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Wyniki wyszukiwania dla: AKTYWNE MODELE KSZTAŁTU - ACTIVE SHAPE MODELS
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New 2-[(4-Amino-6-N-substituted-1,3,5-triazin-2-yl)methylthio]-N-(imidazolidin-2-ylidene)-4-chloro-5-methylbenzenesulfonamide Derivatives, Design, Synthesis and Anticancer Evaluation
PublikacjaIn the search for new compounds with antitumor activity, new potential anticancer agents were designed as molecular hybrids containing the structures of a triazine ring and a sulfonamide fragment. Applying the synthesis in solution, a base of new sulfonamide derivatives 20–162 was obtained by the reaction of the corresponding esters 11–19 with appropriate biguanide hydrochlorides. The structures of the compounds were confirmed...
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Exploration of the Solubility Hyperspace of Selected Active Pharmaceutical Ingredients in Choline- and Betaine-Based Deep Eutectic Solvents: Machine Learning Modeling and Experimental Validation
PublikacjaDeep eutectic solvents (DESs) are popular green media used for various industrial, pharmaceutical, and biomedical applications. However, the possible compositions of eutectic systems are so numerous that it is impossible to study all of them experimentally. To remedy this limitation, the solubility landscape of selected active pharmaceutical ingredients (APIs) in choline chloride- and betaine-based deep eutectic solvents was...
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Processing of LiDAR and Multibeam Sonar Point Cloud Data for 3D Surface and Object Shape Reconstruction
PublikacjaUnorganised point cloud dataset, as a transitional data model in several applications, usually contains a considerable amount of undesirable irregularities, such as strong variability of local point density, missing data, overlapping points and noise caused by scattering characteristics of the environment. For these reasons, further processing of such data, e.g. for construction of higher order geometric models of the topography...
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A Pilot Study on Machining Difficult-to-Cut Materials with the Use of Tools Fabricated by SLS Technology
PublikacjaThe growing use of contemporary materials in various industrial sectors, such as aerospace, automotive, as well as the oil and gas industry, requires appropriate machining methods and tools. Currently, apart from the necessity to obtain high-dimensional and shape accuracy, the efficiency and economic aspects of the selected manufacturing process are equally important, especially when difficult-to-cut materials, such as hard and...
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Book review: Simulation-Driven Design Optimisation and Modelling for Microwave Engineering
PublikacjaCelem książki jest przedstawienie aktualnego stanu badań dotyczących projektowania układów mikrofalowych poprzez modelowanie i optymalizacje wspomagane symulacjami elektromagnetycznymi. Grupa międzynarodowych ekspertów zajmujących się rożnymi aspektami komputerowo wspomaganego projektowania układów mikrofalowych, podsumowuje i dokonuje przeglądu ostatnich osiągnięć w tej dziedzinie oraz przedstawia szereg praktycznych zastosowań....
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MultiRegional PCA for leakage detection and localisation in DWDS - Chojnice case study
PublikacjaThis chapter considers pipe leakage detection and localisation in Drinking Water Distribution Systems (DWDS) by using a novel approach the MultiRegional Principal Component Analysis (MR-PCA). The MR-PCA is an extension of well known PCA method. The main idea of MR-PCA consists in designing a number of regional PCA models and analysing their responses caused by the pipe faults. Moreover, DWDS is decomposed into suitable subnetworks...
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On dynamic modeling of piezomagnetic/flexomagnetic microstructures based on Lord–Shulman thermoelastic model
PublikacjaWe study a time-dependent thermoelastic coupling within free vibrations of piezomagnetic (PM) microbeams considering the flexomagnetic (FM) phenomenon. The flexomagneticity relates to a magnetic field with a gradient of strains. Here, we use the generalized thermoelasticity theory of Lord–Shulman to analyze the interaction between elastic deformation and thermal conductivity. The uniform magnetic field is permeated in line with...
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Numerical analysis on axial capacity of steel built-up battened columns
PublikacjaThis paper deals with the numerical analysis aimed at study the bearing capacity of pinended steel built-up columns under axial compression. Finite element (FE) models were performed for the columns presented in the literature. The main problem discussed in the article is the shape and magnitude of geometric imperfections introduced into the numerical FE model, necessary to obtain the load capacity consistent with the experimental...
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Influence of Holes Manufacture Technology on Perforated Plate Aerodynamics
PublikacjaTranspiration flow is a very important and still open subject in many technical applications. Perforated walls are useful for the purpose of “flow control”, as well as for the cooling of walls and blades (effusive cooling) in gas turbines. We are still not able to include large numbers of holes in the numerical calculations and therefore we need physical models. Problems are related also to the quality of the holes in perforated...
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Optimum number of actuators to minimize the cross-sectional area of prestressable cable and truss structures
PublikacjaThis paper describes a new computational method for determining the optimum number of actuators to design the optimal and economic cross-sectional area of pin-jointed assemblies based on the conventional force method. The most active members are selected to be prestressed to redistribute stress in the whole structure, resulting in regulating the internal force of bars that face high stress. Reducing stress in critical members allows...
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Active learning on stacked machine learning techniques for predicting compressive strength of alkali-activated ultra-high-performance concrete
PublikacjaConventional ultra-high performance concrete (UHPC) has excellent development potential. However, a significant quantity of CO2 is produced throughout the cement-making process, which is in contrary to the current worldwide trend of lowering emissions and conserving energy, thus restricting the further advancement of UHPC. Considering climate change and sustainability concerns, cementless, eco-friendly, alkali-activated UHPC (AA-UHPC)...
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Reduced-Cost Two-Level Surrogate Antenna Modeling using Domain Confinement and Response Features
PublikacjaElectromagnetic (EM) simulation tools have become indispensable in the design of contemporary antennas. Still, the major setback of EM-driven design is the associated computational overhead. This is because a single full-wave simulation may take from dozens of seconds up to several hours, thus, the cost of solving design tasks that involve multiple EM analyses may turn unmanageable. This is where faster system representations (surrogates)...
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The influence of a change in the meniscus cross-sectional shape on the medio-lateral translation of the knee joint and meniscal extrusion
PublikacjaObjective The purpose of this study was to evaluate the influence of a change in the meniscus cross sectional shape on its position and on the biomechanics of a knee joint. Methods One main finite element model of a left knee joint was created on the basis of MRI images. The model consisted of bones, articular cartilages, menisci and ligaments. Eight variants of this model with an increased or decreased meniscus height were then...
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High Efficiency Dual-Active-Bridge Converter with Triple-Phase-Shift Control for Battery Charger of Electric Vehicles
PublikacjaAn optimal modulation scheme with triple-phase-shift (TPS) control could increase the efficiency in the entire load range for a dual-active-bridge (DAB) converter under wide output voltage range conditions. Therefore, this study proposes a convergent approach to TPS mode selection, coupled with an optimal modulation scheme, ensuring the circuit’s efficiency over the entire range in the realm of a high-power and high-efficiency...
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Experimental investigation on straight and u-bend double tube heat exchanger with active and passive enhancement methods
PublikacjaAuthors in this work want to demonstrate the possibility to increase the heat transfer efficiency by using simple wire coil inserts to create turbulent flow in the boundary layer as well as air blowing into the annulus of the pipe. In the study, Wilson plot approach was applied in order to estimate heat transfer coefficients for all heat exchanger (HX) configurations. The study focuses on experimental values of heat transfer coefficient...
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Nanosize effect of clay mineral nanoparticles on the drug diffusion processes in polyurethane nanocomposite hydrogels
PublikacjaStudies of swelling and release of naproxen sodium (NAP) solution by polyurethane nanocomposite hydrogels containing Cloisite® 30B (organically modified montmorillonite (OMMT)) have been performed. Polyurethane nanocomposite hydrogels are hybrid, nontoxic biomaterials with unique swelling and release properties in comparison with unmodified hydrogels. These features enable to use nanocomposite hydrogels as a modern wound dressing....
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Load Testing of GFRP Composite U-Shape Footbridge
PublikacjaThe paper presents the scope of load tests carried out on an innovative shell composite footbridge. The tested footbridge was manufactured in one production cycle and has no components made from materials other than GFRP laminates and PET foam. The load tests, performed on a 14-m long structure, were the final stage of a research program in the Fobridge project carried out in cooperation with: Gdańsk University of Technology (leader),...
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Novel 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives as potent anticancer agents – Synthesis, molecular structure, QSAR studies and metabolic stability
PublikacjaA series of new 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives have been synthesized and evaluated in vitro by MTT assays for their antiproliferative activity against cell lines of colon cancer HCT-116, cervical cancer HeLa and breast cancer MCF-7. The obtained results indicated that these compounds display prominent cytotoxic effect. The best anticancer properties have been observed for derivatives...
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Modelling of spirometry - the application for diagnostic purposes
PublikacjaThe process of the tissue oxygen supply is the fundamental process of the human life. The lung functioning consists of three processes: the ventilation, the perfusion and the diffusion. The paper deals with one of these processes which is the ventilation process. The quality of the pulmonary ventilation has a strong influence on the patient's health condition. Numerous limitations are imposed on conditions of the lung quality measurement,...
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A coarse‐grained approach to NMR ‐data‐assisted modeling of protein structures
PublikacjaThe ESCASA algorithm for analytical estimation of proton positions from coarse-grained geometry developed in our recent work has been implemented in modeling protein structures with the highly coarse-grained UNRES model of polypeptide chains (two sites per residue) and nuclear magnetic resonance (NMR) data. A penalty function with the shape of intersecting gorges was applied to treat ambiguous distance restraints, which automatically...
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Assessment of the Relationship between the Shape of the Lateral Meniscus and the Risk of Extrusion Based on MRI Examination of the Knee Joint
PublikacjaBackground Meniscus extrusion is a serious and relatively frequent clinical problem. For this reason the role of different risk factors for this pathology is still the subject of debate. The goal of this study was to verify the results of previous theoretical work, based on the mathematical models, regarding a relationship between the cross-section shape of the meniscus and the risk of its extrusion. Materials and Methods Knee...
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Swapping Space for Time: An Alternative to Time-Domain Interferometry
PublikacjaYoung's double-slit experiment [1] requires two waves produced simultaneously at two different points in space. In quantum mechanics the waves correspond to a single quantum object, even as complex as a big molecule. An interference is present as long as one cannot tell for sure which slit is chosen by the object. The more we know about the path, the worse the interference. In the paper we show that quantum mechanics allows for...
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Smart Materials in Architecture: Useful Tools with Practical Applications or Fascinating Inventions for Experimental Design?
PublikacjaFor at least several decades smart or so-called intelligent materials, being the result of great advancements in material engineering, appear in architecture in different applications. Most of them are called "smart" because of their inherent properties: a real-time response to environmental stimuli. There are also those considered to be "smart" due to smart design: their original structure or the composition of their materials...
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Cyclodextrin polymers as efficient adsorbents for removing toxic non-biodegradable pimavanserin from pharmaceutical wastewaters
PublikacjaPresence of even small amount of active pharmaceutical ingredients in the environment carries risks tohuman and animal health, presenting an important issue. The paper presents issues related to the newdrug - pimavanserin (PMV). Biological treatment efficiency of pimavanserin (PMV) was evaluated usinglab-scale Sequencing Batch Reactor (SBR). It has been shown to have a negative effect on aquatic or-ganisms by classifying it as...
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Analiza porównawcza metod obliczeniowych stopnia turbinowego
PublikacjaRozwój technologii komputerowych i ciągły wzrost dostępności do odpowiednich zasobów mocy obliczeniowej spowodował popularyzację obliczeń numerycznych. Aktualnie korzysta się na szeroką skalę z numerycznej mechaniki płynów, czyli tak zwanych obliczeń CFD. Właściwie przygotowane modele obliczeniowe pozwalają uzyskać bardzo dokładne wyniki na podstawie przeprowadzonych symulacji trójwymiarowych. Odpowiednio skorelowana symulacja...
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Fast Low-fidelity Wing Aerodynamics Model for Surrogate-Based Shape Optimization
PublikacjaVariable-fidelity optimization (VFO) can be efficient in terms of the computational cost when compared with traditional approaches, such as gradient-based methods with adjoint sensitivity information. In variable-fidelity methods, the directoptimization of the expensive high-fidelity model is replaced by iterative re-optimization of a physics-based surrogate model, which is constructed from a corrected low-fidelity model. The success...
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A general isogeometric finite element formulation for rotation‐free shells with in‐plane bending of embedded fibers
PublikacjaThis article presents a general, nonlinear isogeometric finite element formulation for rotation-free shells with embedded fibers that captures anisotropy in stretching, shearing, twisting, and bending - both in-plane and out-of-plane. These capabilities allow for the simulation of large sheets of heterogeneous and fibrous materials either with or without matrix, such as textiles, composites, and pantographic structures. The work...
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Application of polymer element in reduction of temporary steel grandstand vibrations
PublikacjaThe numerical analysis focused on reduction of vibrations of a temporary steel scaffolding grandstand has been conducted in this paper. These types of structures are regularly subjected to dynamic loads which, in conjunction with light and quite slender structural members, may induce dangerous vibrations. To increase their safety, temporary steel grandstands are usually strengthened with the diagonal stiffeners of tubular cross...
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Comparison of Selected Neural Network Models Used for Automatic Liver Tumor Segmentation
PublikacjaAutomatic and accurate segmentation of liver tumors is crucial for the diagnosis and treatment of hepatocellular carcinoma or metastases. However, the task remains challenging due to imprecise boundaries and significant variations in the shape, size, and location of tumors. The present study focuses on tumor segmentation as a more critical aspect from a medical perspective, compared to liver parenchyma segmentation, which is the...
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A Novel Approach to Fully Nonlinear Mathematical Modeling of Tectonic Plates
PublikacjaThe motion of the Earth's layers due to internal pressures is simulated in this research with an efficient mathematical model. The Earth, which revolves around its axis of rotation and is under internal pressure, will change the shape and displacement of the internal layers and tectonic plates. Applied mathematical models are based on a new approach to shell theory involving both two and three-dimensional approaches. It is the...
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Polymeric Bearings – A New Base Isolation System to Reduce Structural Damage during Earthquakes
PublikacjaBase isolators, like lead rubber bearings, high damping rubber bearings or friction pendulum systems are extensively used in practice in many seismically active regions to protect structures against earthquake forces. The present paper reports the results obtained from the experimental study aimed to determine the effectiveness of the Polymeric Bearings in suppressing structural vibrations during dynamic excitations and therefore...
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Bi-GRU-APSO: Bi-Directional Gated Recurrent Unit with Adaptive Particle Swarm Optimization Algorithm for Sales Forecasting in Multi-Channel Retail
PublikacjaIn the present scenario, retail sales forecasting has a great significance in E-commerce companies. The precise retail sales forecasting enhances the business decision making, storage management, and product sales. Inaccurate retail sales forecasting can decrease customer satisfaction, inventory shortages, product backlog, and unsatisfied customer demands. In order to obtain a better retail sales forecasting, deep learning models...
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Shrinking-shifting and amplifying-shifting device using transformation optics
PublikacjaBased on transformation optics (TO), this paper uses geometric divisions and linear coordinate transformations to design “shrinking-shifting—and reshaping”, and “amplifying-shifting—and reshaping” devices. The proposed devices can reshape the sizes and locations of the wrapped-objects inside the core-region. The shrinking-shifting device shrinks the larger object into a smaller one and shifts it to different location, whereas the...
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Oxide nanoparticle exsolution in Lu-doped (Ba,La)CoO3
PublikacjaThis study investigated Lu doping of Ba0.5La0.5CoO3 and its influence on the exsolution of oxide nanoparticles (NPs). As a result of Lu doping, we observed the phase segregation into the main Ba0.4La0.6Co0.85Lu0.15O3 (BLCO–Lu) phase and the secondary Ba0.85La0.15Co0.75Lu0.25O3 (BCO–Lu) phase. We noticed the exsolution of BCO–Lu nanoparticles on the main BLCO–Lu phase. Moreover, the BLCO–Lu phase exsolved in the form of nanoparticles...
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Computer Support of Analysis of Optical Spectra Measurements
PublikacjaThe verification of measurement errors has a big impact on the assessment of the accuracy of conducted measurements and obtained results. In many cases, computer simulation results are compared with measurement results in order to evaluate measurement errors. The purpose of our research was to check the accuracy of measurements made with a Fabry–Perot interferometer working in the transmission mode. In the measurement setup, a...
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Computer support of analysis optical spectra measurements
PublikacjaVerification of measurement errors has a big impact on assessment of accuracy of conducted measurements and obtained results. In many cases computer simulation results are compared with measurement results in order to evaluate measurement errors. The purpose of our research was to check the accuracy of measurements made with Fabry-Perot interferometer working in the transmission mode. In measurement setup, a 1310 nm superluminescent...
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Selected elements of the methodology and method of designing amphibious flood rescue vehicles
PublikacjaThe methodology of designing amphibious flood rescue vehicles at the preliminary stage of the design process has been presented. The study has been focused on the properties of such vehicles when afloat, with their on-land behaviour and performance characteristics having been left aside. In the study, a general assumption has been made that the amphibious flood rescue vehicles should be designed as, above all, watercraft that additionally...
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Novel Vision Monitoring Method Based on Multi Light Points for Space-Time Analysis of Overhead Contact Line Displacements
PublikacjaThe article presents an innovative vision monitoring method of overhead contact line (OCL) displacement, which utilizes a set of LED light points installed along it. A light point is an, LED fed from a battery. Displacements of the LED points, recorded by a camera, are interpreted as a change of OCL shape in time and space. The vision system comprises a camera, properly situated with respect to the OCL, which is capable of capturing...
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Kultura jakości, doskonałości i bezpieczeństwa w organizacji
PublikacjaKultura jakości, bezpieczeństwa oraz doskonałości to ważne, kategorie zasobów każdej organizacji, decydujące o jej niepowtarzalności. Kształtują one nie tylko tożsamość danej organizacji, ale także mają wpływ na jej zdolność do spełniania potrzeb różnych grup interesariuszy oraz na szeroko rozumianą reputację na rynku. Każda z tych kultur wyraża się poprzez swoiste założenia, normy, wartości oraz artefakty. Stanowią one fundament...
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SegSperm - a dataset of sperm images for blurry and small object segmentation
Dane BadawczeMany deep learning applications require figure-ground segmentation. The performance of segmentation models varies across modalities and acquisition settings.
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Advanced Control Structures of Turbo Generator System of Nuclear Power Plant
PublikacjaIn the paper a synthesis of advanced control structures of turbine and synchronous generator for nuclear power plant working under changing operating conditions (supplied power level) is presented. It is based on the nonlinear models of the steam turbine and synchronous generator cooperating with the power system. Considered control structure consists of multi-regional fuzzy control systems with local linear controllers, including...
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Advanced Control Structures of Turbo Generator System of Nuclear Power Plant
PublikacjaIn the paper a synthesis of advanced control structures of turbine and synchronous generator for nuclear power plant working under changing operating conditions (supplied power level) is presented. It is based on the nonlinear models of the steam turbine and synchronous generator cooperating with the power system. Considered control structure consists of multi-regional fuzzy control systems with local linear controllers, including...
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Active Learning on Ensemble Machine-Learning Model to Retrofit Buildings Under Seismic Mainshock-Aftershock Sequence
PublikacjaThis research presents an efficient computational method for retrofitting of buildings by employing an active learning-based ensemble machine learning (AL-Ensemble ML) approach developed in OpenSees, Python and MATLAB. The results of the study shows that the AL-Ensemble ML model provides the most accurate estimations of interstory drift (ID) and residual interstory drift (RID) for steel structures using a dataset of 2-, to 9-story...
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Are the short cationic lipopeptides bacterial membrane disruptors? Structure-Activity Relationship and molecular dynamic evaluation
PublikacjaShort cationic lipopeptides are amphiphilic molecules that exhibit antimicrobial activity mainly against Grampositives. These compounds bind to bacterial membranes and disrupt their integrity. Here we examine the structure-activity relation (SAR) of lysine-based lipopeptides, with a prospect to rationally design more active compounds. The presented study aims to explain how antimicrobial activity of lipopeptides is affected by...
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Napęd żaglowy
Kursy OnlineTreści przedmiotu: > koncepcja napędu żaglowego <> rozwój napędu żaglowego <> środowisko pracy żagli - powietrze i natura wiatru <> systematyka napędu żaglowego <> nomenklatura przedmiotu <> siły generowane na pędniku żaglowym <> teoria płata nośnego - matematyczne modele (wiry związane, wiry swobodne, prędkości indukowane, rozkład cyrkulacji i rozkład ciśnień na powierzchni żagla) <> ...
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A hybrid approach to optimization of radial inflow turbine with principal component analysis
PublikacjaEnergy conversion efficiency is one of the most important features of power systems as it greatly influences the economic balance. The efficiency can be increased in many ways. One of them is to optimize individual components of the power plant. In most Organic Rankine Cycle (ORC) systems the power is created in the turbine and these systems can benefit from effective turbine optimization. The paper presents the use of two kinds...
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Wieloobszarowa regulacja systemu turbogeneratora elektrowni jądrowej =Multiregional control of nuclear power plant turbogenerator system
PublikacjaW artykule przedstawiono propozycję zaawansowanej struktury sterowania układem turbogeneratora w szerokim zakresie zmian zapotrzebowania na moc czynną. Dla potrzeb syntezy tej struktury wykorzystano nieliniowe, dynamiczne modele turbiny parowej i generatora synchronicznego współpracującego z systemem elektroenergetycznym. Zaproponowane algorytmy sterowania oparte są odpowiednio o wieloobszarowe regulatory rozmyte, z lokalnymi regulatorami...
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Active Annotation in Evaluating the Credibility of Web-Based Medical Information: Guidelines for Creating Training Data Sets for Machine Learning
PublikacjaMethods Results Discussion References Abbreviations Copyright Abstract Background: The spread of false medical information on the web is rapidly accelerating. Establishing the credibility of web-based medical information has become a pressing necessity. Machine learning offers a solution that, when properly deployed, can be an effective tool in fighting medical misinformation on the web. Objective: The aim of this study is to...
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Structural studies of a cold-adapted dimeric Beta-D-galactosidase from Paracoccus sp. 32d
PublikacjaThe crystal structure of a novel dimeric [beta]-D-galactosidase from Paracoccus sp. 32d (Par[beta]DG) was solved in space group P212121 at a resolution of 2.4 Å by molecular replacement with multiple models using the BALBES software. This enzyme belongs to glycoside hydrolase family 2 (GH2), similar to the tetrameric and hexameric [beta]-D-galactosidases from Escherichia coli and Arthrobacter sp. C2-2, respectively. It is the second...
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Quantification of Compatibility Between Polymeric Excipients and Atenolol Using Principal Component Analysis and Hierarchical Cluster Analysis
PublikacjaAn important challenge to overcome in the solid dosage forms technology is the selection of the most biopharmaceutically efficient polymeric excipients. The excipients can be selected, among others, by compatibility studies since incompatibilities between ingredients of the drug formulations adversely affect their bioavailability, stability, efficacy, and safety. Therefore, new, fast, and reliable methods for detecting incompatibility...