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Wyniki wyszukiwania dla: ADAPTIVE RESPONSE SCALING
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The cellular response of human colon carcinoma HCT116 cells to 4-methyl-1-nitroacridine derivative C-1748 treatment depending on p53 status
PublikacjaWykazano, że pochodna C-1748 indukuje apoptozę w komórkach linii ludzkich raków jelita grubego HCT116 p53+/+ i p53-/- w sposób zależny od czasu inkubacji i stężenia związku. Wskazują na to: pojawienie się frakcji komórek sub-G1, charakterystyczne zmiany w morfologii jąder komórkowych, zmiany w strukturze błony plazmatycznej. Ponadto, pod wpływem badanego związku komórki HCT116 p53+/+ wykazują większą podatność do ulegania apoptozie...
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Cannabinoid CB1 antagonists and dopamine antagonists produce different effects on a task involving response allocation and effort-related choice in food-seeking behavior
PublikacjaW przeprowadzonych badaniach iniekcja antagonistów dopaminy (DA) szczurom powoduje znaczny spadek użycia siły przez zwierzęta w poszukiwaniu żywności i jednoczesny wzrost spożycia jedzenia laboratoryjnego. Przeciwnie, iniekcja antagonisty AM4113 lub odwrotnego agonisty AM251 receptora CB1 powoduje zmniejszenie ilości jedzenia granulek, ale nie wpływa na zwiększenie konsumpcji jedzenia laboratoryjnego. Efekty wywierane na zwierzęta...
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Effect of alumina oxide nano-powder on the wear behaviour of CrN coating against cylinder liner using response surface methodology: processing and characterizations
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Pure cross-anisotropy for geotechnical elastic potentials
PublikacjaThe pure cross-anisotropy is understood as a special scaling of strain (or stress). The scaled tensor is used as an argument in the elastic stiffness (or compliance). Such anisotropy can be overlaid on the top of any elastic stiffness, in particular on one obtained from an elastic potential with its own stress-induced anisotropy. This superposition does not violate the Second Law. The method can be also applied to other functions...
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Fitting the mobile device characteristics to the user's hearing preferences
PublikacjaA method for fitting the mobile computer audio characteristics to the user's hearing preferences is proposed. The process consists of two stages: calibration and dynamics processing. During the calibration phase the user performs a loudness scaling test giving their response regarding the perceived loudness. The dynamics processing made on above basis sets the loudness to the most comfortable level. The processing accounts both...
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Activation of peroxymonosulfate using carbon black nano-spheres/calcium alginate hydrogel matrix for degradation of acetaminophen: Fe3O4 co-immobilization and microbial community response
PublikacjaHerein, we focused on the degradation of acetaminophen (ACT) drug in liquid phase by peroxymonosulfate (PMS) activated by carbon black nano-spheres (CBNS). The nanostructured activator was immobilized into calcium alginate hydrogel matrix (CAHM) to avoid the washout of the fine nanostructures. The Langmuir modeling showed an insignificant contribution to the adsorption process in the removal of ACT. The basic pH conditions favored...
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Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use.
PublikacjaThe acridinone derivates C-1305 and C-1311 are promising antitumor agents with high activity against several experimental cellular and tumor models and which are under evaluation in pre-clinical and early phase clinical trials. Recent evidence from our laboratories has indicated that both compounds were conjugated by several UGT isoforms with the most active being extrahepatic UGT1A10. The present studies were designed to test...
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Genes encoding proteins regulating fatty acid metabolism and cellular response to lipids are differentially expressed in porcine luminal epithelium during long-term culture
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Application of response surface methodology for silver nanoparticle stir bar sorptive extraction of heavy metals from drinking water samples: a Box–Behnken design
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Application of response surface methodology to optimize pipette tip micro-solid phase extraction of dyes from seawater by molecularly imprinted polymer and their determination by HPLC
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A Specific CD44lo CD25lo Subpopulation of Regulatory T Cells Inhibits Anti-Leukemic Immune Response and Promotes the Progression in a Mouse Model of Chronic Lymphocytic Leukemia
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RESPONSE TO ORTHOSTATIC STRESS PREDICTS OFFICE‐DAYTIME BLOOD PRESSURE DIFFERENCE, BUT NOT NOCTURNAL BLOOD PRESSURE FALL IN MILD ESSENTIAL HYPERTENSIVES: RESULTS OF THE HARVEST TRIAL
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Bioprocess optimization using response surface methodology for production of the anticancer drug paclitaxel by Aspergillus fumigatus and Alternaria tenuissima: Enhanced production by ultraviolet and gamma irradiation
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Implementation of Haar wavelet, higher order Haar wavelet, and differential quadrature methods on buckling response of strain gradient nonlocal beam embedded in an elastic medium
PublikacjaThe present investigation is focused on the buckling behavior of strain gradient nonlocal beam embedded in Winkler elastic foundation. The first-order strain gradient model has been combined with the Euler–Bernoulli beam theory to formulate the proposed model using Hamilton’s principle. Three numerically efficient methods, namely Haar wavelet method (HWM), higher order Haar wavelet method (HOHWM), and differential quadrature method...
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Escherichia coli K-12 suppressor-free mutants lacking early glycosyltransferases and late acyltransferases. Minimal lipopolysaccharide structure and induction of envelope stress response.
PublikacjaTo elucidate the minimal lipopolysaccharide (LPS) structure needed for the viability of Escherichia coli, suppressor-free strains lacking either the 3-deoxy-d-manno-oct-2-ulosonic acid transferase waaA gene or derivatives of the heptosyltransferase I waaC deletion with lack of one or all late acyltransferases (lpxL/M/P) and/or various outer membrane biogenesis factors were constructed. Δ(waaC lpxL lpxM lpxP) and waaA mutants exhibited...
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Multiple output CMOS current amplifier
PublikacjaIn this paper the multiple output current amplifier basic cell is proposed. The triple output current mirror and current follower circuit are described in detail. The cell consists of a split nMOS differential pair and accompanying biasing current sources. It is suitable for low voltage operation and exhibits highly linear DC response. Through cell devices scaling, not only unity, but also any current gains are achievable. As...
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Response of murine gut microbiota to a prebiotic based on oligosaccharides derived via hydrolysis of fungal α-(1→3)-d-glucan: Preclinical trial study on mice
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The influence of polarization of titania nanotubes modified by a hybrid system made of a conducting polymer PEDOT and Prussian Blue redox network on the Raman spectroscopy response and photoelectrochemical properties
PublikacjaIn this work we show the impact of applied potential on network vibrations and photoelectrochemical properties of a composite material containing hydrogenated titania nanotubes and poly (3,4-ethylenedioxythiophene) with iron hexacyanoferrate (H-TiO2/pEDOT:Fehcf) acting as a redox centre. For this purpose, Raman spectroscopy measurements under the working electrode (WE) polarization were carried out, allowing investigation of changes...
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Impact of heat shock transcription factor 1 on global gene expression profiles in cells which induce either cytoprotective or pro-apoptotic response following hyperthermia
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Serum Proteome Signature of Radiation Response: Upregulation of Inflammation-Related Factors and Downregulation of Apolipoproteins and Coagulation Factors in Cancer Patients Treated With Radiation Therapy—A Pilot Study
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Determination of profenofos in seawater and foodstuff samples after its molecularly imprinted polymer pipette-tip micro solid phase extraction optimized by response surface methodology
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Application of response surface methodology for optimization of metal–organic framework based pipette-tip solid phase extraction of organic dyes from seawater and their determination with HPLC
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Analysis of cellular response induced by imidazoacridinone derivative C-1311 in Chinese hamster ovary carcinoma cells CHO with vorious expression level of cytochrome P450 reductase
PublikacjaRodzaj odpowiedzi komórkowej indukowanej przez pochodną C-1311 badany był w komórkach CHO o różnym poziomie reduktazy cytochromu P450. Wszystkie eksperymenty zostały przeprowadzone przy zastosowaniu stężenia związku odpowiadającego dawce EC80. Poziom ekspresji reduktazy cytochromu P450 nie miał istotnego wpływu na rodzaj odpowiedzi komórkowej indukowanej przez pochodną C-1311. Głównym efektem biologicznym wywieranym przez badany...
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Adsorption of lead (Pb-II) using CaO-NPs synthesized by solgel process from hen eggshell: Response surface methodology for modeling, optimization and kinetic studies
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Discussion of “Stress-Displacement Response of Sand–Geosynthetic Interfaces under Different Volume Change Boundary Conditions” by Aliyeh Afzali-Nejad, Ali Lashkari, and Alejandro Martinez
PublikacjaThe influence of normal stiffness of interface on the interpretation of shear box tests
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Enhanced susceptibility of SARS-CoV-2 spike RBD protein assay targeted by cellular receptors ACE2 and CD147: Multivariate data analysis of multisine impedimetric response
PublikacjaSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters the cells through the binding of spike protein to the host cell surface-expressing angiotensin-converting enzyme 2 (ACE2) or by endocytosis mediated by extracellular matrix metalloproteinase inducer (CD147). We present extended statistical studies of the multisine dynamic electrochemical impedance spectroscopy (DEIS) revealing interactions between Spike RBD and...
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The difficult heritage. The reuse of former prison buildings
PublikacjaIn recent years, there has been a trend to reuse abandoned buildings. Adaptive re-use allows preservation of the original structure and implements a new function to it. Such activity could help to preserve the historic value of buildings; moreover, many other advantages can be found in educational, ecological and economic fields. However, the question arises of whether every object can be freely adapted. This article examines the...
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60 GHz Microstrip Van Atta Arrays for Millimeter Wave Identification and Localization
PublikacjaIn this paper performance comparison of co-polarized and cross-polarized microstrip Van Atta arrays working in the 60 GHz frequency range is presented. They can be treated as simple chipless RFID tags with frequency response based identification. Tags with three different nominal resonance frequencies of 57, 62 and 67 GHz are designed by scaling optimized base model. Designed 62 GHz co-polarized and cross-polarized arrays with...
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Genome-Wide Identification of Dickeya solani Transcriptional Units Up-Regulated in Response to Plant Tissues From a Crop-Host Solanum tuberosum and a Weed-Host Solanum dulcamara
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Ionic liquid-assisted sol-gel synthesis of Fe2O3-TiO2 for enhanced photocatalytic degradation of bisphenol a under UV illumination: Modeling and optimization using response surface methodology
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Authors’ response to Dr Finsterer's comment “Exclude differentials before diagnosing SARS-CoV-2-associated acute hemorrhagic necrotizing encephalitis” (THEIJID-D-22-00008)
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Association between P-glycoprotein and lymphoid antigen expression on myeloblasts versus therapy response and survival in de novo acute myeloid leukemia: long-term follow-up results
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Evaluation of the Role of the Pharmacological Inhibition of Staphylococcus aureus Multidrug Resistance Pumps and the Variable Levels of the Uptake of the Sensitizer in the Strain-Dependent Response of Staphylococcus aureus to PPArg2-Based Photodynamic Ina
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Modeling and optimizing the removal of cadmium by Sinapis alba L. from contaminated soil via Response Surface Methodology and Artificial Neural Networks during assisted phytoremediation with sewage sludge
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Differential Response of MDA-MB-231 and MCF-7 Breast Cancer Cells to In Vitro Inhibition with CTLA-4 and PD-1 through Cancer-Immune Cells Modified Interactions
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Tożsamość architektury jako odpowiedź na kontekst funkcji i miejsca na przykładzie budynku muzeum = Identity of architecture as a response to the context of function and place on the example of museum building
PublikacjaArchitektura starożytna, będąca przedmiotem dzieła Witruwiusza stanowi korzenie europejskiej myśli architektonicznej. Klasycyzm określił kanony i archetypy obowiązujące przez stulecia w projektowaniu muzeów. Wielowątkowość współczesnej sztuki, postęp w zakresie technologii budownictwa oraz dążenie do oryginalnością spowodowały odejście od jednej obowiązującej teorii i kanonu piękna w architekturze. Współczesne projekty muzeów reprezentują...
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Cost-efficient design optimization of compact patch antennas with improved bandwidth
PublikacjaIn this letter, a surrogate-assisted optimization procedure for fast design of compact patch antennas with enhanced bandwidth is presented. The procedure aims at addressing a fundamental challenge of the design of antenna structures with complex topologies, which is simultaneous adjustment of numerous geometry parameters. The latter is necessary in order to find a truly optimum design and cannot be executed-at the level of high-fidelity...
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Salinity enhances high optically active L-lactate production from co-fermentation of food waste and waste activated sludge: Unveiling the response of microbial community shift and functional profiling
PublikacjaLactic acid (LA), a versatile platform molecule, can be fermented from organic wastes, such as food waste and waste activated sludge. In this study, an efficient approach using salt, a component of food waste as an additive, was proposed to increase LA production. The LA productivity was increased at 10 g NaCl/L and optical pure L-lactate was obtained at 30 g NaCl/L. The enhancement of LA was in accordance with the increased solubilization...
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Development and optimization of simplified method of fast sequential HR-CS-FAAS analysis of apple juices on the content of Ca, Fe, K, Mg, Mn and Na with the aid of response surface methodology
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Application of Box-Behnken design in response surface methodology for the molecularly imprinted polymer pipette-tip solid phase extraction of methyl red from seawater samples and its determination by spectrophotometery
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Separation and determination of ciprofloxacin in seawater, human blood plasma and tablet samples using molecularly imprinted polymer pipette‐tip solid phase extraction and its optimization by response surface methodology
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Auto adaptation of mobile device characteristics to various acoustic conditions
PublikacjaThe proposed methodology of auto adaptation of the mobile device characteristics to various acoustic conditions is presented in the paper. The first goal of this study was to determine the parameters of the acoustic path of the mobile device, for both transmitting (speaker) and receiver (microphone). Results of the measurement of characteristics of mobile devices were presented. Information about characteristics of individual parts...
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Pipelined sceling of signed residue numbers with the mixed-radix conversion in the programmable gate array
PublikacjaIn this work a scaling technique of signed residue numbers is proposed. The method is based on conversion to the Mixed-Radix System (MRS) adapted for the FPGA implementation. The scaling factor is assumed to be a moduli product from the Residue Number System (RNS) base. Scaling is performed by scaling of terms of the mixed-radix expansion, generation of residue reprezentation of scaled terms, binary addition of these representations...
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Wirówka geotechniczna - historia, modelowanie i współczynniki skali
PublikacjaRozwój modelowania zjawisk geotechnicznych w wirówce. Historia rozwoju urządzenia. Przyczyny wykorzystania wirówki geotechnicznej przez ośrodki naukowe i biura inżynieryjne. Obecny status urządzenia w edukacji i przemyśle. Podstawy teoretyczne badań modelowych w wirówce geotechnicznej. Lista wybranych zależności korelacyjnych. Przegląd i dyskusja wybranych współczynników skali.
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Comprehensive Comparison of a Few Variants of Cluster Analysis as Data Mining Tool in Supporting Environmental Management
PublikacjaA few variants of hierarchical cluster analysis (CA) as tool of assessment of multidimensional similarity in environmental dataset are compared. The dataset consisted of analytical results of determination of metals (Na, K, Ca, Sc, Fe, Co, Zn, As, Br, Rb, Mo, Sb, Cs, Ba, La, Ce, Sm, Hf and Th) in ambient air dried and kept alive, by the means of hydroponics, moss baskets collected in 12 locations on the area of Tricity (Poland)....
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Charakterystyka procesu ciągłej dewulkanizacji termomechanicznej z zastosowaniem metod doświadczalnych
PublikacjaBadano proces termomechanicznej dewulkanizacji rozdrobnionych odpadów gumowych prowadzono przy użyciu wytłaczarki dwuślimakowej współbieżnej o specjalnej konfiguracji układu uplastyczniającej, umożliwiającego wywieranie znacznych sił ścinających na miał gumowy. W badaniach doświadczalnych zastosowano metodę powierzchni odpowiedzi RSM (response surface methodology). Wyznaczono modele matematyczne wyrażające zmienność właściwości...
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Transmission parameters of underwater communication channels
PublikacjaThe underwater environment is tough and demanding as a communication channel for ultrasonic signals. The channel transmission characteristics in marine and inland waters depend much on local bathymetry and changing weather conditions. The architecture and performance of a reliable underwater acoustic communication (UAC) system should allow real-time adaptation of its transmission parameters to a large variety of possible channel...
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Design of Microstrip UWB Balun Using Quasi-TEM Approach Aided by the Artificial Neural Network
PublikacjaThe design procedure for UWB balun realized in the microstrip technology is proposed in the paper. The procedure applies Artificial Neural Network which corrects the dimensions of the approximate design found by appropriate scaling of the dimensions of the prototype. The scale coefficients for longitudinal and transverse dimensions of microstrip lines are determined from electromagnetic modeling based on transmission line equations....
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Authors’ Response to the Letter by Lamarca et al. Entitled “Temozolomide-Capecitabine Chemotherapy for Neuroendocrine Neoplasms: The Dilemma of Treatment Duration” Regarding “Activity and Safety of Standard and Prolonged Capecitabine/Temozolomide Administration in Patients with Advanced Neuroendocrine Neoplasms”
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Low-energy positron scattering from gas-phase benzene
PublikacjaIn this paper we are presenting calculations of the elastic cross section of positrons with gas-phase benzene for the energy range from 0.25 eV to 9.0 eV. The calculations are done with the molecular R-matrix method for positron-scattering from poly-atomic molecules using a scaling factor to scale the electron-positron interaction. The scaling factor influences the position of the poles of the R-matrix. We adjust the scaling factor...