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Search results for: ASPERGILLUS FUMIGATUS, AZOLE RESISTANCE, CYP51A
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Active Linear Tunable Resistance Element and Application to Feedforward Linearization of CMOS Transconductance Amplifier
PublicationW pracy przedstawiono koncepcję układową przestrajalnego rezystora liniowego MOS wykorzystującego tranzystory pracujące w zakresie triodowym. Opracowana struktura, jak wykazały symulacje komputerowe, charakteryzuje się dobrymi właściwościami zarówno jeżeli chodzi o zakres przestrajania jak i liniowość charakterystyk przejściowych. Pozwoliło to efektywnie wykorzystać prezentowany element do linearyzacji operacyjnego wzmacniacza...
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Metabolic transformations of antitumor imidazoacridinone, C-1311, with microsomal fractions of rat and human liver
PublicationWykazano, że enzymatyczna aktywacja jest konieczna dla aktywności biologicznej pochodnej C-1311 (Symadex R), która znajduje się w II fazie badań klinicznych. Zbadano przemiany enzymatyczne tego związku w obecności frakcji enzymatycznych mikrosomalnych komórek wątroby szczura i ludzkiej. Badania te wykazały, że związek C-1311 jest bardziej podatny na przemiany w obecności frakcji mikrosomalnej niż S9 i cytozolowej. Inkubacja związku...
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Psychological consequences of multiple sclerosis and assistance possibilities
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Morphology and degradation of polyurehanes in different environments.
PublicationW pracy przedstawiono wyniki badań degradacji poli(estro-uretanów) (PEsUA i PEsUB) oraz poli(etero-uretano-mocznika)(PEtUU) w roztworach buforowych o zmiennym pH (168 godz., 70 oC), w środowisku trypsyny (37 oC, 1 m-c), Aspergillys niger (12 m-cy), kompoście z osadem czynnym (12 m-cy) i w wodzie morskiej (12 m-cy). Analizowano zmiany w morfologii i właściwościach fizykomechanicznych. Ustalono następujące sekwencje w zmianach zależności...
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The effect of cabbage juice and it's active components on the protein level and expression of CYP19 in MCF-7 breast cancer cells
PublicationWiadomo, że bioaktywne skladniki kapusty mają chemoprewencyjne działanie w przypadku nowotworów piersi, między innymi ze względu na hamowanie aktywności enzymu aromatazy uczestniczącego w biosyntezie estrogenów. Badania prowadzono przy użyciu komórek raka piersi i stwierdzono, że soki z kapusty, zarówno pochodzącej z uprawy ekologicznej jak i przemysłowej, znacząco hamowały ekspresję genu CYP19 kodującego wspomniany enzym. Sugeruje...
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Izoenzymy cytochromu P450 w metabolizmie związków endo- i egzogennych.
PublicationCytochromy P450 (CYP) należą do enzymatycznych białek hemowych występujących we wszystkich organizmach żywych. W komórkach eukariotycznych katalizują biosyntezę związków endogennych, głównie lipidów i ich pochodnych, ale także metabolizm ksenobiotyków, w tym leków. W reakcjach tych substraty ulegają C-oksydacji (hydroksylacja, epoksydacja, peroksydacja), N-oksydacji, S-oksydacji oraz oksydacyjnej O-, S-, i N-dealkilacji. W konsekwencji...
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Estimation of Screw Displacement Pile-Bearing Capacity Based on Drilling Resistances
PublicationThis article presents an engineering, empiricalmethod of estimating the bearing capacity and settlementcharacteristics Q-s of screw displacement piles andcolumns, based on soil resistance encountered during thedrilling to form piles/columns in the ground. The methodwas developed on the basis of correlation analyses of thetest results of 24 piles made during the “DPDT-Auger”research project (Krasiński et al., 2022a). In the proposedmethod,...
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Novel Baroreflex Activation Therapy in Resistant Hypertension
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Starter cultures as a reservoir of antibiotic resistant microorganisms
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Unilateral Carotid Body Resection in Resistant Hypertension
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Reactive metabolites of acridinone antitumor agents, C-1311 and C-1305, are trapped within the active site of CYP1A2 and CYP3A4, causing irreversible enzymes inactivation
PublicationZwiązki C-1305 i C-1311, zsyntetyzowane w Katedrze Technologii Leków i Biochemii, wykazują najsilniejsze właściwości przeciwnowotworowe wśród pochodnych, odpowiednio, triazolo- i imidazoakrydonu. Obecnie prowadzone są badania mające na celu określenie biochemicznego mechanizmu działania, jak również potencjalnych szlaków biotransformacji C-1305 i C-1311.W bieżącym etapie podjęto próbę określenia mechanizmu obserwowanej inhibicji...
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Does the chemical modification of Nystatin A1 affect the drug's ability to overcome the multidrug resistance of fungi?
PublicationAlthough the contemporary medicine keeps moving forward, disseminated infections caused by fungal pathogens are an emerging challenge. The dramatic rise of fungal diseases, especially the most life-threatening systemic mycoses is associated with a permanently growing number of immunodeficient patients. Undoubted difficulties in the treatment of fungal infections are caused by lack of highly effective and selective antifungal drugs,...
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Analysis of miRNA expression associated with gene Lr34 responsible for resistance mechanisms to wheat leaf rust
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Relieving the Measuring System of the Trailer for Tyre/Road Rolling Resistance Measurements from the Inertia Force
PublicationIn the article the principle of measuring of tyre/road rolling resistance tyres in road conditions applied in a special measuring trailer is presented. This trailer was built in Faculty of Mechanical Engineering at Gdansk University of Technology. The construction of two special devices used in this trailer was discussed. These devices eliminate the influence of some chosen confounding measurements factors such as: the inertia...
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The effect of the wood temperature upon specific cutting resistance during machining with narrow-kerf saws
PublicationW pracy przedstawiono wyniki badań eksperymentalnych właściwego powierzchniowego oporu skrawania drewna sosny w funkcji wilgotności drewna, temperatury drewna oraz prędkości posuwu podczas przecinania cienkimi piłami. Proces cięcia prowadzono na pilarce ramowej wielopiłowej PRW15M. Sosnowe próbki przed badaniami mrożono w komorze klimatycznej - temperatura drewna -5 C deg., -20 C deg., +20 C deg. Czas wymrażania przed próbami określano...
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Virulence and Drug-Resistance of Staphylococcus aureus Strains Isolated from Venous Ulcers in Polish Patients
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Effects of Laser Remelting at Cryogenic Conditions on Microstructure and Wear Resistance of the Ti6Al4V Alloy Applied in Medicine
PublicationThe titanium and its alloys can be subjected to surface treatment, including laser treatment. In this work a new laser treatment at cryogenic conditions of Ti6Al4V alloy has been described. The work has been aimed at establishing whether such surface treatment could be suitable for implants working under wear in biological corrosive environment. The remelting has been made with the use of CO2 continuous work laser at laser power...
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Resistance changes of carbon nanotubes decorated with platinum nanoparticles in the presence of hydrogen at different and constant concentrations
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Increased Expression of Several Collagen Genes is Associated with Drug Resistance in Ovarian Cancer Cell Lines
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Contrast Tempo of Movement and Its Effect on Power Output and Bar Velocity During Resistance Exercise
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Antibiotic Resistance of Uropathogens Isolated from Patients Hospitalized in District Hospital in Central Poland in 2020
PublicationThe aim of this study was to determine antibiotic resistance patterns and the prevalence of uropathogenes causing urinary tract infections (UTIs) in patients hospitalized in January–June 2020 in central Poland. Antimicrobial susceptibility testing was performed using the disk-diffusion method. Escherichia coli (52.2%), Klebsiella pneumoniae (13.7%), Enterococcus faecalis (9.3%), E. faecium (6.2%), and Proteus mirabilis (4,3%) were...
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Removal of selected sulfonamides and sulfonamide resistance genes from wastewater in full-scale constructed wetlands
PublicationSulfonamides are high-consumption antibiotics that reach the aquatic environment. The threat related to their presence in wastewater and the environment is not only associated with their antibacterial properties, but also with risk of the spread of drug resistance in bacteria. Therefore, the aim of this work was to evaluate the occurrence of eight commonly used sulfonamides, sulfonamide resistance genes (sul1–3) and integrase genes...
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Recycled polyethylene and crumb rubber composites modified asphalt with improved aging resistance and thermal stability
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A new method of fault loop resistance measurement in low voltage systems with residual current devices
PublicationThis paper presents a new method of fault loop resistance measurement in low voltage systems with residual current devices. The method enables measuring fault loop resistance without nuisance tripping of residual current devices, by application an unconventional waveform of measurement current. It is important for proper verification of the effectiveness of protection against electric shock.
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Antimicrobial resistance of Pseudomonas spp. isolated from wastewater and wastewater-impacted marine coastal zone
PublicationIn this study, species distribution and antimicrobial susceptibility of cultivated Pseudomonas spp. were studied in influent (INF), effluent (EFF), and marine outfall (MOut) of wastewater treatment plant (WWTP). The susceptibility was tested against 8 antimicrobial classes, active against Pseudomonas spp.: aminoglycosides, carbapenems, broad-spectrum cephalosporins from the 3rd and 4th generation, extended-spectrum penicillins,...
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Fabrication, Microstructure and High Temperature Corrosion Resistance of Porous Alloys for Solid Oxide Fuel Cells
PublicationPorous alloys find use in modern Solid Oxide Fuel Cells as the supporting structures. As they are exposed to high temperatures (> 500°C) an oxide scale forms on their surface due to high temperature corrosion phenomena. Since the ratio between the surface area and volume is much higher than for planar samples, formation of the oxide can lead to a breakaway oxidation after relatively short times. Therefore corrosion properties of...
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ANALYSIS OF ROLLING RESISTANCE OF TIRES WITH RUN FLAT INSERT APPLYING DRUM METHOD AND RADIAL CHARACTERISTIC
PublicationThis paper presents analysis of rolling resistance of tires with RUN FLAT insert applying drum method and radial characteristic. The conducted studies indicated changes in operational properties of wheel, occurring as a result of inflation pressure drop in the wheel. As regards radial elasticity, such changes result in significant drop of radial rigidity and increase of static deflection and increase of tire rolling resistance....
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Non-Pharmacological Treatments for Insulin Resistance: Effective Intervention of Plant-Based Diets—A Critical Review
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The impact of resistance exercise range of motion on the magnitude of upper-body post-activation performance enhancement
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Comparison of buckling resistance of columns modelled by beam and shell elements using non-linear analysis
PublicationThe aim of the paper is to investigate the stability process in the axially compressed columns modelled by beam and shell elements using static and dynamic finite element analysis by taking both the geometric and material non-linearity into account. The perfect columns and columns with geometric imperfections were analysed. The differences between the results of static and dynamic analyses in shell and beam models were discussed.
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Noise and Rolling Resistance Properties of Various Types of Winter Tyres Compared to Normal Car Tyres
PublicationTo cope with winter weather conditions, potentially including snow and ice, it is common to use winter tyres, or ”all-seasons” tyres assumed to be safe both in summer and winter. In some northern countries, winter tyres are mandatory. Traditionally, it has been assumed that winter tyres are noisier than normal tyres (here called summer tyres) and winter tyres equipped with studs are assumed to be very noisy.This paper presents...
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Scuffing and rolling contact fatigue resistance of discrete laser spot hardened austempered ductile iron
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The problems of resistance to scuffing of heavily loaded lubricated friction joints with WC/C-coated parts
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Effect of the Post-Weld Surface Condition on the Corrosion Resistance of Austenitic Stainless Steel AISI 304
PublicationSurfaces of welded elements made of corrosion-resistant (stainless) steels develop temper colours. The removal of thickened oxide layers off steels exposed to temperatures below 300°C is necessary and entails the restoring of high corrosion resistance of the stainless steel. The article presents tests concerned with the effect of a method applied to remove post-weld temper on the corrosion resistance of austenitic stainless steel...
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Buckling resistance of a metal column in a corrugated sheet silo - experiments and non-linear stability calculations
PublicationThe results of experimental and numerical tests of a single corrugated sheet silo column’s buckling resistance are presented in this study. The experiments were performed in a real silo with and without bulk solid (wheat). A very positive impact of the bulk solid on the column buckling resistance occurred. The experimental results were first compared to the buckling resistance calculated by Eurocode 3 formulae. The comparison revealed that...
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The Significance of MicroRNAs Expression in Regulation of Extracellular Matrix and Other Drug Resistant Genes in Drug Resistant Ovarian Cancer Cell Lines
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Parallel implementation of a Sailing Assistance Application in a Cloud Environment
PublicationSailboat weather routing is a highly complex problem in terms of both the computational time and memory. The reason for this is a large search resulting in a multitude of possible routes and a variety of user preferences. Analysing all possible routes is only feasible for small sailing regions, low-resolution maps, or sailboat movements on a grid. Therefore, various heuristic approaches are often applied, which can find solutions...
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Corrosion and Cavitation Resistances of Low Alloy Steel After Frictional-Mechanical Treatment
PublicationPaper presents the results of the studies of wear, corrosion and cavitation resistances of the S355J2 low alloy medium carbon steel subjected to surface modification by friction-mechanical treatment, as tested in sea water simulated solution. To evaluate the effect of the surface treatment, the comparative studies of the corrosive properties of the steel before and after treatment have been considered. The treatment due to a severe...
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Technical and Training Related Aspects of Resistance Training Using Blood Flow Restriction in Competitive Sport - A Review
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Fatigue resistance investigation of the IC engine MB11 bearings, working under conditions of dynamic unidirectional loadings
PublicationThe slide bearing material MB11 fatigue resistance has been investigated with the application of SMOK - test stand in which dynamic unidirectional loadings to the test bearing is generated. Slide bearing layer consists of the bronze MB11 ( Cu Pb22 Sn 3 ) sintered to the steel shell. Each of the tested bearing has been subject to the standard 20-hour test, under conditions of the full fluid lubrication. Methodology of the experiments,...
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Application possibilities of the low-temperature repairs on creep-resistance turbine components from material GX23CrMoV12-1
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Impact analysis of surface roughness of the plate-plate measuring system on resistance torque in interaction with MR fluid
PublicationMagnetorheological (MR) fluids are complex suspensions of magnetic particles in a non-magnetic carrier fluid. They exhibit ‘smart’ properties that enable them to change their rheological parameters in response to a change in the external magnetic field applied. This behavior is used in some engineering solutions, e.g. MR clutches or brakes. For such systems to work correctly, the resistance torque achieved by contact with the...
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Selected metrological aspects of permeation cells used for testing the resistance of polymeric materials to penetration by liquid chemicals
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Analysis of miRNA expression associated with the Lr46 gene responsible for APR resistance in wheat (Triticum aestivum L.)
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Associative and Physical Mapping of Markers Related to Fusarium in Maize Resistance, Obtained by Next-Generation Sequencing (NGS)
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Corrosion resistance examinations of Ti6Al4V alloy with the use of potentiodynamic method in Ringer`s and artificial saliva solutions
PublicationThe research results of corrosion resistance of the Ti6Al4V alloy in the simulated body fluids (SBF) are presented. The polished specimens have shown better corrosion resistance than grinded surfaces in both liquids. The artificial saliva has revealed more aggressive test solution than Ringer`s solution. The pitting tendency has been observed in Ringer`s solution for grinded specimens.
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Functional Interfaces, Biological Pathways, and Regulations of Interferon-Related DNA Damage Resistance Signature (IRDS) Genes
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Corrigendum: Contrast Tempo of Movement and Its Effect on Power Output and Bar Velocity During Resistance Exercise
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Effect of plasma nitriding process on the fatigue and high temperature corrosion resistance of Inconel 740H nickel alloy
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The ability to overcome multidrug resistance of tumor cell lines by novel acridine cytostatics with condensed heterocyclic rings
PublicationZbadano aktywność cytotoksyczną, in vitzo dwóch nowych grup cytostatyków akrydynowych zawierających skondensowane pierścienie heterocykliczne w stosunku do komórek nowotworowych linii wrażliwych i opornych. Otrzymane wyniki potwierdziły naszą wcześniejszą hipotezę o istotnej roli pierścieni hetero-cyklicznych w pokonywaniu krzyżowej oporności wielolekowej.