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Search results for: drug screening platform
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ANALYSIS OF THE PUNCHING FAILURE MECHANISM IN WORKING PLATFORMS
PublicationPaper presents an analysis of the shear failure mechanism which occurs from the punching of a working platform layer in relation to its thickness, grain size arrangement and mechanical properties, taking into consideration the interaction with soft subgrade. The study is based on the observations of performance of natural scale structures (Streefkerk) and the results of model investigations numerically represented with the use...
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Adaptive filtering approach to dynamic weighing: a checkweigher case study
PublicationDynamic weighing, i.e., weighing of objects in motion, with out stopping them on the weighing platform, allows one to increase the rate of operation of automatic weighing systems used in industrial production processes without compromising their accuracy. The paper extends and compares two approaches to dynamic weighing, based on system identification and variable-bandwidth filtering, respectively. Experiments, carried on a conveyor...
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Eye tracking within near-to-eye display
PublicationIn this paper we investigate the effectiveness of the gaze interaction within near-to-eye display. The practical aspect of the paper is about combining an eye tracker with smart glasses. Presented research is related with the eGlasses project, which is focused on the development of an open platform in the form of multisensory electronic glasses and related interaction methods. One of the implemented interaction methods is the one...
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Multi-objective Tabu-based Differential Evolution for Teleportation of Smart Virtual Machines in Private Computing Clouds
PublicationWe propose a multi-objective approach for using differential evolution algorithm with tabu search algorithm as an additional mutation for live migration (teleportation) of virtual machines. This issue is crucial in private computing clouds. Teleportation of virtual machines is supposed to be planned to determine Pareto-optimal solutions for several criteria such as workload of the bottleneck host, communication capacity of the...
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Application of smart glasses for fast and automatic color correction in health care
PublicationIn recent years different applications of smart glasses in health care have been proposed. In this paper we present the experiments related to automatic color correction using smart glasses platform developed within the eGlasses project. The color pattern is proposed and tested enabling the automatic detection of the pattern and automatic correction of colors. Additionally, the method for encoding and decoding of patient ID in...
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Intermolecular Interactions as a Measure of Dapsone Solubility in Neat Solvents and Binary Solvent Mixtures
PublicationDapsone is an effective antibacterial drug used to treat a variety of conditions. However, the aqueous solubility of this drug is limited, as is its permeability. This study expands the available solubility data pool for dapsone by measuring its solubility in several pure organic solvents: N-methyl-2-pyrrolidone (CAS: 872-50-4), dimethyl sulfoxide (CAS: 67-68-5), 4-formylmorpholine (CAS: 4394-85-8), tetraethylene pentamine (CAS:...
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Docking simulations, Molecular properties and ADMET studies of novel Chromane6,7diol analogues as potential inhibitors of Mushroom tyrosinase
PublicationResearch on inhibition of tyrosinase enzyme has attained significant value, because tyrosinase inhibitors have potential applications in medicine, cosmetics (as whitening agents) and in agriculture (as bioinsecticides). Determination and elucidation of new tyrosinase inhibitors are not only beneficial for medical purposes, but their promising applications in improving food quality and nutritional...
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Activation Energy and Inclination Magnetic Dipole Influences on Carreau Nanofluid Flowing via Cylindrical Channel with an Infinite Shearing Rate
PublicationThe infinite shear viscosity model of Carreau fluid characterizes the attitude of fluid flow at a very high/very low shear rate. This model has the capacity for interpretation of fluid at both extreme levels, and an inclined magnetic dipole in fluid mechanics has its valuable applications such as magnetic drug engineering, cold treatments to destroy tumors, drug targeting, bio preservation, cryosurgery, astrophysics, reaction kinetics,...
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Sustainable polymers targeted at the surgical and otolaryngological applications: Circularity and future
PublicationThe ongoing climate changes, high air and noise pollution have significant impact on humans’ health. This influence is especially visible in otolaryngology, which focuses on respiratory and hearing systems disfunctions. However, even though surgeries are done in response to diseases related to climate changes, they also have a negative impact on the environment, mostly connected with the inherence of single-use fossil fuel derived...
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Protokoły łączności do transmisji strumieni multimedialnych na platformie KASKADA
PublicationPlatforma KASKADA rozumiana jako system przetwarzania strumieni multimedialnych dostarcza szeregu usług wspomagających zapewnienie bezpieczeństwa publicznego oraz ocenę badań medycznych. Wydajność platformy KASKADA w znaczącym stopniu uzależniona jest od efektywności metod komunikacji, w tym wymiany danych multimedialnych, które stanowią podstawę przetwarzania. Celem prowadzonych prac było zaprojektowanie podsystemu komunikacji...
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Peptydy penetrujące – rodzaje i mechanizmy przenikania przez błony komórkowe
PublicationPeptydy penetrujące z pewnością są wyjątkową i ciekawą grupą związków peptydowych. Zostały odkryte ponad dwadzieścia lat temu, ale wiedza na ich temat wciąż jest rozbudowywana. Liczne badania nad mechanizmami ich przenikania do wnętrza komórek pozwalają zrozumieć jakie cechy strukturalne warunkują ich zdolność do penetracji komórek. Wiedza ta pozwala na projektowanie nowych, bardziej efektywnych peptydów penetrujących., które mogą...
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Termin zgłaszania wystapień do eTEE 2022
Events8. ogólnopolska konferencja "e-Technologie w Kształceniu Inżynierów". Zgłaszanie propozycji wystapień w zakładce "Zgłaszanie abstraktów" na stronie konferencji eTEE: www.pg.edu.pl/etee.
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Etyka zawodu architekta, III semestr, rok akademicki 2021/2022
e-Learning CoursesWelcome to e-learning course of Architect's Proffesional Ethics. Classes will be conducted via TEAMS platform. Link to clasess below: https://teams.microsoft.com/l/meetup-join/19%3ameeting_NGYyZjU0OTItMjgwZC00N2MxLTg5ZjItZDliZDY2YTNiNGUw%40thread.v2/0?context=%7b%22Tid%22%3a%2286760356-0022-486f-b793-a2d470bba5a5%22%2c%22Oid%22%3a%22744d498a-011e-4d0b-8a3d-08b49c9156ff%22%7d
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Light4Health eLearning Course: health research for interior lighting design. Re-thinking design approaches based on science
PublicationThis paper presents the results of 'Light4Health' (L4H), a three-year EU Erasmus+ Strategic Partnership grant project (2019-2021), which investigated, systematized and taught health-related research on the impact of natural and artificial light on human health and well-being relevant to indoor lighting design. The objective was to re-think evidence-based lighting design approaches for residential, working/educational, and healthcare...
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Misje i misjonarska retoryka w zarządzaniu platformami mediów
PublicationTrudno o bardziej znane i poruszające zbiorową wyobraźnię przekazy cyfrowych platforma, niż zapisy ich misji. Nie tylko łatwo wyjaśniają one rolę organizacji, ale zapewniają racjonalizację tego, kto lub czym jest coś lub jak działa. Dla Facebooka, Google i wielu innych organizacji pragnących „zmienić świat na lepszy” są elementem samonapędzającego się mechanizmu utwierdzającego w słuszności obranej drogi. W przypadku cyfrowych...
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SPECTRAL RESPONSE OF STATIONARY JACK-UP PLATFORMS LOADED BY SEA WAVES AND WIND USING PERTURBATION METHOD
PublicationThe paper addresses non-linear vibrations of offshore jack-up drilling platforms loaded by sea waves and wind in their stationary condition using the perturbation method. Non-linearity of dynamic equations of motion for fixed offshore platforms yields from two factors. The first is load excitation generating non-linear velocity coupling in a dynamic system. This coupling is inherent in the modified Morison equation, involving the...
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Platforma edX - nowe podejście do kursów online
PublicationWspółczesne metody nauczania na odległość zmieniają się dynamicznie. Powstają światowe konsorcja podejmujące starania zapewnienia dostępu do edukacji na najwyższym poziomie z wykorzystaniem Internetu. Jedną z takich prób jest platforma edX. Jej rozwój zapoczątkowały niemal 2 lata temu MIT i Harvard. Obecnie zespół liczy już 30 uczelni z całego świata. Renoma ośrodków naukowych biorących udział w projekcie przyciągnęła już ponad...
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Physical and Mechanical Evaluation of Silicone-Based Double-Layer Adhesive Patch Intended for Keloids and Scar Treatment Therapy
PublicationGrowing interest in silicone elastomers for pharmaceutical purposes is due to both theirbeneficial material effect for scar treatment and their potential as drug carriers. Regarding their morphological structure, silicone polymers possess unique properties, which enable a wide range of applicability possibilities. The present study focused on developing a double-layer adhesive silicone film (DLASil) by evaluating its physical...
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Analytical procedures for determination of cocaine and its metabolites in biological samples
PublicationThe dangerous effects and increased usage of illicit drugs have inspired the development of analytical methodologies. We based our review of analytical procedures for determination of cocaine (COC) and its metabolites on literature from the past two decades. Our main aim was to compare the capabilities of different analytical techniques. The diversity of matrices from which COC is determined (e.g., blood, hair, saliva, plasma,...
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Magdalena Brzozowska-Woś dr hab. inż.
PeopleMagdalena Brzozowska-Woś is a graduate of the Faculty of Management and Economics of the Gdańsk University of Technology (specialization: management systems). She is also a graduate of Postgraduate Studies in Advertising (Faculty of Management and Economics, GUT) and Postgraduate Studies in Public Relations (SWPS University of Humanities and Social Sciences). In the years 2000-2003, she cooperated with Panorama Internet sp. z o....
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Geo-location of the commune of an IP user
PublicationThis paper describes a system of geo-location of an IP user that would enable VoIP users to call 112. Basic requirement is fast (under 50ms) determination of the commune of the subscriber. To obtain as accurate information as possible aggregation of several methods was proposed: using a database of locations of IP ranges created by specialized companies, traceroute using history of user locations to assume his current one.It is...
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Multidisciplinary Open System Transferring Knowledge for R2B Development
PublicationDespite many efforts, there is still a serious problem in transferring knowledge from research to business. The problem is especially visible in Poland – the cooperation of R2B is ineffective. We are trying to solve this problem using some IT support. The manuscript presents some solutions developed at the Gdańsk University of Technology. In particular, the platform called “MOST Knowledge” is deeply described. Its layer architecture,...
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A Stand for Measurement and Prediction of Scattering Properties of Diffusers
PublicationIn this paper we present a set of solutions which may be used for prototyping and simulation of acoustic scattering devices. A system proposed is capable of measuring sound field. Also a way to use an open source solution for simulation of scattering phenomena occurring in proximity of acoustic diffusers is shown. The result of our work are measurement procedure and a prototype of the simulation script based on FEniCS - an open source...
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SURVEY SIMULATOR – PLATFORMA VR DLA EDUKACJI W PRZEMYŚLE MORSKIM
PublicationArtykuł przedstawia założenia, architekturę i główne funkcje programu DNVGL Survey Simulator. Program, bazujący na wizualizacji 3D okrętów i platform wiertniczych, został stworzony w celu wspomagania profesjonalnego szkolenia załóg pływających. Realizuje on model kształcenia w znacznej mierze odmienny od akademickiego, skoncentrowany przede wszystkim na problemach praktycznych i procedurach obowiązujących w przemyśle. Przedstawione...
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AffecTube — Chrome extension for YouTube video affective annotations
PublicationThe shortage of emotion-annotated video datasets suitable for training and validating machine learning models for facial expression-based emotion recognition stems primarily from the significant effort and cost required for manual annotation. In this paper, we present AffecTube as a comprehensive solution that leverages crowdsourcing to annotate videos directly on the YouTube platform, resulting in ready-to-use emotion-annotated...
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Predicting sulfanilamide solubility in the binary mixtures using a reference solvent approach
PublicationBackground. Solubility is a fundamental physicochemical property of active pharmaceutical ingredients. The optimization of a dissolution medium aims not only to increase solubility and other aspects are to be included such as environmental impact, toxicity degree, availability, and costs. Obtaining comprehensive...
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Molecular dynamics and verisimilitude - to what extent can one trust a computational simulation?
PublicationFor the last several tens of years, computer simulations have become of undeniable importance. Molecular Dynamics (MD) simulation techniques are used to examine the phenomena which occur at the level that cannot be observed directly. Thus, they can be successfully exploited in many different scientific fields such as: materials science, applied mathematics and theoretical physics, biochemistry, biophysics or drug design. Despite...
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Development of polyurethanes for bone repair
PublicationThe purpose of this paper is to review recent developments on polyurethanes aimed at the design, synthesis, modifications, and biological properties in the field of bone tissue engineering. Different polyurethane systems are presented and discussed in terms of biodegradation, biocompatibility and bioactivity. A comprehensive discussion is provided of the influence of hard to soft segments ratio, catalysts, stiffness and hydrophilicity...
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Novel 1,2,3-Triazole Derivatives as Mimics of Steroidal System—Synthesis, Crystal Structures Determination, Hirshfeld Surfaces Analysis and Molecular Docking
PublicationHerein, we present the synthesis and crystal structures determination of five 4-(1-phenyl-1H-1,2,3-triazol-4-yl)phenol derivatives containing halogen atoms, 6a–e, which may be used as an excellent mimic of steroids in the drug development process. Good quality crystals obtained for all of the synthesized compounds allowed the analysis of their molecular structures. Subsequently, the determined crystal structures were used to calculate...
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The Usefulness of Cyclic Diamidines with Different Core-substituents as Antitumor Agents
PublicationA series of related polycationic compds. has been screened for potential antitumor activity by the NCI's in vitro testing (one dose primary anticancer assay and the NCI-60 full panel screening). The GI50 values of triazines 3 and 4 are on av. 1.9 μM and 2.4 μM, resp. Furan 8 deserves mention too (1.9 μM). The biol. test results showed that carbazole 10 possessed cytotoxic activity in the nanomolar range, much better than...
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The data exchange between smart glasses and healthcare information systems using the HL7 FHIR standard
PublicationIn this study we evaluated system architecture for the use of smart glasses as a viewer of information, as a source of medical data (vital sign measurements: temperature, pulse rate, and respiration rate), and as a filter of healthcare information. All activities were based on patient/device identification procedures using graphical markers or features based on visual appearance. The architecture and particular use cases were implemented...
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Evaluation of Respiration Rate Using Thermal Imaging in Mobile Conditions
PublicationRespiratory rate is very important vital sign that should be measured and documented in many medical situations. The remote measurement of respiration rate can be especially valuable for medical screening purposes (e.g. severe acute respiratory syndrome (SARS), pandemic influenza, etc.). In this chapter we present a review of many different studies focused on the measurements and estimation of respiration rate using thermal imaging...
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Machine Learning and Electronic Noses for Medical Diagnostics
PublicationThe need for noninvasive, easy-to-use, and inexpensive methods for point-of-care diagnostics of a variety of ailments motivates researchers to develop methods for analyzing complex biological samples, in particular human breath, that could aid in screening and early diagnosis. There are hopes that electronic noses, that is, devices based on arrays of semiselective or nonselective chemical sensors, can fill this niche. Electronic...
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Determination of aminoglycoside antibiotics: current status and future trends
PublicationThe use of aminoglycoside antibiotics is prevalent in medicine and agriculture. Their overuse increases their mobility in the environment, resulting in a need for reliable methods for their determination in a variety of matrices. However, the properties of aminoglycosides, in particular their high polarity, make the development of such methods a non-trivial task, inciting researchers to tackle this complex issue from different...
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Efficient optimization approaches for microwave assisted extraction of high-quality antioxidant compounds from Salvia officinalis L.: UHPLC-HRMS differential analysis of phenolic profiles obtained by ultrasound and microwave extraction
PublicationThe study aims to optimize MAE of total phenolic compounds (TPC) and antioxidant capacity from Salvia officinalis L. leaves using a definitive screening design (DSD) and I-optimal design. UHPLC-HRMS analysis was used to identify and compare the composition of MAE and UAE optimal extracts. The results showed that DSD and I-optimal design were successfully applied for the optimization of MAE targeting phenolics and other antioxidants...
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eTEE 2017
EventsKonferencja ma na celu pokazanie zastosowania najnowszych technologii w edukacji inżynierskiej oraz badań prowadzonych w tym zakresie.
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The Metal-Free Regioselective Deuteration of 2-Methylquinolin-8-ol and 2,5-Dimethylquinolin-8-ol, Spectroscopic and Computational Studies
PublicationAbstract: Aim and Background: Introducing deuterium to a molecule is of interest to a wide variety of research, including investigation of reaction mechanisms or kinetics, analysis of drug metabolism, structural elucidation of molecules, and syntheses of isotopically labeled materials used for NMR spectroscopy and medicinal research. Objective: The transition-metal-free regioselective deuteration of 2-methylquinolin-8-ol...
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Antibiotic-Based Conjugates Containing Antimicrobial HLopt2 Peptide: Design, Synthesis, Antimicrobial and Cytotoxic Activities
PublicationRecent studies have shown that modified human lactoferrin 20−31 fragment, named HLopt2, possesses antibacterial and antifungal activity. Thus, we decided to synthesize and evaluate the biological activity of a series of conjugates based on this peptide and one of the antimicrobials with proven antibacterial (ciprofloxacin, CIP, and levofloxacin, LVX) or antifungal (fluconazole, FLC) activity. The drugs were covalently connected...
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Diminshed toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells
PublicationThe narrow "therapeutic window" of anti-tumour therapy may be the result of drug metabolism leading to the activation or detoxification of antitumour agents. The aim of this work is to examine (i) whether the diminished toxicity of a potent antitumour drug, C-1748, 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine, compared with its 4-demethyl analogue, C-857, results from the differences between the metabolic pathways for the...
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Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione: characteristics of non-enzymatic and glutathione S-transferase-mediated reactions
PublicationUnsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. A significant route of phase II drug metabolism is conjugation with glutathione (GSH), which can be non-enzymatic and/or catalyzed by GSH-dependent enzymes. The aim of this work was to investigate the GSH-mediated metabolic pathway of a representative UA, C 2028. GSH supplemented incubations of C-2028 with rat, but not with human, liver...
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Imidazoacridinone antitumor agent C-1311 as a selective mechanism- based inactivator of human cytochrome P450 1A2 and 3A4 isoenzymes.
Publication5-Diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311), a promising antitumor agent that is also active against autoimmune diseases, was determined to be a selective inhibitor of the cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Therefore, C-1311 might modulate the effectiveness of other drugs used in multidrug therapy. The present work aimed to identify the mechanism of the observed C-1311-mediated inactivation of CYP1A2...
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Removal of selected sulfonamides and sulfonamide resistance genes from wastewater in full-scale constructed wetlands
PublicationSulfonamides are high-consumption antibiotics that reach the aquatic environment. The threat related to their presence in wastewater and the environment is not only associated with their antibacterial properties, but also with risk of the spread of drug resistance in bacteria. Therefore, the aim of this work was to evaluate the occurrence of eight commonly used sulfonamides, sulfonamide resistance genes (sul1–3) and integrase genes...
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Koncepcja systemu informatycznego dla potrzeb SZwWP
PublicationImplementacja zaawansowanego, zintegrowanego systemu sterowania dla potrzeb Systemu Zaopatrzenia w Wodę Pitną (SZwWP), wymaga odpowiednich platform sprzętowych i programowych - systemu informatycznego. Zaproponowane rozwiązania muszą pozwolić na realizację niezbędnych funkcji systemu - sterowania czy monitorowania, zapewniając jednocześnie dużą niezawodność działania oraz bezpieczeństwo przetwarzanych danych. Ponadto wykorzystywana...
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Wiarygodna integracja systemów ESB oraz Web services
PublicationW pracy przedstawiono problem wiarygodnej integracji aplikacji rozproszonych z wykorzystaniem technologii Enterprise Service Bus oraz Web services. Przeprowadzono badania trzech platform integracji serwisów: Sun Open ESB, Windows Workflow Foundation oraz Mule ESB wraz z najbardziej popularnymi serwerami Web services. Badania wykazały, że delkarowane i zaimplementowane możliwości współpracy w platformach integracji różnią się w...
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Using Alpha-beta filtration for robustness improvement of a quadrocopter positioning system
PublicationQuadrocopter is an unmanned aerial vehicle (UAV) platform. The position of the robot is determined based on readings from an accelerometer and a gyroscope, but the measurement signals contain broadband noise. This article describes a solution for filtering out the noise based on an Alpha – beta filter. It also presents the methodology of designing and implementing such a filter for noise cancellation in measurement signals from...
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Finite element matrix generation on a GPU
PublicationThis paper presents an efficient technique for fast generation of sparse systems of linear equations arising in computational electromagnetics in a finite element method using higher order elements. The proposed approach employs a graphics processing unit (GPU) for both numerical integration and matrix assembly. The performance results obtained on a test platform consisting of a Fermi GPU (1x Tesla C2075) and a CPU (2x twelve-core...
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Knowledge-Grid Modelling for Academic Purposes
PublicationNowadays, we face a huge amount of data and information sharing on the Web by different users worldwide. A multidimensional perspective in describing a university ontology seems to be very important for the modelling of higher education resources. This paper proposes a multi-dimensional knowledge model, designed to distribute and manage knowledge resources efficiently. We propose our model as the foundation of an advanced knowledge...
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GPU based implementation of Temperature-Vegetation Dryness Index for AVHRR3 Satellite Data
PublicationPaper presents an implementation of TVDI (Temperature-Vegetation-Dryness Index) algorithm on GPU (Graphics Processing Unit). Calculation of this index is based on LST (Land Surface Temperature) and NDVI (Normalized Difference Vegetation Index). Discussed results are based on multi-spectral imagery retrieved from AVHRR3 sensors for area of Poland. All phases of TVDI implementation on GPU are modified in respect to CUDA platform....
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A shared curriculum for daylighting education to meet the educational needs of society
PublicationThis article describes the collaborative creation of the curriculum for a new eLearning programme on daylighting design of buildings targeting both traditional and lifelong learners. The programme consists of an online platform integrated with a summer school for practical applications. The process was conducted through several workshops with professionals, representatives of national bodies on building regulations, academics,...
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WIND-TU-PLA Design and analysis of the foundation and anchoring systems of offshore wind turbine platforms for the southern Baltic
ProjectsProject realized in Department of Theory and Ship Design according to MARTECII/1/2013 agreement from 2014-02-19