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Modulation of UDP-glucuronidation by acridinone antitumor agents C-1305 and C-1311 in HepG2 and HT29 cell lines, despite slight impact in noncellular systems.
PublikacjaBackground Among the studied antitumor acridinone derivatives developed in our laboratory, 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305) and 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) exhibited cytotoxic and antitumor properties against several cancer types and were selected to be evaluated in preclinical and early-phase clinical trials. In the present work, we investigated the impact of C-1305...
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Multiple Cues-Based Robust Visual Object Tracking Method
PublikacjaVisual object tracking is still considered a challenging task in computer vision research society. The object of interest undergoes significant appearance changes because of illumination variation, deformation, motion blur, background clutter, and occlusion. Kernelized correlation filter- (KCF) based tracking schemes have shown good performance in recent years. The accuracy and robustness of these trackers can be further enhanced...
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Fluorescence Imaging Using Methylene Blue Sentinel Lymph Node Biopsy in Melanoma
PublikacjaIntroduction: Fluorescence imaging of sentinel node biopsy in melanoma is a novel method. Both indocyanine green (ICG) and methylene blue (MB) have fl uorescent properties. The aim of this study was to present, for the fi rst time in a clinical series of patients, the possible usage of MB as a fl uorescent dye for sentinel node biopsy during surgery for melanoma. Material and methods: Twenty patients with...
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Hotspot of human verbal memory encoding in the left anterior prefrontal cortex
PublikacjaBackground: Treating memory and cognitive deficits requires knowledge about anatomical sites and neural activities to be targeted with particular therapies. Emerging technologies for local brain stimulation offer attractive therapeutic options but need to be applied to target specific neural activities, at distinct times, and in specific brain regions that are critical for memory formation. Methods: The areas that are critical...
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Anticancer Properties of Amino Acid and Peptide Derivatives of Mycophenolic Acid
PublikacjaBackground: Although Mycophenolic Acid (MPA) is applied as prodrugs in clinic as an immunosuppressant, it also possesses anticancer activity. MPA acts as Inosine-5’-Monophosphate Dehydrogenase (IMPDH) inhibitor, where the carboxylic group at the end of the side chain interacts with Ser 276 of the enzyme via hydrogen bonds. Therefore, MPA derivatives with other polar groups indicated high inhibition too. On the other hand, potent...
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Synthesis, characteristics, and photocatalytic activity of zinc oxide nanoparticles stabilized on the stone surface for degradation of metronidazole from aqueous solution
PublikacjaAbstract Background: The presence of antibiotics such as metronidazole in wastewater even at low concentrations requires searching for a suitable process such as advanced oxidation process (AOP) to reduce the level of pollutants to a standard level in water. Methods: In this study, zinc oxide (ZnO) nanoparticles were synthesized by thermal method using zinc sulfate (ZnSO4) as a precursor, then, stabilized on stone and was used...
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Honey antibacterial activity: A neglected aspect of honey quality assurance as functional food
PublikacjaBackground Honey is considered as a functional food with health-promoting properties. Its potent antibacterial and antibiofilm effects are the major attributes of so called ‘medical-grade honey’ which is topically used for the treatment of burns, wounds and skin disorders. Nevertheless, the current set of honey quality parameters adopted in the European Union do not include its biological properties. Furthermore, in light of the...
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Effect of the integration into Global Value Chains on the employment contract in Central and Eastern European countries
PublikacjaResearch background: In the era of globalization, there is a need to address decent work deficits in Global Value Chains (GVCs). The forms of working conditions reveal a broad dispersion of contents. The literature review exposes hardly any Europe-focused research assessing the socioeconomic impact of global production links and going beyond their pure economic effects assessed in terms of employment, productivity or wages. Purpose...
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S09-4 The development of the Physical Activity Environment Policy Index (PA-EPI): a tool for monitoring and benchmarking government policies and actions to improve physical activity
PublikacjaBackground Insufficient physical activity (PA) is a global issue for health. A multifaceted response, including government action, is essential to improve population levels of PA. The purpose of this study was to develop the ‘Physical Activity Environment Policy Index’ (PA-EPI) monitoring framework to assess government policies and actions for creating a healthy PA environment. Methods An iterative process was undertaken. This...
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The impact of mass-media campaigns on physical activity: a review of reviews through a policy lens
PublikacjaBackground This review of reviews aimed to: (1) summarize the evidence from published reviews on the effectiveness of mass-media campaigns to promote physical activity (PA) or PA-related determinants (intermediate psychological and proximal outcomes) and (2) to identify policy-relevant recommendations related to successful PA campaigns. Methods An extensive literature search was performed on 1 March 2021. Reviews that evaluated...
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Sustainable Urban Mobility Plans: implementation process and indicators to evaluate effects on physical activity
PublikacjaBackground: Active mobility and public transport increase physical activity (PA) levels. With varying intensity and effectiveness, European cities implement Sustainable Urban Mobility Plans (SUMPs) to spur transport-related PA. Therefore, we aim to examine drivers and barriers to SUMP implementation and assess its influence on PA across European cities. Methods: We screened policy reports to gain insights into SUMP implementation...
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The Physical Activity Environment Policy Index for monitoring government policies and actions to improve physical activity
PublikacjaBackground A multifaceted response, including government action, is essential to improve population levels of physical activity (PA). This article describes the development process of the ‘Physical Activity Environment Policy Index’ (PA-EPI) monitoring framework, a tool to assess government policies and actions for creating a healthy PA environment. Methods An iterative process was undertaken. This involved a review of policy...
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Transcriptomic landscape of blood platelets in healthy donors
PublikacjaBACKGROUND Blood platelet RNA-sequencing is increasingly used among the scientific community. Aberrant platelet transcriptome is common in cancer or cardiovascular disease, but reference data on platelet RNA content in healthy individuals are scarce and merit complex investigation. METHODS We sought to explore the dynamics of platelet transcriptome. Datasets from 204 healthy donors were used for the analysis of splice variants,...
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Similarities and differences in the production of renewable energy in Central and Eastern Europe countries
PublikacjaResearch background: In the era of climate change, environmental degradation, but also growing pub-lic awareness, there is a need to look for new ecological energy sources. This condition can be met by renewable energy sources (RES). The EU seeks to have a 32% share of its gross final energy consumption from renewable sources by 2030. While the EU as a whole is on course to meet its...
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Wystawy światowe w Barcelonie: Problemy zachowania dziedzictwa kulturowego
PublikacjaW prezentowanej Państwu książce przedmiotem analizy są obiekty architektoniczne wystaw światowych, które - pomimo tymczasowego charakteru imprez wystawowych - pozostają jako obiekty stałe. Konstrukcja książki wykorzystuje zasadę od ogółu do szczegółu, gdzie na tle subiektywnie wyselekcjonowanych przykładów historycznych, tymczasowych obiektów wystawowych przedstawiam przypadek dwóch szczegółowo przeanalizowanych pawilonów hiszpańskich...
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A novel cold-active beta-D-galactosidase from the Paracoccus sp. 32d - gene cloning, purification and characterization
PublikacjaBeta-D-galactosidase (EC 3.2.1.23) catalyze the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. Cold-active beta-D-galactosidases have recently become a focus of attention of researchers and dairy product manufactures owing to theirs ability to: (I) eliminate of lactose from refrigerated milk for people afflicted with lactose intolerance, (II) convert lactose to glucose and galactose which...
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The cement-bone bond is weaker than cement-cement bond in cement-in-cement revision arthroplasty. A comparative biomechanical study
PublikacjaThis study compares the strength of the native bone-cement bond and the old-new cement bond under cyclic loading, using third generation cementing technique, rasping and contamination of the surface of the old cement with biological tissue. The possible advantages of additional drilling of the cement surface is also taken into account. Femoral heads from 21 patients who underwent a total hip arthroplasty performed for hip arthritis...
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Frequency of use, moral incongruence, and religiosity and their relationships with self-perceived addiction to pornography, internet use, social networking and online gaming
PublikacjaBackground and Aims Moral incongruence involves disapproval of a behaviour in which people engage despite their moral beliefs. Although considerable research has been conducted on how moral incongruence relates to pornography use, potential roles for moral incongruence in other putative behavioural addictions have not been investigated. The aim of this study was to investigate the role of moral incongruence in self‐perceived...
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Chemical composition of water from roof in Gdańsk, Poland
PublikacjaThis study deals with the assessment of roof runoff waters from the region of Gdansk collected during the winter season (2007/2008). The chemical analysis includes 16 chemical variables: major ions, PAHs and PCBs measured at 3 sampling sites for 6-14 rain events. Although the data set is of limited volume the statistical data treatment using self-organizing maps (SOM) reveals the main factors controlling roof runoff water quality...
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Exploring the impact of cultural context on eye-tracking studies of architectural monuments in selected European cities: Sustainable heritage management.
PublikacjaSustainable management of architectural heritage requires conducting an inclusive diagnosis of users’ opinions, considering both residents and tourists as the recipients of urban space. Given the cultural diversity within these groups, proposing the use of eye-trackers (ET) as an alternative to traditional public consultation prompts the need to assess the method’s advantages and disadvantages. It remains uncertain whether individuals...
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Development and evaluation of RADA-PDGF2 self-assembling peptide hydrogel for enhanced skin wound healing
PublikacjaBackground: Wound healing complications affect numerous patients each year, creating significant economic and medical challenges. Currently, available methods are not fully effective in the treatment of chronic or complicated wounds; thus, new methods are constantly sought. Our previous studies showed that a peptide designated as PDGF2 derived from PDGF-BB could be a promising drug candidate for wound treatment and that RADA16-I...
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Screening of predicted synergistic multi-target therapies in glioblastoma identifies new treatment strategies
PublikacjaAbstract Background IDH-wildtype glioblastoma (GBM) is a highly malignant primary brain tumor with a median survival of 15 months after standard of care, which highlights the need for improved therapy. Personalized combination therapy has shown to be successful in many other tumor types and could be beneficial for GBM patients. Methods We performed the largest drug combination screen to date in GBM, using a high-throughput effort...
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Effect of lag screw on stability of first metatarsophalangeal joint arthrodesis with medial plate
PublikacjaBackground: First metatarsophalangeal joint (MTP-1) arthrodesis is a commonly performed procedure in the treatment of disorders of the great toe. Since the incidence of revision after MTP-1 joint arthrodesis is not insignificant, a medial approach with a medially positioned locking plate has been proposed as a new technique. The aim of the study was to investigate the effect of the application of a lag screw on the stability and...
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Generating actionable evidence from free-text feedback to improve maternity and acute hospital experiences: A computational text analytics & predictive modelling approach
PublikacjaBackground Patient experience surveys are a key source of evidence for supporting decision-making and quality improvement in healthcare services. These surveys contain two main types of questions: closed and open-ended, asking about patients’ care experiences. Apart from the knowledge obtained from analysing closed-ended questions, invaluable insights can be gleaned from free-text data. Advanced analytics techniques are increasingly...
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The effect of impacted third molars on second molar external root resorption, a cross-sectional cone beam computed tomography study
PublikacjaBackground: Third molars have the highest prevalence of impaction in teeth and can cause pathological damage on the adjacent second molars. This study aims to evaluate the effects of factors related to impacted third molars on external root resorption (ERR) in adjacent second molars using cone-beam computed tomography (CBCT). Material and Methods: In CBCTs, the effect of impacted third molars on the root surface of adjacent second...
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Pial artery and subarachnoid width response to apnoea in normal humans
PublikacjaBackground: Little is known about intracranial pressure (ICP)-cerebral haemodynamic interplay during repetitive apnoea. A recently developed method based on near-infrared transillumination/backscattering sounding (NIR-T/BSS) noninvasively measures changes in pial artery pulsation (cc-TQ) as well as subarachnoid width (sas-TQ) in humans. Method: We tested the complex response of the pial artery and subarachnoid width to apnoea...
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Pollutant deposition via dew in urban and rural environment, Cracow, Poland
PublikacjaThis study is a comparative analysis of dew in rural and urban environment. Dew samples were collected between May and October, 2009 in two reference stations in southern Poland: Cracow and Gaik-Brzezowa. The investigation included comparison of volume and chemistry of the collected samples. Due to its formation mechanisms, dew is a good indicator of air pollution. Following parameters were analyzed in 159 collected samples: pH,...
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Characterization of a single-stranded DNA-binding-like Protein from Nanoarchaeum equitans - a nucleic acid binding protein with broad substrate specificity
PublikacjaBackground SSB (single-stranded DNA-binding) proteins play an essential role in all living cells and viruses, as they are involved in processes connected with ssDNA metabolism. There has recently been an increasing interest in SSBs, since they can be applied in molecular biology techniques and analytical methods. Nanoarchaeum equitans, the only known representative of Archaea phylum Nanoarchaeota, is a hyperthermophilic, nanosized,...
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Job Demands, Engagement, and Turnover Intentions in Polish Nurses: The Role of Work-Family Interface
PublikacjaBackground: Poland has lower ratios of employed registered nurses per 1,000 inhabitants than the EU average. Polish nurses work under miserable conditions without assisting personnel, and they reconcile their professional demands with responsibilities for their families; 96% of them are women. Rationale/Aims: This study uses Hobfoll’s conservation of resources (CORs) theory to explain the role of various resources in the improvement...
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US not bright but right method of thyroid volume estimation even in large and substernal extended goitres. Comparison of US and three methods of CT thyroid evaluation - prospective study.ON LINE
PublikacjaBackground Ultrasound is nowadays a method of choice for thyroid volume assessment. However, its disadvantage is some inaccuracy, which is said to be higher in huge, especially substernally extended goitres. Aims The aim of the study was to compare the US and CT thyroid volumetric measurements: multi-observers (CT MO) and one-observer (CT OO) to CT planimetry results (CT Pl) in patients with large goitres. Materials & Methods The...
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Organisational culture and change management in courts, based on the examples of the Gdańsk area courts
PublikacjaABSTRAKT Background. Courts are by definition bureaucratic, hierarchical organisations, epitomised by low levels of networking potential, which basically lack mechanisms of information exchange, or those of sharing information both at the level of the organisation of the justice system (the macro scale) and within a given court (the micro scale). Research aims. The aims of this article was implementing modern management methods...
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Cloning and characterization of a novel cold-active glycoside hydrolase family 1 enzyme with beta-glucosidase, beta-fucosidase and beta-galactosidase activities.
PublikacjaBackground: Cold-active enzymes, sourced from cold-adapted organisms, are characterized by high catalytic efficiencies at low temperatures compared with their mesophilic counterparts, which have poor activity. This property makes them advantageous for biotechnology applications as it: (i) saves energy costs, (ii) shortens the times for processes operated at low temperatures, (iii) protects thermosensitive substrates or products...
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Knowledge engineer – more than only technical position. The concept of knowledge engineering education at the Faculty of Management and Economics
PublikacjaOrganizational learning means an effective knowledge management. Management is nothing more than the constant decision-making. Therefore organizational learning must be seen through the prism of decisions taken at all levels. Unfortunately decisions are never taken within comfortable conditions. Decision maker suffers from a lack of any support. There is often a problem with human resources having right skills, sometimes they do...
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Characterization of single-stranded DNA-binding proteins from the psychrophilic bacteria Desulfotalea psychrophila, Flavobacterium psychrophilum, Psychrobacter arcticus, Psychrobacter cryohalolentis, Psychromonas ingrahamii, Psychroflexus torquis, and Photobacterium profundum
PublikacjaBackground: Single-stranded DNA-binding proteins (SSBs) play essential roles in DNA replication, recombination and repair in Bacteria, Archaea and Eukarya. In recent years, there has been an increasing interest in SSBs, since they find numerous applications in diverse molecular biology and analytical methods. Results: We report the characterization of single-stranded DNA-binding proteins from the psychrophilic bacteria Desulfotalea...
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Host and pathogen factors in Klebsiella pneumoniae upper urinary tract infections in renal transplant patients
PublikacjaPurpose . To analyse the role of virulence factors (VFs) and host in Klebsiella pneumoniae upper urinary tract infections (UTIs) in renal transplant (RTx) recipients. Methodology. Clinical and demographic data were registered prospectively. Phylogenetic background of K. pneumoniae isolates was analysed by PCR melting profiles (MP) and the following VFs genes: fimH-1, uge, kpn, ycfM, mrkD, rmpA, magA, hlyA, cnf-1, irp-1, irp-2,...
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FACES OF MODERNISM - URBAN PLANNING OF SOCIAL HOUSING ESTATES IN GDANSK AND HAMBURG-ALTONA
PublikacjaThe paper aims to compare the modernistic social housing estates built during the interwar period in the Free City of Gdansk and in Altona, the small neighbour of Hamburg. The comparison is based on the analysis of the factors, which significantly affected the decisions regarding spatial transformations and the development of both cities in that time. These factors include primarily: poor living conditions, resulting from the explosive...
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Exchange-traded products in Germany: development and substitution of exchange-traded funds, exchange-traded commodities and exchange-traded notes.
PublikacjaResearch background: Exchange-traded products (ETPs) are one of the most rapidly growing categories of financial products. Their fast development has been boosted by innovative features. Three main categories of ETPs are exchange-traded funds (ETFs), exchange-traded commodities (ETCs) and exchange-traded notes (ETNs). ETCs and ETNs remain least known, even though their number on some stock exchanges is high. In Europe, Germany...
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Nutrient transport and acquisition by diatom chains in a moving fluid
PublikacjaThe role of fluid motion in delivery of nutrients to phytoplankton cells is a fundamental question in biological and chemical oceanography. In the study of mass transfer to phytoplankton, diatoms are of particular interest. They are non-motile, are often the most abundant components in aggregates and often form chains, so they are the ones expected to benefit most from enhancement of nutrient flux due to dissipating turbulence....
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Sensitivity analysis as a tool to optimise Human Development Index
PublikacjaResearch background: Composite indicators are commonly used as an approximation tool to measure economic development, the standard of living, competitiveness, fairness, effectiveness, and many others being willingly implemented into many different research disciplines. However, it seems that in most cases, the variable weighting procedure is avoided or erroneous since, in most cases, the so-called...
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The forecasts-based instrument rule and decision making. How closely interlinked? The case of Sweden
PublikacjaResearch background: The Central Bank of Sweden declared in years 1999–2006 the implementation of the Svensson’s concept of inflation forecast targeting (IFT). It means that the repo rate decision-making process depends on the inflation forecasts. The concept evolved from the strict IFT with the decision-making algorithm called ‘the rule of thumb’ to the flexible IFT. Purpose of the article: The aim of...
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The role of the One-Belt One-Road initiative in China's exports and global value chains
PublikacjaResearch background: China is regarded as the “world factory” highly involved in international trade and plays an increasingly important role in the global value chains (GVC). Additionally, the “One-Belt One-Road” (OBOR) initiative was proposed by the Chinese government to further promote China in the international market. Purpose of the article: The article explores the role of the OBOR in China’s exports and global value...
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Significance of Dermoscopy in Association with Clinical Features in Differentiation of Basal Cell Carcinoma and Benign Trichoblastic Tumours
PublikacjaBackground: Although basal cell carcinoma (BCC) can, in the majority of cases, be diagnosed based on clinical and dermoscopic assessment, a potential overlap with benign adnexal skin tumours seems to exist, including trichoblastic tumours (TT). Methods: Retrospective analysis of clinical and dermoscopic features of benign TT and BCC cases was performed to develop a diagnostic algorithm with a potential utility in clinical practice....
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Active Annotation in Evaluating the Credibility of Web-Based Medical Information: Guidelines for Creating Training Data Sets for Machine Learning
PublikacjaMethods Results Discussion References Abbreviations Copyright Abstract Background: The spread of false medical information on the web is rapidly accelerating. Establishing the credibility of web-based medical information has become a pressing necessity. Machine learning offers a solution that, when properly deployed, can be an effective tool in fighting medical misinformation on the web. Objective: The aim of this study is to...
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Towards a modification of a regulatory framework aiming at bunker oil spill prevention from ships - A design aspect of bunker tanks vents location guided by CFD simulations
PublikacjaAlthough accidental bunker oil spills at seaway are relatively rare events, they can be pose real threat to the natural marine environment. One of the reasons for the bunker spill to occur is a design failure; one of the ways it can demonstrate is an improper location or height of vent heads, leading to a bunker oil discharge during heavy rolling, due to sloshing phenomenon. Design of a ship and her systems is guided by various...
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Usability of mobile applications: a systematic literature study
PublikacjaSince the release of the first mobile devices, the usability of on-board applications has been the concern not only of software vendors but hardware manufacturers as well. The academia community later willingly joined the discussion on usability in terms of theory and empirical measurement, having experience and knowledge in desktop settings. At first sight, such a background should guarantee a solid foundation to conduct research...
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ANALYSIS OF THE RESULTS OF THE AUDIT OF LIGHTING PARAMETERS AT PEDESTRIAN CROSSINGS IN WARSAW
PublikacjaThe night time, based on many world studies, generates an increased risk of serious accidents (with fatalities and serious injuries). This is especially true for accidents with pedestrians. Pedestrian crossings are very sensitive to the influence of the time of day in terms of pedestrian safety, elements of road infrastructure. This is visible on the example of Poland, where numerous accidents at crosswalks are recorded, characterized...
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GVC and wage dispersion. Firm-level evidence from employee-employer database
PublikacjaResearch background: Wage inequalities are still part of an interesting policy-oriented research area. Given the developments in international trade models (heterogeneity of firms) and increasing availability of micro-level data, more and more attention is paid to wage differences observed within and be-tween firms. Purpose of the article: The aim of the paper is to address the research gap concerning limited cross-country evidence...
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Algorithmic Human Resources Management - Perspectives and Challenges
PublikacjaTheoretical background: Technology – most notably processes of digitalisation, the use of artificial intelligence, machine learning, big data and prevalence of remote work due to pandemic – changes the way organizations manage human resources. One of the increasing trends is the use of so-called “algorithmic management”. It is notably different than previous e-HRM or HRIS (human resources information systems) applications, as it...
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Sub-national structures matter when evaluating physical activity promotion: Lessons from Germany
PublikacjaBackground Public policies are increasingly acknowledged as important part of promoting physical activity (PA). However, especially in states with sub-national administrative structures such as Germany, national and sub-national approaches differ considerably. In Germany, sport for all (SfA) promotion is mostly organized at sub-national level, which is usually not covered in national evaluations. Knowledge of these structures helps...
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Systematic review examining the evidence for impact of school policies on physical activity
PublikacjaBackground Epidemiological evidence has demonstrated that physical activity can have substantive health benefits for children and young people. The 'Policy Evaluation Network' is a multi-disciplinary research network across 7 European countries and New Zealand aimed at building capacity and evaluating the level of impact of policy interventions for promoting healthy lifestyles. The Toronto Charter identified 'whole-of-school' programmes...