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Search results for: HUMAN NOROVIRUS
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The Effect of Hyperbaric Storage on the Nutritional Value and Retention of Certain Bioactive Proteins in Human Milk
PublicationHuman milk (HM) contains the essential macronutrients and bioactive compounds necessary for the normal growth and development of newborns. The milk collected by human milk banks is stored frozen and pasteurized, reducing its nutritional and biological value. The purpose of this study was to determine the effect of hyperbaric storage at subzero temperatures (HS-ST) on the macronutrients and bioactive proteins in HM. As control samples,...
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Metabolic transformations of antitumor imidazoacridinone, C-1311, with microsomal fractions of rat and human liver
PublicationWykazano, że enzymatyczna aktywacja jest konieczna dla aktywności biologicznej pochodnej C-1311 (Symadex R), która znajduje się w II fazie badań klinicznych. Zbadano przemiany enzymatyczne tego związku w obecności frakcji enzymatycznych mikrosomalnych komórek wątroby szczura i ludzkiej. Badania te wykazały, że związek C-1311 jest bardziej podatny na przemiany w obecności frakcji mikrosomalnej niż S9 i cytozolowej. Inkubacja związku...
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The influence of fresh cabbage and sauerkraut juices on the activity of protective enzymes in human cell lines
PublicationMechanizmami przeciwrakotwórczego działania związków zawartych w kapuście jest m.in. metaboliczna aktywacja enzymów II fazy detoksykacji, indukcja enzymów naprawczych DNA oraz aktywnośc przeciwutleniająca. Do enzymów II fazy odtruwania należą m.in. S-transferazy glutationowe (GST) oraz oksydoreduktaza chinonowa NQO1 zwana też DT-diaforazą. GST katalizują reakcję sprzęgania glutationu z wieloma różnymi typami ksenobiotyków, ułatwiając...
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Human factor and functional Safety analysis = Czynniki ludzkie i analiza bezpieczeństwa funkcjonalnego
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Longitudinal study of vitamins A, E and lipid oxidative damage in human milk throughout lactation
PublicationCelem pracy było zbadanie zmian wartości całkowitego potencjału antyoksydacyjnego (TAS), stężeń witamin antyoksydacyjnych i izoprostanów (markery stresu oksydacyjnego) w siarze i mleku dojrzałym. Badaniami objęto 49 kobiet po pełno terminowej ciąży i naturalnym porodzie. Kryteria wyłączenia to czynne i bierne palenie tytoniu, ostre i przewlekłe schorzeniach oraz farmakoterapia inna niż suplementacja witamin. Próbki siary pobierano...
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MIC1-MAG1-SAG1 chimeric protein, a most effective antigen for detection of human toxoplasmosis
PublicationThis study describes a Toxoplasma gondii IgG ELISA test based on a new chimeric antigen containing three immunodominant regions from MIC1, MAG1 and SAG1 proteins of a parasite and shows that this test is useful for diagnostic purposes and may replace the lysed and whole-cell antigens.
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Determination of Formaldehyde and Cyanide Ion in Human Nasal Discharge by Using Simple Spectrophotometric Methods
PublicationEnvironmental tobacco smoke (ETS) contains many toxic compounds which include substances classified as aldehydes (e.g. formaldehyde) and inorganic substances such as cyanide ions. The information on the determination of these compounds in water is available, but the monitoring data on the level of these substances in human body fluids are still lacking. In this work the procedure for determining cyanide ions and formaldehyde in...
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Metabolic transformations of antitumor imidazoacridinone, C-1311, with microsomal fractions of rat and human liver
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Local anaesthetics upregulate nitric oxide generation in cord blood and adult human neutrophils
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The role of the LB structural loop and its interactions with the PDZ domain of the human HtrA3 protease
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Proteomic-Biostatistic Integrated Approach for Finding the Underlying Molecular Determinants of Hypertension in Human Plasma
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Serum of obstructive sleep apnea patients impairs human coronary endothelial cell migration
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Managing safety of industrial hazardous installations with emphasis on the control systems, interfaces and human factors
PublicationIn the paper a procedure for the layer of protection analysis (LOPA) as a tool to evaluate the risk of accident scenarios occurrence in hazardous installations is outlined. In such installations several protection layers exist. Human operator performance in each layer is unavoidable, but the role and tasks are different and depend on the context of situation. Based on suggestions form literature (EEMUA, CREAM) and own proposals...
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New sorbent materials for selective extraction of cocaine and benzoylecgonine from human urine samples
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Does Human Potentiality Affect IT Professionals’ Organizational Behavior? An Experimental Study in Poland and Germany
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Robust HPLC–MS/MS method for levofloxacin and ciprofloxacin determination in human prostate tissue
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Enhancing human performance in ship operations by modifying global design factors at the design stage
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Optimization of Novel Human Acellular Dermal Dressing Sterilization for Routine Use in Clinical Practice
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IL-22 modulates inflammatory properties of human primary aortic smooth muscle cells
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Public Attitudes toward Biobanking of Human Biological Material for Research Purposes: A Literature Review
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Coexpression of human chorionic gonadotropin beta subunit and its receptor in nontrophoblastic gynecological cancer
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A new approach to modeling of selected human respiratory system diseases, directed to computer simulations
PublicationThis paper presents a new versatile approach to model severe human respiratory diseases via computer simulation. The proposed approach enables one to predict the time histories of various diseases via information accessible in medical publications. This knowledge is useful to bioengineers involved in the design and construction of medical devices that are employed for monitoring of respiratory condition. The approach provides the...
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Human Factors and Functional Safety Analysis in Designing the Control Rooms of Industrial Hazardous Plants
PublicationIn this work some aspects of human factors and functional safety analysis in designing the control rooms of industrial hazardous plants are presented. The “defence in depth” (D-in-D) concept is outlined. Some designing issues of the alarm system (AS) with regard to human factors to be supported using the human reliability analysis (HRA) are discussed. The AS and decision support system (DSS), when properly designed, would contribute...
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New conjugates of tuftsin and muramyl dipeptide as stimulators of human monocytes-derived dendritic cells
PublicationMuramyl dipeptide (MDP) and tuftsin are known biologically active compound displaying a significant influence on various cell populations of innate immune response. MDP, as a fragment of bacterial cell wall, stimulates not only macrophages and monocytes, but also dendritic cells. In contrast, little is known about tuftsin influence on these cells. Therefore it seemed vital to access whether tuftsin or its derivatives conjugated...
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Pre-analytical aspects in metabolomics of human biofluids – sample collection, handling, transport, and storage
PublicationMetabolomics is the field of omics research that offers valuable insights into the complex composition of biological samples. It has found wide application in clinical diagnostics, disease investigation, therapy prediction, monitoring of treatment efficiency, drug discovery, or in-depth analysis of sample composition. A suitable study design constitutes the fundamental requirements to ensure robust and reliable results from the...
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The protocol for using elastic wall model in modeling blood flow within human artery
PublicationMedical diagnostic tools will play a major role in the future for an effective patient treatment and reduction their mortality, related to the cardiovascular system diseases (CVDs). There is an urgent need for developing diagnostic procedure to be robust, reliable, accurate and efficient, in the framework of a paradigm shift. Application of numerical techniques is seen as a perspective tool for such purpose. Nevertheless, existing...
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Development of chromatographic and mass spectrometry conditions for untargeted lipidomic analysis of human breast milk
PublicationHuman breast milk (HBM) is a complex biofluid containing components which are essential for the proper growth of the newborn (for example nutrients such as carbohydrates, proteins, lipids) and also bioactive substances. According to the literature, most of studies involving HBM nutrients investigations focused essentially on the determination of proteins. The molecular composition of lipids in HBM is not well known as the protein...
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The bile salt content of human bile impacts on simulated intestinal proteolysis of β-lactoglobulin
PublicationThe gastrointestinal hydrolysis of food proteins has been portrayed in scientific literature to predominantly depend on the activity and specificity of proteolytic enzymes. Human bile has not been considered to facilitate proteolysis in the small intestine, but rather to assist in intestinal lipolysis. However, human bile can potentially influence proteins that are largely resistant to gastric digestion, and which are mainly hydrolysed...
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Human awareness versus Autonomous Vehicles view: comparison of reaction times during emergencies
PublicationHuman safety is one of the most critical factors when a new technology is introduced to the everyday use. It was no different in the case of Autonomous Vehicles (AV), designed to replace generally available Conventional Vehicles (CV) in the future. AV rules, from the start, focus on guaranteeing safety for passengers and other road users, and these assumptions usually work during normal traffic conditions. However, there is still...
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Comparative Lipidomic Study of Human Milk from Different Lactation Stages and Milk Formulas
PublicationIn this report, we present a detailed comparison of the lipid composition of human milk (HM) and formula milk (FM) targeting different lactation stages and infant age range. We studied HM samples collected from 26 Polish mothers from colostrum to 19 months of lactation, along with FM from seven brands available on the Polish market (infant formula, follow-on formula and growing-up formula). Lipid extracts were analysed using liquid...
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A miniaturized solid-contact potentiometric multisensor platform for determination of ionic profiles in human saliva
PublicationThis paper describes a miniaturized multisensor platform (MP-ISES) consisting of electrodes: a reference one (RE) and ion-selective electrodes (ISEs) for monitoring Na+, K+, Ca2+, Mg2+, Cl−, and SCN− ions and pH in human saliva. Gold electrode surface was modified by deposition of two layers: electrosynthesized PEDOT:PSS forming an intermediate layer, and ion-selective membrane. The developed ISEs were characterized by a wide linear...
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Dynamic analysis of temporary steel grandstand subjected to human-induced excitations due to jumping
PublicationSteel grandstands are structures that are frequently used during sport games and many other non-sporting events, such as festivals, music concerts, or even politicians rallies, with participation of a large number of attendees. Unfortunately, the presence of unexpected excessive dynamic loads due to unpredictable behaviour of spectators (e.g. synchronized harmonic jumping or swaying) may lead to...
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Structural, functional, and stability change predictions in human telomerase upon specific point mutations,
PublicationOverexpression of telomerase is one of the hallmarks of human cancer. Telomerase is important for maintaining the integrity of the ends of chromosomes, which are called telomeres. A growing number of human disease syndromes are associated with organ failure caused by mutations in telomerase (hTERT or hTR). Mutations in telomerase lead to telomere shortening by decreasing the stability of the telomerase complex, reducing its accumulation,...
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Neurotrophic factors in human milk in early lactation and the effect of Holder and microwave pasteurization on their concentrations
PublicationObjective: The objective of this study was to determine the level of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) in human milk in the first two weeks of breastfeeding and compare of the effects of Holder pasteurization (HoP, 62.5°C, 30 minutes) and microwave pasteurization (MP) at constant temperature (62.5°C) on the concentraion of both neurotrophic factors (NFs). Methods: Concentration...
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The effect of new non-cross resistant antitumor agents on the energy state of human erythrocytes
PublicationPrzebadano pochodne benzoperimidynowe i antrapirydonowe odnośnie ich wpływu na stan energetyczny ludzkich erytrocytów. Stwierdzono, że poziom nukleotydów jak i wartość AEC erytrocytów nie zmienił się w ciągu 24 h inkubacji z powyższymi związkami. Jest to wynik obiecujący w odniesieniu do ich zastosowania jako związków aktywnych w pokonywaniu oporności wielolekowej.
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Non invasive optical cellular imaging in humans.
PublicationOne of the most appealing and still unsolved problems in biological and medical imaging is the possibility of noninvasive visualization of tissue in vivo with an accuracy of microscopic examination. A major difficulty to solve in biomedical imaging is a degradation of image quality caused by the presence of optical inhomogeneity of tissue. Is there any chance to develop a microscopic method that allows non-invasive observation...
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Cigarette Smoking Increases Sympathetic Outflow in Humans
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Hunan Daxue Xuebao/Journal of Hunan University Natural Sciences
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An inter-laboratory validation of methods of lipid peroxidation measurement in UVA-treated human plasma samples
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Haloperidol, but not olanzapine, may affect expression of PER1 and CRY1 genes in human glioblastoma cell line
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Sulforaphane, a cruciferous vegetable-derived isothiocyanate, inhibits protein synthesis in human prostate cancer cells
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Nonlinear dynamic analysis of the pure “buckling” mechanism during blow-out trauma of the human orbit
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Bulky DNA adducts in human sperm: relationship with fertility, semen quality, smoking, and environmental factors
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Chemistry of human breast milk – a comprehensive review of the composition and role of milk metabolites in child development
PublicationEarly nutrition has an enormous influence on a child's physiological function, immune system maturation and cognitive development. Human breast milk (HBM) is recognized as the gold standard for human infant nutrition. Accordingly to WHO report breastfeeding is consider as an unequalled way of providing ideal food to the infant, which is required for his healthy growth and development. HBM contains various macronutrients (carbohydrates,...
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Podstawowe sposoby zwiększania wiarygodności wykonania przebiegów wymagających udziału człowieka w human workflow
PublicationOpisano pojęcie procesu biznesowego oraz przepływu pracy w kontekście automatyzacji mającej na celu optymalizację działań i podniesienie jakości usługi. Przedstawiono charakterystykę procesów pracy angażujących człowieka oraz wykorzystujących dedykowane wzorce przepływów tego typu. Zaproponowano zwiększenie stopnia automatyzacji wykonania procesu wraz z metodami zwiększania wiarygodności wykonania przebiegów pracy przez kontrolę...
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Transcriptional profile of in vitro expanded human epidermal progenitor cells for the treatment of non-healing wounds
PublicationBackground Epidermal progenitor cells (EPCs) have been under extensive investigation due to their increasing potential of application in medicine and biotechnology. Cultured human EPCs are used in the treatment of chronic wounds and have recently became a target for gene therapy and toxicological studies. One of the challenges in EPCs culture is to provide a high number of undifferentiated, progenitor cells displaying high viability...
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Deep neural networks for human pose estimation from a very low resolution depth image
PublicationThe work presented in the paper is dedicated to determining and evaluating the most efficient neural network architecture applied as a multiple regression network localizing human body joints in 3D space based on a single low resolution depth image. The main challenge was to deal with a noisy and coarse representation of the human body, as observed by a depth sensor from a large distance, and to achieve high localization precision....
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Unsupervised machine-learning classification of electrophysiologically active electrodes during human cognitive task performance
PublicationIdentification of active electrodes that record task-relevant neurophysiological activity is needed for clinical and industrial applications as well as for investigating brain functions. We developed an unsupervised, fully automated approach to classify active electrodes showing event-related intracranial EEG (iEEG) responses from 115 patients performing a free recall verbal memory task. Our approach employed new interpretable...
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The dispersive micro-solid phase extraction method for MS-based lipidomics of human breast milk*
PublicationA simple and rapid microextraction method ensuring high lipidome coverage was developed for liquid chromatography mass spectrometry (LC-MS)-based lipidomics of human breast milk. The dispersive microsolid phase extraction (D-µ-SPE) technique, coupled with the design of experiment (DoE) method, enabled the study of the influence of several conditions (desorption solvent, stationary phase ratio, and sorption and desorption time)...
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Biochemical properties of thyroid peroxidase (TPO) expressed in human breast and mammary-derived cell lines
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