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Wyniki wyszukiwania dla: life cycle cost
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Modulation of cellular response to anticancer treatment by caffeine:inhibition of cell cycle checkpoints, DNA repair and more
PublikacjaKofeina i inne metyloksantyny wywołują bardzo różne efekty fizjologiczne w organizmie człowieka. W pracy przedstawiamy, które z tych efektów mogą wpływać na skuteczność terapii przeciwnowotworowych. Kofeina może bezpośrednio wpływać na transport oraz aktywację metaboliczną cząsteczek leków do komórki, poprzez tworzenie kompleksów z lekami zawierającymi układy poliaromatyczne. Kofeina hamuje aktywność kinaz ATM/ATR co prowadzi do...
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Investigations of Ammonia Emissions from Euro 5 Passenger Cars Over a Legislative Driving Cycle
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Temperament and ovarian reproductive hormones in women: Evidence from a study during the entire menstrual cycle
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Effects of flavonoids on expression of genes involved in cell cycle regulation and DNA replication in human fibroblasts
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Process Monitoring in Heavy Duty Drilling Rigs—Data Acquisition System and Cycle Identification Algorithms
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Organic Rankine cycle turbogenerator cooling – Optimization of the generator water jacket heat exchange surface
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Thermodynamic Analysis of a Closed-Cycle Ocean Thermal Energy Conversion Power Plant for Offshore Platforms
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Exergetic Analysis of the nCO2PP Cycle with Particular Reference to the Exergy Destruction of Sewage Sludge Due to Gasification
PublikacjaAn exergy analysis is carried out on the negative CO2 emission gas power plant (nCO2PP), which integrates the process sections of fuel preparation, power generation and carbon capture. Processes of exergy destruction are studied with particular focus on the process in the gasification unit of the fuel preparation section, where a large amount of exergy is destroyed in various chemical reactions from sewage sludge to producer gas...
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Personalized nutrition in ageing society: redox control of major-age related diseases through the NutRedOx Network (COST Action CA16112)
PublikacjaA healthy ageing process is important when it is considered that one-third of the population of Europe is already over 50 years old, although there are regional variations. This proportion is likely to increase in the future, and maintenance of vitality at an older age is not only an important measure of the quality of life but also key to participation and productivity. So, the binomial “nutrition and ageing” has different aspects...
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Pointing device for elders with low cost and mixed manual-gaze control interface
PublikacjaW artykule przedstawiono projekt interfejsu pozwalającego na zastąpienie standardowej myszki komputerowej sterowaniem wzrokowym, z nieznacznym manualnym wspomaganiem. Manualne wspomaganie ma na celu korekcję współrzędnych kursora.
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Cost-performance framework for the assessment of Modular Multilevel Converter in HVDC transmission applications
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Experimental research on low-cost cold gas propulsion for a space robot platform
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Application of Hybrid FEM-DIC Method for Assessment of Low Cost Building Structures
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RECENT DEVELOPMENTS IN POLYURETHANE FOAMS CONTAINING LOW-COST AND PRO-ECOLOGICAL MODIFIERS
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Photodegradation of single and mixture of parabens – Kinetic, by-products identification and cost-efficiency analysis
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Cost-Effectiveness of Open Repair of Abdominal Aortic Aneurysms with a Novel Perioperative Protocol
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Optimization of The Shortest-Path Routing with Equal-Cost Multi-Path Load Balancing
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Cost minimization of locating construction machinery park with the use of simulation and optimization algorithms
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Low-Cost Surrogate Modeling of Miniaturized Microwave Components Using Nested Kriging
PublikacjaIn the paper, a recently reported nested kriging methodology is employed for modeling of miniaturized microwave components. The approach is based on identifying the parameter space region that contains high-quality designs, and, subsequently, rendering the surrogate in this subset. The results obtained for a miniaturized unequal-power-split rat-race coupler and a compact three-section impedance transformer demonstrate reliability...
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Stormwater runoff in the urbanized coastal basin of Gdańsk Urbanized basin of Gdańsk
PublikacjaAnthropopressure strongly affects the primal water cycle. Alternation of the natural basins imposes changes of drainage patterns, reduction of bioretention, infiltration and base flow. As a result the overland flow predominates and greater runoff rates flow into storm water collection systems and reservoirs. Moreover changing climatic conditions increase the frequency of rapid extreme weather events. Infrastructures of urban areas...
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Transcriptomic Effects of Estrogen Starvation and Induction in the MCF7 Cells. The Meta-analysis of Microarray Results
PublikacjaEstrogen is one of the most important signaling molecules which targets a number of genes. Estrogen levels regulate cell proliferation and a plethora of metabolic processes, which may interfere with a range of medical conditions and drug metabolism. The MCF7 breast cancer cell line, expressing the estrogen receptor α, is a well-studied model of cellular answer to estrogen. The aim of this study was to characterize transcriptomic...
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Impact of digital signal processing on FOC current feedback in high-speed PMSM drive
PublikacjaIn applications where size and weight of the electric motor are among major design concerns, Permanent Magnet Synchronous Motors (PMSMs) with wide operational speed-range are commonly preferred. Due to limited inverter switching frequency, high-speed operation of a drive results in a low ratio between the switching frequency and the fundamental frequency of motor voltage. Such operating conditions have been recently identified...
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Design and Evaluation of the Compact and Autonomous Energy Subsystem of a Wave Energy Converter
PublikacjaThis paper presents the results of the design process focused on the development of the energy subsystem (ES) of a wave energy converter (WEC). The ES is an important electrical part that significantly affects the energy reliability and energy efficiency of the entire WEC device. The designed ES was intended for compact WECs powering IoT network devices working in the distributed grid. The developed ES is an electronic circuit...
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Expermental investigation on adsorption of methylene blue dye from waste water using corncob cellulose-based hydrogel
PublikacjaHydrogel from corncob cellulose was synthesized in this investigation. The synthesized Hydrogel was characterized by SEM, XRD, and FTIR instruments. As the results indicate the synthesized hydrogel has required and important features, these suggest the suitability of hydrogel for the adsorption of methylene blue dye (MBD). Three important process variables (dosage, contact time, and initial concentration) with three levels were...
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CYP3A4 overexpression enhances apoptosis induced by anticancer agent imidazoacridinone C-1311, but does not change the metabolism of C-1311 in CHO cells
PublikacjaWe examine whether CYP3A4 overexpression influences the rate and pattern of antitumor imidazoacridinone C-1311 metabolism, in relation to the impact of this overexpression on cell cycle progression and final cellular response of CHO cells following C-1311 treatment. Methods: Three CHO cell lines: CHO-WT, wild type, CHO-HR, overexpressing cytochrome P450 reductase (CPR) and CHO-HR-3A4, coexpressing CPR and CYP3A4 were applied....
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Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use.
PublikacjaThe acridinone derivates C-1305 and C-1311 are promising antitumor agents with high activity against several experimental cellular and tumor models and which are under evaluation in pre-clinical and early phase clinical trials. Recent evidence from our laboratories has indicated that both compounds were conjugated by several UGT isoforms with the most active being extrahepatic UGT1A10. The present studies were designed to test...
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Novel 5-Substituted 2-(Aylmethylthio)-4-chloro-N-(5-aryl-1,2,4-triazin-3-yl)benzenesulfonamides: Synthesis, Molecular Structure, Anticancer Activity, Apoptosis-Inducing Activity and Metabolic Stability
PublikacjaA series of novel 5-substituted 2-(arylmethylthio)-4-chloro-N-(5-aryl-1,2,4-triazin-3-yl) benzenesulfonamide derivatives 27–60 have been synthesized by the reaction of aminoguanidines with an appropriate phenylglyoxal hydrate in glacial acetic acid. A majority of the compounds showed cytotoxic activity toward the human cancer cell lines HCT-116, HeLa and MCF-7, with IC50 values below 100 M. It was found that for the analogues 36–38...
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Application of foam made of post-consumer pet materials for the construction of footbridges
PublikacjaThe article presents the possibility of application in civil engineering of highly ecological PET foam, manufactured from 100% recycled plastic packaging. It may find uses in construction of numerous engineering structures, such as pedestrian and cycle footbridges. Properly processed waste from post-consumer PET packaging may constitute a quality structural core for use in multilayered composite materials, commonly referred to...
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DIAGNOSTIC INFORMATION ANALYSIS OF QUICKLY CHANGING TEMPERATURE OF EXHAUST GAS FROM MARINE DIESEL ENGINE PART I SINGLE FACTOR ANALYSIS
PublikacjaIn this paper, attention was paid to the problem of low controllability of marine medium- and high-speed engines during operation, which significantly limits the parametric diagnosis. The measurement of quickly changing temperature of engine exhaust gas was proposed, the courses of which can be a source of diagnostic information. The F statistic of the Fisher-Snedecor distribution was chosen as a statistical tool. Laboratory tests...
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Sources and composition of chemical pollution in Maritime Antarctica (King George Island), part 1: Sediment and water analysis for PAH sources evaluation in the vicinity of Arctowski station
PublikacjaThe paper presents a study regarding the identification of polycyclic aromatic hydrocarbons (PAHs) in fresh waters and surface sediments on the western shore of Admiralty Bay over four sampling seasons from 2017 to 2018. The results were compared to literature data from 2016 to provide a more comprehensive image of the environmental fate of PAHs over the years. The highest value of Σ PAHs was 82.9 ng/L and 445 ng/g dw in water...
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Modelling AOB-NOB competition in shortcut nitrification compared with conventional nitrification-denitrification process
PublikacjaIn particular, mainstream deammonification and/or shortened nitrificationdenitrification via nitrite (so-called “nitrite shunt”) is a promising new treatment concept that has the potential to revolutionise how nitrogen removal is achieved at WWTPs. Understanding the role of the AOB/NOB competition in the nitrogen cycle in wastewater treatment systems will change operational strategies of the novel nitrogen removal processes. The...
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Coastal cliff erosion as a source of toxic, essential and nonessential metals in the marine environment
PublikacjaDue to the rising environmental awareness, emissions and releases of pollutants, including metals, have been considerably reduced in the last decades. Therefore, the remobiliza-tion of natural and anthropogenic contaminants is gaining importance in their biogeochemical cycle. In the marine coastal zone, this process occurs during the erosion of a shore, especially the most vulnerable cliffs. The research was conducted in the...
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Locust bean gum as green and water-soluble binder for LiFePO4 and Li4Ti5O12 electrodes
PublikacjaLocust Bean Gum (LBG, carob bean gum) was investigated as an environmentally friendly, natural, and water-soluble binder for cathode (LFP) and anode (LTO) in lithium-ion batteries (Li-ion). For the frst time, we show LBG as an electrode binder and compare to those of the most popular aqueous (CMC) and conventional (PVDF) binders. The electrodes were characterized using TGA/DSC, the galvanostatic charge–discharge cycle test, cyclic...
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Implementation of advanced micropollutants removal technologies in wastewater treatment plants (WWTPs) - Examples and challenges based on selected EU countries
PublikacjaThe accumulation of micropollutants (MPs) and their increasing concentration in the aquatic environment are an emerging issue for water quality in the world. The complex web of exposure pathways, as well as the variety in the chemical structure and potency of MPs, represents enormous challenges for researchers and policy initiatives. In order to manage MPs, it has to be decided which of them have to be reduced and to what extent,...
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Thermodynamic analysis of the Compressed Air Energy Storage system coupled with the Underground Thermal Energy Storage
PublikacjaImprovement of flexibility is one of the key challenges for the transformation of the Polish Power System aiming at a high share of renewable energy in electricity generation. Flexible and dispatchable power plants will contribute to this ongoing transformation process as they compensate for fluctuations in electricity generation from renewable energy sources such as wind and photovoltaics. In this context, CAES storage tanks are...
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Sources of contamination in sediments of retention tanks and the influence of precipitation type on the size of pollution load
PublikacjaDensification of cities and urban population contributes to increased runoff and suspended solids and alteration of the urban water cycle. Nowadays, Blue-Green Infrastructure is promoted to increase a city’s resilience to floods; however, stormwater drainage systems, supported with retention tanks are still important in protecting urban areas against floods. Sediment accumulation in stormwater infrastructure relates to an issue...
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Effect of Arc Strikes on High Strength Low Alloy Steels Welded by SMAW
PublikacjaWet welding with covered electrodes (Shielded Metal Arc Welding – SMAW) is the most commonly used method of carrying out welding repair works in a water environment. Limited visibility and the inability to move freely under water result in an increased risk of formation of welding imperfections such as lack of fusion, lack of penetration and arc strikes. The work focused on changes in the properties and structure of steel subjected...
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Polymer derived SiOC/Sn nanocomposites from a low-cost single source precursor as anode materials for lithium storage applications
PublikacjaMetal- based materials capable of lithium (Li) alloy formation are key to realization of the next generation of high-energy density anodes for Li-ion batteries, owing to their high storage capacity. Designing a good sup- porting matrix is essential for homogeneously nesting these metallic nanodomains, to effectively utilize their high capacity while tackling the volume expansion issues. Silicon oxycarbides (SiOC), obtained via...
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Tool Life and Process Dynamics in High Speed Ball End Milling of Hardened Steel
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Fatigue ''safe-life'' criterion for metal elements under multiaxial constant and periodic loads.
PublikacjaRozpatrywane jest okresowe naprężenie którego kartezjańskie składowe są zadane w postaci szeregów Fouriera. Dla uwzględnienia naprężenia średniego wykorzystano uogólnioną formułę Soderberga dla materiałów ciągliwych. Zdefiniowano naprężenie równoważne o synchronicznych składowych i sformułowano kryterium zmęczenia, które obejmuje warunki zarówno wytrzymałości statycznej jak i bezpieczeństwa zmęczeniowego. Kryterium to zawiera stałe...
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Fracture surface topography investigation and fatigue life assessment of notched austenitic steel specimens
PublikacjaThe objectives of this study were to investigate the fracture surface topography of X8CrNiS18-9 austenitic stainless-steel specimens for different loadings and notch radii and to supplement the knowledge about the fracture mechanisms for fatigue performance. Cases with three different values of the notch radius ρ and the stress amplitude σa were analysed. The fracture topographies were quantified by the areas over their entire...
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Prediction of corrosion fatigue crack propagation life for welded joints under cathodic potentials
PublikacjaPrzy ochronie katodowej poniżej potencjału optymalnego obserwuje się przyspieszenie propagacji pęknięcia korozyjno-zmęczeniowego w porównaniu do konstrukcji nie chronionej. Zaproponowano własną formułę empiryczną na wpływ potencjału ochronnego na prędkość propagacji pęknięcia oraz własny wzór na [delta]K w złączu pachwinowym. Wyprowadzono wzór na krzywą ''S-Np'' (naprężenie - długość okresu propagacji pęknięcia). Zaprezentowana...
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Multiaxial fatigue life assessment in notched components based on the effective strain energy density
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The role of purpose in life and social support in reducing the risk of workaholism among women in Poland
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The role of purpose in life and social support in reducing the risk of workaholism among women in Poland
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Blood plasma protein and lipid profile changes in calves during the first week of life
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Aquaporin 2: Identification and analysis of expression in calves’ urine during their first month of life
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Brain Fog and Quality of Life at Work in Non-Hospitalized Patients after COVID-19
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Comparison Analysis of Blade Life Cycles of Land-Based and Offshore Wind Power Plants
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New Life of an Old Drug: Caffeine as a Modulator of Antibacterial Activity of Commonly Used Antibiotics
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