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Search results for: ALLOSTERIC MODULATOR
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Broadband, optical Internet-based, modular, interactive information system for research deptartment in university environment: part II
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Klasyfikator SVM w zastosowaniu do synchronizacji sygnału OFDM zniekształconego przez kanał wielodrogowy
PublicationW pracy przedstawiono analizę przydatności klasyfikatora SVM bazującego na uczeniu maszynowym do estymacji przesunięcia czasowego odebranego symbolu OFDM. Przedstawione wyniki wykazują, że ten klasyfikator potrafi zapewnić synchronizację dla różnych kanałów wielodrogowych o wysokim poziomie szumu. Eksperymenty przeprowadzone w Matlabie z użyciem modeli modulatora i demodulatora wykazały, że w większości przypadków klasyfikator...
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Modulation of CYP19 expression by cabbage juices and their active components: indole-3-carbinol and 3,30-diindolylmethene in human breast epithelial cell lines
PublicationThe aim of this study was to evaluate the effect of white cabbage and sauerkraut juices of different origin and indole-3-carbinol (I3C) and diindolylmethane (DIM) on expression of CYP19 gene encoding aromatase, the key enzyme of estrogen synthesis.Remarkable differences in the effect on CYP19 transcript and protein level were found between the cab- bage juices (in 2.5-25 mL/L concentrations) and indoles (in 2.5-50 lM doses) in...
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Diverging frequency-modulated 50-kHz vocalization, locomotor activity and conditioned place preference effects in rats given repeated amphetamine treatment
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Inter-individual diversity and intra-individual stability of amphetamine-induced sensitization of frequency-modulated 50-kHz vocalization in Sprague–Dawley rats
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P.0253 Two-week lithium treatment modulates translocator protein expression in brain regions in the animal models of acute bipolar episodes
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Modulation of mRNA and protein levels of CYP1A1, 1A2, and 1B1 in nontumorigenic breast epithelial cells (MCF10A) by cabbage juice and its active components
PublicationZbadano wpływ soków z kapusty oraz występujących w nich pochodnych indolowych i sulforafanu na poziom ekspresji enzymów odpowiedzialnych za metabolizm ksenobiotyków w tym estrogenów. Wykazano, że soki z kapusty i izolowane substancje mają podobny wpływ na poziom mRNA i białek enzymatycznych.
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Electrochromic foil-based devices: optical transmittance and modulation range, effect of ultraviolet irradiation,and quality assessment by 1/f current noise
PublicationPrzedstawiono technologię wytwarzania elementów wykazujących zjawisko elektrochromizmu - zmiany transmitancji optycznej pod wpływem gromadzenia ładunku. Pokazano, że zastosowanie warstwy odbijającej może poprawić stopień zmian transmitancji optycznej. Ponadto, pokazano, że zjawiska losowe generujące szum typu 1/f w tych elementach może być wykorzystane do oceny ich jakości.
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Structure and the space vector modulation for a medium-voltage power-electronic-transformer based on two seven-level cascade H-bridge inverters
PublicationThis study presents the structure and the space vector pulse-width modulation (SVPWM) for power electronic transformer (PET) based on two seven-level cascade H-bridge (CHB) inverters. The DC links of CHB inverters are coupled with nine dual-active bridge (DAB) converters with medium-frequency transformers. The DC-link voltages are equalised with two methods – through the control of DAB voltages...
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Multicast Traffic Throughput Maximization through Joint Dynamic Modulation and Coding Schemes Assignment, and Transmission Power Control in Wireless Sensor Networks
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Rats showing low and high sensitization of frequency-modulated 50-kHz vocalization response to amphetamine differ in amphetamine-induced brain Fos expression
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Modulation of carcinogen metabolizing cytochromes p450 in rat liver and kidney by cabbage and sauerkraut juices: comparison with the effects of indole-3-carbinol and phenethyl isothiocyanate
PublicationThis study investigated the effect of raw cabbage and sauerkraut juices on the activity and expression of CYP1A1, 1A2, 1B1 and 2B in Wistar rat liver and kidney. The results were compared with those of two commercially available products of glucosinolates degradation: indole-3-carbinol (I3C) and phenethyl isothiocyanate (PEITC). Significant differences in the effect of the cabbage juices as well as I3C and PEITC between the liver...
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Different expression level of CYP3A4 isoenzyme modulate cellular response of CHO cells following treatment with the CYP3A4 inhibitor, C-1311 compound
PublicationEfektywność terapii przeciwnowotworowej może być zmieniana przez różne czynniki. Jednym z ograniczeń jest odmienny u każdego pacjenta poziom enzymów metabolizujących odpowiedzialnych za aktywację i detoksykację leków, co może zmieniać jego odpowiedź na zastosowaną terapię. Co więcej, enzymy metabolizujące często są celem molekularnym wielu ksenobiotyków, co dodatkowo może zmieniać skuteczność terapii. Zatem zrozumienie oddziaływań...
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INVESTIGATION OF THE EFFECT OF THE ROCKET'S SUBORBITAL FLIGHT ON BIOFILM, ENZYMES AND BIOSYNTHESIS ON AUTONOMOUS, MODULAR AND SCALABLE PLATFORM FOR CONDUCTING EXPERIMENTS OF AN ASTROBIOTECHNOLOGICAL NATURE
PublicationWith new incentives for human space exploration, biotechnological experiments in orbit became imperative.Answering this need, we build an autonomous, modular, and scalable platform that enables those experiments onrockets. We called it AMBER. The aim of the payload of the R6 suborbital rocket is to perform an experiment tostudy the influence of rocket flights on biofilm, molecular...
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Recurrent Neural Network Based Adaptive Variable-Order Fractional PID Controller for Small Modular Reactor Thermal Power Control
PublicationThis paper presents the synthesis of an adaptive PID type controller in which the variable-order fractional operators are used. Due to the implementation difficulties of fractional order operators, both with a fixed and variable order, on digital control platforms caused by the requirement of infinite memory resources, the fractional operators that are part of the discussed controller were approximated by recurrent neural networks...
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Investigation of the Effect of the Rocket's Suborbital Flight on Biofilm, Enzymes and Biosynthesis on Autonomous, Modular and Scalable Platforms For Conducting Experiments of an Astrobiotechnological Nature
PublicationWith new incentives for human space exploration, biotechnological experiments in orbit became imperative. Answering this need, we build an autonomous, modular, and scalable platform that enables those experiments on rockets. We called it AMBER. The aim of the payload of the R6 suborbital rocket is to perform an experiment to study the influence of rocket flights on biofilm, molecular biology enzymes and biosynthesis using our platform....
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Diverging changes in rat striatal extracellular dopamine and DOPAC levels and in frequency-modulated 50-kHz ultrasonic vocalizations rate during repeated amphetamine treatment
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Modulation of UDP-glucuronidation by acridinone antitumor agents C-1305 and C-1311 in HepG2 and HT29 cell lines, despite slight impact in noncellular systems.
PublicationBackground Among the studied antitumor acridinone derivatives developed in our laboratory, 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305) and 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) exhibited cytotoxic and antitumor properties against several cancer types and were selected to be evaluated in preclinical and early-phase clinical trials. In the present work, we investigated the impact of C-1305...
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Modulation of the FeII spin crossover effect in the pentadecanuclear {Fe9[M(CN)8]6} (M = Re, W) clusters by facial coordination of tridentate polyamine ligands
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<title>Modular version of SIMCON, FPGA based, DSP integrated, LLRF control system for TESLA FEL part I: SIMCON 3.0 motherboard</title>
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Pulse-Modulated Radio-Frequency Alternating-Current-Driven Atmospheric-Pressure Glow Discharge for Continuous-Flow Synthesis of Silver Nanoparticles and Evaluation of Their Cytotoxicity toward Human Melanoma Cells
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Extracting functional groups of ALLINI to design derivatives of FDA‐approved drugs: Inhibition of HIV‐1 integrase
PublicationHIV‐1 integrase (IN) is crucial for integration of viral DNA into the host genome and a promising target in development of antiretroviral inhibitors. In this work, six new compounds were designed by linking the structures of two different class of HIV‐1 IN inhibitors (active site binders and allosteric IN inhibitors (ALLINIs)). Among newly designed compounds, INRAT10b was found most potent HIV‐1 IN inhibitor considering different...
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Two-step mechanism of J-domain action in driving Hsp70 function
PublicationJ-domain proteins (JDPs), obligatory Hsp70 cochaperones, play critical roles in protein homeostasis. They promote key allosteric transitions that stabilize Hsp70 interaction with substrate polypeptides upon hydrolysis of its bound ATP. Although a recent crystal structure revealed the physical mode of interaction between a J-domain and an Hsp70, the structural and dynamic consequences of J-domain action once bound and how Hsp70s...
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Comparative study of a bottoming SRC and ORC for Joule–Brayton cycle cooling modular HTR exergy losses, fluid-flow machinery main dimensions, and partial loads
PublicationEnergy conversion efficiency increase in power plants with high-temperature gas-cooled reactors via implementation of the bottoming cycle was investigated under nominal and minimal thermal load of a high-temperature reactor (HTR). Heat transfer surface area and turbine outlet volumetric flow rate in bottoming cycles was also investigated. Water and two low-boiling point working fluids (ammonia and ethanol) were analyzed. Analyzed...
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<title>Modular version of SIMCON, FPGA based, DSP integrated, LLRF control system for TESLA FEL part II: measurement of SIMCON 3.0 DSP daughterboard</title>
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Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints
PublicationOur previous studies have shown that murine fibroblast cells, in which PARP-1 gene was inactivated by gene disruption, are extremely sensitive to triazoloacridone compound C-1305, an inhibitor of DNA topoisomerase II with unusual properties. Here, we show that pharmacological inhibition of PARP-1 activity by its inhibitor compound NU1025, sensitizes human cervical carcinoma HeLa cells to compound C-1305 compared to treatment with...
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Shallow Water Experiment of OFDM Underwater Acoustic Communications
PublicationThe large variability of communication properties of underwater acoustic channels, and especially the strongly varying instantaneous conditions in shallow waters, is a challenge for the designers of underwater acoustic communication (UAC) systems. The use of phase modulated signals does not allow reliable data transmission through such a tough communication channel. However, orthogonal frequency-division multiplexing (OFDM), being...
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The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma-Recent Findings and Review
PublicationThe inflammatory process plays a significant role in the development of colon cancer (CRC). Intestinal cytokine networks are critical mediators of tissue homeostasis and inflammation but also impact carcinogenesis at all stages of the disease. Recent studies suggest that inflammation is of greater importance in the serrated pathway than in the adenoma-carcinoma pathway. Interleukins have gained the most attention due to their...
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Discovery of small-molecule regenerative drugs using a model of complex tissue injury in mice. Transcriptomic responses of neurodevelopmental genes during pharmacologically induced regeneration
PublicationDespite significant development in regenerative medicine, there is a deficit of effective therapies for wound healing and tissue regeneration. Research performed using animal wound models allows for a better understanding of this complex process, searching for compounds with pro-regenerative properties, and assessing their efficacy and safety. Unfortunately, the lack of adequate preclinical models proves to be an issue as no animal...
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Morphology control through the synthesis of metal-organic frameworks
PublicationDesignable morphology and predictable properties are the most challenging goals in material engineering. Features such as shape, size, porosity, agglomeration ratio significantly affect the final properties of metal- organic frameworks (MOFs) and can be regulated throughout synthesis parameters but require a deep under- standing of the mechanisms of MOFs formation. Herein, we systematically summarize the effects of the indi- vidual...
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Distinct hippocampal-prefrontal neural assemblies coordinate memory encoding, maintenance, and recall
PublicationShort-term memory enables incorporation of recent experience into subsequent decision-making. This processing recruits both the prefrontal cortex and hippocampus, where neurons encode task cues, rules, and outcomes. However, precisely which information is carried when, and by which neurons, remains unclear. Using population decoding of activity in rat medial prefrontal cortex (mPFC) and dorsal hippocampal CA1, we confirm that mPFC...
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Problems of exact generation ofinverter output voltage
PublicationW pracy przedstawiono nową modyfikację modulatora szerokości impulsów. Rozważono problemy generacji dokładnej wartości napięcia wyjściowego falownika. Zaproponowano dwie metody generacji małej wartości napięcia.
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Bearing estimation using double frequency reassignment for a linear passive array
PublicationThe paper demonstrates the use of frequency reassignment for bearing estimation. For this task, signals derived from a linear equispaced passive array are used. The presented method makes use of Fourier transformation based spatial spectrum estimation. It is further developed through the application of two-dimensional reassignment, which leads to obtaining highly concentrated energy distributions in the joint frequency-angle domain...
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Analysis of AC/DC/DC Converter Modules for Direct Current Fast-Charging Applications
PublicationThe paper is a comprehensive laboratory comparison study of two galvanic isolated solution off-board battery chargers: (1) Si-based cost-effective case, and (2) SiC-bidirectional ready for vehicle to grid concept case. All circuits are modular, and in both cases the DC/DC converter can be replaced according to the end user requirements (the coupled transformer remains the same and is constructed based on 12xC100 cores to avoid...
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Enhanced Activity of P4503A4 and UGT1A10 Induced by Acridinone Derivatives C-1305 and C-1311 in MCF-7 and HCT116 Cancer Cells: Consequences for the Drugs’ Cytotoxicity, Metabolism and Cellular Response
PublicationActivity modulation of drug metabolism enzymes can change the biotransformation of chemotherapeutics and cellular responses induced by them. As a result, drug-drug interactions can be modified. Acridinone derivatives, represented here by C-1305 and C-1311, are potent anticancer drugs. Previous studies in non-cellular systems showed that they are mechanism-based inhibitors of cytochrome P4503A4 and undergo glucuronidation via UDP-glucuronosyltranspherase...
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High Frequency Harmonics Emission in Smart Grids
PublicationPulse-width modulated rectifiers are nowadays commonly used for AC to DC power conversion. PWM rectification technology is very effective and allows for bidirectional power flow with the possibility of power factor improvement and low-order harmonic emission limitation. Unfortunately, employed PWM boost topology results with generation of input current harmonic distortions in a frequency range tightly correlated to modulation frequency....
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Low Frequency Conducted Emissions of Grid Connected Static Converters
PublicationPulse-width modulated rectifiers are nowadays commonly used for AC to DC power conversion. PWM rectification technology is very effective and allows for bidirectional power flow with the possibility of power factor improvement and low-order harmonic emission limitation. Unfortunately, employed PWM boost topology results with generation of input current harmonic distortions in a frequency range tightly correlated to modulation frequency....
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The effects of gas exposure on the graphene/AlGaN/GaN heterostructure under UV irradiation
PublicationThis work demonstrates a graphene/AlGaN/GaN sensing device with two-dimensional electron gas (2DEG) toward nitrogen dioxide (NO2), tetrahydrofuran, and acetone detection under UV light irradiation. We propose combining measurements of the DC characteristics with a fluctuation-enhanced sensing method to provide insight into the gas detection mechanisms in the synergistic structure of highly stable GaN and gas-sensitive graphene....
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Four Level Diode-Clamped Back-To-Back Converter with Active DC Link Voltage Control
PublicationThis article presents the design and control of 4L-DC back-to-back converter. To solve the DC link voltage balancing problem in four-level converter a new three-level double chopper topology based on PO-PWM modulation was designed and successfully tested. Also, the paper describes two phase space vector pulse width modulation 2P-SVPWM based on the shape function of finite elements. The control structure with modified Dead-Beat...
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Molecular basis and potential activity of HIV-1 reverse transcriptase toward trimethylamine-based compounds
PublicationReverse transcriptase (RT) inhibitors are currently used to treat human immunodeficiency virus (HIV)-1 infections. In this work, novel triethylamine derivatives were designed and studied by rigid and flexible docking and molecular dynamics (MD) approaches. An apo form of HIV-1 RT was also studied by MD simulation to analyze comparative response of protein in ligand-bound and ligand-unbound forms. Among newly designed HIV-1 RT inhibitors,...
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Estimation of interior-permanent-magnet-synchronous-motor rotor position by analysis of phase-current derivatives
PublicationThis paper describes an algorithm for estimation of IPMSM rotor angular position. The algorithm uses derivatives of motor phase currents resulting from PWM modulation to obtain the rotor position. The presented method is designed for medium- and high-speed range, since it is based on determination of the EMF vector. Calculation of the motor position is performed in every PWM cycle. The standard SV-PWM method is used to determine...
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An Extended Control of the Input Angle for Matrix Converters Connected with the Non-Unity Power Factor Loads.
PublicationThis paper proposes a novel PWM modulation algorithm for Multiphase Conventional Matrix Converters (MCMC), with 3 inputs and k outputs, using the transfer function of the load angle. The proposed approach extends the range of power angle control at the input during the operation with a maximum voltage transfer ratio. The proposed concept is based on the Direct Analytic Voltage PWM (DAV--PWM) modulation with an elliptical trajectory...
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Characterization of corrosion in reinforced concrete beams using destructive and non-destructive tests
PublicationThe paper presents both non-destructive and destructive experimental tests on steel-reinforced concrete beams subjected to electrochemical corrosion. To examine the condition and behavior of the specimens, destructive tests were carried out, i.e., a three-point bending together with a modulated ultrasonic wave test. In addition, a series of non-destructive experiments were conducted, such as the potential measurement method, low-frequency...
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Identification of aromatic compounds in odours mixture by gas chromatography and field olfactometry techniques
PublicationThis paper shows the results of investigation on identification aromatic compounds present in odorous mixture in atmospheric air samples collected in a vicinity of the oil refinery LOTOS S.A., located in Gdansk, during March and April period have be presented. The studies were conducted by the use of comprehensive two-dimensional gas chromatograph equipped with a cryogenic modulator and coupled with a time-of-flight mass spectrometer,...
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Pomiary grubości cienkich warstw metodą modulacji chromatycznej.
PublicationTematem artykułu jest pomiar grubości struktur cienkowarstwowych szerokostosowanych w optoelektronice, transparentnych warstw dielektrycznych. Grubość jest najistotniejszym parametrem warstwy i determinuje jej właściwościoptyczne. Metoda pomiaru grubości cienkich warstw powinna być bezkontaktowa, nieniszcząca, niekosztowna oraz odporna na zakłócenia
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IPMSM rotor position estimator based on analysis of phase current derivatives
PublicationThis paper describes an algorithm for estimation of IPMSM angular rotor position. The algorithm uses derivatives of motor phase currents resulting from PWM modulation to obtain the rotor position. The presented method is designed for medium- and high-speed range, since it is based on determination of the EMF vector. Algorithm is characterised by a very simple formulae. The calculation of rotor position is performed in every PWM...
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Modified SPWM Technique with Zero-Sequence Voltage Injection for a Five-Phase, Three-Level NPC Inverter
PublicationThis article presents a modified sinusoidal pulse-width modulation (SPWM) scheme for a five-phase, three-level neutral-point-clamped inverter. The modulation scheme deploys a modified min–max function to inject the zero-sequence components into the reference modulating signals; hence enabling the effective utilization of the DC-link voltage. Balanced split-input DC-link voltages were achieved through further incorporation of adjustable...
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Increasing the Utilization of dc-link Voltage of a Five-Leg VSI Based on Rotor Angle Control of Dual Induction Motors
PublicationThis paper introduces an increased utilization of the dc-link voltage of a five-leg voltage source inverter (VSI) based on the rotor flux angle control technique for dual induction motors, IM. The main purpose is to utilize additional abilities provided by a multi-motor drive system in limited operating conditions. Generally, a multi-motor drive system is widely used in electric vehicles (EVs), traction systems and in several industrial...
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Kompletna dwuwymiarowa chromatografia gazowa - nowoczesne narzędzie analityczne
PublicationW pracy przedstawiono informacje o:- zasadzie działania wielowymiarowego chromatografu gazowego;- opisie procesu rozdzielania dla techniki GCxGC;- budowie modulatorów jako niezbędnego elementu zestawu do GCxGC.
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Układy antenowe MIMO w telekomunikacji bezprzewodowej.
PublicationPrzedmiotem pracy są podstawy techniki zbiorczego nadawania i odbioru dla przyszłych systemów telekomunikacji bezprzewodowej. Przedstawiono genezę powstania koncepcji MIMO oraz opisano w sposób systemowy tor transmisyjny rozwiązania użytkowego tej koncepcji. Scharakteryzowano działanie poszczególnych bloków tego toru, w szczególności podano macierze sygnałowe różnych rodzajów modulatora przestrzenno-czasowego.