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Demonstrator technologii C-IED
PublikacjaArtykuł przedstawia budowę i działanie opracowanego na Politechnice Gdańskiej demonstratora technologicznego systemu AEGIS, przeznaczonego do przeciwdziałania atakom z wykorzystaniem prowizorycznych urządzeń wybuchowych detonowanych drogą radiową (RCIED — Radio Controlled Improvised Explosive Devices). Przedstawiono zaimplementowaną oryginalną metodę generowania sygnału zagłuszającego o dowolnie ukształtowanym widmie częstotliwościowym,...
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Mechanical properties of the human stomach under uniaxial stress action
PublikacjaThe aim of this study was to estimate the range of mechanical properties of the human stomach in order to use the collected data in numerical modelling of surgical stapling during resections of the stomach. The biomedical tests were conducted in a self-developed tensile test machine. Twenty-two fresh human stomach specimens were used for the experimental study of its general strength. The specimens were obtained from morbidly obese...
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Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione: characteristics of non-enzymatic and glutathione S-transferase-mediated reactions
PublikacjaUnsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. A significant route of phase II drug metabolism is conjugation with glutathione (GSH), which can be non-enzymatic and/or catalyzed by GSH-dependent enzymes. The aim of this work was to investigate the GSH-mediated metabolic pathway of a representative UA, C 2028. GSH supplemented incubations of C-2028 with rat, but not with human, liver...
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Cognitive memory for intelligent systems of decision-making, based on human psychology
PublikacjaA model of memory, which allows to expand the functionality of autonomous decision-making systems for robotic and human-system-interface purposes, is discussed. The model provides functions and features which make the prospective robotic and interfacing systems more human-like as well as more efficient in solving interactive issues.
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Cognitive memory for intelligent systems of decision-making, based on human psychology
PublikacjaA model of memory, which allows to expand the functionality of autonomous decision-making systems for robotic and human-system-interface purposes, is discussed. The model provides functions and features which make the prospective robotic and interfacing systems more human-like as well as more efficient in solving interactive issues.
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Electrochemical simulation of metabolism for antitumor-active imidazoacridinone C-1311 and in silico prediction of drug metabolic reactions
PublikacjaThe metabolism of antitumor-active 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) has been investigated widely over the last decade but some aspects of molecular mechanisms of its metabolic transformation are still not explained. In the current work, we have reported a direct and rapid analytical tool for better prediction of C-1311 metabolism which is based on electrochemistry (EC) coupled on-line with electrospray...
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Comparative in vitro research of the Human Aortic Bioprosthesis
PublikacjaE valuate of the usefulness and reliability of structures based on the analysis of recorded parameters determining the flow through the Human Aortic Bioprosthesis (HAB) have been dealt with. By flow parameters changes determining the performance environment of prosthesis analyzed change of the motion dynamics of the valve leaflets as a function of pressure, thereby determining the degree of alignment of the prosthesis to the performance...
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Structure generation and performance comparison of elliptic Gm-C filters.
PublikacjaW oparciu o zestaw macierzy opisujący ogólną topologię filtrów typu Gm-C opracowano procedurę efektywnej generacji struktur filtrów dolnoprzepustowych. Dla filtrów tego typu podano wyrażenia pozwalające analizować właściwości wrażliwościowe oraz określono zestaw odpowiednich kryteriów porównawczych. Szczegółowe badania porównawcze przeprowadzono dla wybranych filtrów 3-go rzędu w tym realizowanych w strukturach LF(leapfrog) i...
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Analogowy filtr Gm-C odbiornika GSM z automatycznym dostrajaniem częstotliwości
PublikacjaW referacie przedstawiono scalony analogowy filtr CMOS Gm-C z układem automatycznego dostrajania charakterystyk częstotliwościowych, spełniający wymagania filtru kanałowego odbiornika telefonii komórkowej GSM. Jest to w pełni różnicowy dolnoprzepustowy filtr eliptyczny 5-go rzędu, charakteryzujący się niskim poborem mocy (2,4 mW) i małą powierzchnią struktury krzemowej (0,31 mm2). Częstotliwość graniczna filtru jest dostrajana...
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Optoelectronic investigation of nanodiamond interactions with human blood
PublikacjaWe present optoelectronic investigation of in vitro interactions of whole human blood with different nanodiamond biomarkers. Plasmo-chemical modifications of detonation nanodiamond particles gives the possibility for controlling their surface for biological applications. Optical investigations reveal the biological activity of nanodiamonds in blood dependent on its surface termination. We compare different types of nanodiamonds:...
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Journal of Human Kinetics
Czasopisma -
The effect of local anaesthetics on apoptosis and NETosis of human neutrophils in vitro: comparison between lidocaine and ropivacaine
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Anticancer Imidazoacridinone C-1311 is Effective in Androgen-Dependent and Androgen-Independent Prostate Cancer Cells
PublikacjaAndrogen receptor (AR) plays a crutial role in prostate cancer (PCa) development and metastasis. Here, we reported potent anti-PCa activity of a small molecule imidazoacridinone C-1311. In AR-positive PCa cells, C-1311 was found to inhibit the transcriptional activity of AR uncovering a novel mechanism that may be relevant for its anticancer effect. Mechanistically, C-1311 decreased AR binding to prostate-specific antigen (PSA)...
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The reality of the ''Lower'' and the ''Higher'' man within the human being: towards the new type of philosophical anthropology of infrastructures of the personal human being
PublikacjaW artykule, pt. " The Reality of the "Lower" and the "Higher" Man within the Human Being: Towards the New Type of Philosophical Anthropology of Infrastructures of the Personal Human Being" ("Realność "niższego" i "wyższego" człowieka w obrębie ludzkiego bytu. Ku nowemu typowi antropologii filozoficznej infrastruktur osobowego bytu ludzkiego") usiłowałem pokazać, że realność "niższego" i "wyższego" człowieka w obrębie...
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Nanotechnology and the human environment "Nanotechnologia a środowisko człowieka"
Kursy Online -
Scarabaeidae as human food – A comprehensive review
PublikacjaRising global population and sustainable protein demand have sparked interest in unique food sources. Entomophagy, or insect consumption, presents a solution and Scarab beetles, part of the Scarabaeidae family, offer a novel food option. The comprehensive review underscores their potential as human food, with strong nutrition, low environmental impact, and the ability to ease strain on conventional agriculture. Nutritional analysis...
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Dibutyl phthalate disrupts conserved circadian rhythm in Drosophila and human cells
PublikacjaPeople are constantly exposed to phthalates, due to their common use in the production of plastics, pharmaceuticals, cosmetics and skin care products. The ability of phthalates to disrupt endocrine signaling, leading to developmental, reproductive and metabolic defects, has been studied, yet how phthalates interfere with these biological functions is still unclear. To uncover DBP interacting molecular pathways, we raised Drosophila...
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The evaluation of the vibration measurement usability of electronic indicator lemag "premet C"
PublikacjaThe measuring possibilities of modern compression and combustion pressure analyzers are extended with additional functions. One of them is parallel to the pressure measurement, the measurement of vibrations in the region of the cylinder head. The paper presents a general assessment of the vibration measurement function of the electronic indicator LEMAG "PREMET C". This feature is very rarely offered by manufacturers of these devices....
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Designing issues of the alarm system in context of functional safety and human factors
PublikacjaThis article addresses selected aspects of the alarm system and human factors that should be evaluated during the design and operation of an industrial hazardous installation. In such installations the layer of protection analysis (LOPA) methodology is often applied for simplified risk analysis based on defined accident scenarios. To reduce and control the risks the safety instrumented functions (SIFs) are identified and their...
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Analogowy filtr GM-C odbiornika GSM z automatycznym dostrajaniem częstotliwości
PublikacjaW referacie przedstawiono scalony analogowy filtr CMOS Gm-C z układem automatycznego dostrajania charakterystyk częstotliwościowych, spełniający wymagania filtru kanałowego odbiornika telefonii komórkowej GSM. Jest to w pełni różnicowy dolnoprzepustowy filtr eliptyczny 5-go rzędu, charakteryzujący się niskim poborem mocy (2,4 mW) i małą powierzchnią struktury krzemowej (0,31 mm2). Częstotliwość graniczna filtru jest dostrajana...
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CYP3A4 overexpressin enhances the cytotoxicity of the antitumor triazoloacridinone derivative C-1305 in CHO cells
PublikacjaW pracy badano wpływ nadekspresji izoenzymu CYP3A4 na cytotoksyczność i odpowiedź komórkową indukowaną przez przeciwnowotworową pochodną triazoloakrydonu w modelowym układzie komórek CHO: dzikego typu, z nadekspresją reduktazy cytochromu P450 (CHO-HR) oraz z koekspresją reduktazy i izoenzymu CYP3A4 (CHO-HR-3A4). Wykazano, że komórki CHO wykazywały różną wrażliwość na badany związek, a linia CHO-HR okazała się najbardziej wrażliwa,...
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Accelerometer signal pre-processing influence on human activity recognition
PublikacjaA study of data pre-processing influence on accelerometer-based human activity recognition algorithms is presented. The frequency band used to filter-out the accelerometer signals and the number of accelerometers involved were considered in terms of their influence on the recognition accuracy.
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Human-Computer Interaction, sem. letni 2018/2019
Kursy Online -
Human Feedback and Knowledge Discovery: Towards Cognitive Systems Optimization
PublikacjaCurrent computer vision systems, especially those using machine learning techniques are data-hungry and frequently only perform well when dealing with patterns they have seen before. As an alternative, cognitive systems have become a focus of attention for applications that involve complex visual scenes, and in which conditions may vary. In theory, cognitive applications uses current machine learning algorithms, such as deep learning,...
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Human voice modification using instantaneous complex frequency
PublikacjaThe paper presents the possibilities of changing human voice by modifying instantaneous complex frequency (ICF) of the speech signal. The proposed method provides a flexible way of altering voice without the necessity of finding fundamental frequency and formants' positions or detecting voiced and unvoiced fragments of speech. The algorithm is simple and fast. Apart from ICF it uses signal factorization into two factors: one fully...
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Atom-economic thiophosphoroselenenylations of C–H acid esters and amides
PublikacjaThree improved thiophosphoroselenenylation procedures of CHacids, including derivatives of malonic and acetyl-, phosphono-, 4-nitrophenyl- and 3-pyridylacetic acids, have been described and compared to previously reported thiophosphoroselenylation of diethyl malonate using bis(disopropoxyphosphinothioyl)diselenide alone or with the aid of methyl iodide. The use of iodine makes it possible to utilize both equivalents of the selenenylating...
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Synthesis and biological evaluation of N-acylated tyramine sulfamates containing C-F bonds as steroid sulfatase inhibitors
PublikacjaSteroid sulfatase (STS) is responsible for the hydrolysis of biologically inactive sulfated steroids into their active un-sulfated forms and promotes the growth of various hormone-dependent cancers (e.g., breast cancer). Therefore, the STS enzyme is a promising therapeutic target for the treatment of steroid-sensitive cancers. Herein, we report the synthesis and biological evaluation of sulfamate analogs as potential STS inhibitors...
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Human capital quality indicators for measuring regional knowledge economy advances
PublikacjaBuilding Knowledge Economies (KE) is a long-term process. However, civilizational and technological changes together with EU's Lisbon Strategy help in creating solutions that may speed up economical growth of countries and their regions. This seems to be a very important issue, as during last two centuries history shown, that wisdom and human invention and innovation are the most important factor driving economical growth. In this...
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Electron collisions with X(CH3)4 molecules (X = C, Si, Ge)
PublikacjaAbsolute grand-total cross sections (TCSs) for electron scattering from tetramethylmethane [C(CH3)4], tetramethylsilane [Si(CH3)4], and tetramethylgermane [Ge(CH3)4] molecules have been measured at electron-impact energies extending from around 0.5 to 300 eV in the linear electron-transmission experiment. The measured TCS energy dependences show very pronounced broad enhancement, peaking near 5.5 eV for Si(CH3)4 and Ge(CH3)4 molecules...
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Badanie i analiza właściwości szerokopasmowej sieci dostępowej C-MUX firmy Marconi Communications
PublikacjaPrzeanalizowano właściwości szerokopasmowej sieci dostępowej C-MUX firmy Marconi Communications i opracowano szczegółową metodologię badań. Przedstawiono i omówiono wyniki badań sieci C-MUX i opracowano wnioski szczegółowe.
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The Reduced Folate Carrier (SLC19A1) c.80G>A Polymorphism is Associated with Red Cell Folate Concentrations Among Women
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A Simple Model of Linkage Disequilibrium and Genetic Drift in Human Genomic SNPs: Importance of Demography and SNP Age
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Longitudinal study of vitamins A, E and lipid oxidative damage in human milk throughout lactation
PublikacjaCelem pracy było zbadanie zmian wartości całkowitego potencjału antyoksydacyjnego (TAS), stężeń witamin antyoksydacyjnych i izoprostanów (markery stresu oksydacyjnego) w siarze i mleku dojrzałym. Badaniami objęto 49 kobiet po pełno terminowej ciąży i naturalnym porodzie. Kryteria wyłączenia to czynne i bierne palenie tytoniu, ostre i przewlekłe schorzeniach oraz farmakoterapia inna niż suplementacja witamin. Próbki siary pobierano...
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Human Factors and Functional Safety Analysis in Designing the Control Rooms of Industrial Hazardous Plants
PublikacjaIn this work some aspects of human factors and functional safety analysis in designing the control rooms of industrial hazardous plants are presented. The “defence in depth” (D-in-D) concept is outlined. Some designing issues of the alarm system (AS) with regard to human factors to be supported using the human reliability analysis (HRA) are discussed. The AS and decision support system (DSS), when properly designed, would contribute...
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Human Capital Management by Ralf Knegtmans XI edition
Kursy Online -
Human Capital Management by Ralf Knegtmans XII edition
Kursy Online -
Possible directions for development of C-ITS services in cities on the example of the TRISTAR System
PublikacjaDuring the previous EU financial perspective (2007 - 2013), we observed an intensification of the evelopment of transport management systems using ITS services in Polish cities. One of the biggest territorially and functionally system is Tri-city TRISTAR system, the implementation of which was completed in 2015. The concept of the TRISTAR system and its architecture was developed in the years 2002-2007. Currently, we can observe...
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Comparing the permeability of human and porcine small intestinal mucus for particle transport studies
PublikacjaThe gastrointestinal mucus layer represents the last barrier between ingested food or orally administered pharmaceuticals and the mucosal epithelium. This complex gel structure plays an important role in the process of small intestinal absorption. It provides protection against hazardous particles such as bacteria but allows the passage of nutrients and drug molecules towards the intestinal epithelium. In scientific research, mucus...
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Methods of determination of C coefficient for period of rolling vessel in calm water for example of pax cargo ship
PublikacjaThis article presents a different approach to calculate the C coefficient needed to determine the period of own rolling vessel in calm water. The C coefficient is usually adopted as the approximate value from the available literature, usually depending on the type of vessel, and less dependent on the loading condition. In experimental studies of marine properties (seakeeping) often have a problem with the selection of the correct...
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Właściwości dynamiczne filtrów Gm-C zmiennych stanu trybu napięciowego i prądowego
PublikacjaW pracy przedstawiono analizę zakresu dynamicznego dla filtrów Gm-C zmiennych stanu realizowanych w strukturach napięciowych i prądowych. W analizie wykorzystano ogólny model filtrów Gm-C oraz jego opis algebraiczny. W przypadku filtrów napięciowych opierano się na wcześniejszych wynikach otrzymanych przez Groenewoldła. W przypadku struktur prądowych wzięto pod uwagę zależność transkonduktancji elementów aktywnych od częstotliwości....
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Using human behavior to develop knowledge-based virtual organisations
PublikacjaPropozycja modelu opartego na zachowaniach ludzkich dla potrzeb budowy wirtuanych organizacji opartych na wiedzy.Virtual organizations promote dynamic interaction between individuals, groups, and organizations, who share their capabilities and resources to pursue a common goal and maximize their benefits. Among these resources, knowledge is a critical one that requires special attention in order to support problem-solving activities...
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Human Factors and Cognitive Engineering in Functional Safety Analysis
PublikacjaHuman factors and cognitive engineering are considered nowadays as important multidisciplinary domains that focus on improving the relations between humans, technology and systems to be supervised and operated. The industrial automation and control systems (IACS) in hazardous plants are increasingly computerized and perform various safety functions. These are usually designed and implemented according to the functional safety requirements....
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Spectroelectroanalytical properties of antitumor agent C1311
PublikacjaZastosowano kilka metod woltamperometrycznych dla charakterystyki właściwości elektrochemicznych przeciwnowotworowej pochodnej imidazoakrydonu o symbolu C-1311. Wyniki wskazały, że możliwym będzie zastosowanie metod elektrochemicznych do badania oddziaływań badanego związku z DNA. Badania spektroelektrochemiczne ujawniły, że oscylacyjne zmiany absorbcji związku obserwowane po cyklicznej polaryzacji elektrody. Oscylacje te znikały...
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Tensile and flexural moduli for human orbital wall bones – comparative study
PublikacjaThe main aims of the current research were: (1) to analyze in detail the tensile modulus and ultimate tensile strength (UTS) of orbital wall bones separately for the left and right orbit of the same cadaver and (2) to compare the obtained results with a flexural modulus of the left and right orbit reported earlier by A. C. van Leeuwen et al. [14]. A set of 54 specimens of orbital superior and/or medial walls harvested from 16 human...
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Cyclic deformation and fracture behaviour of additive manufactured maraging steel under variable-amplitude loading
PublikacjaThe cyclic deformation and fracture behaviour of 18Ni300 maraging steel produced by laser beam powder bed fusion is studied under variable-amplitude loading. The tests were conducted under fully-reversed strain-controlled conditions with a loading sequence comprising three ascending cycles and three descending cycles repeated sequentially until failure. After the tests, fracture surfaces were examined using height and volume surface...
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Massively parallel linear-scaling Hartree–Fock exchange and hybrid exchange–correlation functionals with plane wave basis set accuracy
PublikacjaWe extend our linear-scaling approach for the calculation of Hartree–Fock exchange energy using localized in situ optimized orbitals [Dziedzic et al., J. Chem. Phys. 139, 214103 (2013)] to leverage massive parallelism. Our approach has been implemented in the ONETEP (Order-N Electronic Total Energy Package) density functional theory framework, which employs a basis of non-orthogonal generalized Wannier functions (NGWFs) to achieve...
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Natural Resources for Human Health: A New Interdisciplinary Journal Dedicated to Natural Sciences
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Coupled evolution of preferential paths for force and damage in the pre-failure regime in disordered and heterogeneous, quasi-brittle granular materials.
PublikacjaMetoda elementów dyskretnych (DEM) została wykorzystana do symulacji betonu poddanego jednoosiowemu rozciąganiu. Beton modelowano jako materiał losową heterogeniczy 2/3-fazowy, złożony z cząstek kruszywa, matrycy cementowej i stref przejściowych międzyfazowej. Odkryto dowody na zoptymalizowaną transmisję siły, scharakteryzowaną przez dwa nowe wzorce, które przewidują i wyjaśniają sprzężoną ewolucję ścieżki siły i uszkodzenia od...
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Early prediction of macrocrack location in concrete and other granular composite materials
PublikacjaHeterogeniczne kruche kompozyty, takie jak beton, ceramika i skały składają się z ziaren połączonych wiązaniami. Pytanie, czy ścieżka pęknięcia, która prowadzi do zniszczenia może być przewidziania na podstawie znanych cech mikrostrukturalnych, a mianowicie łączności wiązań, rozmiaru, energii pękania, wytrzymałości pozostają otwarte. Istnieje wiele kryteriów pęknięć. Najczęściej używane są oparte na postulowanym ekstremum naprężenia...
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Hotspot of human verbal memory encoding in the left anterior prefrontal cortex
PublikacjaBackground: Treating memory and cognitive deficits requires knowledge about anatomical sites and neural activities to be targeted with particular therapies. Emerging technologies for local brain stimulation offer attractive therapeutic options but need to be applied to target specific neural activities, at distinct times, and in specific brain regions that are critical for memory formation. Methods: The areas that are critical...