMPs' cleavage of carrier-linked DOX, into dsDNA was investigated using stationary and time-resolved fluorescence spectroscopy, UV-Vis...
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Peptide dendrimers as antifungal agents and carriers for potential antifungal agent—N3‐(4‐methoxyfumaroyl)‐(S)‐2,3‐ diaminopropanoic acid—synthesis and antimicrobial activity
PublicationA series of peptide dendrimers and their conjugates with antimicrobial agent FMDP (N3‐(4‐methoxyfumaroyl)‐(S)‐2,3‐diamino‐propanoic acid) were synthesized. The obtained compounds were tested for the antibacterial and antifungal activity. All novel dendrimers displayed much better activity against the tested strains than FMDP itself. Moreover, their conjugates with FMDP also exhibited antimicrobial activity. The most promising molecules...
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The equations for interactions of polarization modes in optical fibres including the kerr effect
PublicationWe have derived coupled nonlinear Schro¨ dinger equations (CNLSE) for arbitrary polarized light propagation in a single-mode fibre employing electromagnetic field complete description. We used a basis of transverse eigenmodes with appropriate projecting; hence, the nonlinear constants depend on the waveguide geometry. Accounting for a weak nonlinearity, which is connected to the Kerr effect, we have given explicit expressions for...
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<title>Octopus-Like-Shape Cored Optical Fibres /OLSCF/</title>
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The effect of macro polymer fibres length and content on the fibre reinforced concrete
PublicationThe paper presents studies of a ready-mix concrete containing polymer fibres of three different lengths: 24, 38 and 54 mm. The performed tests allowed to determine the effect of fibre volume fraction and length on the concrete strength. The basic parameters of concrete mixture (consistency, air content and bulk density) were identified. Fibre reinforced concrete belongs to a group of composite materials. The polymer fibres are...
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New matrix-free reference material for ethene in the form of optical fibres
PublicationReference materials are indispensable in the qualitycontrol and quality assurance of analytical measurements. Onenovel approach to the generation of standard gaseous mixturesof toxic, reactive, volatile, labile, and malodorous substancesinvolves thermal decomposition or rearrangement, under definedtemperature conditions, of compounds immobilized, bychemical bonding, on the surface of an appropriate carrier torelease specific amounts...
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Mechanical Properties of Bio-Composites Based on Epoxy Resin and Nanocellulose Fibres
PublicationThe aim of our research was to investigate the effect of a small nanocellulose (NC) addition on an improvement of the mechanical properties of epoxy composites. A procedure of chemical extraction from pressed lignin was used to obtain nanocellulose fibers. The presence of nanoparticles in the cellulose pulp was confirmed by FTIR/ATR spectra as well as measurement of nanocellulose particle size using a Zetasizer analyzer. Epoxy...
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Conjugates of tuftsin and muramyl dipeptide as stimulators of monocyte-derived dendritic cells
PublicationOstatnio coraz częściej bada się związki oddziałujące na komórki dendrytyczne. Muramylodipeptyd i jego analogi przyspieszają dojrzewanie i aktywację komórek dendrytycznych. Do naszych badań otrzymaliśmy komórki dendrytyczne na drodze ekspansji z monocytów krwi obwodowej. Właściwa suplementacja hodowli monocytów czynnikami wzrostowymi - GM-CSF i IL-4, pozwoliła na uzyskanie niedojrzałych komórek dendrytycznych, które stymulowano...
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Influence of cyclic frozen and defrost on mechanical properties of polytetrafluoroethylene (PTFE)-coated woven fabrics
PublicationThis research aims to determine the influence of the cyclic process of freezing and defrosting on the mechanical properties of the chosen glass fibres and PTFE-coated woven fabrics. The specimens were subjected to freezing at about −20 °C for 4 h and thawing by full immersion into the water at about +20 °C for 4 h. The fabric samples after 25 and 50 frozen cycles were air-dried at room temperature for one week and then subjected...
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Influence of Water-Induced Degradation of Polytetrafluoroethylene (PTFE)-Coated Woven Fabrics Mechanical Properties
PublicationThe impact of water-induced degradation on the mechanical properties of the chosen two PTFE-coated, glass threads woven fabrics is investigated in this paper. The paper begins with a survey of literature concerning the investigation and determination of coated woven fabric properties. The authors carried out the uniaxial tensile tests with an application of flat and curved grips to establish the proper values of the ultimate tensile...
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Influence of water soaking on the ultimate tensile strength of polyester-based coated woven fabrics
PublicationThis research aims to determine the influence of water-soaking on polyester-based coated woven fabrics for ultimate tensile strength and elongation at break under uniaxial tensile tests. The paper begins with a short survey of literature concerning the investigation of the determination of coated woven fabric properties. The authors carried out the uniaxial tensile tests with an application of a flat grip to establish the values...
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Structural Modelling of Blackout Fabrics Patterned by Weave. Used as a Curtains in Interior Public Spaces
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Taste-active peptides and amino acids of pork meat as components of dry-cured meat products: An in-silico study
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