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Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints
PublicationOur previous studies have shown that murine fibroblast cells, in which PARP-1 gene was inactivated by gene disruption, are extremely sensitive to triazoloacridone compound C-1305, an inhibitor of DNA topoisomerase II with unusual properties. Here, we show that pharmacological inhibition of PARP-1 activity by its inhibitor compound NU1025, sensitizes human cervical carcinoma HeLa cells to compound C-1305 compared to treatment with...
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The effect of metal cluster deposition route on structure and photocatalytic activity of mono- and bimetallic nanoparticles supported on TiO2 by radiolytic method
PublicationTiO2 (P25) was modified with small and relatively monodisperse mono- and bimetallic clusters (Ag, Pd, Pt, Ag/Pd, Ag/Pt and Pd/Pt) induced by radiolysis to improve its photocatalytic activity. The as-prepared samples were characterized by X-ray fluorescence spectrometry (XRF), photoluminescence spectrometry (PL), diffuse reflectance spectroscopy (DRS), X-ray powder diffractometry (XRD), scanning transition electron microscopy (STEM)...
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Transport deficiency is the molecular basis of Candida albicans resistance to antifungal oligopeptides
Publication(FMDP), an inhibitor of glucosamine-6-phosphate synthase, exhibited growth inhibitory activity against Candida albicans, with minimal inhibitory concentration values in the 0.05–50 mg/L range. Uptake by the peptide permeases was found to be the main factor limiting an anticandidal activity of these compounds. Di- and tripeptide containing FMDP (F2 and F3) were transported by Ptr2p/Ptr22p peptide transporters (PTR) and FMDP-containing...
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Teloxantron inhibits the processivity of telomerase with preferential DNA damage on telomeres
PublicationTelomerase reactivation is one of the hallmarks of cancer, which plays an important role in cellular immortalization and the development and progression of the tumor. Chemical telomerase inhibitors have been shown to trigger replicative senescence and apoptotic cell death both in vitro and in vivo. Due to its upregulation in various cancers, telomerase is considered a potential target in cancer therapy. In this study, we identified...
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Badanie wybranych właściwości wyłączników różnicowoprądowych typu F
PublicationW instalacjach elektrycznych niskiego napięcia instaluje się coraz więcej przekształtników energoelektronicznych (systemy fotowoltaiczne, instalacje ładowania pojazdów elektrycznych, układy napędowe o regulowanej prędkości obrotowej silnika), a mają one wpływ na dobór typu wyzwalania wyłączników różnicowoprądowych (AC, A, F lub B). W obwodach, w których pojawia się prąd różnicowy zawierający składowe o częstotliwości innej niż...
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Schwannoma, NOS - Male, 40 - Tissue image [7130729588551241]
Open Research DataThis is the histopathological image of OTHER AND ILL-DEFINED SITES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Testis, unspecified - Male, 39 - Tissue image [7220729599718021]
Open Research DataThis is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Schwannoma, NOS - Male, 46 - Tissue image [7060729599335601]
Open Research DataThis is the histopathological image of OTHER AND ILL-DEFINED SITES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Schwannoma, NOS - Male, 46 - Tissue image [7060729599339671]
Open Research DataThis is the histopathological image of OTHER AND ILL-DEFINED SITES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Schwannoma, NOS - Male, 46 - Tissue image [7060729599336601]
Open Research DataThis is the histopathological image of OTHER AND ILL-DEFINED SITES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Schwannoma, NOS - Male, 46 - Tissue image [7060729599332631]
Open Research DataThis is the histopathological image of OTHER AND ILL-DEFINED SITES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Testis, unspecified - Male, 39 - Tissue image [7220729599713421]
Open Research DataThis is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Testis, unspecified - Male, 39 - Tissue image [7220729599711411]
Open Research DataThis is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Schwannoma, NOS - Male, 40 - Tissue image [71307295885571]
Open Research DataThis is the histopathological image of OTHER AND ILL-DEFINED SITES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Testis, unspecified - Male, 39 - Tissue image [7220729599717081]
Open Research DataThis is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Testis, unspecified - Male, 39 - Tissue image [722072959971731]
Open Research DataThis is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Schwannoma, NOS - Male, 40 - Tissue image [7130729588547951]
Open Research DataThis is the histopathological image of OTHER AND ILL-DEFINED SITES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Testis, unspecified - Male, 39 - Tissue image [722072959971471]
Open Research DataThis is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Schwannoma, NOS - Male, 46 - Tissue image [7060729599334471]
Open Research DataThis is the histopathological image of OTHER AND ILL-DEFINED SITES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Elimination and migration of hydrogen in the vacuum-ultraviolet photodissociation of pyridine molecules
PublicationElimination of the excited hydrogen atoms H(n), n = 4–7, and hydrogen migration in formation of the excited NH(A 3Π) free radicals in the photodissociation of pyridine, C5H5N, molecules have been studied over the 17.5–70 eV photon energy range. In the measurements the photon-induced fluorescence spectroscopy technique has been applied. Both fragments are produced through excitation of pyridine molecules into higher-lying superexcited...
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Graph classes generated by Mycielskians
PublicationIn this paper we use the classical notion of weak Mycielskian M'(G) of a graph G and the following sequence: M'_{0}(G) =G, M'_{1}(G)=M'(G), and M'_{n}(G)=M'(M'_{n−1}(G)), to show that if G is a complete graph oforder p, then the above sequence is a generator of the class of p-colorable graphs. Similarly, using Mycielskian M(G) we show that analogously defined sequence is a generator of the class consisting of graphs for which the...
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Unicyclic graphs with equal total and total outer-connected domination numbers
PublicationLet G = (V,E) be a graph without an isolated vertex. A set D ⊆ V (G) is a total dominating set if D is dominating and the in- duced subgraph G[D] does not contain an isolated vertex. The total domination number of G is the minimum cardinality of a total domi- nating set of G. A set D ⊆ V (G) is a total outer–connected dominating set if D is total dominating and the induced subgraph G[V (G)−D] is a connected graph. The total outer–connected...
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Power Hardware-In-the-Loop Approach for Autonomous Power Generation System Analysis
PublicationThe article presents the Power Hardware-In-the-Loop (PHIL) dynamic model of a synchronous generator of 125 kVA for autonomous power generation system analysis. This type of system is typically composed of electrical energy sources in the form of several diesel generator units with synchronous machines, the main distribution switchboard and different loads. In modern power distribution systems, the proposed power management strategies...
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High performance super-twisting sliding mode control for a maritime autonomous surface ship (MASS) using ADP-Based adaptive gains and time delay estimation
PublicationThis research addresses two kinds of problems related to optimal trajectory tracking of a Maritime Autonomous Surface Ship (MASS): those caused by the time-varying external disturbances including winds, waves and ocean currents as well as those resulting from inherent dynamical uncertainties. As the paper shows, an accurate and robust optimal controller can successfully deal with both issues. An improved Optimal Adaptive Super-Twisting...
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High performance super-twisting sliding mode control for a maritime autonomous surface ship (MASS) using ADP-Based adaptive gains and time delay estimation
PublicationThis research addresses two kinds of problems related to optimal trajectory tracking of a Maritime Autonomous Surface Ship (MASS): those caused by the time-varying external disturbances including winds, waves and ocean currents as well as those resulting from inherent dynamical uncertainties. As the paper shows, an accurate and robust optimal controller can successfully deal with both issues. An improved Optimal Adaptive Super-Twisting...
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Fluoroaromatic substituents attached to carbon nanotubes help to increase oxygen concentration on biocathode in biosensors and biofuel cells
PublicationBased on the known ability of perfluorodecalin/perfluorohydrocarbons to enhance oxygen solubility we modified oxygen sensitive biocathode by adding perfluorinated components to the catholite. This procedure improved the efficiency of the oxygen sensitive cathodes. Glassy carbon electrodes covered with single-wall carbon nanotubes (SWCNTs) with covalently bonded perfluoroaromatic groups were shown to be more sensitive to oxygen,...
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3D Metamaterial Ultra-Wideband Absorber for curved surface
PublicationThis paper proposes a three-dimensional metamaterial absorber based on a resistive film patch array to develop a low-cost, lightweight absorber for curved surfaces. An excellent absorption over a large frequency band is achieved through two different yet controllable mechanisms; In the first mechanism, a considerable attenuation in the wave power is achieved via graphite resistive films. The absorption is then intensified through...
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Space Vector Pulsewidth Modulation Strategy for Multilevel Cascaded H-Bridge Inverter With DC-Link Voltage Balancing Ability
PublicationSpace vector pulsewidth modulation (SVPWM) algorithms for cascaded H-bridge multilevel (CHB ML) inverter usually provide the possibility of using several combinations of active voltage vectors to generate the same output voltage vector. For preselected H-bridges, some of them may generate output voltages opposite to the assumed direction. This results in the change of the dc-link voltages of these H-bridges in the opposite direction...
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On extremal sizes of locally k-tree graphs
PublicationA graph G is a locally k-tree graph if for any vertex v the subgraph induced by the neighbours of v is a k-tree, k>=0, where 0-tree is an edgeless graph, 1-tree is a tree. We characterize the minimum-size locally k-trees with n vertices. The minimum-size connected locally k-trees are simply (k + 1)-trees. For k >= 1, we construct locally k-trees which are maximal with respect to the spanning subgraph relation. Consequently, the...
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Perspectives of Fluctuation-Enhanced Gas Sensing by Two-Dimensional Materials
PublicationWe present the results of gas sensing using the fluctuation-enhanced sensing method in selected two-dimensional materials (2DMs). We claim that gas sensing selectivity can be improved further by considering semiconducting two-dimensional materials doped by noble metal nanoparticles. The 2DMs' structures exhibit some imperfections defined by their structure, occurring repeatedly there. These imperfections are adsorption-desorption...
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NUMERICAL SIMULATIONS OF GAP FLOW ABOVE ROTATING DISK
PublicationA rotating disk can be considered a basic configuration for the investigati ons of the impact of various conditions on the flow through the clearance between the s hrouded turbine blade and the casing. Numerical calculations using Fine/Turbo Numeca were conducted to examine the influence of the rotational velocity and the pressure differ ence across the disk on the flow conditions, especially the mass flow through the clearance....
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Enhanced Mobility and Large Linear Nonsaturating Magnetoresistance in the Magnetically Ordered States of TmNiC2
PublicationWe have studied the magnetic, magnetotransport, and galvanomagnetic properties of TmNiC2. We find that the antiferromagnetic and field induced metamagnetic and ferromagnetic orderings do not suppress the charge density wave. The persistence of Fermi surface pockets, open as a result of imperfect nesting accompanying the Peierls transition, results in an electronic carriers mobility of the order of 4 × 103 cm2 V−1 s−1 in ferromagnetic...
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Radio- and photosensitization of DNA with compounds containing platinum and bromine atoms
Publication. Irradiations of plasmid DNA by both X-rays and UV light in the presence and absence of compounds containing platinum and bromine atoms were performed in order to asses the sensitization potential of these compounds. Plasmid DNA pBR322 was incubated with platinum (II) bromide, hydrogen hexabromoplatinate (IV), hydrogen hexahydroxyplatinate (IV) and sodium hexahydroxyplatinate (IV). Incubation was followed by X-ray or UV irradiations....
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Magnetic field effects in dye-sensitized solar cells controlled by different cell architecture
PublicationThe charge recombination and exciton dissociation are generally recognized as the basic electronic processes limiting the efficiency of photovoltaic devices. In this work, we propose a detailed mechanism of photocurrent generation in dye-sensitized solar cells (DSSCs) examined by magnetic field effect (MFE) technique. Here we demonstrate that the magnitude of the MFE on photocurrent in DSSCs can be controlled by the radius and...
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Tailoring Physicochemical Properties of V2O5 Nanostructures: Influence of Solvent Type in Sol-Gel Synthesis
PublicationThe influence of different solvents, including aqueous and nonaqueous types, on the physicochemical properties of V2O5 nanostructures was thoroughly investigated. Various characterization techniques, such as XRD, XPS, FTIR, Raman spectroscopy, UV-vis DRS, SEM, TEM, and BET, were employed to analyze the obtained materials. Additionally, the adsorption properties of the synthesized V2O5 nanostructures for methylene blue were examined,...
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New approach for the synthesis of Ag3PO4-graphene photocatalysts
PublicationA facile and effective plasma sputtering method for the preparation of a visible light active photocatalyst - rhombic dodecahedral silver phosphate Ag3PO4 covered with nanographene (Ag3PO4-GR) with improved stability has been developed. Proposed method allows for the usage of readily available materials for nanographene sputtering and for easy scaling-up. The stability improvement, confirmed by visible light-induced phenol degradation...
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Linear antenna microwave chemical vapour deposition of diamond films on long-period fiber gratings for bio-sensing applications
PublicationThe growth processes of nanocrystalline diamond (NCD) thin films on fused silica optical fibers with UV-induced long-period gratings (LPGs) were investigated with regard to biosensing applications. The films were deposited using a linear antenna microwave plasma enhanced chemical vapor deposition system, which allows for the growth of diamond at temperatures below 350°C. The films exhibited a high refractive index n = 2.32, as...
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Load Tests of the Movable Footbridge Over the Port Canal in Ustka
PublicationThe paper presents the acceptance tests carried out on the open footbridge over the port canal in the Port of Ustka. The steel footbridge construction is created by a single pylon to which a movable truss span is suspended with a theoretical span of 52.3 m. The studies about load test of the object included static and dynamic extortion and measurements. In static tests the ballast was of pallets with concrete blocks. Dynamic studies...
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Corrosion behavior of concrete produced with diatomite and zeolite exposed to chlorides
PublicationChloride induced reinforcement corrosion is widely accepted to be the most frequent mechanism causing premature degradation of reinforced concrete structures. The electrochemical impedance of reinforcing steel in diatomite- and zeolite-containing concrete exposed to sodium chloride was assessed. Chemical, physical and mineralogical properties of three concrete samples (20% diatomite, 20% zeolite, and a reference containing neither)...
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Microwave treatment in waste rubber recycling – recent advances and limitations
PublicationEnvironmentally-friendly microwave heating is increasingly used in polymer chemistry and technology. The selectivity and highly efficiency in the heat transfer present a huge advantage in systems based on recycling, improving their productivity and economic competitiveness. In case of the industrial recycling of waste rubbers, especially end-of-life tires, microwave-induced devulcanization and pyrolysis are nowadays considered...
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Verification of Formulas for Periods of Adjacent Buildings Used to Assess Minimum Separation Gap Preventing Structural Pounding during Earthquakes
PublicationInsufficient separation distance between adjacent buildings may lead to serious damages during earthquakes due to structural pounding. The best way to prevent collisions is to provide sufficiently large separation distance between the structures. In this paper, the periods of two closely-spaced linear and nonlinear buildings have been investigated so as to accurately assess the minimum in-between separation gap. A new equation...
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Nonlinear phenomena of small-scale sound in a gas with exponential stratification
PublicationThe nonlinear dynamics of perturbations, quickly varying in space, with comparatively large characteristic wavenumbers k: k>1/H, is considered. H is the scale of density and pressure reduction in unperturbed gas, as the coordinate (H is the so-called height of the uniform equilibrium gas). Coupling nonlinear equations which govern the sound and the entropy mode in a weakly nonlinear flow are derived. They describe the dynamics...
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Activation of endogenous regenerative potential in mammals using epigenetic inhibitor zebularine
PublicationIn this work, a nucleoside inhibitor of DNA methyltransferases, zebularine, was investigated as a wound healing and regeneration promoting agent. It was found that a high dose of intraperitoneally delivered zebularine improved punch wound closure in the ear pinna in mice. Both cytidine, a zebularine analogue, and uridine, a zebularine metabolite, did not promote ear pinna hole closure. The effect of zebularine on ear pinna healing...
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Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under hypoxia
PublicationInduction of proteins involved in drug metabolism and in drug delivery has a significant impact on drug-drug interactions and on the final therapeutic effects. Two antitumor acridine derivatives selected for present studies, C-1748 (9-(2’-hydroxyethylamino)-4-methyl-1-nitroacridine) and C-1305 (5-dimethylaminopropylamino-8-hydroxy-triazoloacridinone), expressed high and low susceptibility to metabolic transformations with liver...
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Modulation of CYP3A4 activity and induction of apoptosis, necrosis and senescence by the antitumor imidazoacridinone C-1311 in human hepatoma cells
PublicationThere is increasing evidence that the expression level of drug metabolic enzymes affects the final cellular response following drug treatment. Moreover, anti-tumour agents may modulate enzymatic activity and/or cellular expression of metabolic enzymes in tumour cells. We investigated the influence of CYP3A4 overexpression on the cellular response induced by the anti-tumour agent C-1311 in hepatoma cells. C-1311-mediated CYP3A4...
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The relationship between standard reduction potentials of catechins and biological activities involved in redox control
PublicationRedox homeostasis involves factors that ensure proper function of cells. The excess reactive oxygen species (ROS) leads to oxidative stress and increased risk of oxidative damage to cellular components. In contrast, upon reductive stress, insufficient ROS abundance may result in faulty cell signalling. It may be expected that dietary antioxidants, depending on their standard reduction potentials (E°), will affect both scenarios....
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EFEKTYWNOŚĆ STOSOWANIA ZDERZAKÓW STYROPIANOWYCH POMIĘDZY ZDERZAJĄCYMI SIĘ KONSTRUKCJAMI STALOWYMI
PublicationPodczas wstrząsów sejsmicznych o różnym natężeniu, wielokrotnie obserwowano zjawisko zde-rzania się konstrukcji ze sobą sąsiadujących, co mogło prowadzić nawet do jej całkowitego zniszczenia. Na podstawie obserwacji, badań numeryczny i eksperymentalnych stwierdzono, że przyczyną kolizji jest niedostateczna przerwa pomiędzy konstrukcjami. Ponadto czynnikami, które również mogą doprowadzić do zderzeń są różnice w masach lub sztywnościach...
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A quasi-2D small-signal MOSFET model - main results
PublicationDynamic properties of the MOS transistor under small-signal excitation are determined by kinetic parameters of the carriers injected into the channel, i.e., the low-field mobility, velocity saturation, mobility at the quiescent-point (Q-point), longitudinal electric field in the channel, by dynamic properties of the channel, as well as by an electrical coupling between the perturbed carrier concentration in the channel and the...
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Digital structures for high-speed signal processing
PublicationThe work covers several issues of realization of digital structures for pipelined processing of real and complex signals with the use of binary arithmetic and residue arithmetic. Basic rules of performing operations in residue arithmetic are presented along with selected residue number systems for processing of complex signals and computation of convolution. Subsequently, methods of conversion of numbers from weighted systems to...
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Leakage Current Measurements of Surge Arresters
PublicationThe paper presents the methods of assessing the technical condition of varistor surge arresters used in laboratory tests and in operation—performed without disconnecting the arresters from the network. The analysis of the diagnostic methods was supplemented with the results of the measurements of the leakage current of arresters coming directly from their production and used in the power industry. Among the available methods of...