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Wyniki wyszukiwania dla: TRANSCRIPTOME NEXT-GENERATION SEQUENCING REGENERATION MMP-9
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Generating amplicon reads for microbial community assessment with next‐generation sequencing
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Tracking Clonal Evolution of Multiple Myeloma Using Targeted Next-Generation DNA Sequencing
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Next Generation Digital
PublikacjaThe paper outlines the major objectives of the MENAID research project, eimed at novel architectures of digital documents. Such documents will enable reduction of information overflow and strain, a major threat to the growth of a digital society. They will be forward compatible, technology neutral and lightweight, allowing workers of network organizations to use personal devices of any type.
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The Challenges Of The Next Generation Leader 5.0
Publikacjahttp://ak.aos.sk/images/repozitar/zborniky/NTPP_clanky23/10_Balcerzyk.pdf
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Matrix metalloproteinase 9 (MMP-9) is indispensable for long term potentiation in the central and basal but not in the lateral nucleus of the amygdala
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Next generation automatic IP configuration deployment issues
PublikacjaAlthough Dynamic Host Configuration Protocol for IPv6 (DHCPv6) protocol was defined in 2003, it was designed as a framework rather than a complete solution to the automatic configuration in IPv6 networks. There are still some unsolved problems and new options yet to be defined. One example of such case is Fully Qualified Domain Name (FQDN) option, which final version has been published in late 2007. It describes DHCPv6 client...
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Toward the next generation of air quality monitoring: Mercury
PublikacjaMercury is a global pollutant that is ubiquitous in the environment. Enrichment of mercury in the biosphere as the result of human activities and subsequent production of methylmercury (MeHg) has resulted in elevated concentrations in fish, wildlife and marine mammals globally. Elemental mercury (Hg0) is the most common form of mercury in the atmosphere, and the form that is most readily transported long distances from its emission...
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Expression of metalloproteinase 2 (MMP-2) and metalloproteinase 9 (MMP-9) in THP-1 macrophages cultured with three-dimensional titanium mini-plate systems used for surgical treatment of condylar fractures
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Transcriptome sequencing of Brassica napus highlights the complex issues with soil supplementation with sewage sludge
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Modeling of Wireless Traffic Load in Next Generation Wireless Networks
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Doped Two-Dimensional Silicon Nanostructures as a Platform for Next-Generation Sensors
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Choosing source of microorganisms and processing technology for next generation beet bioinoculant
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Next generation ITS implementation aspects in 5G wireless communication network
PublikacjaIn the paper the study of Intelligent Transportation systems implementation in the 5G wireless communication network is presented. Firstly, small-cell concept in Ultra Dense Heterogeneous network was analyzed. Secondly, the 5G network requirements were presented which are important from the point of view of transportation systems development. Next, the study on the 5G network architectures proposals dedicated to the ITS systems...
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Multi-Technique Investigation of Grave Robes from 17th and 18th Century Crypts Using Combined Spectroscopic, Spectrometric Techniques, and New-Generation Sequencing
PublikacjaThe textile fragments of the funeral clothes found in the 17th and 18th century crypts were subjected to spectroscopic, spectrometric, and microbial investigation. The next-generation sequencing enabled DNA identification of microorganisms at the genus and in five cases to the species level. The soft hydrofluoric acid extraction method was optimized to isolate different classes of dyes from samples that had direct contact with...
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Which Simulator to Choose for Next Generation Wireless Network Simulations? NS-3 or OMNeT++
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In vitro to in vivo extrapolation to support the development of the next generation risk assessment (NGRA) strategy for nanomaterials
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Colonization of axenic beet by rhizosphere bacteria takes place in discreet phases regardless of bioinculation with next generation bioinoculant
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Transcriptomic landscape of blood platelets in healthy donors
PublikacjaBlood platelet RNA-sequencing is increasingly used among the scientific community. Aberrant platelet transcriptome is common in cancer or cardiovascular disease, but reference data on platelet RNA content in healthy individuals are scarce and merit complex investigation. We sought to explore the dynamics of platelet transcriptome. Datasets from 204 healthy donors were used for the analysis of splice variants, particularly with...
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Transcriptomic landscape of blood platelets in healthy donors
PublikacjaBACKGROUND Blood platelet RNA-sequencing is increasingly used among the scientific community. Aberrant platelet transcriptome is common in cancer or cardiovascular disease, but reference data on platelet RNA content in healthy individuals are scarce and merit complex investigation. METHODS We sought to explore the dynamics of platelet transcriptome. Datasets from 204 healthy donors were used for the analysis of splice variants,...
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Triazoloacridone C-1305 impairs XBP1 splicing by acting as a potential IRE1α endoribonuclease inhibitor
PublikacjaInositol requiring enzyme 1 alpha (IRE1α) is one of three signaling sensors in the unfolding protein response (UPR) that alleviates endoplasmic reticulum (ER) stress in cells and functions to promote cell survival. During conditions of irrevocable stress, proapoptotic gene expression is induced to promote cell death. One of the three signaling stressors, IRE1α is an serine/threonine-protein kinase/endoribonuclease (RNase) that...
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Metody metagenomiczne w badaniu mikrobiomu jelitowego człowieka
PublikacjaMikroorganizmy zamieszkujące ciało człowieka to nie tylko komensale i groźne patogeny, ale także organizmy symbiotyczne pełniące kluczową rolę w zachowaniu homeostazy gospodarza. Badania metagenomiczne wykorzystujące techniki sekwen-cjonowania nowej generacji i metody bioinformatyczne pozwalają na dogłębne po-znanie mikrobiomu ludzkiego i poszukiwanie jego związku ze stanem zdrowia czło-wieka. Celem pracy jest omówienie różnych...
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Traffic Modeling in IMS-based NGN Networks
PublikacjaIn the modern world the need for accurate and quickly delivered information is becoming more and more essential. In order to fulfill these requirements, next generation telecommunication networks should be fast introduced and correctly dimensioned. For this reason proper traffic models must be identified, which is the subject of this paper. In the paper standardization of IMS (IP Multimedia Subsystem) concept and IMS-based NGN...
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Application of MARKAL model to optimisation of electricity generation structure in Poland in the long-term time horizon. Part II. Model and forecasts assumptions
PublikacjaIn this paper, the next in a series of publications on the subject, assumptions are presented of a power system development model in terms of electricity generation technology infrastructure in Poland, in the long term perspective until 2060. The model is based on the mathematical structure of the MARKAL optimization package. Among other things developed are a forecast of the final demand for electricity and heat, the current...
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Neotenic phenomenon in gene expression in the skin of Foxn1- deficient (nude) mice - a projection for regenerative skin wound healing
PublikacjaMouse fetuses up to 16 day of embryonic development and nude (Foxn1- deficient) mice are examples of animals that undergo regenerative (scar-free) skin healing. The expression of transcription factor Foxn1 in the epidermis of mouse fetuses begins at embryonic day 16.5 which coincides with the transition point from scar-free to scar-forming skin wound healing. In the present study, we tested the hypothesis that Foxn1 expression...
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The microbial community, its biochemical potential, and the antimicrobial resistance of Enterococcus spp. in Arctic lakes under natural and anthropogenic impact (West Spitsbergen)
PublikacjaThe sustainable management of small human communities in the Arctic is challenging. In this study, both a water supply system (Lake 1) under the natural impact of a bird-nesting area, and a wastewater receiver (Lake 2) were analysed in the vicinity of the Polish Polar Station on West Spitsbergen. Microbial community composition, abundance and activity were assessed in samples of the treated wastewater, lake water and sediments...
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Personalized prediction of the secondary oocytes number after ovarian stimulation: A machine learning model based on clinical and genetic data
PublikacjaControlled ovarian stimulation is tailored to the patient based on clinical parameters but estimating the number of retrieved metaphase II (MII) oocytes is a challenge. Here, we have developed a model that takes advantage of the patient’s genetic and clinical characteristics simultaneously for predicting the stimulation outcome. Sequence variants in reproduction-related genes identified by next-generation sequencing were matched...
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Evaluation of Partial Nitritation/Anammox (PN/A) Process Performance and Microorganisms Community Composition under Different C/N Ratio
PublikacjaA one-stage partial nitritation/anammox (PN/A) process with intermittent aeration is possible under sidestream conditions, but implementation in a mainstream is a challenge due to increased Carbon/Nitrogen (C/N) ratios in domestic wastewater. This study investigated the effect of C/N ratios on process efficiency and the effect of narrowing non-aeration time on process improvement at high chemical oxygen demand (COD) load. An increase...
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Anticancer Imidazoacridinone C-1311 is Effective in Androgen-Dependent and Androgen-Independent Prostate Cancer Cells
PublikacjaAndrogen receptor (AR) plays a crutial role in prostate cancer (PCa) development and metastasis. Here, we reported potent anti-PCa activity of a small molecule imidazoacridinone C-1311. In AR-positive PCa cells, C-1311 was found to inhibit the transcriptional activity of AR uncovering a novel mechanism that may be relevant for its anticancer effect. Mechanistically, C-1311 decreased AR binding to prostate-specific antigen (PSA)...
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Immunophenotyping and transcriptional profiling of in vitro cultured human adipose tissue derived stem cells
PublikacjaAdipose-derived stem cells (ASCs) have become an important research model in regenerative medicine. However, there are controversies regarding the impact of prolonged cell culture on the ASCs phenotype and their differentiation potential. Hence, we studied 10 clinical ASCs replicates from plastic and oncological surgery patients, in six-passage FBS supplemented cultures. We quantified basic mesenchymal cell surface marker transcripts...
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Konkursy studenckie jako narzędzie w określaniu potencjału rewitalizacyjnego miejskich terenów zdegradowanych.
PublikacjaZgodnie z zasadami prowadzenia działań rewitalizacyjnych określonych w ustawie o rewitalizacji obowiązującej od 9 października 2015 r. oraz horyzontalnych wytycznych w zakresie rewitalizacji w programach operacyjnych na lata 2014-2020 faza przygotowawcza procesu rewitalizacji powinna zawierać wielopłaszczyznowe analizy zakończone wnioskami aplikacyjnymi ujętymi w gminnych programach rewitalizacji obszarów zurbanizowanych. Artykuł...
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Transcriptome profiling reveals distinctive traits of retinol metabolism and neonatal parallels in the MRL/MpJ mouse
PublikacjaBackground: The MRL/MpJ mouse is a laboratory inbred strain known for regenerative abilities which are manifested by scarless closure of ear pinna punch holes. Enhanced healing responses have been reported in other organs. A remarkable feature of the strain is that the adult MRL/MpJ mouse retains several embryonic biochemical characteristics, including increased expression of stem cell markers. Results: We explored the transcriptome...
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Structure and the Biochemical Potential of the Bacterial Community in Wastewater Treatment Plant Effluent and in Receiving Waters: Northern Poland Case Study
PublikacjaWastewater treatment processes are monitored mainly in terms of biogenic substance removal efficiency. Little is known about the treated wastewater microbiome and its influence on the recipient. In this study, a wide range of methods (cultivation, microscopic analysis, New Generation Sequencing and Real Time PCR) were employed to determine the bacterial community composition of the treated wastewater and its receiver. Preliminary...
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ASON/GMPLS connection control servers in virtual computer environment
PublikacjaIn the paper ASON/GMPLS connection control servers layer in the context of Next Generation Network (NGN) is described. The implementation of ASON/GMPLS connection control servers in virtual computer environment as well as performed measurements are presented. Some aspects of virtual environment installation are depicted. Remarks regarding application of the virtual computer environment to realization of communication between NGN...
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The Influence of Cooperation on the Operation of an MPC Controller Pair in a Nuclear Power Plant Turbine Generator Set
PublikacjaThe paper discusses the problem of cooperation between multiple model predictive control (MPC) systems. This approach aims at improving the control quality in electrical energy generation and forms the next step in a series of publications by the authors focusing on the optimization and control of electric power systems. Cooperation and cooperative object concepts in relation to a multi MPC system are defined and a cooperative control...
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Pounding between high-rise buildings with different structural arrangements
PublikacjaEarthquake-induced structural pounding has led to significant damages during previous earthquakes. This paper investigates the effect of pounding on the dynamic response of colliding high-rise buildings with different structural arrangements. Three 3-D buildings are considered in the study, including 5-storey building, 7-storey building and 9-storey building. Three pounding scenarios are also taken into account, i.e. pounding between...
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Simulation Model of IMS/NGN with Transport Stratum Based on MPLS Technology
PublikacjaIn the paper we continue our research on traffic modelling in the Next Generation Network (NGN) architecture, which includes the IP Multimedia Subsystem (IMS) elements. A simulation model of a single NGN domain with transport stratum based on the Multiprotocol Label Switching (MPLS) technology is proposed, which allows evaluation of mean response time of this stratum. The simulation model is applied to verify the results obtained...
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Color Processing for Color-Blind Individuals Using Smart Glasses
PublikacjaIn this paper we investigated image processing methods for color-blind individuals. In particular we experimentally verified color naming procedure, generation of maps with color perception differences for average observers and for dichromats, and two color transformation methods. In experiments 7 mobile devices were used: 3 smart glasses and 4 smartphones. User studies were performed with 38 average observers and 9 dichromats....
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For Your Eyes Only – Biometric Protection of PDF Documents
PublikacjaThe paper introduces a concept of a digital document content encryption/decryption with facial biometric data coming from a legitimate user. Access to the document content is simple and straightforward, especially during collaborative work with mobile devices equipped with cameras. Various contexts of document exchange are presented with regard to the next generation pro-active digital documents proposed by authors. An important...
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Combinated treatment of landfill leachates with wastewater in a sequencing batch reactor (SBR)
PublikacjaSanitary landfill leachates are treated usually by multistage systems using physical, chemical and biological processes. One of the most economic and efficient method is combined treatment of landfill leachates with municipal wastewater in a sequencing batch reactor (SBR. The main advantage of such co-treatment is that landfill leachates variability (in quality and quantity) do not influence the effectiveness of biological processes....
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Specyfikacja Systemu IP QoS opartego na architekturze DiffServ
PublikacjaArtykuł przedstawia ogólną specyfikację systemu IP QoS (ang. Internet Protocol Quality of Service), który to system jest obecnie implementowany w ramach projektu krajowego "Zarządzanie ruchemw sieciach IP". System ten jest zgodny z architekturą DiffServ (ang. Differentiated Services) i architekturą NGN (Next Generation Networks). W szczególności, artykuł pokrótce omawia architekturęsystemu, oferowane klasy usług w systemie oraz...
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TRAFFIC MODEL OF A MULTIDOMAIN IMS/NGN
PublikacjaIn this paper we continue our research and present an analytical traffic model of a multidomain Next Generation Network (NGN), which is standardized for delivering multimedia services based on the IP Multimedia Subsystem (IMS). The model takes into account several service scenarios (including registration, intra- and inter-operator calls) and a large set of network parameters. Using the model mean Call Set-up Delay and mean Call...
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Nitrogen removal via the nitrite pathway during wastewater co-treatment with ammonia-rich landfill leachates in a sequencing batch reactor
PublikacjaThe biological treatment of ammonia-rich landfill leachates due to an inadequate C to N ratio requires expensive supplementation of carbon from an external carbon source. In an effort to reduce treatment costs, the objective of the study was to determine the feasibility of nitrogen removal via the nitrite pathway during landfill leachate co-treatment with municipal wastewater. Initially, the laboratory-scale sequencing batch reactor...
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Quality of Cryptocurrency Mining on Previous Generation NVIDIA GTX GPUs
PublikacjaCurrently, there is a lot of previous generation NVIDIA GTX graphical processing units (GPUs) available on the market, which were ousted from by next-gen RTX units. Due to this fact, numerous fully-operational devices remain underused, which are available at an affordable price. First, this paper presents an analysis of the cryptocurrency market. Next, in this context, the results of research on the performance of NVIDIA graphics...
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Review of Diameter protocol implementations for realization of communication in NGN networks
PublikacjaIn the paper Diameter protocol as well as its applications in the context of Next Generation Network (NGN) are described. Diameter message content and Attribute-Value Pairs (AVPs) concept are presented. Critical review of open source Diameter implementations is carried out. The performed analysis takes into consideration programming language, availability, support and documentation aspects. Basing on the review project fulfilling...
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Insights into the microbial community of treated wastewater, its year-round variability and impact on the receiver, using cultivation, microscopy and amplicon-based methods
PublikacjaApart from chemical constituents, wastewater treatment plant (WWTP) effluents also release microorganisms that can be important to the receiving water bodies either from a sanitary point of view, or taking to the account the biogeochemical potential of the recipients. However, little is known about the treated wastewater microbial community, its composition, seasonal changes, functions and fate in the waters of the receiver. Thus,...
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Analysis of IMS/NGN call processing performance using G/G/1 queuing systems approximations
PublikacjaThe paper concerns the Next Generation Network (NGN), which is standardized for distribution of multimedia services based on the IP Multimedia Subsystem (IMS). To guarantee quality, accurate traffic models of IMS/NGN should be proposed. In the paper we compare results obtained with our analytical and simulation model of a single IMS/NGN domain, where various queuing systems are used in the analytical model (M/G/1 and approximations...
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Zastosowanie koncepcji SDN w warstwie transportowej sieci IMS/NGN
PublikacjaKoncepcja sieci Next Generation Network, wykorzystująca w warstwie usług architekturę IP Multimedia Subsystem, zakłada centralizację funkcji sterowania zasobami sieciowymi w warstwie transportowej. Analogiczne założenie jest podstawą koncepcji Software Defined Networks. Na podstawie tej analogii, zaproponowano integrację obu koncepcji, przedstawiono architekturę zintegrowanej sieci, scenariusze sterowania zasobami oraz przygotowano...
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Chemical, thermal and laser processes in recycling of photovoltaic silicon solar cells and modules
PublikacjaIn recent years, photovoltaic power generation systems have been gaining unprecedented attention as an environmentally beneficial method to solve the energy problem. From the economic point of view the pure silicon, which can be recapture from the used cells, is the most important material due to its cost and shortage. In the paper selected methods of used or damaged module and cells recycling and experimental results are presented....
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Virtual Engineering Object / Virtual Engineering Process: A specialized form of Cyber Physical System for Industrie 4.0
PublikacjaThis paper reviews the theories, parallels and variances between Virtual Engineering Object (VEO) / Virtual Engineering Process (VEP) and Cyber Physical System (CPS). VEO and VEP is an experience based knowledge representation of engineering objects and processes respectively. Cyber–physical systems (CPSs) are the next generation of engineered systems in which computing, communication, and control technologies are tightly integrated....
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The Impact of Material Selection on Durability of Exhaust Valve Faces of a Ship Engine – A Case Study
Publikacjawo alloys were used in order to extend the service life of marine engine exhaust valve head. Layers of cobalt base alloys were made of the powders with with chemical composition as follow: the layer marked L12; C-1,55%; Si-1,21%; Cr-29,7%; W-9%; Ni-2%; Mo<0,01%; Fe-1,7%; Co-54,83% and the layer marked N; C-1,45%; Co-38,9%; Cr-24,13%; Ni-10,43%; W-8,75%; Fe-7,64%; Mo-7,56%; Si-2,59%. Base metal was valve steel after heat treatment....