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Wyniki wyszukiwania dla: PASSIVE HOUSES
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Genome-wide DNA methylation profiling of the regenerative MRL/MpJ mouse and two normal strains
PublikacjaAims We aimed to identify the pivotal differences in the DNA methylation profiles between the regeneration capable MRL/MpJ mouse and reference mouse strains. Materials and Methods Global DNA methylation profiling was performed in ear pinnae, bone marrow, spleen, liver, heart from uninjured adult females of the MRL/MpJ and C57BL/6J and BALB/c. Results and conclusion A number of differentially methylated regions distinguishing between...
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Transcriptome profiling reveals distinctive traits of retinol metabolism and neonatal parallels in the MRL/MpJ mouse
PublikacjaBackground: The MRL/MpJ mouse is a laboratory inbred strain known for regenerative abilities which are manifested by scarless closure of ear pinna punch holes. Enhanced healing responses have been reported in other organs. A remarkable feature of the strain is that the adult MRL/MpJ mouse retains several embryonic biochemical characteristics, including increased expression of stem cell markers. Results: We explored the transcriptome...
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Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers
PublikacjaMultidrug resistance (MDR) remains a primary hindrance to curative cancer therapy. Thus, introduction of novel strategies to overcome MDR is of paramount therapeutic significance. Sequestration of chemotherapeutics in lysosomes is an established mechanism of drug resistance. Here, we show that MDR cells display a marked increase in lysosome number. We further demonstrate that imidazoacridinones (IAs), which are cytotoxic fluorochromes,...
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Dynamic Charging of Electric Buses as a Way to Reduce Investment Risks of Urban Transport System Electrification
PublikacjaNight charging and fast charging are currently the two most common systems for charging electric buses. Despite the fact that numerous trial installations were started, neither of these two systems has obtained unqualified approval of the users. The alternative is to charge vehicles in motion - dynamic charging which combines the advantages of trolleybus transport and of electric buses. One of the advantages is the reduction of...
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Performance measurements and optimization of visualization of routes traveled in the distributed dispatcher and teleinformation system for visualization of multimedia data for the Border Guard
PublikacjaMonitoring of country maritime border is an important task of the Border Guard. This activity can be enhanced with the use of the technology enabling gathering information from distributed sources, processing of that information and its visualization. The system presented in the paper is an advancement of the previously developed distributed map data exchange system. The added functionality allows to supplement the map data with...
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Biofilm Growth Causes Damage to Silicone Voice Prostheses in Patients after Surgical Treatment of Locally Advanced Laryngeal Cancer
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A Study of Mutual Coupling Suppression between Two Closely Spaced Planar Monopole Antenna Elements for 5G New Radio Massive MIMO System Applications
Publikacja5G NR (new radio) introduces the concept of massive MIMO (multiple-input-multiple-output) technology, in which a larger number of antenna arrays are installed on the transceiver. Due to the increased number of antenna elements allocated close to each other (approximately at half-wavelength distance), mutual coupling becomes a serious problem leading to performance degradation of the MIMO communication system. In this communication,...
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Geodezyjne osnowy realizacyjne i pomiary w morskim pasie brzegowym
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A Biofeedback System that Uses the Game to Study Electrical Muscle Activity
PublikacjaThe aim of this project was to design a system that will allow performing repetitive muscle exercises using a biofeedback device. It is supposed to enhance the motivation and attractiveness of the performed tasks thanks to an interactive game developed for mobile devices with the Android operating system. The built-in calibration mechanisms enable the users to play a game that is independent of their abilities which evens out the...
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The uses of the pressuremeter test for the design of north transversal tunnel in Grenoble
PublikacjaWyniki otrzymane z badań presjometrycznych wykorzystano do obliczeń statycznych za pomocą programu Extreme, którym wyznacza się wartość średnią X, odchylenie standardowe, wartość charakterystyczną Xk i rozkład teoretyczny każdego z parametrów. Obliczono wartość charakterystyczną kąta tarcia wewnętrznego dla każdego rodzaju gruntów z prawdopodobieństwem Alfa (równym 5%). Badano rozkłady: normalny, log normalny, wykładniczy, Weybulla,...
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The Peritoneal Neovagina after Davydov's Laparoscopic Procedure in Mayer-Rokitansky-Küster-Hauser Syndrome: Morphology and Ultrastructure Investigation of the New Epithelium
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Comparison of the powers of energy losses in a variable capacity displacement pump determined without or with taking into account the power of hydraulic oil compression
PublikacjaPowers of energy losses in a variable capacity displacement pump are compared with or without taking into account the power of hydraulic oil compression. Evaluation of power of liquid compression in the pump was made possible by the use of method, proposed by the Author, of determining the degree of liquid aeration in the pump. In the method of determining the liquid aeration in the pump and of powers of volumetric losses of liquid...
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Opinion about causes of framing of Kingston chest (box cooler) damage, on PSV vessel VS4411 DF-PSV (B-855)
PublikacjaThe subject of analysis is a damage of welded connection of box cooler framing segments, made as separate bars 50mm thickness, connected by the welds in corners. Studies of documents delivered by Customer shows cracks on the fusion of filet welds and twisting of box cooler frame. The subject of analysis is a damage of welded connection of box cooler framing segments, made as separate bars 50mm thickness, connected by the welds...
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Analysis of road accident causes in the voivodships in the years 2014-2021 in the aspect of socio-economic costs – towards the implementation of sustainable development
PublikacjaThe article addresses the topic of road safety. The objective of the research was to assess road accidents caused by voivodships. The analysis took account of the socio-economic differences in the voivodships, which deter-mine the unit costs of fatalities and injuries. A descriptive analysis is given to show the dynamics of changes in the years 2014-2021 in the voivodships and how different factors influenced change. The article...
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Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models
PublikacjaThe proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfunction by genetic manipulation delays mortality, cell death, and cognitive deficits in fly and cell culture AD models. We developed...
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Antitumor Effects of Vitamin D Analogs on Hamster and Mouse Melanoma Cell Lines in Relation to Melanin Pigmentation
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Perturbations of the hepatic proteome behind the onset of metabolic disorders in mouse offspring developed following embryo manipulation
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Role of method of implementing multi-factorial falls prevention in nursing homes for elderly persons. The EUNESE project
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Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models
PublikacjaThe proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfunction by genetic manipulation delays mortality, cell death, and cognitive deficits in fly and cell culture AD models. We developed...
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Vibration testing in buildings and safety of their operation
PublikacjaThe paper presents the issue of vibrations in residential buildings located near roads. It describes the measurement methodology and criteria for assessing the impact of vibrations generated by passing trucks. The article specifies a method to establish the impact on the operation of the examined facilities and it promotes the idea of employing a Bayesian network to determine probabilistically the level of risk to single-family...
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Artemisia dracunculus (Tarragon): A Review of Its Traditional Uses, Phytochemistry and Pharmacology
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Possible uses of crisis situation aiding system in virtual world simulation
PublikacjaMany of the real world crisis situations like spreading fire, hostile units attack, flood, and etc. are commonly used in computer games where a simulation of extensive virtual world is crucial. This paper presents some ideas for possible uses of existing crisis situation aiding system in such environments. Moreover, it shows how this kind of system can be taught during subsequent games with a large number of players. As an example...
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Possible uses of crisis situation aiding system in virtual world simulation
PublikacjaMany of the real world crisis situations like spreading fire, hostile units attack, flood, and etc. are commonly used in computer games where a simulation of extensive virtual world is crucial. This paper presents some ideas for possible uses of existing crisis situation aiding system in such environments. Moreover it shows how this kind of system can be taught during subsequent games with a large number of players.
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Natural sweeteners: Sources, extraction and current uses in foods and food industries
PublikacjaFood producers have leaned towards alternative natural and synthetic sweeteners in food formulations to satisfy market demands. Even so, several synthetic sweeteners (e.g., aspartame, saccharin, sucralose) are becoming less popular due to health-related concerns, lower nutritional values, and controversies around their safety. Conversely, natural sweeteners confer favourable customer perceptions due to their association to a healthier...
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Mangiferin: A comprehensive review on its extraction, purification and uses in food systems
PublikacjaWith the target of fabricating healthier products, food manufacturing companies look for natural-based nutraceuticals that can potentially improve the physicochemical properties of food systems while being nutritive to the consumer and providing additional health benefits (biological activities). In this regard, Mangiferin joins all these requirements as a potential nutraceutical, which is typically contained in Mangifera indica...
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Determination of mercury in mosses by novel cold vapor generation atmospheric pressure glow microdischarge optical emission spectrometry after multivariate optimization
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Antibiotic Resistance Carriage Causes a Lower Survivability Due to Stress Associated with High-Pressure Treatment among Strains from Starter Cultures
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Wpływ właściwości czynników chłodniczych na straty egzergii w pompie ciepła (Influence of Refrigerants Properties for Exergy Losses in Heat Pump)
PublikacjaArtykuł poświęcony jest wpływowi występujących w pompie ciepła strat egzergii na jej efektywność energetyczną, a co za tym idzie koszty funkcjonowania instalacji. Autorzy prezentują tu metodologię obliczeniową, która może być zastosowana w procesach projektowania układów cieplno-przepływowych. Obliczenia zostały wykonane na podstawie typowego układu powietrznej pompy ciepła pracującej w klimacie środkowo-europejskim. Ponadto w...
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EXTRAORDINARY RAINFALLS IN GDANSK (NORTHERN POLAND) IN THE 21ST CENTURY
PublikacjaIn the 21st century Gdansk had been affected by two rainfall events with a total precipitation amount of over 120 mm each. Rainfall parameters exceeded the regional values of the rain occurring once every 100 years. At the meteorological station of Gdansk University of Technology, July 9th 2001 was recorded 123.5 mm and July 14th 2016, 150.8 mm rainfall (within 24 hours observation period). Despite the same seasons of summer months...
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A pilot study to assess an in-process inspection method for small diameter holes produced by Direct Metal Laser Sintering
PublikacjaPurpose The purpose of this research is to evaluate the geometric quality of small diameter holes in parts printed by DMLS technology. An in-process optical inspection method is proposed and assessed during a pilot study. The influence of the theoretical hole diameter assumed in a CAD system and the sample thickness (hole length) on the hole clearance was analysed. Design/methodology/approach The samples made of two different...
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Localization of key amino acid residues in the dominant conformational epitopes on thyroid peroxidase recognized by mouse monoclonal antibodies
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The role of uropathogenic Escherichia coli adhesive molecules in inflammatory response- comparative study on immunocompetent hosts and kidney recipients
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Correlational nutritional relationships and interactions between expansive holoparasite Orobanche laxissima and woody hosts on metal-rich soils
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Sequence variants of p21 gene of the MRL/MpJ mouse: a possible association with the deficit of p21 protein and regenerative phenotype.
PublikacjaThe MRL/MpJ mouse is known for its enhanced regeneration abilities that manifested themselves by scarless ear-hole wound closure. The deficit of p21 found in the MRL is associated with the regenerative capacity as the p21 gene knockout in a mouse strain unrelated to the MRL mouse results in an ear-hole closure effect, similar to that observed in the MRL mouse. Cdkn1a gene encodes p21 protein, a cyclin-dependent kinase inhibitor,...
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Reducing Air Pollutant Emissions from the Residential Sector by Switching to Alternative Energy Sources in Single-Family Homes
PublikacjaThe paper discusses a scenario for adapting residential buildings to the requirements of the EU climate and energy package. It analyzes the option of reducing pollutant emissions to ambient air by switching to alternative energy sources in a typical single-family residential building. The most common sources of energy in central heating and ventilation systems and water heating systems were compared, and the analyzed energy carriers...
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Fracture Surface Behavior of 34CrNiMo6 High-Strength Steel Bars with Blind Holes under Bending-Torsion Fatigue
PublikacjaThe present study evaluates the fracture surface response of fatigued 34CrNiMo6 steel bars with transverse blind holes subjected to bending with torsion loading. The analysis of the geometric product specification was performed by means of height parameters Sx, functional volume parameters Vx, and fractal dimension Df. Surface topography measurements were carried out using an optical profilometer with focus variation technology....
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Stock Markets’ Reactions to the Announcement of the Hosts. An Event Study in the Analysis of Large Sporting Events in the Years 1976–2032
PublikacjaThis study attempts to estimate the impact of the announcements of hosts of large sporting events on domestic stock markets. The research problem is to establish a connection between the uniqueness of a sporting event and investors’ beliefs through stock price behavior. Using appropriate estimation windows, 13 different sporting events classified as large, including mega and major events, were tested. The obtained results show...
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Signal conditioning for examination of shallow-water acoustic noise correlation properties
PublikacjaThe article describes the process of signal conditioning for examination of acoustic noise correlation properties in shallow water. Knowledge of these properties is very important for the design processes of passive and active hydroacoustic systems. This paper focuses on the above issue from the point of view of passive sonar. In sonar systems, signal processing algorithms operate on both useful acoustic signals, and accompanying...
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MANAGING LEARNING PROCESS WITH E-LEARNING TOOL
PublikacjaThis article presents one possibility to employ Moodle, the free e-Leaning platform, to organize learning understood as a process. Behavioral approach and application to massive courses are assumed. A case study is presented, where the introduction of Moodle resulted in better student performance in homework
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Thermoluminescence glow curves and deconvoluted glow peaks of Ge doped flat fibers at ultra-high doses of electron radiation
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Application of Extreme Doses of Aluminium for Growth Control of Filmentous Bacteria Microthrix Parvicella in an Activated Sludge System - Laboratory Investigations
PublikacjaLaboratory investigations of aluminium (PAX-16) application for control of population of filamentous bacteria Microthrix Parvicella in a three-phase bioreactor in lab-scale were performed. Dosing of small aluminium doses (approximately 0.5 mgAl/gMLSS·d) in the period preceding seasonal growth of M.Parvicella failed to prevent mass growth of this microorganism leading to activated sludge bulking phenomenon (SVI-250 ml/gMLSS)...
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Preliminary Research towards Acute Effects of Different Doses of Caffeine on Strength–Power Performance in Highly Trained Judo Athletes
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Expression of high affinity choline transporter during mouse development in vivo and its upregulation by NGF and BMP-4 in vitro
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Experimental study of the impact of notches and holes made in the front edge of adherends on the properties of static and fatigue strength of adhesive joints
PublikacjaThe paper presents the results of experimental studies aimed at determining the effect of holes and notches at the front edge of adherends on the strength of adhesive joints. Single-lap joints made of S235JR steel sheets joined with Araldite 2014-2 epoxy adhesive were tested. Comparative tests of static strength in the shear test as well as high-cycle fatigue strength tests were carried out. Joints with three holes with a diameter...
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Radiation Therapy-Related Changes in Serum Proteome Patterns Are Affected by Medium Doses of Radiation Delivered to Large Volumes of Normal Tissue
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Concomitant consumption of Aronia melanocarpa aqueous extract and low cadmium doses improve serum and bone antioxidative status in a rat model
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Thioamides and selenoamides with chirality solely due to hindered rotation about the C-N bond: enantioselective complexation with optically active hosts
PublikacjaBariera rotacji wokół wiązania C-N w tioamidach jest średnio o 3-5 kcal/mol wyższa niż w odpowiednich amidach, a w analogicznych selenoamidach wzrasta jeszcze o 1 kcal/mol. Dzięki temu związki te występują w dwu enancjomerycznych formach, których wzajemna przemiana zachodzi w wyniku rotacji wokół wiązań C-N. Bariera rotacji jest wystarczająco wysoka, aby można było podjąć próbę ich rozdziału na enancjomery w temperaturze pokojowej....
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A review of the traditional uses, phytochemistry, pharmacology, and clinical evidence for the use of the genus Alchemilla (Rosaceae)
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Increasing the Seismic Resistance of Wood-frame Buildings by Applying PU Foam as Thermal Insulation
PublikacjaWood-frame buildings are very common in regions that are exposed to earthquakes. Most of residential buildings are constructed using this technology; therefore, the seismic resistance of them is really essential in order to prevent human losses and structural damage. The aim of the present article is to show the results of the detailed numerical FEM analysis focused on the seismic behaviour of the wood-frame house with different...
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Mild X-linked Alport syndrome due to the COL4A5 G624D variant originating in the Middle Ages is predominant in Central/East Europe and causes kidney failure in midlife
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