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Algebraic periods and minimal number of periodic points for smooth self-maps of 1-connected 4-manifolds with definite intersection forms
PublicationLet M be a closed 1-connected smooth 4-manifolds, and let r be a non-negative integer. We study the problem of finding minimal number of r-periodic points in the smooth homotopy class of a given map f: M-->M. This task is related to determining a topological invariant D^4_r[f], defined in Graff and Jezierski (Forum Math 21(3):491–509, 2009), expressed in terms of Lefschetz numbers of iterations and local fixed point indices of...
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Influence of the femoral offset on the muscles passive resistance in total hip arthroplasty
PublicationBackground Soft tissue tension is treated as a crucial factor influencing the post-THA dislocation. The femoral offset is regarded as one of the major parameters responsible for the stabilization of the prosthesis. It is unclear which soft tissue is mostly affected by the offset changes. Methods A finite element model of the hip was created. The model comprised muscles, bones, a stem, the acetabular component and a liner. The muscles...
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Efficient and robust quadratures for isogeometric analysis: Reduced Gauss and Gauss–Greville rules
PublicationThis work proposes two efficient quadrature rules, reduced Gauss quadrature and Gauss–Greville quadrature, for isogeometric analysis. The rules are constructed to exactly integrate one-dimensional B-spline basis functions of degree p, and continuity class C^{p−k}, where k is the highest order of derivatives appearing in the Galerkin formulation of the problem under consideration. This is the same idea we utilized in Zou et al....
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COMPREHENSIVE MODELLING OF THE COST EFFECTIVNESS OF RAILWAY LINE ELECTRIFICATION
PublicationSubject of this paper is the mathematical model estimating the Economical threshold between usage of combustion engine traction and electrical traction for new and modernized railway passenger communication lines. Currently available models do not coincide with the whole complexity of the problem. The proposed model was implemented into Matlab and then validated on “Pomorska Kolej Metropolitalna” investment time-frame and its cost...
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Analysis of measurement uncertainty for contact-less method used to measure the position of catenary contact wire, performed with the use of Monte Carlo method
PublicationCurrently the majority of main railway lines in Europe are electrified, and electric trains have the biggest share in the entire amount of rail transport. Reliability of electrified railways is closely related to the issue of supplying traction vehicles with energy. The problems connected with diagnostics of energy consumption node, namely the contact line and the current collector, are therefore of fundamental importance for maintaining...
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PHOTON LUMINESCENCE STUDIES OF TETRAHYDROFURAN FOLLOWING TRIHYDROGEN CATIONS IMPACT IN THE 20–1000 EV ENERGY RANGE
PublicationPhoton emission arising during tetrahydrofuran (C4H8O, THF) fragmentation initiated by H3 + ion impact has been studied experimentally. Luminescence fragmentation spectra and the relative emission cross-sections of the excited fragments have been measured using collision-induced emission spectroscopy in the 20–1000 eV energy range. The main features in the spectra are the H Balmer series lines, whose intensities decrease with increasing...
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Amygdalin: Toxicity, Anticancer Activity and Analytical Procedures for Its Determination in Plant Seeds
PublicationAmygdalin (D-Mandelonitrile 6-O--D-glucosido--D-glucoside) is a natural cyanogenic glycoside occurring in the seeds of some edible plants, such as bitter almonds and peaches. It is a medically interesting but controversial compound as it has anticancer activity on one hand and can be toxic via enzymatic degradation and production of hydrogen cyanide on the other hand. Despite numerous contributions on cancer cell lines, the clinical...
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Koncepcja połączenia kolejowego Morskiego Portu Gdynia S.A. z Kolejową Obwodnicą Trójmiasta
PublicationZapotrzebowanie na połączenie rozwijającego się Morskiego Portu Gdynia z Kolejową Obwodnicą Trójmiasta. Utworzenie tak zwanych „długich pociągów”. Wpływ katastrof kolejowych na warunki gruntowe i środowisko. Potrzeba modernizacji linii kolejowych. Kolejowa Obwodnica Trójmiasta jako alternatywa dla przejazdu pociągów przez obszar Aglomeracji Trójmiejskiej.
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New generation of the satellite hydraulic pumps
PublicationHydraulic satellite machines are known and produced in many versions, recognizable by the number of humps on their inner rotor and external gear, and therefore by the number of cooperating gears (satellites). All known shapes were however designed on the base of preliminary assumption that rotor’s and external gear’s pitch lines are formed by merging arcs, tangent to each other in the. This assumption makes calculations easier,...
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Novel 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives as potent anticancer agents – Synthesis, molecular structure, QSAR studies and metabolic stability
PublicationA series of new 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives have been synthesized and evaluated in vitro by MTT assays for their antiproliferative activity against cell lines of colon cancer HCT-116, cervical cancer HeLa and breast cancer MCF-7. The obtained results indicated that these compounds display prominent cytotoxic effect. The best anticancer properties have been observed for derivatives...
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Synthesis, crystal structure and cytotoxic activity of ruthenium(II) piano-stool complex with N,N-chelating ligand
PublicationA mononuclear compound of the general formula [(η6-p-cymene)RuIICl(2,2′-PyBIm)]PF6 has been synthesized from a bidentate N,N-donor ligand, viz. 2,-(2′-pyridyl)benzimidazole (2,2′-PyBIm) and the corresponding chloro-complex [(η6-p-cymene)Ru(μ-Cl)Cl]2 (precursor). The isolated coordination compound was characterized by IR, UV–vis and 1H, 13C NMR spectroscopies. The single crystal X-ray analysis of the complex reveals that the asymmetric...
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New 2-[(4-Amino-6-N-substituted-1,3,5-triazin-2-yl)methylthio]-N-(imidazolidin-2-ylidene)-4-chloro-5-methylbenzenesulfonamide Derivatives, Design, Synthesis and Anticancer Evaluation
PublicationIn the search for new compounds with antitumor activity, new potential anticancer agents were designed as molecular hybrids containing the structures of a triazine ring and a sulfonamide fragment. Applying the synthesis in solution, a base of new sulfonamide derivatives 20–162 was obtained by the reaction of the corresponding esters 11–19 with appropriate biguanide hydrochlorides. The structures of the compounds were confirmed...
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Anticancer Properties of Amino Acid and Peptide Derivatives of Mycophenolic Acid
PublicationBackground: Although Mycophenolic Acid (MPA) is applied as prodrugs in clinic as an immunosuppressant, it also possesses anticancer activity. MPA acts as Inosine-5’-Monophosphate Dehydrogenase (IMPDH) inhibitor, where the carboxylic group at the end of the side chain interacts with Ser 276 of the enzyme via hydrogen bonds. Therefore, MPA derivatives with other polar groups indicated high inhibition too. On the other hand, potent...
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Analysis of the Possibility of Using New Types of Protective Coatings and Abrasion-Resistant Linings under the Operating Conditions of the Spiral Classifier at KGHM Polska Miedź S.A. Ore Concentration Plant
PublicationA study was carried out to select the appropriate coatings for corrosion protection of the spiral classifier working at KGHM Polska Miedź S.A. Ore Concentration Plant. The abrasion resistance of selected protective coatings and wear-resistant linings was investigated using a DT-523 rotary abrasion tester with Taber CS-10 rubber abrasive discs. The average weight loss of the coatings after a cycle of 2000 revolutions was determined....
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Wpływ wprowadzenia norm europejskich na konstrukcję wsporczych napowietrznych linii elektroenergetycznych
PublicationKonstrukcje wsporcze linii elektroenergetycznych były i są projektowane zgodnie ze specjalistycznymi normami, innymi niż stosowane w budownictwie. Dotyczą one zarówno oddziaływań środowiskowych, takich jak temperatura, wiatr, oblodzenie i oddziaływania stałe (naciąg, przewodów, osprzęt), jak i zasad wymiarowania. W artykule przedstawiono wyniki analiz porównawczych dotyczących wpływu zmian wprowadzanych w normach europejskich na...
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Sensitivity analysis of critical forces of trusses with side bracing
PublicationThe present research is devoted to the study of out-of-plane buckling of trusses with elastic side bracing. Inthis paper, a sensitivity analysis of critical buckling loads of a truss due to bracing stiffness is carried out. A method based on the sensitivity analysis for the determination of the threshold bracing stiffness conditionfor full bracing of a truss is proposed. The influence lines of the unit change of the bracing stiffness...
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Estimation of a Stochastic Burgers' Equation Using an Ensemble Kalman Filter
PublicationIn this work, we consider a difficult problem of state estimation of nonlinear stochastic partial differential equations (SPDE) based on uncertain measurements. The presented solution uses the method of lines (MoL), which allows us to discretize a stochastic partial differential equation in a spatial dimension and represent it as a system of coupled continuous-time ordinary stochastic differential equations (SDE). For such a system...
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Designing control strategies of aeration system in biological WWTP
PublicationThe paper presents the complete design processes of a novel aeration control systems in the SBR (Sequencing Batch Reactor) wastewater treatment plant (WWTP). Due to large energy expense and high influence on biological processes, the aeration system plays a key role in WWTP operation. The paper considers the aeration system for a biological WWTP located in the northeast of Poland. This system consists of blowers, the main collector...
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On the low-cost design of abbreviated multisection planar matching transformer
PublicationA numerically demanding wideband matching transformer composed of three nonuniform transmission lines (NUTLs) has been designed and optimized at a low computational cost. The computational feasibility of the design has been acquired through the exploitation of low-fidelity NUTL models in most steps of the design procedure and an implicit space mapping optimization engine, providing high accuracy results with only a handful of EM...
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The Doppler effect in a bistatic system for determining the position of moving targets
PublicationThe article presents the theoretical analysis and the results of numerical calculations of the Doppler effect it occurs in a system designed to determine the position and speed of a moving target. The transmitter is the source of the signal and it emits a sinusoidal, acoustic and continuous wave. Signal reflected off a moving target is received by four hydrophones. Based on the signals, four Doppler shifts are determined and inserted...
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Analysis of positioning error and its impact on high frequency properties of differential signal coupler
PublicationThis paper presents the analysis of the effect of differential signal coupler positioning accuracy on its high frequency performance parameters for contact-less high speed chip-to-chip data transmission on PCB application. Our considerations are continuation of the previous works on differential signal coupler concept, design methodology and analysis for high speed data transmission monitoring. The theoretical analysis of possible...
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Straightened characteristics of McKendrick-von Foerster equation
PublicationWe study the McKendrick-von Foerster equation with renewal (that is the age-structured model, with total population dependent coefficient and nonlinearity). By using a change of variables, the model is then transformed to a standard age-structured model in which the total population dependent coefficient of the transport term reduces to a constant 1. We use this transformation to get existence, uniqueness of solutions of the problem...
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Effective Drug Concentration and Selectivity Depends on Fraction of Primitive Cells
PublicationPoor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has been driving the search for more active and specific compounds. In this work, we show how cell density-dependent stage culture profiles can be used in drug development workflows to achieve more robust drug activity (IC50 and EC50) results. Using flow cytometry and light microscopy, we characterized the cytological stage profiles of the HL-60-,...
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The Influence of the Co-Dopant Dexamethasone Phosphate on the Electrodeposition Process and Drug-Release Properties of Polypyrrole-Salicylate on Iron
PublicationIn this work, the influence of incorporation of two anti-inflammatory drugs dexamethasone phosphate and sodium salicylate on the electrodeposition process of polypyrrole (PPy) film on iron has been studied. The incorporation of the agents into PPy has been carried out in a one-step electropolymerization process on oxidizable iron. The role of each drug agent during the deposition process has been discussed. The morphological and...
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Investigation of the vertical distribution of the sound speed of the Gulf of Gdansk in the years 2000-2010
PublicationThe conditions of the acoustic wave propagation in the southern Baltic are much more complex than in other shallow waters. In the typical shallow water, seasonal changes in acoustical conditions in the upper layer, of the depth of about 60-70 m, are observed. They are caused by variation of the annual meteorological conditions. Most often, in the deep water layer, acoustical conditions are stable throughout the year. However, in...
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Influence of conductive carbon and MnCo2O4 on morphological and electrical properties of hydrogels for electrochemical energy conversion
PublicationIn this work, a strategy for one-stage synthesis of polymer composites based on PNIPAAm hydrogel was presented. Both conductive particles in the form of conductive carbon black (cCB) and MnCo2O4 (MCO) spinel particles were suspended in the three-dimensional structure of the hydrogel. The MCO particles in the resulting hydrogel composite acted as an electrocatalyst in the oxygen evolution reaction. Morphological studies confirmed...
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Influence of Additional Loads on Chosen Gait Parameters and Muscles Activity
PublicationThis paper is devoted to human motion analysis and comparison of chosen kinematics parameters during normal gait with and without additional load in a form of backpack. A stability in both cases were compared in both frontal and sagittal planes, by applying a video tracking system. Experimental tests performed on treadmill, passive markers, placed on volunteers bare skin were used. Additionally, an infra-red camera was employed...
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Design and Characterization of a Planar Structure Wideband Millimeter-Wave Antenna with Wide Beamwidth for Wearable off-body Communication Applications
PublicationThis letter presents the design of a planar single-layer wideband antenna featuring wide beamwidth has well as high and stable in-band gain. The proposed antenna is a planar monopole fed by a bottom-grounded coplanar waveguide to realize wide beamwidth in both the xz- and yz-planes. Simultaneous optimization of all adjustable antenna parameters, carried out at the full-wave electromagnetic simulation level. The constructive interference...
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A Survey of Fast-Recovery Mechanisms in Packet-Switched Networks
PublicationIn order to meet their stringent dependability requirements, most modern packet-switched communication networks support fast-recovery mechanisms in the data plane. While reactions to failures in the data plane can be significantly faster compared to control plane mechanisms, implementing fast recovery in the data plane is challenging, and has recently received much attention in the literature. This survey presents a systematic,...
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Topological Model of an Electromagnetic Environment Inside a Ship for Electromagnetic Compatibility (EMC) Analysis
PublicationThe mutual electromagnetic (EM) interactions between electrical and electronic devices in a segmented space, such as a ship's environment, ared described. Firstly, the topological structure of a ship's segmented internal environment, which consists of many electrical screening walls (shielding planes), is presented. Then, taking into account the ship's topological structure, a general description of the EM disturbance distribution,...
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The electrochemical determination of isatin at nanocrystalline boron-doped diamond electrodes: stress monitoring of animals
PublicationUltra-thin nanocrystalline boron-doped diamond electrodes (B:NCD) were used for the electrochemical determination of isatin in dog urine samples using cyclic voltammetry and square wave voltammetry in a phosphate buffer saline, pH = 7.2. No additional modification or pretreatment of the electrode surface was required in this approach, being of high importance for the facile detection procedure. The increase of the peak current...
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Detecting Objects of Various Categories in Optical Remote Sensing Imagery Using Neural Networks
PublicationThe effective detection of objects in remote sensing images is of great research importance, so recent years have seen a significant progress in deep learning techniques in this field. However, despite much valuable research being conducted, many challenges still remain. A lot of research projects focus on detecting objects of a single category (class), while correctly detecting objects of different categories is much harder. The...
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Using concentrated spectrogram for analysis of audio acoustic signals
PublicationThe paper presents results of time-frequency analysis of audio acoustic signals using the method of Concentrated Spectrograph also known as ''Cross-spectral method'' or ''Reassignment method''. Presented algorithm involves signal's local group delay and channelized instantaneous frequency to relevantly redistribute all Short-time Fourier transform lines in time-frequency plain. The main intention of the paper is to compare various...
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Novel structure and EM-driven design of miniaturized microstrip rat-race coupler
PublicationIn this paper, a novel structure and design procedure of a miniaturized microstrip rat-race coupler (RRC) is described. Small size of the RRC is achieved by folding the transmission lines of the conventional circuit into its interior, as well as by implementation of the structure on three layers. The final size of the coupler realized for the operating frequency of 1 GHz is only 220 mm2, which gives over 95% footprint reduction...
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Load Tests of the Movable Footbridge Over the Port Canal in Ustka
PublicationThe paper presents the acceptance tests carried out on the open footbridge over the port canal in the Port of Ustka. The steel footbridge construction is created by a single pylon to which a movable truss span is suspended with a theoretical span of 52.3 m. The studies about load test of the object included static and dynamic extortion and measurements. In static tests the ballast was of pallets with concrete blocks. Dynamic studies...
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Earth wires currents calculation by tableau analysis
PublicationThe paper presents a new method to compute a phase-to-earth fault current distribution in overhead transmission line. The method is based on the tableau analysis of an unbalanced, multi-wire model of a transmission line. It allows for the calculation of current distribution in overhead earth wires along the transmission line. Additionally, it may be used to calculate currents in a tower’s earthing system as well as voltages over...
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The influence of accumulation area and the length of pedestrian route on functioning of roundabouts with traffic signals
Publicationtraffic volumes. This kind of intersection is commonly used in the centres of Polish cities on multilane roads and fairly common in the case of tram lines running through a central island. The increase of traffic flow volumes on left turn and U-turn has made this type of roundabout difficult to operate. Small storage areas around central islands are critical places that significantly influence the capacity of this kind of intersection....
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Complex multidisciplinary optimization of turbine blading systems
PublicationThe paper describes the methods and results of direct optimization of turbine blading systems using a software package Opti_turb. The final shape of the blading is obtained from minimizing the objective function, which is the total energy loss of the stage, including the leaving energy. The current values of the objective function are found from 3D RANS computations (from a code FlowER) of geometries changed during the process...
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PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells
PublicationTwo cellular proteins encoded by the breast and ovarian cancer type 1 susceptibility (BRCA1 and BRCA2) tumor suppressor genes are essential for DNA integrity and the maintenance of genomic stability.Approximately 5-10% of breast and ovarian cancers result from inherited alterations or mutations in these genes.Remarkably, BRCA1/BRCA2-deficient cells are hypersensitive to selective inhibition of poly(ADPribose) polymerase 1 (PARP-1),...
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Carbonic anhydrase inhibitors. Synthesis, and molecular structure of novel series N-substituted N'-(2-arylmethylthio-4-chloro-5- methylbenzenesulfonyl)guanidines and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII
PublicationA series of novel N-substituted N'-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)guanidines 9 e41 have been synthesized and investigated as inhibitors of four isoforms of zinc enzyme carbonic anhydrase (CA.EC 4.2.1.1), that is the cytosolic CA I and II, and cancer-associated isozymes CA IX and XII. Against the human CA I investigated compounds showed KI in the range of 87e6506 nM, toward hCA II ranging from 7.8 to 4500 nM,...
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Anticancer Study on IrIII and RhIII Half-Sandwich Complexes with the Bipyridylsulfonamide Ligand
PublicationTwo non-platinum compounds, organometallic half-sandwich complexes [(η 5 -Cp)IrCl(L)]PF 6 (1) and [(η 5 -Cp)RhCl(L)]PF 6 (2) were prepared by treating pentamethylcyclopentadienyl chloride dimers of iridium(III) or rhodium(III) with the obtained 4-amino-N-(2,2'-bipyridin-5- yl)benzenesulfonamide ligand (L) and ammonium hexafluorophosphate. The crystal structures of ligand (L) and complexes 1 and 2 were obtained and then analyzed. Coordination...
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Experiment-Based Study of Heat Dissipation from the Power Cable in a Casing Pipe
PublicationThe paper deals with the important challenges in terms of electricity transmission by means of underground cable lines. The power cable’s performance is characterized by an ampacity that represents its maximum electric current-carrying capacity. The ampacity of power cables depends on their ability to diffuse the heat generated by the current flow into the environment. In the performed research, the analysis of the efficiency of...
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Diamond Nanofilm Normalizes Proliferation and Metabolism in Liver Cancer Cells
PublicationPurpose: Surgical resection of hepatocellular carcinoma can be associated with recurrence resulting from the degeneration of residual volume of the liver. The objective was to assess the possibility of using a biocompatible nanofilm, made of a colloid of diamond nanoparticles (nfND), to fill the side after tumour resection and optimize its contact with proliferating liver cells, minimizing their cancerous transformation. Methods:...
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Voltammetric and biological studies of folate-targeted non-lamellar lipid mesophases
PublicationFolate-targeted lipid nanostructures are promising strategies for the development of biocompatible drug delivery systems. The objective of this study was to evaluate the efficacy of drug delivery to cancer cells by folate-targeted lipid mesophases, cubosomes (CUB) and hexosomes (HEX), loaded with doxorubicin (DOX). Three cancer-derived cell lines (KB, HeLa, T98G) exhibiting different expressional levels of folate receptor protein...
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Automatic Regularization by Quantization in Reducible Representations of CCR: Point-Form Quantum Optics with Classical Sources
PublicationElectromagnetic fields are quantized in a manifestly covariant way by means ofa class of reducible "center-of-mass N-representations" of the algebra of canonical commutationrelations (CCR). The four-potential Aa(x) transforms in these representations as aHermitian four-vector field in Minkowski four-position space (without change of gauge), butin momentum space it splits into spin-1 massless photons and two massless scalars. Whatwe...
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Przegląd badań na temat Wikipedii oraz z wykorzystaniem Wikipedii jako instrument badawczego
PublicationW badaniach dotychczas prowadzonych w Polsce Wikipedia była zarówno przedmiotem badań, jak i instrumentem badawczym. Badania na jej temat oraz na temat skutków społecznych jej używania prowadzili przedstawiciele nauk humanistycznych, społecznych, ekonomicznych i prawnych. Dla wielu badaczy (zwłaszcza z dziedziny informatyki) Wikipedia była instrumentem pomocnym w prowadzeniu różnorodnych analiz i dociekań naukowych. Niniejszy artykuł...
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SIMULATION OF PROCEED® SURGICAL MESH APPLIED TO VENTRAL HERNIA REPAIR
PublicationIn the present research, Proceed® implant is considered. The system is subjected to short-time dynamic pressure load, similar to post-operative cough naturally occurring in human abdomen. The model refers to a clinical case of 5cm of hernia operated by Proceed implant fixed by 15 joints every 3cm around the orifice. The simulations of the implanted mesh are performed by means of the Finite Element Method. The implant is modelled...
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Influence of soil–structure interaction on seismic pounding between steel frame buildings considering the effect of infill panels
PublicationThe present research aims to study the influence of the soil-structure interaction (SSI) and existence or absence of masonry infill panels in steel frame structures on the earthquake-induced pounding-involved response of adjacent buildings. The study was further extended to compare the pounding-involved behavior versus the independent behavior of structures without collisions, focusing much on dynamic behavior of single frames....
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Rapid Design Tuning of Miniaturized Rat-Race Couplers Using Regression-Based Equivalent Network Surrogates
PublicationA simple technique for fast design tuning of compact rat-race couplers is presented. Our approach involves equivalent circuit representation, corrected by nonlinear functions of frequency with coefficients extracted through nonlinear regression. At the same time, the tuning process connects two levels of coupler representation: EM simulation of the entire circuit and re-optimization of the coupler building blocks (slow-wave cells...
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Extended phase diagram of RNiC2 family: Linear scaling of the Peierls temperature
PublicationPhysical properties for the late-lanthanide-based RNiC2 (R = Dy, Ho, Er, and Tm) ternary compounds are reported. All the compounds show antiferromagnetic ground state with the Néel temperature ranging from 3.4 K for HoNiC2 to 8.5 K for ErNiC2. The results of the transport and galvanomagnetic properties confirm a charge density wave state at and above room temperature with transition temperatures TCDW = 284, 335, 366, and 394 K for...