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Search results for: AGENT GRID
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Prophylaxis of Non-communicable Diseases: Why Fruits and Vegetables may be Better Chemopreventive Agents than Dietary Supplements Based on Isolated Phytochemicals?
PublicationThe World Health Organization (WHO) report from 2014 documented that non-communicable socalled civilization diseases such as cardiovascular disease, chronic respiratory diseases, cancer or type 2 diabetes are responsible for over 50% of all premature deaths in the world. Research carried out over the past 20 years has provided data suggesting that diet is an essential factor influencing the risk of development of these diseases....
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Role of Human UDP-Glucuronosyltransferases in the Biotransformation of the Triazoloacridinone and Imidazoacridinone Antitumor Agents C-1305 and C-1311 : Highly Selective Substrates for UGT1A10
Publication5-Diethylaminoethylamino-8-hydroxyimidazoacridinone, C-1311 (NSC-645809), is an antitumor agent shown to be effective against breast cancer in phase II clinical trials. A similar compound, 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone, C-1305, shows high activity against experimental tumors and is expected to have even more beneficial pharmacological properties than C-1311. Previously published studies showed that these...
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Student model representation for pedagogical virtual mentors
PublicationThe paper concerns technological aspects of virtual mentors construction, especially concentrating on the student model representation. The article distinguishes several types of information that is gathered by the pedagogical agents and other educational platforms, including student knowledge model, student progress tracking, interaction process patterns and learner preferences. A set of technologies used for the student model...
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Optimization and Modeling of Cr (VI) Removal from Tannery Wastewater onto Activated Carbon Prepared from Coffee Husk and Sulfuric Acid (H2SO4) as Activating Agent by Using Central Composite Design (CCD)
PublicationThe primary goal of this research is to lower the hexavalent chromium (Cr (VI)) concentration that has occurred from the growth of the tannery industry. As a result, the potential for heavy metal concentration is increasing day by day. Industrial effluent containing Cr (VI) contributes significantly to water pollution. Chromium hexavalent ion (Cr (VI)) in wastewater is extremely hazardous to the environment. It is critical to address...
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Handelingen der Maatschappij voor Geschiedenis en Oudheidkunde te Gent
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Algorithms and Tools for Intelligent Control of Critical Infrastructure Systems
PublicationCritical Infrastructure Systems (CIS) are spatially distributed and of a network structure. The dynamics are nonlinear, uncertain and with several time scales. There is a variety of different objectives to be reliably met under a wide range of operational conditions. The operational conditions are influenced by the disturbance inputs, operating ranges of the CIS, faults in the sensors and actuators and abnormalities occurring in...
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Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice
PublicationThe ear pinna is a complex tissue consisting of the dermis, cartilage, muscles, vessels, and nerves. Ear pinna healing is a model of regeneration in mammals. In some mammals, including rabbits, punch wounds in the ear pinna close spontaneously; in common-use laboratory mice, they remain for life. Agents inducing ear pinna healing are potential regenerative drugs. We tested the effects of selected bioactive agents on 2 mm ear pinna...
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Modelowanie i ograniczanie skutków ataków uzurpacji uprawnień w systemach teleinformatycznych wspierających różnicowanie poziomu QoS
PublicationW wieloagentowych systemach teleinformatycznych pracujących w paradygmacie Klient-Serwer i wspierających różnicowanie poziomu QoS poważnym zagrożeniem są ataki uzurpacji uprawnień metodą Fałszywego VIPa. Ich celem jest zapewnienie Klientowi nienależnie wysokiego poziomu QoS, co powoduje nadużycie zasobów Serwera i szkody dla innych Klientów. W referacie podjęto próbę sforma-lizowania modelu takich ataków oraz zaproponowa-no obustronnie...
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INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
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Nanoemulsion Structural Design in Co-Encapsulation of Hybrid Multifunctional Agents: Influence of the Smart PLGA Polymers on the Nanosystem-Enhanced Delivery and Electro-Photodynamic Treatment
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Essential Oils, Silver Nanoparticles and Propolis as Alternative Agents Against Fluconazole Resistant Candida albicans, Candida glabrata and Candida krusei Clinical Isolates
PublicationDevelopment of effective and safe therapeutic treatment of fungal infections remains one of the major challenge for modern medicine. The aim of presented investigation was to analyze the in vitro antifungal activity of selected essential oils, ethanolic extracts of propolis and silver nanoparticles dropped on TiO2 against azole-resistant C. albicans (n = 20), C. glabrata (n = 14) and C. krusei (n = 10) clinical isolates. Among...
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Cancer stem cells in drug resistance and drug screening: can we exploit the cancer stem cell paradigm in search for new antitumor agents?
PublicationPraca przedstawia przegląd literatury dotyczącej hipotezy komórek pierwotnych nowotworu, w szczególności w ich oporności na istniejące terapie. Dyskutowane jest także zagadnienie możliwości wykorzystania wiedzy o tych komórkach do konstrukcji nowych testów do badań przesiewowych in vitro w celu poszukiwania nowych leków przeciwnowotworowych.
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CYP3A4-dependent cellular response does not relate to CYP3A4-catalysed metabolites of C-1748 and C-1305 acridine antitumor agents in HepG2 cells
PublicationHigh CYP3A4 expression sensitizes tumor cells to certain antitumor agents while for others it can lower their therapeutic ef fi cacy. We have elucidated the in fl uence of CYP3A4 overexpression on the cellular response induced by antitumor acridine derivatives, C-1305 and C-1748, in two hepatocellular carcinoma (HepG2) cell lines, Hep3A4 stably transfected with CYP3A4 isoenzyme, and HepC34 expressing empty vector. The compounds...
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Elucidation of chemical compounds in different extracts of two Lavandula taxa and their biological potentials: Walking with versatile agents on the road from nature to functional applications
PublicationDue to their health-promoting and nutraceutical properties, lavenders are frequently employed in the food and pharmaceutical industries. Here, we focused on investigate the chemical profile of hexane, MeOH, and water extracts of leaf, flower, and root of L. pedunculata and L. stoechas and to assess their antioxidant, enzyme inhibitory, and antibacterial properties. The highest total polyphenolic and flavonoids contents were recorded...
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Inteligentne hybrydowe systemy wyszukiwania informacji
PublicationIstnieje wiele metod wyszukiwania informacji. Artykuł przedstawia możliwości połączenia tych metod i skonstruowania uniwersalnego, hybrydowego systemu wyszukiwania. W artykule zaproponowana została architektura personalnego agenta wyszukiwania (PAW). Posiada on cechy systemu ekspertowego, wyszukiwarki oraz agenta komputerowego. PAW pozwala na pozyskiwanie informacji personalnych tj. numery telefonów osób znajomych. Ponadto umożliwia...
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Optymalizacja strategii sieci inteligentnych agentów za pomocą programowania genetycznego w systemie rozproszonym realizującym paradygmat volunteer computing
PublicationDynamicznie rosnąca złożoność i wymagania w odniesieniu do rozproszonych systemów informatycznych utrudnia zarządzanie dostępnymi zasobami sprzętowymi i programistycznymi. Z tego powodu celem rozprawy jest opracowanie wielokryterialnej metody programowania genetycznego, która pozwala na optymalizację strategii zespołu inteligentnych agentów programistycznych w zakresie zarządzania systemem realizującym paradygmat volunteer computing....
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Piotr Jaskuła dr hab. inż.
PeopleI am a Faculty member (Associate Professor, Highway and Transportation Research Department) at the Faculty of Civil and Environmental Engineering, Gdansk University of Technology, Poland).My main research interests include: pavement structures, interlayer bonding, pavement materials, recycling of road pavements, asphalt mixtures, bitumens, construction and maintenance of pavement structures.My lectures at the University include:...
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Inteligentne systemy agentowe w systemach zdalnego nauczania
PublicationW pracy omówiono inteligentne systemy agentowe w systemach zdalnego nauczania. Po krótkim przedstawieniu ewolucji systemów zdalnego nauczania i ich wybranych zastosowań, scharakteryzowano inteligentne agenty edukacyjne. Omówiono wykorzystanie programowania genetycznego oraz algorytmów neuro-ewolucyjnych do implementacji oprogramowania tej klasy. Ponadto, nawiązano do modelu Map-Reduce, który efektywnie wspiera architekturę nowoczesnego...
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Acridinone antitumor agents: C-1311, C-1330 and C-1305 are metabolized by flavin-containing monooxygenase isoenzymes: FMO1, FMO3 and FMO5 with different rates
PublicationRekombinantowe ludzkie monooksygenazy flawinowe: FMO1, FMO3, FMO5 indukują przemiany metaboliczne wybranych do badań pochodnych akrydonu. Biotransformacja związków C-1311, C-1330 i C-1305 przez FMO prowadzi do jednego produktu o strukturze N-tlenku. Wyniki badań wskazują, że najbardziej podatna na przemiany wobec FMO jest pochodna triazoloakrydonu C-1305. Wydaje się więc, że głównymi enzymami pierwszej fazy przemian metabolicznych...
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Modulation of UDP-glucuronidation by acridinone antitumor agents C-1305 and C-1311 in HepG2 and HT29 cell lines, despite slight impact in noncellular systems.
PublicationBackground Among the studied antitumor acridinone derivatives developed in our laboratory, 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305) and 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) exhibited cytotoxic and antitumor properties against several cancer types and were selected to be evaluated in preclinical and early-phase clinical trials. In the present work, we investigated the impact of C-1305...
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Down-regulation of DNA topoisomerase IIalpha leads to prolonged cell cycle transit in G2 and early M phases and increased survival to microtubule-interacting agents
PublicationInhibitory polimeryzacji mikrotubul wykazują preferencyjną toksyczność wobec komórek mitotycznych. W ramach tego projektu badaliśmy czy oporność komórek ludzkich białaczek na inhibitor mikrotubul, winkrystynę, prowadzi do zmian w regulacji progresji cyklu komórkowego. Nasze wyniki wskazują, że oporności na winkrystynę towarzyszą zmiany w długości fazy G2 i M w nieobecności i obecności inhibitora wrzeciona mitotycznego, nokodazolu....
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Reactive metabolites of acridinone antitumor agents, C-1311 and C-1305, are trapped within the active site of CYP1A2 and CYP3A4, causing irreversible enzymes inactivation
PublicationZwiązki C-1305 i C-1311, zsyntetyzowane w Katedrze Technologii Leków i Biochemii, wykazują najsilniejsze właściwości przeciwnowotworowe wśród pochodnych, odpowiednio, triazolo- i imidazoakrydonu. Obecnie prowadzone są badania mające na celu określenie biochemicznego mechanizmu działania, jak również potencjalnych szlaków biotransformacji C-1305 i C-1311.W bieżącym etapie podjęto próbę określenia mechanizmu obserwowanej inhibicji...
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Harmony Search for Data Mining with Big Data
PublicationIn this paper, some harmony search algorithms have been proposed for data mining with big data. Three areas of big data processing have been studied to apply new metaheuristics. The first problem is related to MapReduce architecture that can be supported by a team of harmony search agents in grid infrastructure. The second dilemma involves development of harmony search in preprocessing of data series before data mining. Moreover,...
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Integrated monitoring, control and security of Critical Infrastructure Systems
PublicationModern societies have reached a point where everyday life relies heavily on desired operation of critical infrastructures, in spite of accidental failures and/or deliberate attacks. The issue of desired performance operation of CIS at high security level receives considerable attention worldwide. The pioneering generic methodologies and methods are presented in the paper project for designing systems capable of achieving these...
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Chitosan, Collagen and Gelatin in the design of novel materials with antimicrobial acticity
PublicationMedical devices containing and releasing antiinfective agents directly on the site of injury are a common group of materials available and widely used in treating difficult to heal wounds. Sustained contact of the active agent to the damaged tissue, needed to inhibit infection and preservation of microbiological purity of the wound, is provided by the immobilization antimicrobial agents on the surface of the matrix material or...
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AUTOMATED NEGOTIATIONS OVER COLLABORATION PROTOCOL AGREEMENTS
PublicationThe dissertation focuses on the augmentation of proactive document - agents with built-in intelligence to recognize execution context provided by devices visited during a business process, and to reach collaboration agreement despite conflicting requirements. The proposed solution, based on intelligent bargaining using neural networks to improve simple multi-issue negotiation between the document and thedevice, requires practically...
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Synchronizacja wiedzy w systemach agentowych
PublicationAgenty inteligentne są jednym z komponentów stosowanych w pro- jektowaniu rozproszonych inteligentnych systemów obliczeniowych. W rozdziale wskazano istotne aspekty systemów agentowych, a na- stępnie omówiono wybrane metody synchronizacji wiedzy między agentami będącymi częścią systemu agentowego. Omówiono podej- ście właściwe dla agentów zaufanych oraz jego modyfikację dla agen- tów, które mogą celowo próbować wprowadzać inne...
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Jakub Miler dr inż.
PeopleAcademic career: 2000: Master of Science - Gdansk University of Technology, Faculty of Electronics, Telecommunications and Informatics, thesis "Computer system for supporting risk management in a software engineering project", supervisor prof. Janusz Górski 2005: PhD - Gdansk University of Technology, Faculty of Electronics, Telecommunications and Informatics, thesis "A Method of Software Project Risk Identification and Analysis",...
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Waldemar Korłub dr inż.
PeopleWaldemar Korłub obtained an Eng. degree in 2011, MSc.Eng. degree in 2012 and PhD in Computer Science in 2017 granted by the Faculty of Electronics, Telecommunications and Informatics at Gdansk University of Technology. His research interests include: distributed systems mainly grid and cloud computing platforms, autonomous systems capable of self-optimization, self-management, self-healing and self-protection, artificial intelligence...
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Contribution of UDP-glucuronosyltransferases (UGTs) in metabolism of acridinone antitumor agents, C-1311, C-1305, and their less active structural analogues, C-1330 and C-1299
PublicationCelem prowadzonych badań było określenie roli UDP-glukuronylotransferaz, uważanych za najważniejsze enzymy detoksykujące, w metabolizmie pochodnych imidazo- i triazoloakrydonu. Wykazano, że najbardziej aktywne przeciwnowotworowo związki z obu grup, tj. C-1311 i C-1305 są transformowane do O-glukuronidów, w przeciwieństwie do ich metoksylowych analogów, odpowiednio związku C-1330 i C-1299. Analiza składu mieszanin reakcyjnych zawierających...
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Novel 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives as potent anticancer agents – Synthesis, molecular structure, QSAR studies and metabolic stability
PublicationA series of new 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives have been synthesized and evaluated in vitro by MTT assays for their antiproliferative activity against cell lines of colon cancer HCT-116, cervical cancer HeLa and breast cancer MCF-7. The obtained results indicated that these compounds display prominent cytotoxic effect. The best anticancer properties have been observed for derivatives...
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Simulating Malware with MAlSim
PublicationThis paper describes MAlSim - Mobile Agent Malware Simulator - a mobile agent framework developed to address one of the most important problems related to the simulation of attacks against information systems i.e. the lack of adequate tools for reproducing behaviour of malicious software (malware). The framework can be deployed over the network of an arbitrary information system and it aims at simulating behaviour of each instance...
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Simulating malware with MAlSim
PublicationThis paper describes MAlSim - Mobile Agent Malware Simulator - a mobile agent framework developed to address one of the most important problems related to the simulation of attacks against information systems, i.e. the lack of adequate tools for reproducing behaviour of malicious software (malware). The framework can be deployed over the network of an arbitrary information system and it aims at simulating behaviour of each instance...
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The Influence of the Co-Dopant Dexamethasone Phosphate on the Electrodeposition Process and Drug-Release Properties of Polypyrrole-Salicylate on Iron
PublicationIn this work, the influence of incorporation of two anti-inflammatory drugs dexamethasone phosphate and sodium salicylate on the electrodeposition process of polypyrrole (PPy) film on iron has been studied. The incorporation of the agents into PPy has been carried out in a one-step electropolymerization process on oxidizable iron. The role of each drug agent during the deposition process has been discussed. The morphological and...
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Integration of Software Engineering and Agent Technology
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European Workshop on Multi-Agent Systems
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A proposition for integrating elements of game universe by means of behavioral trees
PublicationModern computer games often involve autonomous beings collaborating and competing with each other to reach their objectives in the game universe. It seems only natural to use agent-oriented approach in such cases. This article identifies the rules of building a game universe as an environment for executing agents. The paper also covers a method for decomposing compound behaviors into behavioral trees. Dividing complex behaviors...
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Systemy Agentowe - 2022
e-Learning Courses{mlang pl}Systemy Agentowe{mlang}{mlang en}Agent Systems{mlang}
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Systemy Agentowe - 2023
e-Learning Courses{mlang pl}Systemy Agentowe{mlang}{mlang en}Agent Systems{mlang}
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Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under hypoxia
PublicationInduction of proteins involved in drug metabolism and in drug delivery has a significant impact on drug-drug interactions and on the final therapeutic effects. Two antitumor acridine derivatives selected for present studies, C-1748 (9-(2’-hydroxyethylamino)-4-methyl-1-nitroacridine) and C-1305 (5-dimethylaminopropylamino-8-hydroxy-triazoloacridinone), expressed high and low susceptibility to metabolic transformations with liver...
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JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
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The absorption and fluorescence spectra of C-1305 derivatives (IKE1-IKE8), potential antifungal agents
Open Research DataOptical measurements of C-1305 derivatives (IKE1-IKE8). The absorption spectra were recorded at 300 - 800 nm for solutions with 16 μg / mL derivative concentration. The fluorescence emission spectra were determined at 420-800 nm with the excitation wavelengths 360 or 415 nm for solutions with 1 μg / mL derivative concentration. All measurements were...
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Rola agentów edukacyjnych w środowiskach zdalnego nauczania
PublicationAgent edukacyjny jest inteligentnym i autonomicznym programem, który może być zastosowany w środowiskach kształcenia na odległość. W artykule podano definicję oraz klasyfikację agentów edukacyjnych ze szczególnym wskazaniem na agenty pedagogiczne, których celem jest wsparcie dla zdobywania kompetencji przez uczniów. Wskazano także miejsce agentów w kompleksowych środowiskach nauczania za pośrednictwem Internetu. W artykule omówiono...
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Application of wireless communication to small WECS with induction generator
PublicationWind energy conversion systems (WECS) seem to be self-evident elements of the future smart grids. Among many generator types the squirrel cage induction generator (SCIG) characterizes robustness and low cost. A full-scale power converter can perform smooth grid connection over wide speed range of multiple-stage geared SCIG. Increasing number of sensors can improve the WECS control and diagnostics but increasing number of thin wires...
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Voltage Transients Transfer over Medium Voltage Instrument Transformers
PublicationThis paper presents voltage harmonic transfer accuracy problems through voltage transformers which are used in power quality monitoring systems in medium and high voltage grids. A simplified lumped parameters circuit model of the voltage transformer is proposed and verified by simulation and experimental investigations. A number voltage transformers typically used in medium voltage grid has been tested in the conducted disturbances...
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International Conference on Grid Computing and Applications
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International Conference on Grid and Cooperative Computing
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International Conference on Semantics Knowledge and Grid
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International Workshop on Middleware for Grid Computing
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PL-Grid n/d
ProjectsProject realized in Academic Computer Centre TASK from 2009-06-01