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Wyniki wyszukiwania dla: PROBABILITIES IN THE FINAL PROPOSAL
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Longitudinal drug synergy assessment using convolutional neural network image-decoding of glioblastoma single-spheroid cultures
PublikacjaAbstract Background In recent years, drug combinations have become increasingly popular to improve therapeutic outcomes in various diseases, including difficult to cure cancers such as the brain cancer glioblastoma. Assessing the interaction between drugs over time is critical for predicting drug combination effectiveness and minimizing the risk of therapy resistance. However, as viability readouts of drug combination experiments...
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Combination of hydrodynamic cavitation and SR-AOPs for simultaneous degradation of BTEX in water
PublikacjaHydrodynamic cavitation (HC) is an emerging technology gaining interest in water treatment for use in elimination of a wide range of organic pollutants. The energy released during cavitation phenomenon has number of applications and, particularly, it can be utilized for activation of persulfate (PS) and peroxymonosulfate (PMS). In the present study, hybrid techniques: HC combined with persulfates – HC-PS and HC-PMS were tested...
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Accelerated Gradient-Based Optimization of Antenna Structures Using Multi-Fidelity Simulations and Convergence-Based Model Management Scheme
PublikacjaThe importance of numerical optimization has been steadily growing in the design of contemporary antenna structures. The primary reason is the increasing complexity of antenna topologies, [ a typically large number of adjustable parameters that have to be simultaneously tuned. Design closure is no longer possible using traditional methods, including theoretical models or supervised parameter sweeping. To ensure reliability, optimization...
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Transport of Particles in Intestinal Mucus under Simulated Infant and Adult Physiological Conditions: Impact of Mucus Structure and Extracellular DNA
PublikacjaThe final boundary between digested food and the cells that take up nutrients in the small intestine is a protective layer of mucus. In this work, the microstructural organization and permeability of the intestinal mucus have been determined under conditions simulating those of infant and adult human small intestines. As a model, we used the mucus from the proximal (jejunal) small intestines of piglets and adult pigs. Confocal...
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Molecular dynamics study on the role of solvation water in the adsorption of hyperactive AFP to the ice surface
PublikacjaUsing computer simulations, the early stages of the adsorption of the CfAFP molecule to the ice surface were analyzed. We found that the ice and the protein interact at least as early as when the protein is about 1 nm away from the ice surface. These interactions are mediated by interfacial solvation water and are possible thanks to the structural ordering of the solvent. This ordering leads to positional preference of the protein...
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Interactions between bioactive components determine antioxidant, cytotoxic and nutrigenomic activity of cocoa powder extract
PublikacjaNumerous studies have shown, rather disappointingly, that isolated bioactive phytochemicals are not as biologically effective as natural plant products. Such a discrepancy may be explained by the concept of food synergy, which was verified in this research for cocoa extract versus its major components with regard to cancer chemoprevention. The evaluation embraced the relationship between redox properties evaluated in cell-free systems...
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Piezoelectric Transducer for Mechanical Assessment of Soft Tissues. Concept, Implementation and Analysis
PublikacjaThe main goal of this work was following: preparation of a new concept, implementation and analysis of the piezoelectric resonant sensor/actuator for measuring the aging process of human skin. The research work has been carried out in the framework of cooperation between the INP-ENSEEIHT-LAPLACE, Toulouse, France, and at the Gdansk University of Technology, Faculty of Electrical and Control Engineering, Research Group of...
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COOPERATION BETWEEN UNIVERSITY AND EXTERNAL COMPANY IN ARCHITECTURAL INVENTORY USING INNOVATIVE MEASURING TECHNOLOGY
PublikacjaArchitectural inventories are the main field for using innovative technology ( remote sensing). The main purpose of using ie. Laser scanning or photogrammetry is to capture all of the important details of structure. Regarding the extents of inventory works, it may only apply to external details, such as facades, supporting structures and surroundings, whilst in terms of advanced inventory, the building's interior is also expected...
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The Influence of Calcium Glycerophosphate (GPCa) Modifier on Physicochemical, Mechanical, and Biological Performance of Polyurethanes Applicable as Biomaterials for Bone Tissue Scaffolds Fabrication
PublikacjaIn this paper we describe the synthesis of poly(ester ether urethane)s (PEEURs) by using selected raw materials to reach a biocompatible polyurethane (PU) for biomedical applications. PEEURs were synthesized by using aliphatic 1,6-hexamethylene diisocyanate (HDI), poly(ethylene glycol) (PEG), α,ω-dihydroxy(ethylene-butylene adipate) (Polios), 1,4-butanediol (BDO) as a chain extender and calcium glycerolphosphate salt (GPCa) as...
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The Effect of Laser Re-Solidification on Microstructure and Photo-Electrochemical Properties of Fe-Decorated TiO2 Nanotubes
PublikacjaFossil fuels became increasingly unpleasant energy source due to their negative impact on the environment; thus, attractiveness of renewable, and especially solar energy, is growing worldwide. Among others, the research is focused on smart combination of simple compounds towards formation of the photoactive materials. Following that, our work concerns the optimized manipulation of laser light coupled with the iron sputtering to...
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The Environmental Benefits of Photovoltaic Systems: The Impact on the Environment in the Production of Photovoltaic Systems: With a Focus on Metal Recovery
PublikacjaGreenhouse gases (GHGs) such as carbon dioxide, nitrous oxide and methane, trap heat and energy, thus preventing solar radiation from escaping back into space. As the quantity of greenhouse gases in the atmosphere increases so does the trapped heat and corresponding global temperature. As a result, storms become more violent, droughts more prevalent, glaciers melt, and sea levels rise, to name but a few effects of a rapidly changing...
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Application of COSMO-RS-DARE as a Tool for Testing Consistency of Solubility Data: Case of Coumarin in Neat Alcohols
PublikacjaCoumarin is a naturally occurring lactone-type benzopyrone with various applications in the pharmaceutical, food, perfume, and cosmetics industries. This hydrophobic compound is poorly soluble in water but dissolves well in protic organic solvents such as alcohols. Despite the extensive use of coumarin, there are only a few reports documenting its solubility in organic solvents, and some reported data are incongruent, which...
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Improving automatic surveillance by sound analysis
PublikacjaAn automatic surveillance system, based on event detection in the video image can be improved by implementing algorithms for audio analysis. Dangerous or illegal actions are often connected with distinctive sound events like screams or sudden bursts of energy. A method for detection and classification of alarming sound events is presented. Detection is based on the observation of sudden changes in sound level in distinctive sub-bands...
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Long range molecular dynamics study of regulation of eukaryotic glucosamine-6-phosphate synthase activity by UDP-GlcNAc
PublikacjaGlucosamine-6-phosphate (GlcN-6-P) synthase catalyses the first and practically irreversible step in hexosamine metabolism. The final product of this pathway, uridine 5' diphospho N-acetyl-D-glucosamine (UDPGlcNAc), is an essential substrate for assembly of bacterialand fungal cell walls. Moreover, the enzyme is involved in phenomenon of hexosamine induced insulin resistance in type II diabetes, which makes it a potential target...
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Sequential treatment of landfill leachate by electrocoagulation/aeration, PMS/ZVI/UV and electro-Fenton: Performance, biodegradability and toxicity studies
PublikacjaThis study presents a systematic study on sequential treatment of highly resistant landfill leachate by electrocoagulation (EC)/aeration, sulfate radical advanced oxidation process (SR-AOP) and electro-Fenton (EF). In case of SR-AOP, peroxymonosulfate (PMS) catalyzed by zero valent iron (ZVI) and ultraviolet irradiation (UV) system was developed. Treatment process was optimized in respect to COD removal. Analysis of results revealed...
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Development of a spray-ejector condenser for the use in a negative CO2 emission gas power plant
PublikacjaOne promising solution for developing low-emission power technologies is using gaseous fuel combustion in pure oxygen when the exhaust gas mixture is composed of H2O and CO2, and where CO2 is separated after steam condensation. The paper presents the results of computational analyses providing to the Spray-Ejector Condenser (SEC) development, which is one of the crucial components of the negative CO2 gas power plant (nCO2PP) cycle...
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Towards an experience based collective computational intelligence for manufacturing
PublikacjaKnowledge based support can play a vital role not only in the new fast emerging information and communication technology based industry, but also in traditional manufacturing. In this regard, several domain specific research endeavors have taken place in the past with limited success. Thus, there is a need to develop a flexible domain independent mechanism to capture, store, reuse, and share manufacturing knowledge. Consequently,...
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Forced vibrations in a dynamic system that is damped by a mechanism that trans-pass through its singular position
PublikacjaIn the paper, vibrations of a hybrid multibody-continuous system are investigated. For all the mechanical devices, effective damping methods are crucial in the design process. To obtain it, installation of viscous dampers or elasto-viscous elements is dominant. In the paper, an alternative method is investigated. It is based on modal disparity. To describe the method briefly, when structural damping is present in continuous systems,...
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THE ART OF VIRTUAL INFORMATION EXCHANGE AND ITS INFLUENCE ON REAL CITY SPACE
PublikacjaThe paper investigates the impact of the new genres of contemporary public art based on the virtual information exchange in real spaces of the cities. On the basis of theoretical approaches, trans-disciplinary surveys and case studies, the paper focuses on the art that not only relies on the technological support but also refers to the new public sphere, where people are co-creators of the art object giving their personal input...
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Emulsification alters simulated gastrointestinal proteolysis of β-casein and β-lactoglobulin
PublikacjaWe have studied the effect of the adsorption of milk proteins at the oil-water interface on their digestibility in simulated gastrointestinal environment. The investigations aimed to characterize how both the breakdown of the adsorbed proteins and the interactions with physiological surfactants, phosphatidylcholine (PC) and bile salts (BS), influence structural transformations of model, protein-stabilized food emulsions in the...
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User -friendly E-learning Platform: a Case Study of a Design Thinking Approach Use
PublikacjaE-learning systems are very popular means to support the teaching process today. These systems are mainly used by universities as well as by commercial training centres. We analysed several popular e-learning platforms used in Polish universities and find them very unfriendly for the users. For this reason, the authors began the work on the creation of a new system that would be not only useful, but also usable for students, teachers...
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Determination of Surfactants in Environmental Samples. Part III. Non-Ionic Compounds
PublikacjaNon-ionic surface active agents are a diverse group of chemicals which have an uncharged polar head and a non-polar tail. They have different properties due to amphiphilic structure of their molecules. Commercial available non-ionic surfactants consist of the broadest spectrum of compounds in comparison with other types of such agents. Typically, non-ionic compounds found applications in households and industry during formulation...
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Improving platelet‐RNA‐based diagnostics: a comparative analysis of machine learning models for cancer detection and multiclass classification
PublikacjaLiquid biopsy demonstrates excellent potential in patient management by providing a minimally invasive and cost-effective approach to detecting and monitoring cancer, even at its early stages. Due to the complexity of liquid biopsy data, machine-learning techniques are increasingly gaining attention in sample analysis, especially for multidimensional data such as RNA expression profiles. Yet, there is no agreement in the community...
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Composite as a Material of the Future in the Era of Green Deal Implementation Strategies
PublikacjaComposite materials have become synonymous with modernity, desired in nearly every aspect of our daily lives, from simple everyday objects to sanitary facilities, pipelines, the construction of modern sewer networks, their renovation, water supply, and storage reservoirs, to complex structures—automotive, planes, and space science. Composites have seen a considerable rise in attention owing to their characteristics, durability,...
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Household Ability of Expenditures on Electricity and Energy Resources in the Countries That Joined the EU after 2004
PublikacjaThe purpose of the following article is to present the situation of the energy market from a household perspective between 2010 and 2020 in selected EU countries (the group of member states which joined EU after 2004). The selected countries when joining the EU had similar economic indicators and to some extent were similar in other macro-economic situations (personal income, unemployment rate, GDP level and annual growth). This...
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Development of a vortex-assisted switchable-hydrophilicity solvent-based liquid phase microextraction for fast and reliable extraction of Zn (II), Fe (II), Pb (II), and Cd (II) from various baby food products
PublikacjaThis manuscript describes the development of a novel liquid phase microextraction (LPME) method for the extraction and determination of Zn (II), Fe (II), Pb (II), and Cd (II) in various infant/baby food and supplements products. The method is based on vortex-assisted extraction combined with a switchable-hydrophilicity solvent (SHS) sample preparation. The SHS, which undergoes reversible phase changes triggered by pH change, enables...
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The role of the combined nitrogen-sulfur-carbon cycles for efficient performance of anammox-based systems
PublikacjaThe combined anammox/mixotrophic denitrification process was conducted in two granular sequencing batch reactors (SBRs) during a 200-day operation. Both reactors were fed with synthetic medium, but SBR2 was enriched with additional sulfate (SO4 2 ) which influenced sulfate reduction ammonium oxidation (SRAO) and heterotrophic reduction of SO4 2 by sulfate reducing bacteria. It was hypothesized that the addition of SO4 2 could...
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Testing Stability of Digital Filters Using Optimization Methods with Phase Analysis
PublikacjaIn this paper, novel methods for the evaluation of digital-filter stability are investigated. The methods are based on phase analysis of a complex function in the characteristic equation of a digital filter. It allows for evaluating stability when a characteristic equation is not based on a polynomial. The operation of these methods relies on sampling the unit circle on the complex plane and extracting the phase quadrant of a function...
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A framework for accelerated optimization of antennas using design database and initial parameter set estimation
PublikacjaThe purpose of this paper is to exploit a database of pre-existing designs to accelerate parametric optimization of antenna structures is investigated. Design/methodology/approach The usefulness of pre-existing designs for rapid design of antennas is investigated. The proposed approach exploits the database existing antenna base designs to determine a good starting point for structure optimization and its response sensitivities....
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‘The Urban Walk Architecture Talk’— Bridging Socially Engaged Art, Urban Processes and Cultural Development
Publikacja“Urban Walk—Architecture Talk” is a project based on an elective seminar under the same title organized at the Faculty of Architecture of Gdańsk University of Technology. It aims at getting familiar with the topic of multi-layer and multi-sensory reception of public space, mainly by recognizing the needs of its users. Additionally, it deals with the consequences of such perception and the use of space in order to build more complete...
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The issue of uncertainty of visual measurement techniques for long distance measurements based on the example of applying electric traction elements in diagnostics and monitoring
PublikacjaRail transport is the most economical and energy-effective in the field of land transport, in particular electrified. In order to ensure efficient and reliable operation of electrified rail transport, the issues of monitoring and diagnostics of the traction infrastructure and vehicles are extremely important. The most critical point in the transmission of electric energy to the vehicle is the sliding contact of the current collector...
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Self-standing Nanoarchitectures
PublikacjaDespite there are structures invisible for the human eye, they mastered the world of advanced electronic devices, sensors, novel cosmetics or drugs. When the dimensions of the materials go down to the nanometres scale, their properties change dramatically comparing to the observable objects. Because of their tiny size, they gained the name of nanomaterials but simultaneously their importance has significantly grown up. Nanomaterials...
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A Novel Method for the Deblurring of Photogrammetric Images Using Conditional Generative Adversarial Networks
PublikacjaThe visual data acquisition from small unmanned aerial vehicles (UAVs) may encounter a situation in which blur appears on the images. Image blurring caused by camera motion during exposure significantly impacts the images interpretation quality and consequently the quality of photogrammetric products. On blurred images, it is difficult to visually locate ground control points, and the number of identified feature points decreases...
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Complex multidisciplinary optimization of turbine blading systems
PublikacjaThe paper describes the methods and results of direct optimization of turbine blading systems using a software package Opti_turb. The final shape of the blading is obtained from minimizing the objective function, which is the total energy loss of the stage, including the leaving energy. The current values of the objective function are found from 3D RANS computations (from a code FlowER) of geometries changed during the process...
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Glucosamine-6-phosphate synthase with an oligoHis insert
PublikacjaGlucosamine-6-phosphate (GlcN-6-P) synthase known also as L-Glutamine: D-fructose-6-phosphate aminotransferase (EC 2.6.1.16), catalyzes the first committed step in the amino sugar biosynthetic pathway in prokaryotic and eukaryotic organisms. The final product of this pathway is an activated precursor of numerous macromolecules containing amino sugars, including chitin and mannproteins in fungi, peptydoglican and lipopolysaccharides...
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Organic Rankine cycle as bottoming cycle to a combined Brayton and Clausius - Rankine cycle
PublikacjaA preliminary evaluation has been made of a possibility of bottoming of a conventional Brayton cycle cooperating with the CHP power plant with the organic Rankine cycle installation. Such solution contributes to the possibility of annual operation of that power plant, except of operation only in periods when there is a demand for the heat. Additional benefit would be the fact that an optimized backpressure steam cycle has the advantage...
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Late Aortic Remodeling after Endovascular Repair of Complicated Type B Aortic Dissection—TEVAR Protects Only the Covered Segment of Thoracic Aorta
PublikacjaIntroduction: TEVAR is the preferred way of treatment of complicated type B aortic dissection. The purpose of the study was to assess the impact of TEVAR on aortic remodelling in the thoracic and abdominal segment in long-term follow-up. Methods: 23 patients with complicated type B aortic dissection were treated by TEVAR in years 2004-2012 in our Department. Aortic remodelling was rated based on preoperative and final follow-up...
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Reliability and types of diagnosis in the process of diesel engine operation
PublikacjaThe article presents complexity of the problem concerning development of diagnosis with defined reliability by a diagnosing system (SDG) on technical condition of marine combustion engines, especially main engines. It was shown that development of the final diagnosis, the so-called initial operation diagnosis, on the operational usability (fDG on PEx) of a main engine in particular, is not possible without prior development of...
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Hydrothermal synthesis of vanadium ammonium compounds – the crucial role of the pressure
PublikacjaDue to the structural diversity and chemical activity, vanadium oxides and their derivatives are continuingly in the great interest of scientist. In a large family of vanadium compounds, one of the most interesting are ammonium vanadates (with the general formula (NH4)xVyOz). They have received much attention because of their promising application as cathode material in mono- and multivalent-ion batteries [1]. Hydrothermal synthesis...
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Underwater in situ local heat treatment by additional stitches for improving the weldability of steel
PublikacjaIn this paper the influence of in situ local heat treatment performed by additional stitches on the weldability of high-strength low-alloy (HSLA) S355J2C+N steel was tested. The investigated steel is characterized by high susceptibility to cold cracking. It is necessary to find a method to improve the quality of welded joints. The local heat treatment was applied as an eect of bead-on plate welding made on the face of a Tekken...
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Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under hypoxia
PublikacjaInduction of proteins involved in drug metabolism and in drug delivery has a significant impact on drug-drug interactions and on the final therapeutic effects. Two antitumor acridine derivatives selected for present studies, C-1748 (9-(2’-hydroxyethylamino)-4-methyl-1-nitroacridine) and C-1305 (5-dimethylaminopropylamino-8-hydroxy-triazoloacridinone), expressed high and low susceptibility to metabolic transformations with liver...
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Modulation of CYP3A4 activity and induction of apoptosis, necrosis and senescence by the antitumor imidazoacridinone C-1311 in human hepatoma cells
PublikacjaThere is increasing evidence that the expression level of drug metabolic enzymes affects the final cellular response following drug treatment. Moreover, anti-tumour agents may modulate enzymatic activity and/or cellular expression of metabolic enzymes in tumour cells. We investigated the influence of CYP3A4 overexpression on the cellular response induced by the anti-tumour agent C-1311 in hepatoma cells. C-1311-mediated CYP3A4...
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Formation of Porous Structure of the Metallic Materials Used on Bone Implants
PublikacjaResearch on improvement of structure and fabrication methods of the bone implants are carried out for many years. Research are aimed to shape the structures, that will have a Young's modulus value similar to the value of the human bones Young's modulus. Depending on theporosity, Young's moduli can even be tailored to match the modulus of bone closer than solid metals can, thus reducing the problems associated with stress shielding...
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Investigations on fracture in reinforced concrete beams in 3-point bending using continuous micro-CT scanning
PublikacjaThis study explores a fracture process in rectangular reinforced concrete (RC) beams subjected to quasi-static three-point bending. RC beams were short and long with included longitudinal reinforcement in the form of a steel or basalt bar. The ratio of the shear span to the effective depth was 1.5 and 0.75. The focus was on the load–deflection diagram and crack formation. Three-dimensional (3D) analyses of the size and distribution...
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Knowledge-based performance-driven modeling of antenna structures
PublikacjaThe importance of surrogate modeling techniques in the design of modern antenna systems has been continuously growing over the recent years. This phenomenon is a matter of practical necessity rather than simply a fashion. On the one hand, antenna design procedures rely on full-wave electromagnetic (EM) simulation tools. On the other hand, the computational costs incurred by repetitive EM analyses involved in solving common tasks...
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Model-Based Adaptive Machine Learning Approach in Concrete Mix Design
PublikacjaConcrete mix design is one of the most critical issues in concrete technology. This process aims to create a concrete mix which helps deliver concrete with desired features and quality. Contemporary requirements for concrete concern not only its structural properties, but also increasingly its production process and environmental friendliness, forcing concrete producers to use both chemically and technologically complex concrete...
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The potential of raw sewage sludge in construction industry – A review
PublikacjaExcess sewage sludge produced in any municipal or industrial wastewater treatment plant becomes a serious problem due to its increasing amount. This increase is related to the improvement of treatment technologies, expansion of sewage systems and the development of new industrial plants. The implementation and development of new technologies related to the utilization of sewage sludge is currently based on treating it as a substrate....
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Concentrations of monoaromatic hydrocarbons in the air of the underground car park and individual garages attached to residential buildings
PublikacjaThe paper describes the characteristics of a two-level underground car park and three individual garages attached to residential buildings, differing by the resident utilization habits, located in North Poland (Tri-City agglomeration area). The strategy of collecting the analyte samples from air in mentioned enclosed areas, concerning the determination of benzene, toluene, ethylbenzene, o-xylene and p,m-xylenes (BTEX) concentrations...
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Water chemistry of tundra lakes in the periglacial zone of the Bellsund Fiord (Svalbard) in the summer of 2013
PublikacjaClimate changes observed in the Arctic (e.g. permafrost degradation, glacier retreat) may have significant influence on sensitive polar wetlands. The main objectives of this paper are defining chemical features of water within six small arctic lakes located in Bellsund (Svalbard) in the area of continuous permafrost occurrence. The unique environmental conditions of the study area offer an opportunity to observe phenomena influencing...
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Vehicle detector training with minimal supervision
PublikacjaRecently many efficient object detectors based on convolutional neural networks (CNN) have been developed and they achieved impressive performance on many computer vision tasks. However, in order to achieve practical results, CNNs require really large annotated datasets for training. While many such databases are available, many of them can only be used for research purposes. Also some problems exist where such datasets are not...