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Search results for: SMART INNOVATION ENGINEERING PRODUCT INNOVATION PRODUCT DESIGN SET OF EXPERIENCE DECISIONAL DNA
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Zastosowanie immobilizowanego białka MutS do wychwytywania fragmentów DNA zawierających niesparowane zasady
PublicationBiałko MutS wiąże DNA zawierające błędnie sparowane oraz niesparowane zasady w DNA. Podjęto szereg prób wykorzystania tego białka jako narzędzia do detekcji nieznanych mutacji lub zagęszczania frakcji DNA z niesparowaną zasadą. Dotychczas żadna z metod oparta na użyciu białka MutS nie została wdrożona powszechnie do praktyki laboratoryjnej. Głównym powodem takiego stanu rzeczy jest stosunkowo silne powinowactwo MutS do DNA w pełni...
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Application of Multivariate Analysis Methods in Welding Engineering
PublicationPhenomena and processes taking place during welding are usually very complex and, for this reason, should be described using multivariate methods. The article discusses the methodological basis and selected application areas as regards the solving of welding problems using statistical multivariate methods. In addition, the article presents exemplary applications of the design of experiment, multiple regression analysis, cluster...
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Multi-objective Tabu-based Differential Evolution for Teleportation of Smart Virtual Machines in Private Computing Clouds
PublicationWe propose a multi-objective approach for using differential evolution algorithm with tabu search algorithm as an additional mutation for live migration (teleportation) of virtual machines. This issue is crucial in private computing clouds. Teleportation of virtual machines is supposed to be planned to determine Pareto-optimal solutions for several criteria such as workload of the bottleneck host, communication capacity of the...
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Novel anticancer strategy aimed at targeting shelterin complexes by the induction of structural changes in telomeric DNA: hitting two birds with one stone.
PublicationThe ends of chromosomes in mammals are composed of telomeric DNA containing TTAGGG repeats, which bind specific proteins called shelterins. This telomeric DNA together with shelterins form a cap that protects the ends of chromosomes from being recognized as sites of DNA damage and from chromosomal fusions. Many very successful antitumor drugs used in the treatment of cancer patients bind to DNA, some of them with a prominent sequence...
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Ella4Life virtual assistant - user centered design strategy - evaluation following labolatory tests
PublicationIn the paper, we summarize the evaluation of Anne4Care system after laboratory tests. A group of end users, seniors over 55 years of age, rated a virtual assistant by completing a questionnaire. The objectives of the pilot evaluations are mainly to assess the feasibility, usability, acceptance and functionality of the system and the ability of the potential target user to use the system and receive valuable information from it...
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Digital Innovations and Smart Solutions for Society And Economy: Pros and Cons
PublicationRecent developments in artificial intelligence (AI) may involve significant potential threats to personal data privacy, national security, and social and economic stability. AI-based solutions are often promoted as “intelligent” or “smart” because they are autonomous in optimizing various processes. Be-cause they can modify their behavior without human supervision by analyzing data from the environ-ment, AI-based systems may be...
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Introduction to Higher Physics (PG_00055138), Design and Production Engineering, sem. 01, 2023/24
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Smart future of knowledge management
PublicationW pracy przedstawiono kierunek przyszłościowego rozwoju obszaru zarządzania wiedzą pod kątem jego użyteczności w tworzeniu sztucznej inteligencji.
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The concept of smart and secure laboratory.
PublicationW chwili obecnej, w erze globalizacji istnieje niezbędna konieczność rozwoju struktur gwarantujących zapewnienie bezpieczeństwa dla zasadniczych wyzwań stawianych przed ludzkością. Stąd potrzeba ujęcia aspektu bezpieczeństwa w kategoriach globalnych. Instytucje akademickie dostosowują się w tym zakresie stosunkowo szybko i zaczynają wyznaczać nowe trendy oraz prowadzą współpracę z instytucjami pozaakademickimi. Tego typu kooperacja,...
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Technical physics (Data Engineering)
e-Learning CoursesField of study: Data Engineering; Subject name: Technical physics; Lecture notes and other course materials.
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Improving listeners' experience for movie playback through enhancing dialogue clarity in soundtracks
PublicationThis paper presents a method for improving users' quality of experience through processing of movie soundtracks. The dialogue clarity enhancement algorithms were introduced for detecting dialogue in movie soundtrack mixes and then for amplifying the dialogue components. The front channel signals (left, right, center) are analyzed in the frequency domain. The selected partials in the center channel signal, which yield high disparity...
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Molecular differences in mitochondrial DNA (mtDNA) genomes of dogs with malignant mammary tumours
Open Research DataThe aim of this study was to determine molecular defects in mitochondrial DNA with the use of large-scale genome analysis in malignant canine mammary gland tumours and indicate whether these changes were linked with the carcinogenesis process. With the use of the NGS technology, we sequenced 27 samples of mtDNA isolated from blood and tumours obtained...
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Design of residential buildings in architecture education
PublicationThis article is based on an analysis of residential building designs made by students of the Faculty of Architecture at Gdańsk University of Technology (FA-GUT), Poland, and on the results of a survey conducted among these students. The purpose of the survey was to verify the broad, interdisciplinary knowledge of the students required in preparation for taking up design issues, as well as their ability to use this knowledge in...
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Preparation of DNA films for studies under vacuum conditions. The influence of cations in buffer solutions
PublicationBadania zostały przeprowadzone w celu określenia optymalnych warunków wymaganych do przygotowania jednolitych filmów superskręconego plazmidowego DNA do wykorzystania w doświadczeniach napromieniowania w warunkach wysokiej próżni. Badania pokazują, że znaczne szkody w DNA powstają w wyniku odpompowywania filmów DNA z roztworów zawierających jedynie czysta wodę.
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Variable-fidelity CFD models and co-Kriging for expedited multi-objective aerodynamic design optimization
PublicationPurpose – Strategies for accelerated multi-objective optimization of aerodynamic surfaces are investigated, including the possibility of exploiting surrogate modeling techniques for computational fluid dynamic (CFD)-driven design speedup of such surfaces. The purpose of this paper is to reduce the overall optimization time. Design/methodology/approach – An algorithmic framework is described that is composed of: a search space reduction,...
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Modelling and simulations in time-fractional electrodynamics based on control engineering methods
PublicationIn this paper, control engineering methods are presented with regard to modelling and simulations of signal propagation in time-fractional (TF) electrodynamics. That is, signal propagation is simulated in electromagnetic media described by Maxwell’s equations with fractional-order constitutive relations in the time domain. We demonstrate that such equations in TF electrodynamics can be considered as a continuous-time system of...
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MULTI-CRITERIA MODEL IN MULTIFUNCTIONAL BUILDING SYSTEM DESIGN PROCESS
PublicationThe paper presents a multi-criteria approach in multifunctional building system design process. The aim is to develop a theory relative to the engineering system of multifunctional with a mathematical representation defined by a holistic network for the lifecycle of the designed object. The idea of work was to define the structure of a complex system. Background for the presented field is to develop a design strategy for multifunctional...
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Krzysztof Dobrzyński dr inż.
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Usage of Two-Center Basis Function Neural Classifiers in Compact Smart Resistive Sensors
PublicationA new solution of the smart resistance sensorwith the Two-Center Basis Function (TCBF) neuralclassifier, for which the resistance sensor is a component ofan anti-aliasing filter of an ADC is proposed. Thetemperature measurement procedure is based on excitationof the filter by square impulses, sampling time response ofthe filter and processing measured voltage values by theTCBF classifier. All steps of the measurement procedure...
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Interdisciplinarity in Smart Sustainable City education: exploring educational offerings and competencies worldwide
PublicationMore and more higher education institutions are offering specialized study programs for current and future managers of Smart Sustainable Cities (SSCs). In the process, they try to reconcile the interdisciplinary nature of such studies, covering at least the technical and social aspects of SSC management, with their own traditionally discipline-based organization. However, there is little guidance on how such interdisciplinarity...
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Machine Design Selected Problems
e-Learning CoursesIn this course a deepened knowlege of the problems of machine design selected and pointed out by the students is presented
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Road safety inspection as a tool for road safety management – the polish experience
PublicationIn Poland, road inspections were implemented in June 2014 on all national roads. Previously conducted traffic surveys mainly related to the technical condition of roads, signs and markings; other safety issues were overlooked. The main problem that occurs during inspection is an inspector’s subjective qualitative assessment which affects the classification of the sources of hazard on the road.. The paper presents an analysis of...
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Simulation-driven design of compact ultra-wideband antenna structures
PublicationPurpose–The purpose of this paper is to investigate strategies and algorithms for expedited designoptimization and explicit size reduction of compact ultra-wideband (UWB) antennas.Design/methodology/approach–Formulation of the compact antenna design problem aiming atexplicit size reduction while maintaining acceptable electrical performance is presented. Algorithmicframeworks are described suitable for handling various design situations...
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Single-stranded DNA-binding proteins (SSBs) - sources and applicationsin molecular biology
PublicationBiałka wiążące się do jednoniciowego DNA (SSB) odgrywają ważną rolę w replikacji, rekombinacji i naprawie DNA u bakterii, archea i eukariota. Ostatnio wzrosło zainteresowanie białkami SSB jako przydatnymi narzędziami w metodach badawczych biologii molekularnej, analitycznych i diagnostycznych. Większość znanych prokariotycznych białek SSB zbudowanych jest z czterech podjednostek (homotetramer) z jedną domeną wiążąca (OB) jednoniciowe...
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Transport of Particles in Intestinal Mucus under Simulated Infant and Adult Physiological Conditions: Impact of Mucus Structure and Extracellular DNA
PublicationThe final boundary between digested food and the cells that take up nutrients in the small intestine is a protective layer of mucus. In this work, the microstructural organization and permeability of the intestinal mucus have been determined under conditions simulating those of infant and adult human small intestines. As a model, we used the mucus from the proximal (jejunal) small intestines of piglets and adult pigs. Confocal...
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Exploring Impact of Requirements Engineering on Other IT Project Areas – Case Study
PublicationRequirements Engineering (RE) is recognized as one of the most important (yet difficult) areas of software engineering that has a significant impact on other areas of IT projects and their final outcomes. Empirical studies investigating this impact are hard to conduct, mainly due to the great effort required. It is thus difficult for both researchers and industry practitioners to make evidence-based evaluations about how decisions...
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Teloxantron inhibits the processivity of telomerase with preferential DNA damage on telomeres
PublicationTelomerase reactivation is one of the hallmarks of cancer, which plays an important role in cellular immortalization and the development and progression of the tumor. Chemical telomerase inhibitors have been shown to trigger replicative senescence and apoptotic cell death both in vitro and in vivo. Due to its upregulation in various cancers, telomerase is considered a potential target in cancer therapy. In this study, we identified...
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Application of non-classical operational calculus to indicate hazards in numerical solutions of engineering problems
PublicationThe article addresses the application of non- classical operational calculus to approximative solutions of engineering problems. The engineering-sound examples show that a continuous–discrete problem transformation from differential unequivocal problem to a differential wildcard problem, triggering a change in solution quality. A number of approximative methods are capable to alter both quantitative and qualitative...
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Novel DNA-binding protein from Nanoarchaeum equitans Kin4-M binds all kinds of nucleic acids
PublicationNanoarchaeum equitans is the only known representative of Archaea phylum Nanoarchaeota and stands out as one of the tiniest known living organism. What is more it has smallest genome, which is only 490.885 base pairs long. It is also one of the most compact genomes. According to predictions about 95% of the DNA encodes proteins or stable RNA. Nanoarchaeum equitans lacks genes for most vital metabolic pathways including lipid, cofactor,...
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Rapid multi-objective simulation-driven design of compact microwave circuits
PublicationA methodology for rapid multi-objective design of compact microwave circuits is proposed. Our approach exploits point-by-point Pareto set identification using surrogate-based optimization techniques, auxiliary equivalent circuit models, and space mapping as the major model correction method. The proposed technique is illustrated and validated through the design of a compact rat-race coupler. A set of ten designs being trade-offs...
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Urban Design II _ New Urban Living 2023/24
e-Learning CoursesIn the twenty-first century the idea of living in a perfect place combines the need for beauty&identity of the place with the ecology. Metropolises around the world are waiting for concepts that will expose the landscape values and give life in the suburbs high quality including energy efficiency and climate neutrality. A new concepts of are being discussed. Join this trend and look for solutions which merge expression of beauty...
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Genome-Wide DNA Methylation and Gene Expression in Patients with Indolent Systemic Mastocytosis
PublicationMastocytosis is a clinically heterogenous, usually acquired disease of the mast cells with a survival time that depends on the time of onset. It ranges from skin-limited to systemic disease, including indolent and more aggressive variants. The presence of the oncogenic KIT p. D816V gene somatic mutation is a crucial element in the pathogenesis. However, further epigenetic regulation may also affect the expression of genes that...
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Sequence-dependent structural properties of B-DNA: what have we learned in 40 years?
PublicationThe structure of B-DNA, the physiological form of the DNA molecule, has been a central topic in biology, chemistry and physics. Far from uniform and rigid, the double helix was revealed as a flexible and structurally polymorphic molecule. Conformational changes that lead to local and global changes in the helix geometry are mediated by a complex choreography of base and backbone rearrangements affecting the ability of the B-DNA...
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ENG_Architectural Design sem 6_2022_2023_KAMiUP
e-Learning CoursesThe course concerns the shaping of marketplace facilities with accompanying functions. The course presents a multifaceted approach to the issues, including technical, legal, economic, environmental, and cultural issues. The aim of the course, based on a case study in Gdańsk (Marketplace Gdańsk-Wrzeszcz (Targowisko Gdańsk-Wrzeszcz) and its surroundings), is to understand the problem of regeneration of exhibition spaces and to develop...
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Urban planning and design issues
e-Learning CoursesThis course deals with an overview of the contemporary urban planning and design issues
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Implicit Space Mapping for Variable-Fidelity EM-Driven Design of Compact Circuits
PublicationSpace mapping (SM) belongs to the most successful surrogate-based optimization (SBO) methods in microwave engineering. Among available SM variations, implicit SM (ISM) is particularly attractive due to its simplicity and separation of extractable surrogate model parameters and design variables of the circuit/system at hand. Unlike other SM approaches, ISM exploits a set of preassigned parameters to align the surrogate with the...
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Design and construction of an industrial robot controlled by the ROS environment
PublicationThis engineering thesis focuses on the recognition of modern budgetary solutions of roboticarms and on the design and implementation of one of them. Historical solutions are discussedusing the example of the IRB6 robot and the modern approach - the Omron Viper 850. Thepaper includes a description of the design thought of the different parts. Mechanical, electrical andsoftware aspects are presented. In...
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Feasibility Study for Food Intake Tasks Recognition Based on Smart Glasses
PublicationIn this exploratory study 13 adult test subjects have performed different food intake tasks while wearing a three axis accelerometer mounted at a temple of glasses. Two different algorithms for task recognition have been applied and compared. The retrospective data processing leads to better task recognition results when the frequency range of 50 Hz to 100 Hz is analysed within accelerometer signal recordings. A straightforward...
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BETWEEN IDEA AND INTERPRETATION - DESIGN PROCESS AUGMENTATION
PublicationThe following paper investigates the idea of reducing the human digital intervention to a minimum during the advanced design process. Augmenting the outcome attributes beyond the designer's capabilities by computational design methods, data collection, data computing and digital fabrication, altogether imitating the human design process. The primary technical goal of the research was verification of restrictions and abilities used...
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DESIGN THINKING ORIENTED METHODOLOGY IN GROUP PROJECT AS A STEP IN THE CDIO APPROACH
PublicationRecently much scientific research and industrial work is conducted in multidisciplinary teams, where cooperation between specialists from different areas of expertise is required in order to successfully address the challenging goals. Moreover, in start-up small companies the lack of supporting departments calls for additional multidisciplinary, economic and networking skills known as T-shaped personality. Recognizing these shortcomings...
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Vehicle Dynamics - L-15/C-15/L-15/P-15, Design and Production Engineering, WIMiO, undergraduate studies, engineering studies, full-time (stationary) studies, 2021/2022, se06, (M:320383W0), summer semester 2023/2024
e-Learning CoursesModuł przedmiotów wybieralnych, MiBM, I stopień, specjalność w j. angielskim: Design and Production Engineering (DaPE), semestr 6?, (przedmiot dla Chińczyków), Lecture: Throttle by tyred wheel: slip rolling, rolling with tyre strain, vertical and lateral surface reactions, traction, energetic looses, forces in contact path. Drugs of movement: rolling, air, gradient, inertia, cornering and towing. Forces ant torques acting to vehicle...
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Design of Resilient Vehicle-to-Infrastructure Systems
PublicationVehicular ad hoc networks (VANETs) have recently gained noticeable attention due to advantages in improving road traffic safety, shaping the road traffic and providing infotainment opportunities to travellers. However, transmission characteristics following from the IEEE 802.11p standard and the high mobility of VANET nodes remarkably reduce the lifetime, reach and capacity of wireless links, and often lead to simultaneous disruptions...
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Towards defragmented Lighting Design: concatenating research theories for effective use in design practices.
PublicationThis paper aims to provide guidelines for transferring design research to practice in the realm of lighting. It is based on the premise that design research in lighting should function as a development of practice, instead of being a distraction to it. Design research refers to the scholarly inquiry that seeks to advance design by studying and improving it in systematic and scientific ways by expanding, testing and operationalizing...
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RANS-based design optimization of dual-rotor wind turbines
PublicationPurpose An improvement in the energy efficiency of wind turbines can be achieved using dual rotors. Because of complex flow physics, the design of dual-rotor wind turbines (DRWTs) requires repetitive evaluations of computationally expensive partial differential equation (PDE) simulation models. Approaches for solving design optimization of DRWTs constrained by PDE simulations are investigated. The purpose of this study is to determine...
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Nanoemulsion Structural Design in Co-Encapsulation of Hybrid Multifunctional Agents: Influence of the Smart PLGA Polymers on the Nanosystem-Enhanced Delivery and Electro-Photodynamic Treatment
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Defining a novel domain that provides an essential contribution to site-specific interaction of Rep protein with DNA
PublicationAn essential feature of replication initiation proteins is their ability to bind to DNA. In this work, we describe a new domain that contributes to a replication initiator sequence-specific interaction with DNA. Applying biochemical assays and structure prediction methods coupled with DNA–protein crosslinking, mass spectrometry, and construction and analysis of mutant proteins, we identified that the replication initiator of the...
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Extending transition curve in analytical design method
PublicationThe paper presents the problem of extending the transitional curves, using for this purpose an analytical design method. The basis for the analysis of numerical calculations were carried out for a wide set of parameters characterizing the standard geometric system. We considered an importance of the size of radius of the circular arc and return angle of route on the obtained results after the formulation of appropriate theoretical...
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Unraveling the Interplay between DNA and Proteins: A Computational Exploration of Sequence and Structure-Specific Recognition Mechanisms
PublicationMy PhD dissertation focused on DNA-protein interactions and the recognition of specific DNA sequences and structures. I discovered that acidic amino acid residues (Asp/Glu) play a crucial role by exhibiting a preference for cytosine. Their contribution to binding affinity depends on nearby cytosines, balancing electrostatic repulsion with specific interactions. Acidic residues act as negative selectors, discouraging non-cytosine...
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Real-time isothermal DNA amplification monitoring in picoliter volumes using an optical fiber sensor
PublicationRolling circle amplification (RCA) of DNA can be considered as a great alternative to the gold standard polymerase chain reaction (PCR), especially during this pandemic period, where rapid, sensitive, and reliable test results for hundreds of thousands of samples are required daily. This work presents the first research to date on direct, real-time and label-free isothermal DNA amplification monitoring using a microcavity in-line...
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Smart Virtual Bass Synthesis Algorithm Based on Music Genre Classification
PublicationThe aim of this paper is to present a novel approach to the Virtual Bass Synthesis (VBS) algorithms applied to portable computers. The proposed algorithm employed automatic music genre recognition to determine the optimum parameters for the synthesis of additional frequencies. The synthesis was carried out using the non-linear device (NLD) and phase vocoder (PV) methods depending on the music excerpt genre. Classification of musical...