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Search results for: regenerative drugs
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CERVIX UTERI, Exocervix - Female, 34 - Cell image [3180630006437261]
Open Research DataThis is the histopathological image of CERVIX UTERI cell sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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CERVIX UTERI, Exocervix - Female, 35 - Cell image [3180630006439161]
Open Research DataThis is the histopathological image of CERVIX UTERI cell sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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CERVIX UTERI, Exocervix - Female, 44 - Cell image [4140730008823961]
Open Research DataThis is the histopathological image of CERVIX UTERI cell sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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CERVIX UTERI, Exocervix - Female, 33 - Cell image [5040730020274721]
Open Research DataThis is the histopathological image of CERVIX UTERI cell sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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CERVIX UTERI, Exocervix - Female, 36 - Cell image [5040730020275371]
Open Research DataThis is the histopathological image of CERVIX UTERI cell sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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CERVIX UTERI, Exocervix - Female, 37 - Cell image [4200730008417321]
Open Research DataThis is the histopathological image of CERVIX UTERI cell sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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CERVIX UTERI, Exocervix - Female, 43 - Cell image [4200730008415041]
Open Research DataThis is the histopathological image of CERVIX UTERI cell sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Cellulose Nanomaterials in Biomedical, Food, and Nutraceutical Applications: A Review
PublicationNanotechnology with bionanomaterials have tremendous potential to enhance and utilize for nutrient and bioactive absorption, drug delivery systems, pharmaceutical, and nutraceutical field through various applications. Cellulose nanomaterials are green materials that are obtained from renewable sources and possess exceptional mechanical strength and biocompatibility. The associated unique physical and chemical properties have made...
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The mechanism of internalization study of QDgreen−CD−FA−C−2028 conjugate at IC80 value to cancer (H460, Du-145, and LNCaP) and normal (MRC-5 and PNT1A) cells
Open Research DataThe influence of different endocytosis inhibitors on the internalization of QDgreen−CD−FA−C−2028 conjugate at IC80 value in cancer (H460, Du-145, and LNCaP) and normal (MRC-5 and PNT1A) cells. First, the cells were preincubated with: drug-free medium (no inhibitor), at 4 °C, 5 µM Cytochalasin D, 30 µM Amiloride, 80 µM Dynasore, 25 µM Pitstop 2 and 1.5...
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catena-Poly[[(diethyl ether-kO)lithium(I)]-m-1,1,3,3-tetraisopropyltriphosphane-kP2: k2P1,P3-lithium(I)-m-1,1,3,3-tetraisopropyltriphosphane-k2P1,P3:kP2]
PublicationTytułowy związek został otrzymany jako produkt uboczny w reakcji [(Et2PhP)2PtCl2] z iPr2P-P(SiMe3)Li. Jest to drugi znany polimer koordynacyjny w grupie soli litowych trifosfanów. Strukturę związku wyznaczono za pomocą rentgenowskiej analizy strukturalnej.
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The transition of HIV within and between affected populations in Poland
PublicationThe aim of the paper is the estimation of probabilities that describe the transition of HIV within and between the following three populations: homosexual and bisexual men, injecting drug users and heterosexual persons in Poland in the years 1995-2006
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Optymalizacja rozkładu jazdy na kolei z uwzględnieniem efektywności hamowania odzyskowego.
PublicationNa wstępie artykułu przybliżono czytelnikowi, czym jest rozkład jazdy na sieci kolejowej, na czym polega jego optymalizacja oraz odwołano się do literatury opisującej proces jego konstrukcji. W dalszej części przedstawiono kryteria optymalizacji rozkładu jazdy i zaproponowano podejście od strony efektywności wykorzystania energii pochodzącej z hamowania rekuperacyjnego, realizowanego metodą odzysku bezpośrednio do sieci trakcyjnej....
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Removal of phenolic inhibitor compounds from hydrolysates and post-fermentation broths by using a Hydrophobic Magnetic Deep Eutectic Solvent
PublicationHydroxymethylfurfural (HMF), furfural (FF), hydroquinone (HQ), and vanillin (VAN) are among the main inhibitors generated during most of biomass pre-treatments prior to fermentation processes. They are recognized as toxic to several fermentative microorganisms and therefore cause a decrease in biohydrogen or biofuel production (after hydrolysis). Moreover, if they are released into aqueous solutions (after fermentation), they can...
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A simple finite difference approach using unstructured meshes from FEM mesh generators.
PublicationPrezentujemy metodologię używania dwuwymiarowych różnic skończonych wykorzystujących siatki trójkątne z metody FEM. Określiliśmy wyrażenia opisujące pierwsząi drugą pochodną w oparciu o wartości pól w saśiednich punktach. Metodę przetestowaliśmy na strukturze rezonatora z prostokątnym rdzeniem dielektrycznym.
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Recent developmentsinthesynthesisand biological activityofacridine/acridoneanalogues
PublicationMany people in the world struggle with cancer or bacterial, parasitic, viral, Alzheimer's and other diseases. Therefore, many scientists seek new, more effective, more selective and less toxic drugs. Acridine/acridone derivatives constitute a class of compounds with a broad spectrum of biological activity and are of great interest to scientists. Todate, many acridine/acridone analogues have been obtained,which, inter alia, exhibit...
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Rapid determination of multiple aminoglycoside antibiotics in veterinary formulations by ion-pair chromatography coupled with evaporative light scattering detection
PublicationA fast and simple method for simultaneous determination of eight aminoglycoside antibiotics using ion-pairing liquid chromatography (IPLC) coupled with evaporative light scattering detection (ELSD) has been developed and validated. Separation of amikacin, apramycin, gentamicin (as a sum of gentamicin C1, C2 and C1A), kanamycin A, neomycin B, paromomycin, streptomycin and tobramycin was achieved using C18 column with H2O and MeOH/acetone,...
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Zrównoważona odnowa przestrzeni miejskiej
PublicationCelem rozprawy doktorskiej jest ocena metod i instrumentów odnowy przestrzeni miejskiej o oddziaływaniu ponadlokalnym i warunkowanych równoważeniem rozwoju oraz porównanie ich wykorzystania w wybranych krajach Unii Europejskiej. W wyniku badań stworzony został model transformacji przestrzeni miejskiej ze wskazaniem priorytetów działań przestrzennych uwarunkowanych równoważeniem rozwoju w skali regionalnej i lokalnej. Analiza porównawcza...
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Polysaccharides-Based Hybrid Materials for Bio- and Non-Bio Sectors. Edytorial
PublicationThis special edition spotlights the recent research in the design, development, and emerging applications of polysaccharides-based hybrid materials for biotechnological and biomedical purposes. All the articles published in this issue underscore the significance of materials derived from cellulose, alginate, chitosan, starch, and carrageenan for various applications, including enzyme production, encapsulation, targeted drug delivery,...
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Polymer and graphitic carbon nitride based nanohybrids for the photocatalytic degradation of pharmaceuticals in wastewater treatment – A review
PublicationPharmaceuticals, including antibiotics and anti-inflammatory drugs, have been frequently detected in water reservoirs, in concentrations ranging from ng/L to μg/L, owing to their wide use in treatment of human and animal disease. Their uncontrolled use results in their increased release into the environment which is harmful for humans, animals, aquatic life and aquatic system. To remove these pollutants from water bodies, various...
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Recent developments in biological sample testing methods for the confirmation of gestational exposure to tobacco smoke anddrugs of abused
PublicationSubstance use is most prevalent in reproductive-aged people also by women during pregnancy. In national prevalence surveys among women aged 15 to 44 years, 10.8 % of women reported using alcohol during pregnancy, 17 % reported smoking during pregnancy, and 4.4 % reported abusing any illicit substances during pregnancy. Virtually all illegal drugs, such as heroin and cocaine, pose dangers to a pregnant woman. Legal substances, such...
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Nutritional and Pharmaceutical Properties of Bioactive Compounds in Organic and Conventional Growing Kiwifruit
PublicationThe bioactivity of two kiwifruit’s cultivars growing under organic and conventional conditions were studied and compared. The bioactive compounds were extracted with water and ethanol using similar conditions which are applied in pharmaceutical applications and for daily fruit consumption such as tea drink. Antioxidant radical scavenging assays [ferric-reducing/antioxidant power (FRAP); cupric reducing antioxidant capacity (CUPRAC);...
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Monitoring of activities carried out as part of prototyping and implementation of the pilot project in the area of the "Polanki" market and its direct neighbourhood, in the Gdańsk-Oliwa district, step2; stage from June 2021 year.
Open Research DataThe data presents tabular monitoring lists (quantitative and qualitative documentation report in the form of tables) of activities carried out as part of prototyping and implementation of the pilot project in the area of the Polanki market and its immediate vicinity in the Gdańsk-Oliwa district in 2021 year - step 2, stage from June 2021.The monitoring...
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Monitoring of activities carried out as part of prototyping and implementation of the pilot project in the area of the "Polanki" market and its direct neighbourhood, in the Gdańsk-Oliwa district, step2; stage from September 2021 year.
Open Research DataThe data presents tabular monitoring lists (quantitative and qualitative documentation report in the form of tables) of activities carried out as part of prototyping and implementation of the pilot project in the area of the Polanki market and its immediate vicinity in the Gdańsk-Oliwa district in 2021 year - step 2, stage from September 2021.The monitoring...
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Monitoring of activities carried out as part of prototyping and implementation of the pilot project in the area of the "Polanki" market and its direct neighbourhood, in the Gdańsk-Oliwa district, step2; stage from October 2021 year.
Open Research DataThe data presents tabular monitoring lists (quantitative and qualitative documentation report in the form of tables) of activities carried out as part of prototyping and implementation of the pilot project in the area of the Polanki market and its immediate vicinity in the Gdańsk-Oliwa district in 2021 year - step 2, stage from October 2021.The monitoring...
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Monitoring of activities carried out as part of prototyping and implementation of the pilot project in the area of the "Polanki" market and its direct neighbourhood, in the Gdańsk-Oliwa district, step2; stage from July 2021 year.
Open Research DataThe data presents tabular monitoring lists (quantitative and qualitative documentation report in the form of tables) of activities carried out as part of prototyping and implementation of the pilot project in the area of the Polanki market and its immediate vicinity in the Gdańsk-Oliwa district in 2021 year - step 2, stage from July 2021.The monitoring...
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Monitoring of activities carried out as part of prototyping and implementation of the pilot project in the area of the "Polanki" market and its direct neighbourhood, in the Gdańsk-Oliwa district, step2; stage from May 2021 year.
Open Research DataThe data presents tabular monitoring lists (quantitative and qualitative documentation report in the form of tables) of activities carried out as part of prototyping and implementation of the pilot project in the area of the Polanki market and its immediate vicinity in the Gdańsk-Oliwa district in 2021 year - step 2, stage from May 2021.The monitoring...
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Monitoring of activities carried out as part of prototyping and implementation of the pilot project in the area of the "Polanki" market and its direct neighbourhood, in the Gdańsk-Oliwa district, step2; stage from August 2021 year.
Open Research DataThe data presents tabular monitoring lists (quantitative and qualitative documentation report in the form of tables) of activities carried out as part of prototyping and implementation of the pilot project in the area of the Polanki market and its immediate vicinity in the Gdańsk-Oliwa district in 2021 year - step 2, stage from August 2021.The monitoring...
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Nontoxic multinodular goitre - Female, 66 - Tissue image [7110729594544291]
Open Research DataThis is the histopathological image of THYROID GLAND tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Nontoxic multinodular goitre - Female, 66 - Tissue image [7110729594543271]
Open Research DataThis is the histopathological image of THYROID GLAND tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Nontoxic multinodular goitre - Female, 66 - Tissue image [7110729594547851]
Open Research DataThis is the histopathological image of THYROID GLAND tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Nontoxic multinodular goitre - Female, 66 - Tissue image [7110729594544111]
Open Research DataThis is the histopathological image of THYROID GLAND tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Nontoxic multinodular goitre - Female, 66 - Tissue image [7110729594543641]
Open Research DataThis is the histopathological image of THYROID GLAND tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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CERVIX UTERI, Exocervix - Female, 34 - Cell image [4200730008411221]
Open Research DataThis is the histopathological image of CERVIX UTERI cell sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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CERVIX UTERI, Exocervix - Female, 28 - Cell image [5170730007439021]
Open Research DataThis is the histopathological image of CERVIX UTERI cell sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Photo-acoustic response of active biological systems
PublicationZbadano dwie próbki organiczne gatunku Trunculariopsis trunculus,jedną wilgotną, drugą - suchą. W obu przypadkach zaobserwowanointensywne szerokie pasma absorpcyjne w zakresie widzialnym (żółtymi poniżej 330 nm). Widma foto-akustyczne zawierają wszystkie pasma uznane za związane z aktywnością biologiczną.
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TECHNIKI SZYBKIEGO PROTOTYPOWANIA W BUDOWIE MASZYN
PublicationW artykule omówiono przygotowanie oraz wykonanie poszczególnych elementów maszyn za pomocą techniki szybkiego prototypowania. W pierwszej części przedstawiono technologię wydruku przestrzennego oraz właściwości materiału budulcowego. Druga część artykułu została poświęcona przykładowym wydrukom i ich zastosowaniom w maszynach.
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Techniki szybkiego prototypowania w budowie maszyn = Rapid prototyping techniques in machine building
PublicationW artykule omówiono przygotowanie oraz wykonanie poszczególnych elementów maszyn za pomocą techniki szybkiego prototypowania. W pierwszej części przedstawiono technologię wydruku przestrzennego oraz właściwości materiału budulcowego. Druga część artykułu została poświęcona przykładowym wydrukom i ich zastosowaniom w maszynach.
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Wspomagane komputerowo projektowanie oświetlenia elektrycznego drogi rowerowej
PublicationW artykule przedstawiono problemy projektowania energooszczędnego oświetlenia elektrycznego drogi rowerowej. Rozpatrzono trzy warianty oświetlenia: pierwszy - z lampami sodowymi wysokoprężnymi, drugi - z lampami sodowymi niskoprężnymi, trzeci - z lampami diodowymi. W obliczeniach oświetleniowych wykorzystano programy komputerowe DIALux i Excel.
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Design and realization of two-operand modular adders in the FPGA
PublicationW pracy zaprezentowano strukturę sumatorów modularnych w środowisku Xilinx z użyciem rodziny układów Virtex-6. Rozważono dwa typy sumatorów, jeden dla modułów 5-bitowych i drugi dla 6-bitowych. Zaprojektowano ich struktury i podano eksperymentalne wyniki implementacji.
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Chemosensitization of multidrug resistant Candida albicans by the oxathiolone fused chalcone derivatives
PublicationThree structurally related oxathiolone fused chalcone derivatives appeared effective chemosensitizers, able to restore in part sensitivity to fluconazole of multidrug-resistant C.albicans strains. Compound 21 effectively chemosensitized cells resistant due to the overexpression of the MDR1 gene, compound 6 reduced resistance of cells overexpressing the ABC-type drug transporters CDR1/CDR2 and derivative 18 partially reversed fluconazole...
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DEEP LEARNING BASED ON X-RAY IMAGING IMPROVES COXARTHROSIS DETECTION
PublicationObjective: The purpose of the study was to create an Artificial Neural Network (ANN) based on X-ray images of the pelvis, as an additional tool to automate and improve the diagnosis of coxarthrosis. The research is focused on joint space narrowing, which is a radiological symptom showing the thinning of the articular cartilage layer, which is translucent to X-rays. It is the first and the most important of the radiological signs...
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Biomechanics of the medial meniscus in the osteoarthritic knee joint
PublicationBackground. Increased mechanical loading and pathological response of joint tissue to the abnormal mechanical stress can cause degradation of cartilage characteristic of knee osteoarthritis (OA). Despite osteoarthritis is risk factor for the development of meniscal lesions the mechanism of degenerative meniscal lesions is still unclear. Therefore, the aim of the study is to investigate the influence of medial compartment knee OA...
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The overexpression of CPR and P450 3A4 in pancreatic cancer cells changes the metabolic profile and increases the cytotoxicity and pro-apoptotic activity of acridine antitumor agent, C-1748
PublicationDrug resistance is one of the major cause of pancreatic cancer treatment failure. Thus, it is still imperative to develop new active compounds and novel approach to improve drug efficacy. Here we present 9-amino-1-nitroacridine antitumor agent, C-1748, developed in our laboratory, as a candidate for pancreatic cancer treatment. We examined (i) the cellular response of pancreatic cancer cell lines: Panc-1, MiaPaCa-2, BxPC-3 and...
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Mechanism of Binding of Antifungal Antibiotic Amphotericin B to Lipid Membranes: An Insight from Combined Single-Membrane Imaging, Microspectroscopy, and Molecular Dynamics
PublicationAmphotericin B is a lifesaving polyene antibiotic used in the treatment of systemic mycoses. Unfortunately, the pharmacological applicability of this drug is limited because of its severe toxic side effects. At the same time, the lack of a well-defined mechanism of selectivity hampers the efforts to rationally design safer derivatives. As the drug primarily targets the biomembranes of both fungi and humans, new insights into the...
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HYDRAULIKA IS 2022/2023 (lato)
e-Learning CoursesDruga część zajęć z zakresu hydrauliki (po części HYDRAULIKA ZIMA, prowadzonej w semestrze zimowym). Program obejmuje modele przepływów filtracyjnych, obliczanie reakcji hydrodynamicznej, przepływy w korytach otwartych, strumienie swobodne, modelowanie zjawisk i pomiary hydrauliczne.
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HYDRAULIKA IS 2021/2022 (lato)
e-Learning CoursesDruga część zajęć z zakresu hydrauliki (po części HYDRAULIKA ZIMA, prowadzonej w semestrze zimowym). Program obejmuje modele przepływów filtracyjnych, obliczanie reakcji hydrodynamicznej, przepływy w korytach otwartych, strumienie swobodne, modelowanie zjawisk i pomiary hydrauliczne.
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Clinical situations text database for Polish language
Open Research DataDataset contains a database of anonymized texts in Polish for the purposes of building a medical speech corpus, for clinical situations in the following areas: medical interview, interview and description of the result of an oncological examination, description of a radiological examination, description of a pathomorphological examination, description...
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Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects
PublicationSkin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different psoriasis subtypes and the lack of verified biomarkers. Recently, proteomics and metabolomics have been intensively investigated in a broad range of skin diseases with the main purpose...
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Improved cytotoxicity and preserved level of cell death induced in colon cancer cells by doxorubicin after its conjugation with iron-oxide magnetic nanoparticles
PublicationA promising strategy for overcoming the problem of limited efficacy in antitumor drug delivery and in drug release is the use of a nanoparticle-conjugated drug. Doxorubicin (Dox) anticancer chemotherapeutics has been widely studied in this respect, because of severe cardiotoxic side effects. Here, we investigated the cytotoxic effects, the uptake process, the changes in cell cycle progression and the cell death processes in the...
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The influence of ILs on TiO2 microspheres activity towards 5-FU removal under artificial sunlight irradiation
PublicationIn this work, the effect of various ionic liquids (ILs), namely, choline chloride [Chol][Cl], hexadecylpyridynium chloride [HDPy][Cl], and tributylmethylammonium chloride [TBMA][Cl], on the morphology, surface compo-sition in relation to photocatalytic oxidation of 5-fluorouracil (5-FU) and phenol in the presence of TiO2 pho-tocatalysts under artificial sunlight conditions was investigated. The highest photoactivity towards cytostatic...