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Wyniki wyszukiwania dla: DRUG DELIVERY, HYDROXYLATION, CARBON NANOTUBES, MOLECULAR DYNAMIC SIMULATION, ENCAPSULATION, ANTIMICROBIAL PEPTIDE
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Structural changes of a simple peptide—Trpzip-1—in aqueous solutions and the corresponding hydration phenomena under the influence of temperature
PublikacjaTrpzip-1, a simple β-hairpin, is a rare example of peptide with stable secondary structure and can be a convenient model to study temperature-related processes that potential prion or amyloid proteins undergo. Although its sequence is simple, the exact processes which the peptide undergoes in aqueous solutions are quite complex and not well understood. The selection of well-established experimental (DSC, FTIR) and theoretical methods...
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Lipidated Analogs of the LL-37-Derived Peptide Fragment KR12—Structural Analysis, Surface-Active Properties and Antimicrobial Activity
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Activated Cu catalysts for alcohol CVD synthesized non-magnetic bamboo-like carbon nanotubes and branched bamboo-like carbon nanotubes
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Molecular dynamics studies of polyurethane nanocomposite hydrogels
PublikacjaPolyurethane PEO-based hydrogels have a broad range of biomedical applicability. They are attractive for drug-controlled delivery systems, surgical implants and wound healing dressings. In this study, a PEO based polyurethane hydrogels containing Cloisite R 30B, an organically modified clay mineral, was synthesized. Structure of nanocomposite hydrogels was determined using XRD technique. Its molecular dynamics was studied by means...
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Molecular modeling and evaluation of novel dibenzopyrrole derivatives as telomerase inhibitors and potential drug for cancer therapy
PublikacjaDuring previous years, many studies on synthesis, as well as on anti-tumor, anti-inflammatory and anti-bacterial activities of the pyrazole derivatives have been described. Certain pyrazole derivatives exhibit important pharmacological activities and have proved to be useful template in drug research. Considering importance of pyrazole template, in current work the series of novel inhibitors were designed by replacing central...
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Peptide Permeases in Candida albicans
PublikacjaAims: The aim of this work was to characterize oligopeptide uptake in Candida albicans mutants in which the genes encoding putative peptide permeases were selectively disrupted. Initial velocities of transport of model oligopeptides, (Ala)2, (Ala)3, (Ala)4, and sensitivity of mutants to antifungal oligopeptides containing N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP) were determined and compared to those of the wild-type...
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Antimicrobial Activity of Honey
PublikacjaHoney has had a valued place in traditional medicine for centuries. It was used to overcome liver, cardiovascular and gastrointestinal problems and for treatment of some types of infectious disease. Particularly, good results were achieved in the case of application of this product for therapy of infected, difficult to heal wounds. The high health-promoting properties of honey have been recently confirmed in many research investigations....
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Unusual interfacial phenomena at a surface of fullerite and carbon nanotubes
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Synthesis of Multiwalled Carbon Nanotubes by Catalytic Combustion of Polypropylene
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Comparative study on purity evaluation of singlewall carbon nanotubes
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Single-walled carbon nanotubes fractionation via electrophoresis
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Selective oxidation of metallic single-walled carbon nanotubes
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Boron doped carbon nanotubes via ceramic catalysts
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Oxidation and reduction of multiwalled carbon nanotubes — preparation and characterization
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In situ observations of fullerene fusion and ejection in carbon nanotubes
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Formation of novel nanostructures using carbon nanotubes as a frame
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Chlorination of Carbon Nanotubes Obtained on the Different Metal Catalysts
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Simultaneous purification and functionalization of carbon nanotubes using chlorination
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Hybrid biobattery based on arylated carbon nanotubes and laccase
PublikacjaJednościenne nanorurki węglowe modyfikowano resztami antracenu i antrachinonu Otrzymany materiał posłużył do modyfikacji elektrody węglowej w celu jej zastosowania do redukcji tlenu w bioogniwie paliwowym. Nanorurki z aromatycznymi grupami zwiększyły powierzchnię elektrody oraz przyczyniły się do zwiększenia bezpośredniego przeniesienia elektronów. Grupy arylowe mogą wnikać do hydrofobowej kieszeni enzymu, w której znajduje się...
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Molecular dynamics simulation of human neurohypophyseal hormone receptors complexed with oxytocin—modeling of an activated state
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Highly sensitive large strain cellulose/multiwalled carbon nanotubes (MWCNTs)/thermoplastic polyurethane (TPU) nanocomposite foams: From design to performance evaluation
PublikacjaAerogel-based polymer composite foams are promising for large strain piezoresistive sensors, but their aerogel skeleton is partially destroyed during the foaming process, limiting their sensitivity. Herein, the thermoplastic polyurethane was synthesized on the aerogel skeleton to obtain cellulose/multiwalled carbon nanotubes (MWCNTs)/thermoplastic polyurethane (TPU) nanocomposite materials foamed with the aid of supercritical carbon...
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Nanoemulsion Structural Design in Co-Encapsulation of Hybrid Multifunctional Agents: Influence of the Smart PLGA Polymers on the Nanosystem-Enhanced Delivery and Electro-Photodynamic Treatment
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Comparative studies of sorption of phenolic compounds onto carbon-encapsulated iron nanoparticles, carbon nanotubes and activated carbon
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Post-critical buckling of truncated conical carbon nanotubes considering surface effects embedding in a nonlinear Winkler substrate using the Rayleigh-Ritz method
PublikacjaThis research predicts theoretically post-critical axial buckling behavior of truncated conical carbon nanotubes (CCNTs) with several boundary conditions by assuming a nonlinear Winkler matrix. The post-buckling of CCNTs has been studied based on the Euler-Bernoulli beam model, Hamilton’s principle, Lagrangian strains, and nonlocal strain gradient theory. Both stiffness-hardening and stiffness-softening properties of the nanostructure...
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Low-Molecular Pyrazine-Based DNA Binders: Physicochemical and Antimicrobial Properties
PublikacjaPyrazine and its derivatives are a large group of compounds that exhibit broad biological activity, the changes of which can be easily detected by a substituent effect or a change in the functional group. The present studies combined theoretical research with the density functional theory (DFT) approach (B3LYP/6-311+G**) and experimental (potentiometric and spectrophotometric) analysis for a thorough understanding of the structure...
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The influence of carbon dioxide on dynamic thermography results
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Targeted Nano-Drug Delivery of Colchicine against Colon Cancer Cells by Means of Mesoporous Silica Nanoparticles
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<p>Nanoparticles And Human Saliva: A Step Towards Drug Delivery Systems For Dental And Craniofacial Biomaterials</p>
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In vitro and in vivo evaluation of sandwich-like mesoporous silica nanoflakes as promising anticancer drug delivery system
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Effect of multi-walled carbon nanotubes properties on the photocatalytic activity of bismuth-based composites synthesised via an imidazolium ionic liquid
PublikacjaThe use of various types of multi-walled carbon nanotubes in the synthesis of bismuth oxybromide semiconductors via imidazolium ionic liquid was studied in detail. The effect of the MWCNT shape, specific surface area, and various diameters on the morphology, surface properties and photoactivity of the Bi-based composites has been investigated for the first time. So far, the literature has only shown the enhancement of photocatalytic...
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A Highly Selective Biosensor Based on Peptide Directly Derived from the HarmOBP7 Aldehyde Binding Site
PublikacjaThis paper presents the results of research on determining the optimal length of a peptide chain to eectively bind octanal molecules. Peptides that map the aldehyde binding site in HarmOBP7 were immobilized on piezoelectric transducers. Based on computational studies, four Odorant Binding Protein-derived Peptides (OBPPs) with dierent sequences were selected. Molecular modelling results of ligand docking with selected peptides were...
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Implementation of high-precision computation capabilities into the open-source dynamic simulation framework YADE
PublikacjaThis paper deals with the implementation of arbitrary precision calculations into the open-source discrete element framework YADE published under the GPL-2+ free software license. This new capability paves the way for the simulation framework to be used in many new fields such as quantum mechanics. The implementation details and associated gains in the accuracy of the results are discussed. Besides the "standard" double (64 bits)...
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Anticancer Properties of Amino Acid and Peptide Derivatives of Mycophenolic Acid
PublikacjaBackground: Although Mycophenolic Acid (MPA) is applied as prodrugs in clinic as an immunosuppressant, it also possesses anticancer activity. MPA acts as Inosine-5’-Monophosphate Dehydrogenase (IMPDH) inhibitor, where the carboxylic group at the end of the side chain interacts with Ser 276 of the enzyme via hydrogen bonds. Therefore, MPA derivatives with other polar groups indicated high inhibition too. On the other hand, potent...
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Evaluation of Linkers’ Influence on Peptide-Based Piezoelectric Biosensors’ Sensitivity to Aldehydes in the Gas Phase
PublikacjaRecent findings qualified aldehydes as potential biomarkers for disease diagnosis. One of the possibilities is to use electrochemical biosensors in point-of-care (PoC), but these need further development to overcome some limitations. Currently, the primary goal is to enhance their metrological parameters in terms of sensitivity and selectivity. Previous findings indicate that peptide OBPP4 (KLLFDSLTDLKKKMSEC-NH2) is a promising...
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Whole-genome sequencing and antimicrobial potential of bacteria isolated from Polish honey
PublikacjaThe aim of this study was the whole-genome analysis and assessment of the antimicrobial potential of bacterial isolates from honey harvested in one geographical location—the north of Poland. In total, 132 strains were derived from three honey samples, and the antimicrobial activity of CFAM (cell-free after-culture medium) was used as a criterion for strain selection and detailed genomic investigation. Two of the tested isolates...
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Effect of nanosized carbon black on thermal stability and flame retardancy of polypropylene/carbon nanotubes nanocomposites
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Catalytic carbonization of polypropylene by the combined catalysis of activated carbon with Ni2O3 into carbon nanotubes and its mechanism
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Using of carbon nanotubes and nano carbon black for electrical conductivity adjustment of pressure-sensitive adhesives
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An influence of molecular weight, deacetylation degree of chitosan xerogels on their antimicrobial activity and cytotoxicity. Comparison of chitosan materials obtained using lactic acid and CO2 saturation.
PublikacjaThis paper presents a comparison of the antimicrobial activity and cytotoxicity against L929 cells of chitosan xerogels prepared by dissolving the polymer in a solution of lactic acid (LA) or carbonic acid (CO2) and then freeze-drying. There was no simple relationship between the antimicrobial activity and cytotoxicity of the samples obtained using both techniques (LA and CO2). Chitosan materials obtained by the LA method in a...
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Structural and dynamic insights on the EmrE protein with TPP+ and related substrates through molecular dynamics simulations
PublikacjaEmrE is a bacterial transporter protein that forms an anti-parallel homodimer with four transmembrane helices in each monomer. EmrE transports positively charged aromatic compounds, such as TPP+ and its derivatives. We performed molecular dynamics (MD) simulations of EmrE in complex with TPP+, MeTPP+, and MBTPP+ embedded in a membrane. The detailed molecular properties and interactions were analysed for all EmrE-ligand complexes....
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Comparative molecular modelling of biologically active sterols
PublikacjaMembrane sterols are targets for a clinically important antifungal agent – amphotericin B. The relatively specific antifungal action of the drug is based on a stronger interaction of amphotericin B with fungal ergosterol than with mammalian cholesterol. Conformational space occupied by six sterols has been defined using the molecular dynamics method to establish if the conformational features correspond to the preferential interaction...
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Osteoblast and bacterial cell response on RGD peptide‐functionalized chitosan coatings electrophoretically deposited from different suspensions on Ti13Nb13Zr alloy
PublikacjaMetallic materials for long-term load-bearing implants still do not provide high antimicrobial activity while maintaining strong compatibility with bone cells. This study aimed to modify the surface of Ti13Nb13Zr alloy by electrophoretic deposition of a chitosan coating with a covalently attached Arg-Gly-Asp (RGD) peptide. The suspensions for coating deposition were prepared in two different ways either using hydroxyacetic acid...
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On determining defects identity in carbon nanotubes using charge probes
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Carbon Nanotubes Derivatized with Mediators for Laccase Catalyzed Oxygen Reduction.
PublikacjaPrzedstawiono konstrukcję elektrody w której wykorzystano nanorurki modyfikowane znanym mediatorem (ABTS). Cząsteczki mediatora przyłączono do ścian bocznych nanorurek oraz do ich końców. Porównano parametry elektrod zbudowanych w oparciu o nanorurki modyfikowane kowalencyjnie w różny sposób. Zaobserwowano pozytywny wpływ modyfikowanych nanorurek na parametry elektrody.
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Novel method controlled synthesis of silica coated carbon nanotubes
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New synthesis method of sword-sheath structured carbon nanotubes
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Chemiresistive gas sensors based on carbon nanotubes - fabrication and application
PublikacjaOpisano przygotowanie i możliwości zastosowania chemirezystancyjnych czujników gazów wykonanych z nanorurek węglowych.
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Carbon Nanotubes Grown with Non-Ferromagnetic Catalysts in Alcohol CVD
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Raman spectroscopy study on concentrated acid treated carbon nanotubes
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Uptake and Release of Double‐Walled Carbon Nanotubes by Mammalian Cells
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