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Wyniki wyszukiwania dla: COPPER PEPTIDES
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Two kinds of oxygen vacancies in lithium titaniate doped with copper as detected by EPR
PublikacjaLithium titanate (Li1+xTi2-xO4) doped with Cu2+ ions was synthesized by sol-gel processing method. The structure and morphology are characterized by X-ray Diffraction (XRD), X-ray Photoemission Spectroscopy (XPS), Scanning Electron Microscopy (SEM) and Electron Paramagnetic Resonance (EPR). Spin Hamiltonian parameters describing Zeeman and hyperfine interaction for 63Cu2+ ions were obtained from EPR spectra simulations. The spectra...
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Structure and thermoelectric properties of nickel-doped copper selenide synthesised in a hydrogen atmosphere
PublikacjaNickel-doped copper selenide—Cu2-xNixSe (x = 0; 0.01; 0.02; 0.03)—materials with high thermoelectric properties were synthesised through reduction of reagents in hydrogen. The impact of the nickel content on both the microstructure and thermoelectric properties was examined. The nickel-doped samples’ microstructure differed significantly from pristine copper selenide. Besides Cu2Se, copper precipitations were present in the materials....
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Peptide conjugates of lactoferricin analogues and antimicrobials—Design, chemical synthesis, evaluation of antimicrobial activity and mammalian cytotoxicity
PublikacjaEight new peptide conjugates composed of modified bovine lactoferricin truncated analogues (LFcinB) and oneof the three antimicrobials — ciprofloxacin (CIP), levofloxacin (LVX), and fluconazole (FLC) — were synthesized. Four different linkers were applied to connect a peptide and an antimicrobial agent. The FLC-containing peptidic conjugates were synthesized using the “click chemistry” method. This novel approach is reported here...
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The influence of substrate peptide length on human β‐tryptase specificity
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Bladder cancer detection using a peptide substrate of the 20S proteasome
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Structural Analysis of a Peptide Fragment of Transmembrane Transporter Protein Bilitranslocase
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Membrane structure and interactions of peptide hormones with model lipid bilayers
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Nutritional value, protein and peptide composition of edible cricket powders
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Synthesis and structure-activity studies of peptide-acridine/acridone conjugates
PublikacjaW artykule opisano strukturę, syntezę i biologiczną aktywność peptydowych koniugatów akrydyny i akrydonu jako potencjalnych leków o aktywności przeciwnowotworowej i przeciwwirusowej.
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Elusive π-helical peptide foldamers spotted by chiroptical studies
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Coulomb-Assisted Dissociative Electron Attachment: Application to a Model Peptide
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Simulating Electron Transfer Attachment to a Positively Charged Model Peptide
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Anticancer Properties of Amino Acid and Peptide Derivatives of Mycophenolic Acid
PublikacjaBackground: Although Mycophenolic Acid (MPA) is applied as prodrugs in clinic as an immunosuppressant, it also possesses anticancer activity. MPA acts as Inosine-5’-Monophosphate Dehydrogenase (IMPDH) inhibitor, where the carboxylic group at the end of the side chain interacts with Ser 276 of the enzyme via hydrogen bonds. Therefore, MPA derivatives with other polar groups indicated high inhibition too. On the other hand, potent...
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Dynamics of Antimicrobial Peptide Encapsulation in Carbon Nanotubes: The Role of Hydroxylation
PublikacjaIntroduction: Carbon nanotubes (CNTs) have been widely employed as biomolecule carriers, but there is a need for further functionalization to broaden their therapeutic application in aqueous environments. A few reports have unraveled biomolecule–CNT interactions as a measure of response of the nanocarrier to drug-encapsulation dynamics. Methods: Herein, the dynamics of encapsulation of the antimicrobial peptide HA-FD-13 (accession...
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DMSO and TMAO—Differences in Interactions in Aqueous Solutions of the K-Peptide
PublikacjaInteractions between a solvent and their co-solute molecules in solutions of peptides are crucial for their stability and structure. The K-peptide is a synthetic fragment of a larger hen egg white lysozyme protein that is believed to be able to aggregate into amyloid structures. In this study, a complex experimental and theoretical approach is applied to study systems comprising the peptide, water, and two co-solutes: trimethylamide...
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New Peptide Based Fluconazole Conjugates with Expanded Molecular Targets
PublikacjaInfections of Candida spp. etiology are frequently treated with azole drugs. Among azoles, the most widely used in the clinical scenario remains fluconazole (FLC). Promising results in treatment of dangerous, systemic Candida infections demonstrate the advantages of combined therapies carried out with combinations of at least two different antifungal agents. Here, we report five conjugates composed of covalently linked FLC and...
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Gemcitabine Peptide-Based Conjugates and Their Application in Targeted Tumor Therapy
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Immunosuppressive properties of amino acid and peptide derivatives of mycophenolic acid
PublikacjaMycophenolic acid (MPA) was coupled with amino acids and biologically active peptides including derivatives of tuftsin to modify its immunosuppressive properties. Both amino acid unit in the case of simple MPA amides and modifications within peptide moiety of MPA - tuftsin conjugates influenced the observed activity. Antiproliferative potential of the obtained conjugates was investigated in vitro and MPA amides with threonine methyl...
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Prediction of Bioactive Peptides From Chicken Feather and Pig Hair Keratins Using In Silico Analysis Based on Fragmentomic Approach
PublikacjaBackground: Keratin is among the most abundant structural proteins of animal origin, however it remains broadly underutilized. Objective: Bioinformatic investigation was performed to evaluate selected keratins originating from mass-produced waste products, i.e., chicken feathers and pig hair, as potential sources of bioactive peptides. Methods: Pepsin, trypsin, chymotrypsin, papain, and subtilisin were used for in silico keratinolysis...
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World Research Journal of Peptide and Protein
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Current Topics in Peptide and Protein Research
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International Journal of Peptide and Protein Research
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Retro analog concept: comparative study on physico-chemical and biological properties of selected antimicrobial peptides
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Effect of Marination Time on the Antioxidant Properties of Peptides Extracted from Organic Dry-Fermented Beef
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Amides as models to study the hydration of proteins and peptides — spectroscopic and theoretical approach on hydration in various temperatures
PublikacjaInteractions with water are one of the key factors which determine protein stability and activity in aqueous solutions. However, the protein hydration is still insufficiently understood. N-methylacetamide (NMA) is regarded as a minimal part of the peptide backbone and the relative simplicity of its structure makes it a good model for studies on protein–water interactions. In this paper, the influence of NMA and N,N-dimethylacetamide...
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Synergistic action of extracts from carnivorous plants and synthetic peptides against plant pathoghenic bacteria
Publikacjaw pracy przedstawiono rezultaty badań nad sprawdzeniem aktywności przeciwbakteryjnej ekstraktów z roślin Drosera capensis i Dionaea muscipula w połączeniu z dwoma syntetycznymi peptydami: CAMEL oraz pexiganan. Najwyższą aktywnością przeciwbakteryjną odznaczał się chloroformowy ekstrakt z D. muscipula z peptydem CAMEL.
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Possible mechanisms for protecting NCα bonds in helical peptides from electron-capture (or transfer) dissociation
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Thermal analysis of copper(II) complexes of general formula [Et4N]2[CuBrnCl4-n]
PublikacjaBadano dekompozycję termiczną związków składających sie z anionów: [CuBrnCl4-n]2- (n=0-4) i kationów tetrametyloamoniowych. Stosowano następujące metody badawcze: TG-FTIR, TG-MS, DTA i DTG. Pomiary przeprowadzono w atmosferze argonu i powietrza w zakresie temperatur od 293 K do 1073 K. Produkty dekompozycji identyfikowano metoda spektroskopii w podczerwieni (IR i FIR) oraz metodą dyfrakcji promieniowania rentgenowskiego.
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Raman investigation of the patina layers on Hungarian copper ingots from a fifteenth century shipwreck
PublikacjaWe report results of the patina study of underwater archeological finding ofmedieval copper objects performed by means of the Raman and complementary spectroscopic techniques. The objects were found submerged in the sea as cargo part of the ship which sunk in the Gulf of Gdańsk in 1408. The excavated collection consists of 230 oval ingots of the size and mass up to about 60 cm and 18 kg (total of 2 tons), respectively. In the Raman...
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Copper and cobalt co-doped ceria as an anode catalyst for DIR-SOFCs fueled by biogas
PublikacjaThe nanocrystalline compounds of Co and Cu co-doped ceria (with up to 20 mol.% of dopants) were fabricated by the reverse microemulsion synthesis method. They were deposited in a form of layers on the surface of SOFC anode in an aim to act as electrochemically active materials for biogas reforming process. Fourier Transformed Infrared Spectroscopy was used to analyze a composition of outlet gases simultaneously with the tests of...
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Technology of braze welding absorber tubes to copper foil in solar collectors by the GTA method
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Relationship between electronic structure and geometry of silanethiols and their derivatives. Elucidation of copper group silanethiolates
PublikacjaWyznaczono strukturę elektronową wybranych silanotioli X3SiSH (dla X=H, C2H5, OCH3, F, Cl i Br) oraz powstalych z nich anionów. Geometrię i funkcje falowe wyznaczono przy użyciu teorii funcjonałów gęstości elektronowej DFT. Przeanalizowano wpływ efektów anomerycznych oraz wielkości calki nakładania sigma(Si-S) na obserwowane skrócenie wiązania Si-S przy deprotonowaniu silanotioli. Podano nowe wyjaśnienie wyjątkowo niskiej kwasowości...
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Deposition of thin titanium–copper films with antimicrobial effect by advanced magnetron sputtering methods
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New Class of Antimicrobial Agents: SBA-15 Silica Containing Anchored Copper Ions
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The biological role of prolyl oligopeptidase and the procognitive potential of its peptidic inhibitors from food proteins
PublikacjaProlyl oligopeptidase (POP) is a conserved serine protease belonging to proline-specific peptidases. It has both enzymatic and non-enzymatic activity and is involved in numerous biological processes in the human body, playing a role in e.g., cellular growth and differentiation, inflammation, as well as the development of some neurodegenerative and neuropsychiatric disorders. This article describes the physiological and pathological...
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Measurement of filling and discharging loads in a full scale hopper.
PublikacjaArtykuł przedstawia wyniki doświadczalne naporu piasku na ścinanie uzyskane podczas napełniania i opróżniania leja silosu o pojemności 2.5 m3. Pokazane zostały wartości naporu w funkcji czasu oraz kształt powierzchni górnej materiału dla poszczególnych etapów napełniania i opróżniania.
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Antifungal dipeptides incorporating an inhibitor of homoserine dehydrogenase
PublikacjaThe antifungal activity of 5‐hydroxy‐4‐oxo‐L‐norvaline (HONV), exhibited under conditions mimicking human serum, may be improved upon incorporation of this amino acid into a dipeptide structure. Several HONV‐containing dipeptides inhibited growth of human pathogenic yeasts of the Candida genus in the RPMI‐1640 medium, with minimal inhibitory concentration values in the 32 to 64 μg mL−1 range. This activity was not affected by multidrug...
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LETTERS IN PEPTIDE SCIENCE
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Synthesis and Evaluation of Biological Activity of Antimicrobial – Pro-Proliferative Peptide Conjugates
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Increased Urinary C-Peptide and Albumin Excretion in Juvenile Borderline Hypertensives
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Synthesis and conformational analysis of salivary proline-rich peptide P-B
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Antimicrobial and conformational studies of the active and inactive analogues of the protegrin-1 peptide
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AMCA to TAMRA long range resonance energy transfer on a flexible peptide
PublikacjaFörster resonance energy transfer between 7-amino-4-methyl-3-coumarinylacetic acid, (AMCA, donor) and 5- carboxytetramethylrhodamine, (TAMRA, acceptor) bound to Lys(AMCA)-Gly-Pro-Arg-Ser-Leu-Ser-Gly-Lys (TAMRA)-NH2 peptide is demonstrated by various spectroscopic techniques in glycerol at room temperature. In particular, nonexponential character of fluorescence intensity decay evidences the distance distribution between the donor...
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Evaluation of Receptor Affinity, Analgesic Activity and Cytotoxicity of a Hybrid Peptide, AWL3020
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Triple helical collagen-like peptide interactions with selected polyphenolic compounds
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Double amino acid – A novel molecule enabling peptide interpenetrating structures
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Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid
PublikacjaThe series of 16 novel amino acid and peptide mycophenolic acid (MPA) derivatives was obtained as potential antibacterial agents. Coupling of MPA with respective amines was optimized with condensing reagents such as EDCI/DMAP and T3P/TEA. Amino acid analogs were received both as methyl esters and also with the free carboxylic group. The biological activity of the products was tested on five references bacterial strains: Klebsiella...
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Modified Peptide Molecules As Potential Modulators of Shelterin Protein Functions; TRF1
PublikacjaIn this work, we present studies on relatively new and still not well-explored potential anticancer targets which are shelterin proteins, in particular the TRF1 protein can be blocked by in silico designed "peptidomimetic" molecules. TRF1 interacts directly with the TIN2 protein, and this protein-protein interaction is crucial for the proper functioning of telomere, which could be blocked by our novel modified peptide molecules....
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Interactions in aqueous solutions of K-peptide and DMSO – spectroscopic and calorimetric studies
PublikacjaIntroduction K-peptide (GILQINSRW) – short 9 amino acid fragment of the hen egg white lysozyme has the ability to form amyloid structures. Dimethyl sulfoxide (DMSO) is an osmolyte which can alter this ability. Our goal was to get an insight into the mechanism of Kpeptide-DMSO interactions in aqueous solutions. Such a knowledge can be helpful to understand processes leading to various neurodegenerative diseases. Methods ATR-FTIR...
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XPS study of the lithium titanate doped by copper
Dane BadawczeLithium titanate doped by copper was measured by X-ray photoemission spectroscopy. For sol-gel synthesis lithium acetate dehydrate from Alfa Aesar GmbH &Co and titanium (IV) butoxide 97% from Aldrich were used as reagents. Copper (II) nitrate from Alfa Aesar was used as a source of Cu dopant. It was added in the proper weight to get an x index equal...