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Wyniki wyszukiwania dla: NEGATIVE UNINTENDED CONSEQUENCES
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Role of cholesterol in substrate recognition by -secretase
Publikacja-Secretase is an enzyme known to cleave multiple substrates within their transmembrane domains, with the amyloid precursor protein of Alzheimer’s Disease among the most prominent examples. The activity of -secretase strictly depends on the membrane cholesterol content, yet the mechanistic role of cholesterol in the substrate binding and cleavage remains unclear. In this work, we used all-atom molecular dynamics simulations to examine...
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On topology optimization of large deformation contact-aided shape morphing compliant mechanisms
PublikacjaA topology optimization approach for designing large deformation contact-aided shape morphing compliant mechanisms is presented. Such mechanisms can be used in varying operating conditions. Design domains are described by regular hexagonal elements. Negative circular masks are employed to perform dual task, i.e., to decide material states of each element and also, to generate rigid contact surfaces. Each mask is characterized by...
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Including the Dark Side of Entrepreneurship in the Entrepreneurship Education
PublikacjaPursuing an entrepreneurial career is often rewarding in terms of both economic and psychological outcomes. However, becoming an entrepreneur also has its darker side that affects professional and personal life. Meanwhile, the positivity bias is prevalent in entrepreneurial education and research. It is recognized as emphasizing the advantages of becoming an entrepreneur and giving considerably less attention to potential downsides....
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Corrosion hazards and inhibitor protection in the seawater injection system on the Baltic sea rig
PublikacjaOil extraction efficiency in LOTOS Petrobaltic Company is increased by means of injection of seawater into an oilfield aquifer, which is implemented on the Baltic Beta rig, operating on the Baltic Sea. Operational experience has shown a significant degree of corrosion aggressiveness in the injected water, which necessitates frequent repairs of the seawater injection installation. Evaluation of the corrosion phenomena is crucial...
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Development of Safirinium dyes for new applications: fluorescent staining of bacteria, human kidney cells, and the horny layer of the epidermis
PublikacjaLow-molecular synthetic fluorophores are convenient tools in bioimaging applications. Several derivatives of Safirinium dyes as well as their reactive N-hydroxysuccinimide (NHS) esters bearing diverse substituents were synthesized and evaluated experimentally in terms of their lipophilicity by means of reverse-phase and immobilized artificial membrane high-performance liquid chromatography. Subsequently, the selected compounds...
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The dynamics of the total outputs of Japanese information and communication technology sectors: A further study
PublikacjaThe purpose of this study is to continue the previous studies which discussed the impacts of the changes of final demands on the total outputs of the Information and Communication Technology (ICT) sectors of the specific country. More specifically, this study aims to conduct a deeper analysis regarding these impacts. This study focuses on the case of Japan. This study employs a demand-pull Input-Output (IO) quantity model, one...
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Potential of novel atomic emission techniques as a tool for investigation of the possibilities of using industrial waste as additives in construction materials
PublikacjaNowadays, due to the global ecological crisis and ways to prevent a climate disaster, more and more attention is paid to green techno-logies and green Chemistry, which are part of the so-called “The Green Deal.” The main assumption is the optimization of the processes of producing necessary goods and the implementation of methods of managing postproduction waste in the least environmentally harmful manner. In the presented research,...
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Bicycle Traffic Model for Sustainable Urban Mobility Planning
PublikacjaModelling tools and transport models are required to assess the impact of measures for the effective planning of cycling routes in cities. This paper presents the methodology for developing a four-stage macroscopic model of bicycle traffic for the city of Gdynia, and its use in planning new bicycle routes, considering a modal shift. The model presented in this paper allows for the evaluation of the influence of the characteristics...
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It is not OK but it works – unproductive entrepreneurship, the case of Poland
PublikacjaThe concept of unproductive entrepreneurs was introduced to science by Baumol, who pointed out the differences in business output between countries. Unproductive behaviour of entrepreneurs is often a consequence of ineffective institutions used by entrepreneurs for rent seeking. The aim of this article is to examine subjective norms (S.N.) and attitudes regarding specified types of unproductive entrepreneurship, which in many cases...
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Synergistic effects in micellization and surface tension reduction in nonionic gemini S-10 and cationic RTAB surfactants mixtures
PublikacjaMixtures of nonionic gemini surfactant S-10 (α,α′-[2,4,7,9-tetrametyl-5-decyne-4,7-diyl]bis[ω-hydroxy -polioxyetylene] with cationic alkyltrimethylammonium bromides of different alkyl chain length (RTAB) were investigated. Basing on surface tension measurements the cmc values and other adsorption parameters were found. The Clint, Rubing’s and Rosen theories were applied for evaluation of the synergistic effects in mixed films and...
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Integrated sectors - diversified earnings: the (mising) impact of offshoring on wages and wage convergence in the EU27
PublikacjaThis paper assesses the impact of international outsourcing/offshoring practices on the process of wage equalization across manufacturing sectors in a sample of EU27 economies (1995–2009). We discriminate between heterogeneous wage effects on different skill categories of workers (low, medium and high skill). The main focus is on the labour market outcomes of vertical integration, so we augment a model of conditional wage convergence through...
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Forecasting of railway track tamping based on settlement of sleepers using fuzzy logic
PublikacjaThe sleepers in a railway track transfer vertical, transverse and longitudinal loads to the track ballast and subgrade. The sleepers allow for keeping the distance between the rails constant. The thickness of ballast should be between 16 and 35 cm depending on the design standard of the track, and it should be densified where the ballast supports the sleeper. The exploitation causes contamination of the ballast, crushing the material...
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Carsharing - Opportunities and Threats for Cities: Proposals of Solutions for Urban Policy
PublikacjaThe carsharing of a current generation is a short-term car renting service with a capability to find in the nearest surrounding a fleet car parked anywhere in the public space where the previous user left it, as well as to book, open, rent and pay of, with the use of a dedicated mobile application. Nowadays, only a minority of municipalities is considering implementing the carsharing in their policies. The lack of awareness of...
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The impact of drying and steaming processes on surface color changes of tension ad normal beech wood
PublikacjaThe aim of the article is to present the influence of high temperature to selected properties of beech wood (Fagus sylvatica L.). The properties such as moisture content, color changes and longitudinal warping were analyzed. The quality of beech wood is determined based on structure and properties of wood, frequency of defects in wood material. The tension wood is considered as an important wood defect causing negative alterations...
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Determination of metal content in sewage sludge and sewage sludge ash to find opportunities to use them in the construction industry
PublikacjaSewage sludge management is becoming an increasing problem in developed and developing countries. Due to their physicochemical properties (mainly high content of heavy metals) a safe method of utilization is sought. Considering environmental protection, energy recycling, reduction in use of the raw materials and the possibility of immobilization hazardous substances, the use of ashes in building materials becomes a very good way...
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Positivity and job burnout in emergency personnel: examining linear and curvilinear relationship
PublikacjaThe aim of this study was to examine whether the relationship between the ratio of job-related positive to negative emotions (positivity ratio) and job burnout is best described as linear or curvilinear. Participants were 89 police officers (12% women) and 86 firefighters. The positivity ratio was evaluated using the Job-related Affective Wellbeing Scale (Van Katwyk, Fox, Spector, & Kelloway, 2000). Exhaustion and disengagement,...
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Sensory Characteristics of Tonic Waters with Various Sweetening Substances vs Young Consumers' Opinion
PublikacjaThe attitude of young consumers towards food products containing low calorie sweeteners was analyzed as well as consumers’ awareness to the medical recommendations regarding artificial sweeteners. The questionnaire was carried out within the group of 97 respondents at the age of 21 – 30. Strongly negative attitude towards consumption of food products containing low calorie sweeteners was declared by almost half of respondents....
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Analysis of Signalized Intersections in the Context of Pedestrian Traffic
PublikacjaGdynia is a city in the Pomeranian Voivod e ship of Poland with a population of about 250,000. It faces a growing motorization rate th at needs to be addressed. Car ownership in Gdynia now exceed s 500 vehicles per 1000 residents. Travel by public transport is decreasing and the rate of walking and cycling remains low. It is necessary to reverse these negative trends by implementing solu tions based...
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Comparative wear test of journal sliding bearings with sintered bronze and Babbitt alloy bushes lubricated by environmentally acceptable/adapted lubricants (EAL)
PublikacjaA growing awareness of the negative effects of mineral oils on the natural environment has resulted in the introduction of new regulations related to environmental protection. One of these regulations requires the use of environmentally acceptable/adapted lubricants (EAL) to lubricate marine main shaft bearings, in place of the mineral lubricating oils that have been used for decades. Classification Societies, which supervise...
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Energetics of formation and stability in high pressure steam of barium lanthanide cobaltite double perovskites
PublikacjaThis study concerns energetics of formation and the stability in high water partial pressure of BaLnCo2O6−δ, (Ln = La, Pr, Nd, and Gd) (BLnC) and BaGd1−xLaxCo2O6−δ, where x = 0.2, 0.5, and 0.7 (BGLC) double perovskite cobaltites. Those materials are extensively studied due to their potential applications as a positrode in electrochemical devices. Therefore, their stability under such conditions is a key issue. All investigated...
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A simple modification of PCR thermal profile applied to evade persisting contamination
PublikacjaThe polymerase chain reaction (PCR), one of the most commonly applied methods of diagnostics and molecular biology has a frustrating downside known as the false positive signal or contamination. Several solutions to avoid and to eliminate PCR contaminations have been worked out to date but the implementation of these solutions to laboratory practice may be laborious and time consuming. A simple approach to circumvent the problem...
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Eksperymentalna analiza wpływu ruchu posuwisto-zwrotnego i obrotowego oraz miejscowych zmian geometrii na skuteczność wypierania cieczy wiertniczych z przestrzeni pierścieniowej
PublikacjaRozprawa przedstawia analizę wpływu ruchu kolumny rur stosowanego w wiertnictwie oraz miejscowych zmian geometrii przestrzeni pierścieniowej na skuteczność procesu wypierania się cieczy. Jest to pierwsze badanie w otwartej literaturze omawiające te czynniki, w którym opisano wyniki eksperymentów na dedykowanym stanowisku badawczym. W pracy omówiony został wpływ węglowodorów na współczesną cywilizację, jak również wpływ skuteczności...
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Praca z drewnem - Przestrzeń eksperymentu w tworzeniu architektury; Crafting Wood - Space of experiment in making architecture
PublikacjaW artykule przedstawiono eksperymenty z materiałem w tworzeniu architektury prowadzące do praktycznych rozwiązań w konstrukcji budynku. Takie podejście do tematyki zastosowania materiałów w architekturze nakreśla praktyczne aspekty tworzenia przestrzeni podczas pracy np. z drewnem. Podejście przedstawiono w kontekście dziedzictwa kulturowego podczas intensywnych warsztatów dotyczących tradycji i kultury budownictwa wybranych regionów...
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Occurrence of Surface Active Agents in the Environment
PublikacjaDue to the specific structure of surfactants molecules they are applied in different areas of human activity (industry, household). After using and discharging from wastewater treatment plants as effluent stream, surface active agents (SAAs) are emitted to various elements of the environment (atmosphere, waters, and solid phases), where they can undergo numerous physic-chemical processes (e.g., sorption, degradation) and freely...
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Influence of electric, magnetic and electromagnetic fields on the circadian system – current stage of knowledge
PublikacjaOne of the side effects of each electrical device work is the electromagnetic field generated near its workplace. All organisms, including humans, are exposed daily to the influence of different types of this field, characterized by various physical parameters. Therefore, it is important to accurately determine the effects of an electromagnetic field on the physiological and pathological processes occurring in cells, tissues and...
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Modelling of FloodWave Propagation with Wet-dry Front by One-dimensional Diffusive Wave Equation
PublikacjaA full dynamic model in the form of the shallow water equations (SWE) is often useful for reproducing the unsteady flow in open channels, as well as over a floodplain. However, most of the numerical algorithms applied to the solution of the SWE fail when flood wave propagation over an initially dry area is simulated. The main problems are related to the very small or negative values of water depths occurring in the vicinity of...
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Analytical procedures for the determination of fuel combustion products, anti-corrosive compounds, and de-icing compounds in airport runoff water samples
PublikacjaThe purpose of this study is to propose and evaluate new procedures for determination of fuel combustion products, anti-corrosive and de-icing compounds in runoff water samples collected from the airports located in different regions and characterized by different levels of the activity expressed by the number of flights and the number of passengers (per year). The most difficult step in the analytical procedure used for the determination...
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Non-isolating bondage in graphs
PublikacjaA dominating set of a graph $G = (V,E)$ is a set $D$ of vertices of $G$ such that every vertex of $V(G) \setminus D$ has a neighbor in $D$. The domination number of a graph $G$, denoted by $\gamma(G)$, is the minimum cardinality of a dominating set of $G$. The non-isolating bondage number of $G$, denoted by $b'(G)$, is the minimum cardinality among all sets of edges $E' \subseteq E$ such that $\delta(G-E') \ge 1$ and $\gamma(G-E')...
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Essays on China's international trade - focus on One-Belt One-Road initiative
PublikacjaThis thesis explores China's international trade from trade, global value chains (GVCs) and export diversity, focusing on the "One-Belt One-Road" (OBOR) initiative proposed at the end of 2013. Specifically, I verify the potential association of OBOR with bilateral imports and exports in the first chapter. Then the relationship between OBOR and GVCs has been explored in Chapter 2. And I have extended the research in GVCs to China's...
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Guanosine Dianions Hydrated by One to Four Water Molecules
PublikacjaIntermolecular interactions such as those present in molecule···water complexes may profoundly influence the physicochemical properties of molecules. Here, we carried out an experimental–computational study on doubly deprotonated guanosine monophosphate···water clusters, [dGMP – 2H]2–·nH2O (n = 1–4), using a combination of negative anion photoelectron spectroscopy (NIPES) with molecular dynamics (MD) and quantum chemical (QM) calculations....
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Role of size scale of ZnO nanoparticles and microparticles on toxicity toward bacteria and osteoblast cancer cells
PublikacjaThe specific role of size scale, surface capping, and aspect ratio of zinc oxide (ZnO) particles on toxicity toward prokaryotic and eukaryotic cells was investigated. ZnO nano and microparticles of controlled size and mor- phology were synthesized by wet chemical methods. Cytotoxicity toward mammalian cells was studied using a human osteoblast cancer cell line and antibacterial activity using Gram-negative bacteria (Escherichia...
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Wage response to global production links: evidence for workers from 28 European countries (2005–2014)
PublikacjaUsing rich individual-level data on workers from 28 European countries, this study provides the first so extensive cross-country assessment of wage response to global production links within GVC in the period 2005–2014. Unlike the other studies, the authors (i) address the importance of backward linkages in globally integrated production structures (capturing imports of goods and services needed in any stage of the production of...
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Suppressors of lapC mutation identify new regulators of LpxC, which mediates the first committed step in lipopolysaccharide biosynthesis
PublikacjaGram-negative bacteria, such as Escherichia coli, are characterized by an asymmetric outer membrane (OM) with lipopolysaccharide (LPS) located in the outer leaflet and phospholipids facing the inner leaflet. E. coli recruits LPS assembly proteins LapB, LapC and LapD in concert with FtsH protease to ensure a balanced biosynthesis of LPS and phospholipids. We recently reported that bacteria either lacking the periplasmic domain of...
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Microplastics removal from aqueous environment by metal organic frameworks
PublikacjaThis paper provides an overview of recent research performed on the applications of metal–organic frameworks (MOFs) for microplastics (MPs) removal from aqueous environments. MPs pollution has become a major environmental concern due to its negative impacts on aquatic ecosystems and human health. Therefore, developing effective and sustainable methods for removing them from aqueous environments is crucial. In recent years, MOFs...
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Analysis of the Surface Stereometry of Alloyed Austenitic Steel after Fibre Laser Cutting using Confocal Microscopy
PublikacjaThe paper extends the concept of cut edge quality and examines the fibre laser cutting process. A Prima Power Platino Fiber Evo device with a reference speed (RS) of 3500 mm/min was used for laser cutting. In order to analyse the influence of the laser cutting speed on the cut edge quality of X5CrNi18-10 stainless steel sheets, macroscopic studies were conducted on a stereoscopic microscope and surface stereometry on a confocal...
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Constant-Factor Approximation Algorithm for Binary Search in Trees with Monotonic Query Times
PublikacjaWe consider a generalization of binary search in linear orders to the domain of weighted trees. The goal is to design an adaptive search strategy whose aim is to locate an unknown target vertex of a given tree. Each query to a vertex v incurs a non-negative cost ω(v) (that can be interpreted as the duration of the query) and returns a feedback that either v is the target or the edge incident to v is given that is on the path towards...
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Application of g-C3N4/ZnO nanocomposites for fabrication of anti-fouling polymer membranes with dye and protein rejection superiority
PublikacjaPolysulfone (PSf) membranes are privileged for water and wastewater treatment, but because of their hydrophobic nature, they suffer from fouling, which lowers their performance and lifetime. In this work, g-C3N4 and g-C3N4/ZnO nanomaterials were synthesized via a hydrothermal method to modify the PSf membrane for effective dye separation and reduction of organic fouling. Since g-C3N4/ZnO possesses –OH and –NH reactive groups, g-C3N4/ZnO/PSf...
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Multi-Channel Virtual Instrument for Measuring Temperature—A Case Study
PublikacjaThe article presents the hardware and software configuration of the developed multi-channel temperature measurement system as well as calibration procedures and measurement results verifying the properties of measurement channels. The system has been developed and dedicated primarily for measuring the temperature distribution in a laboratory model simulating underground power lines. With the adopted configuration of the analog...
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Novel methods for diagnosis of pulmonary microangiopathy in diabetes mellitus
PublikacjaLung microangiopathy is a little known negative influence of diabetes mellitus on the functioning of the lungs. In current medical practice lung microangiopathy is diagnosed by comparing two measurements of lung diffusing capacity - one with the subject standing and one with the subject lying. The necessity to take two measurements is inconvenient. In lung microangiopathy we observe a reduction of diffusing capacity, lung flow...
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Selected problems of decision making modelling in power engineering
PublikacjaThe paper presents the selected problems of decision making modelling in power engineering specially investment risk evaluation methods. The proposed model can be used in the range programming the development and investing process in power engineering. Decision making problems in power engineering and the evaluation of investment effectiveness in particular are closely related to modelling which relatively accurately reflects...
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Review of International Standards and Policy Guidelines for Smart Sustainable Cities
PublikacjaSmart cities are often criticized for preoccupation with technology, for ignoring the negative effects of technology, for irrelevance to the needs of the poor, and for ubiquitous data collection creating perfect conditions for surveillance societies and autocratic states. In response, cities pursue smartness and sustainability simultaneously, becoming global (by participation in global digital networks) and local (by addressing...
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The effect of paleo-environment on hydrocarbon generation potential: Example from Vaca Muerta Formation, Neuquén Basin, Argentina
PublikacjaA 137-m continuous core from the Jurassic-Early Cretaceous marine derived oil shale with the maturity Ro about 0.7 %, representing the oil window in the Vaca Muerta Formation, Neuquén Basin, Argentina, was examined using geological, mineralogical, petrographic, and geochemistry techniques. Three distinct intervals were identified within the core: the upper carbonate-rich section with intense bioturbation, indicating dysoxic to...
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Young Shoots of White and Red Headed Cabbages Like Novel Sources of Glucosinolates as Well as Antioxidative Substances
PublikacjaMost literature data indicate that the diet rich in plant products reduces the risk of developing chronic non-communicable diseases and cancer. Brassica vegetables are almost exclusively synthesizing glucosinolates. Glucosinolates are higher in sprouts than in mature plants, being related to the activity of the specific myrosinase involved in the degradation of glucosinolates during developmental stages. This study compares the...
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COMBINATION OF ARCHITECTURAL, ENVIRONMENTAL, AND SOCIAL ASPECTS IN URBAN STORMWATER MANAGEMENT. A CASE STUDY OF THE UNIVERSITY CAMPUS
PublikacjaIncreasing a city’s resilience against climate change is one of the major concerns of today. Sustainable stormwater management, using Green Infrastructure units (GI) integrated with an urban area, has proved to be effective in flooding control and to offer extra benefits encompassing groundwater recharge, stormwater treatment, mitigation of air pollution, and an urban micro-climate. Moreover, GI brings cultural benefits for the...
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Evolution of magnetic and transport properties in (Cr1−xMnx)2AlC MAX-phase synthesized by arc melting technique
PublikacjaHerein we initiate a comeback to the arc melting technique to produce MAX-phase solid solutions. Bulk samples of (Cr1−xMnx)2AlC MAX-phase with X = 0, 0.025, 0.05 and 0.1 were synthesized and studied by means of X-ray diffractometry, scanning electron microscopy in combination with energy-dispersive X-ray spectroscopy. Samples were established to be homogeneous with an incorporation of Cr7C3, AlCr2 and Al2O3 secondary phases which...
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Inhibitory and antimicrobial activities of OGTI and HV-BBI peptides, fragments and analogs derived from amphibian skin
PublikacjaA series of linear and cyclic fragments and analogs of two peptides (OGTI and HV-BBI) isolated from skin secretions of frogs were synthesized by the solid-phase method. Their inhibitory activity against several serine proteinases: bovine beta-trypsin, bovine alpha-chymotypsin, human leukocyte elastase and cathepsin G from human neutrophils, was investigated together with evaluation of their antimicrobial activities against Gram-negative...
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Determination of polycyclic aromatic hydrocarbons (PAHs) and other organic pollutants in freshwaters on the western shore of Admiralty Bay (King George Island, Maritime Antarctica).
PublikacjaOrganic contamination in freshwater samples has never been investigated at the western shore of Admiralty Bay. Therefore, the presence of polycyclic aromatic hydrocarbons (PAHs) in five different sites distributed along a shore running from the Arctowski Station to the Baranowski Glacier was studied. Moreover, organic compounds such as n-alkanes, toluene and ethylbenzene were also noted. Increased ΣPAHs in late Austral summer 2016...
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The efficiency and technological reliability of biogenic compounds removal during long-term operation of a one-stage subsurface horizontal flow constructed wetland
PublikacjaThe paper presents the results of a study of the efficiency and technological reliability of total nitrogen and total phosphorus removal during long term operation of a one-stage constructed wetland system with subsurface horizontal wastewater flow. The flow rate of the wastewater treatment plant was 1.2m3/d during the research period. Physical and chemical analyses of raw wastewater and treated effluent were carried out in the...
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Biomechanical testing of bioactive bone cements – a comparison of the impact of modifiers: antibiotics and nanometals
PublikacjaApart from its bone filler and fracture stabilizing function, bone cement can be used as a carrier of bioactive substances, and such modified bone cement can protect the implant against microorganisms, treat local infections and combat bacteria introduced during the surgical procedure. In this paper, the effects of modifying antibiotics and nanosilver on the biomechanical properties of bone cement were examined. The following tests...
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Application potential of dummy molecularly imprinted polymers as solidphase extraction sorbents for determination of low-mass polybrominated diphenyl ethers in soil and sediment samples
PublikacjaDespite the introduction of restrictive regulations in the USA and the European Union, polybrominated diphenyl ethers (PBDEs) are still found in various types of environmental and biological samples at significant concentration levels. The presence of these persistent organic pollutants in the environment raises important issues because of their negative impact on immunological and neurological systems, and on the hormonal balances...