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Wyniki wyszukiwania dla: BIOLOGICAL RESPONSE
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Coherent-wave Monte Carlo method for simulating light propagation in tissue
PublikacjaSimulating propagation and scattering of coherent light in turbid media, such as biological tissues, is a complex problem. Numerical methods for solving Helmholtz or wave equation (e.g. finite-difference or finite-element methods) require large amount of computer memory and long computation time. This makes them impractical for simulating laser beam propagation into deep layers of tissue. Other group of methods, based on radiative...
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The use of fungi in biofiltration to remove hydrophobic volatile organic compounds
PublikacjaThe growing importance placed on air quality by environmental regulations and public opinion necessitate the minimization and removal of volatile organic compound emissions (VOCs), including odours. The removal of hydrophobic VOCs from the air by biological methods remains a major technical challenge (despite its importance in the shift to green engineering). A potential solution to this challenge is the use of fungi in biofiltration....
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Właściwości katalityczne i biomedyczne związków zawierających jony rutenu(II) oraz rutenu(III)
PublikacjaRuthenium complexes appear in scientific publications mainly as catalysts in the olefins metathesis process. In this review, we want to indicate the research niche regarding the use of ruthenium(II) and ruthenium(III) complexes in other catalytic processes, i.e. polymerization or epoxidation of olefins and depolymerization. We would like to combine the catalytic properties of ruthenium(II,III) complex compounds with their biomedical...
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Determination of COD Fractionation as a Key Factor for Appropriate Modelling and Monitoring of Activated Sludge Processes
PublikacjaAn operation of wastewater treatment plant is usually controlled by global parameters such as flow, solids retention time, sludge age, concentration of ammonia and dissolved oxygen, etc. It is considered that, together with the chemical and biological oxygen demand (COD and BOD), those parameters indirectly exhibit the effectiveness of activated sludge processes. Especially the BOD indicate the amount of organic pollution that...
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ANTIOXIDANT POWER SERIES (APS) AS A TOOL FOR RATIONAL DESIGN AND ASSESSMENT OF HEALTH PROMOTING PROPERTIES OF FUNCTONAL FOODS BASED ON ANTIOXIDANT PHYTOCHEMICALS
PublikacjaOver past decades, plantborne antioxidants dominated so called "translational research" in the area of food, nutrition, and disease prevention. Among consumers and producers, such phytochemicals are synonyms of nutriceuticals. Popularity and commercial success of antioxidants stems from mechanistic studies suggesting the involvement of reactive oxygen species in etiology of chronic diseases. However, epidemiology failed to provide...
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Electron ionization and low energy electron attachment to molecules of biological interest
PublikacjaEthylenediaminetetraacetic acid (EDTA) and 2-amino-2-(hydroxymethyl)-1,3-propanediol (TRIS) were investigated by electron impact ionization and low energy electron attachment. Both compounds are components of biological buffers and often are used as DNA stabilizers in irradiation studies. hus it is of a great importance to understand their potential interactions with radiation. Our results revealed that at least one of them, EDTA, may...
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Computer-aided analysis of signals from a low-coherence Fabry-Perot interferometer used for measurements of biological samples
PublikacjaThe aim of the study was to develop an automated computer-aided system for analysis of spectrograms obtained from measurements of biological samples performed with a low-coherence Fabry-Pérot interferometer. Information necessary to determine dispersion characteristics of measured materials can be calculated from the positions of the maxima and minima that are present in their spectra. The main challenge faced during the development...
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Electron ionization and low energy electron attachment to molecules of biological interest
PublikacjaEthylenediaminetetraacetic acid (EDTA) and 2-amino-2-(hydroxymethyl)-1,3-propanediol (TRIS) were investigated by electron impact ionization and low energy electron attachment. Both compounds are components of biological buffers and often are used as DNA stabilizers in irradiation studies. hus it is of a great importance to understand their potential interactions with radiation. Our results revealed that at least one of them, EDTA, may...
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Sample Preparation in Foodomics: Miniaturized Solid-Phase Extraction
PublikacjaAnalytical chemists face a challenge to bring comprehensive information on a given food and biological sample by using the best available analytical techniques and meet the requirements of sustainable development and green chemistry at the same time. A key objective of this chapter is to review selected literature data on the utilization of solid-phase extraction techniques with special attention to their miniaturized modes in...
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Modifiers for Medical Grade Polymeric Systems used in FDM 3D Printing - Short Review
PublikacjaFDM 3D printing could find an application in the wide range of biomedical applications. Unfortunately, the quantity of polymeric biomaterials suitable to processing into filaments is limited. The most frequently used biomaterials for medical constructs such as bone grafts, soft tissue scaffolds or another DDS include PCL, PLA, PVA, HPC, EVA copolymer, EC and TPUs. Various modifiers such as TCP, HA, TEC, MMC could be applicated...
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A research on the optimal conditions for separation and identyfication of the components from the Droseraceae extracts by column liquid chromatography
PublikacjaThe isolation of the components with anticipated biological properties i.e. antimicrobial, fungicidal, antioxidant and perhaps anticancer activity is for many years a one of the biggest issues of modern separation science. Their obtaining based on the isolation of the components with the biological activity from in vitro cultured plants by extraction techniques is often more difficult than their production by the chemical synthesis.The...
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Chlorinated solvents in a petrochemical wastewater treatment plant: Anassessment of their removal using self-organising maps
PublikacjaThe self-organising map approach was used to assess the efficiency of chlorinated solvent removal frompetrochemical wastewater in a refinery wastewater treatment plant. Chlorinated solvents and inorganicanions (11 variables) were determined in 72 wastewater samples, collected from three different purificationstreams. The classification of variables identified technical solvents, brine from oil desalting andrunoff sulphates as pollution...
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Angiopoietin-like growth factor-derived peptides as biological activators of adipose-derived mesenchymal stromal cells
PublikacjaAdipose-derived mesenchymal stromal cells (AD-MSCs) are an essential issue in modern medicine. Extensive preclinical and clinical studies have shown that mesenchymal stromal/stem cells, including AD-MSCs, have specific properties (ability to differentiate into other cells, recruitment to the site of injury) of particular importance in the regenerative process. Ongoing research aims to elucidate factors supporting AD-MSC culture...
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The role of biodegradable particulate and colloidal organic compounds in biological nutrient removal activated sludge systems
PublikacjaThe efficiency of denitrification and enhanced biological phosphorus removal in biological nutrient removal activated sludge systems is strongly dependent on the availability of appropriate carbon sources. Due to high costs of commercial compounds (such as methanol, ethanol, acetic acid, etc.) and acclimation periods (usually) required, the effective use of internal substrates is preferred. The aim of this study was to determine...
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Fluoroaromatic substituents attached to carbon nanotubes help to increase oxygen concentration on biocathode in biosensors and biofuel cells
PublikacjaBased on the known ability of perfluorodecalin/perfluorohydrocarbons to enhance oxygen solubility we modified oxygen sensitive biocathode by adding perfluorinated components to the catholite. This procedure improved the efficiency of the oxygen sensitive cathodes. Glassy carbon electrodes covered with single-wall carbon nanotubes (SWCNTs) with covalently bonded perfluoroaromatic groups were shown to be more sensitive to oxygen,...
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Modeling nitrous oxide production by a denitrifying-enhancedbiologically phosphorus removing (EBPR) activated sludge in thepresence of different carbon sources and electron acceptors
PublikacjaIn this study, the IWA Activated Sludge Model No. 2d (ASM2d) was expanded to identify the most important mechanisms leading to the anoxic nitrous oxide (N2O) production in the combined nitrogen (N) and phosphorus (P) removal activated sludge systems. The new model adopted a three-stage denitrification concept and was evaluated against the measured data from one/two-phase batch experiments carried out with activated sludge withdrawn...
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Modelling charge transfer processes in C2+ -tetrahydrofuran collision for ion-induced radiation damage in DNA building blocks
PublikacjaInvestigations of collision-induced processes involving carbon ions and molecules of biological interest in particular DNA building blocks, are crucial to model the effect of radiation on cells in order to improve medical treatments for cancer therapy. Using carbon ions appears to be one of the most efficient ways to increase biological effectiveness to damage cancerous cells by irradiating deep-seated tumors. Therefore, interest...
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Respiration rate estimation for model predictive control of dissolved oxygen in wastewater treatment plant
PublikacjaRespiration rate is very important parameter for biological processes in wastewater treatment plant (WWTP). The sequential algorithm for estimate the respiration rate is proposed and investigated. The Kalman filter (KF) is used. Simulation tests for the benchmark WWTP are presented.Respiracja jest bardzo ważnym parametrem dla prawidłowego przebiegu procesów biologicznych w oczyszczalni ścieków. W artykule przedstawiono i zbadano...
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Influence of composition of raw wastewater on removal of nitrogen compounds in multistage treatment wetlands
PublikacjaInfluence of composition of raw wastewater on the efficiency of organic matter and nitrogen removal in multistage treatment wetlands has been examined. Commonly used indicators, like COD/BOD5 and BOD5/TN ratio, determining wastewater susceptibility to biodegradation in conventional treatment technologies were assessed. It was confirmed that multistage treatment wetland may be used for treatment of wastewater with high loads of...
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Increasing the lifetime of engineering structures through the use of composite laggings
PublikacjaThe use of composite laggings prevents concrete (chemical and biological) corrosion. Columns coated with composite or reinforced composite are more resistant to negative environmental impact on concrete or steel. The mechanical properties of the reinforced casing also cause that these types of columns are more resistant to lateral forces. The applied casing limits carbonization of concrete and cyclical freezing and thawing with...
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Thermal imaging in automatic rodent’s social behaviour analysis
PublikacjaLaboratory rodent social behaviour analysis is an extremely important task for biological, medical and pharmacological researches. In this work thermal images features that facilitate analysis are presented. Methods to distinguish objects on the basis of thermal distribution are tested. Actions of grooming or biting one rodent by another - important social behaviour incidents - are clearly visible...
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Mathematical analysis of a generalised p53-Mdm2 protein gene expression model
PublikacjaWe propose the generalisation of the p53-Mdm2 protein gene expression model introduced by Monk (2003). We investigate the stability of a unique positive steady state and formulate conditions which guarantee the occurrence of the Hopf bifurcation. We show that oscillatory behaviour can be caused not only by time lag in protein transcription process, but also can be present in the model without time delay. Moreover, we investigate...
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Assembly of Lipopolysaccharide in Escherichia coli Requires the Essential LapB Heat Shock Protein
PublikacjaHere, we describe two new heat shock proteins involved in the assembly of LPS in Escherichia coli, LapA and LapB (lipopolysaccharide assembly protein A and B). lapB mutants were identified based on an increased envelope stress response. Envelope stress responsive pathways control key steps in LPS biogenesis and respond to defects in the LPS assembly. Accordingly, the LPS content in ΔlapB or Δ(lapA lapB) mutants was elevated, with...
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Up-to-date strategies and future trends towards the extraction and purification of Capsaicin: A comprehensive review
PublikacjaBackground According to the current need of manufacturing healthier products, food companies are seeking specific biomolecules that may offer additional added value (i.e., biological activities) to the new food formulations. Capsaicin, as the pungent ingredient of chili peppers, has become so far one of the target biomolecules explored since the 1950s. There is evidence demonstrating that capsaicin exhibits important biological...
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imPlatelet classifier: image‐converted RNA biomarker profiles enable blood‐based cancer diagnostics
PublikacjaLiquid biopsies offer a minimally invasive sample collection, outperforming traditional biopsies employed for cancer evaluation. The widely used material is blood, which is the source of tumor-educated platelets. Here, we developed the imPlatelet classifier, which converts RNA-sequenced platelet data into images in which each pixel corresponds to the expression level of a certain gene. Biological knowledge from the Kyoto Encyclopedia...
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Functionalized Peptide Fibrils as a Scaffold for Active Substances in Wound Healing
PublikacjaTechnological developments in the field of biologically active peptide applications in medicine have increased the need for new methods for peptide delivery. The disadvantage of peptides as drugs is their low biological stability. Recently, great attention has been paid to self-assembling peptides that can form fibrils. Such a formulation makes bioactive peptides more resistant to enzymatic degradation and druggable. Peptide fibrils...
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Social Differentiation of the Perception and Human Tissues Donation for Research Purposes.
PublikacjaThe willingness to donate human biological material for research purposes is shaped by socio-cultural factors; however, there is a lack of studies analysing the social perception of different human tissues, which may affect such willingness. This study aimed to distinguish different sociocultural categories of human tissues and types of potential donors based on their willingness to donate material. Quantitative research was...
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Preparation and properties of composite coatings, based on carbon nanotubes, for medical applications
PublikacjaThe coatings based on carbon nanotubes (CNTs) are increasingly developed for their applications, among others, in medicine, in particular for implants in implantology, cardiology, and neurology. The present review paper aims at a detailed demonstration of diferent preparation methods for such coatings, their performance, and relationships between deposition parameters and microstructure and material, mechanical, physical, chemical,...
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Identification of novel psychoactive substances 25B-NBOMe and 4-CMC in biological material using HPLC-Q-TOF-MS and their quantification in blood using UPLC–MS/MS in case of severe intoxications
PublikacjaThis paper describes cases of poisoning caused by new psychoactive substances such as: 25BNBOMe (2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine) and 4-CMC (1-(4-chlorophenyl)-2-(methylamino)-1-propanone). The analytical procedure includes rapid and selective method for the extraction and determination of 4-CMC and 25B-NBOMe in blood samples using UPLC–MS/MS technique. To the best of our knowledge,this is...
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Estimating the Impact of Inflow on the Chemistry of Two Different Caldera Type Lakes Located on the Bali Island (Indonesia)
PublikacjaThis paper is a preliminary attempt to assess the composition of pollutants in two different caldera lakes situated in the Indonesian Archipelago: Batur and Bratan. Both lakes are characterized by largely different physico-chemical regimes; Batur Lake is located in an area that is currently volcanically active, unlike Bratan Lake. The latter is much smaller and shallower than Batur Lake. The concentration of pollutants in the Indonesian...
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Thermodynamic, Anticoagulant, and Antiproliferative Properties of Thrombin Binding Aptamer Containing Novel UNA Derivative
PublikacjaThrombin is a serine protease that plays a crucial role in hemostasis, fibrinolysis, cell proliferation, and migration. Thrombin binding aptamer (TBA) is able to inhibit the activity of thrombin molecule via binding to its exosite I. This 15-nt DNA oligonucleotide forms an intramolecular, antiparallel G-quadruplex structure with a chair-like conformation. In this paper, we report on our investigations on the influence of certain...
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Role of Fungi in Biodegradation of Imidazolium Ionic Liquids by Activated Sewage Sludge
PublikacjaIonic liquids (ILs), due to their specific properties, can play the role of persistent water contaminants. Fungi manifest the ability to decompose hardy degradable compounds, showing potential in the biodegradation of ILs, which has been studied extensively on sewage sludge; however, attention was drawn mainly to bacterial and not fungal species. The aim of the research was to determine the significance of fungi in ILs’ biodegradation...
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Synthesis, Characterization and Biological Investigations of Half-Sandwich Ruthenium(II) Complexes Containing Benzimidazole Moiety
PublikacjaHalf-sandwich Ru(II) complexes belong to group of biologically active metallo-compounds with promising antimicrobial and anticancer activity. Herein, we report the synthesis and characteri- zation of arene ruthenium complexes containing benzimidazole moiety, namely, [(η6-p-cymene)RuC l(bimCOO)] (1) and [(η6-p-cymene)RuCl2(bim)] (2) (where bimCOO = benzimidazole-2-carboxylate and bim = 1-H-benzimidazole). The compounds were characterized...
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A systematic review on cellular responses of Escherichia coli to nonthermal electromagnetic irradiation
PublikacjaInvestigation of Escherichia coli under electromagnetic fields is of significance in human studies owing to its short doubling time and human‐like DNA mechanisms. The present review aims to systematically evaluate the literature to conclude causality between 0 and 300 GHz electromagnetic fields and biological effects in E. coli. To that end, the OHAT methodology and risk of bias tool were employed. Exponentially growing cells exposed...
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Preparation, characterization, and manufacturing of new polymeric materials for 3D printing for medical applications
PublikacjaThis work concerns the synthesis, formation, and characteristics of new filaments for 3D printing in FDM™/FFF technology for medical purposes. Two types of filaments were developed, i.e. degradable polyurethane and biodegradable polylactide-starch. The influence of the 3D printing process on selected filament properties was investigated. A detailed analysis of the filament formation process by the extrusion method was carried out,...
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Pilot scale degradation study of 16 selected volatile organic compounds by hydroxyl and sulfate radical based advanced oxidation processes
PublikacjaThe studies of effective technologies for complete degradation of the volatile organic compounds (VOCs), are very important due to the high biotoxicity of the VOCs which makes the biological technologies ineffective. It also increases the risk of VOCs emission instead of their treatment when using open air biological technologies. In the present study, different types of Advanced Oxidation Processes (AOPs) were investigated for...
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Applications of Raman spectroscopy for detection of selected substances in tissues
PublikacjaThis dissertation explores the applications of Raman spectroscopy for biological tissue analysis. Basics of Raman and surface-enhanced Raman spectroscopy (SERS) are described, along with an analysis of the literature on biodetection and non-invasive blood analysis with emphasis on glucose detection. Instrumentation for Raman measurements is described. The sources of noise and interferences occurring in biological tissue measurements...
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Medical-Grade PCL Based Polyurethane System for FDM 3D Printing—Characterization and Fabrication
PublikacjaThe widespread use of three-dimensional (3D) printing technologies in medicine has contributed to the increased demand for 3D printing materials. In addition, new printing materials that are appearing in the industry do not provide a detailed material characterization. In this paper, we present the synthesis and characterization of polycaprolactone (PCL) based medical-grade thermoplastic polyurethanes, which are suitable for forming...
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Marek Czachor prof. dr hab.
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Surface quality control of a thin SiN layer by optical measurements
PublikacjaFiber optic interferometers have a wide range of applications, including biological and chemical measurements. Nevertheless, in the case of a reflective interferometer setup, standard silver mirrors cannot be used in every measurement, due to their chemical activity. This work investigates the surface quality of a thin optical layer of silicon nitride (SiN), which can serve as an alternative material for silver mirrors. We present...
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Speciation of heavy metals in wastewater and rejected waters from multistage bioreactors (MUCT)
PublikacjaThe objective of the study is to investigate the occurrence and availability of selected heavy metals after subsequent stages of treatment in WWTP with activated sludge (enhanced biological N and P removal). To achieved the target it was necessary to recognize the allocation of selected heavy metals between aqueous and solid phase in wastewater and reject waters. Application of sequential extraction of such metals as Cd Zn, Pb,...
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Cyanobacterial and Algal Strains in the Culture Collection of Baltic Algae (CCBA)
PublikacjaThe dataset titled Microalgal strains from “Culture Collection of Baltic Algae (CCBA)” is a representation of cyanobacterial and microalgal cultures isolated from the Baltic Sea. It is a unique catalogue of strains of the dominant and rare species found in the Baltic phytoplankton and microphytobenthos assemblages. The main purpose of the collection is to extend the knowledge on the Baltic microbial communities by providing...
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Integrated membrane bioreactors modelling: A review on new comprehensive modelling framework
PublikacjaIntegrated Membrane Bioreactor (MBR) models, combination of biological and physical models, have been representing powerful tools for the accomplishment of high environmental sustainability. This paper, produced by the International Water Association (IWA) Task Group on Membrane Modelling and Control, reviews the state-of-the-art, identifying gaps for future researches, and proposes a new integrated MBR modelling framework. In...
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Modified DNA polymerases for PCR troubleshooting
PublikacjaPCR has become an essential tool in biological science. However, researchers often encounter problems with difficult targets, inhibitors accompanying the samples, or PCR trouble related to DNA polymerase. Therefore, PCR optimization is necessary to obtain better results. One solution is using modified DNA polymerases with desirable properties for the experiments. In this article, PCR troubleshooting, depending on the DNA polymerase...
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Automatic system for optical parameters measurements of biological tissues
PublikacjaIn this paper a system allowing execution of automatic measurements of optical parameters of scattering materials in an efficient and accurate manner is proposed and described. The system is designed especially for measurements of biological tissues including phantoms, which closely imitate optical characteristics of real tissue. The system has modular construction and is based on the ISEL system, luminance and color meter and...
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Catalytic Asymmetric Synthesis of Isochroman Derivatives
PublikacjaThe isochroman scaffold constitutes an important structural unit, which is present in various bioactive natural products and synthetic pharmaceutical compounds exhibiting wide arrays of biological properties. Hence the synthesis of this class of heterocyclic compounds in a stereoselective fashion is highly significant and desirable. In the last decade, a substantial advancement has been witnessed ln the catalytic asymmetric...
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The innovative exploitation of Brassica vegetables in the production of quality food for health. From lab bench to field and fork.
PublikacjaThe specific chemical composition of vegetables belonging to Brassicaceace , as regard both nutrients and non-nutrients, renders them particularly suitable for the health food production chain. The ability of these plants to accumulate heavy metals may be utilised for phytoremediation of arable soils, but also as a vehicle to fortify foods in micronutriens such as selenium. The bioactive organosulfur compounds, especially glucosinolates...
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Experience of hybrid constructed wetlands operation in Gdansk region
PublikacjaThe investigation were carried out at five local hybrid constructed wetlands (HCWs), which secured biological treatment of domestic wastewater generated from 15 to 600 pe. Based on over two years monitoring it was indicated that HCWs ensured very effective removal of organic matter from 74.9 to 95.5 COD % in wild range of loadings (1.5 - 17.0g COD/ m3day). Efficiency of total nitrogen removal varied significantly from 23.4 two...
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Antioxidants: a premature scientific hypothesis that reshuffled the traditional food pyramid
PublikacjaAntioxidants present in substantial amounts in foods, plant-based products in particular, have been suggested as chemopreventive agents that can curb the development of undesirable health effects caused by oxidative stress simply by enriching diet in such compounds. This idea has been enthusiastically accepted by consumers, as well as food and pharmaceutical industry, and created great demand for products containing antioxidant...
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Low-energy positron scattering from gas-phase uracil
PublikacjaQuantum scattering calculations are presented for the interaction of low energy positrons with the uracil molecule, an important component of biological systems. The rotational elastic and inelastic cross sections and vibrational inelastic cross sections are reported and compared with existing experiments, indicating a general trend of the cross sections different from the experimental findings and in line with what should be expected...