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Analogues of trypsin inhibitor SFTI-1 modified in the conserved P1′ position by synthetic or non-proteinogenic amino acids retain their inhibitory activity
PublicationA series of linear and monocyclic (with a disulfide bridge only) analogues of trypsin inhibitor SFTI-1 modified in the P-1 and/or P-1' positions were synthesized by the solid-phase method. In the substrate specificity P-1 position, Phe or N-benzylglycine (Nphe) were introduced, whereas the conserved Ser6 in Bownam-Birk (BBI) inhibitors was replaced by Hse (L-homoserine), Nhse [N-(2-hydroxyethyl)glycine], Sar, and Ala. Kinetic studies...
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Implication of the disulfide bridge in trypsin inhibitor SFTI-1 in its interaction with serine proteinases
PublicationFourteen monocyclic analogues of trypsin inhibitor SFTI-1 isolated from sunflower seeds were synthesized by the solid-phase method. The purpose of this work was to establish the role of a disulfide bridge present in inhibitor's side chains of Cys3 and Cys11 in association with serine proteinases. This cyclic fragment was replaced by the disulfide bridges formed by L-pencillamine (Pen), homo-L-cysteine (Hcy), N-sulfanylethylglycine...
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Inhibition of Human and Yeast 20S Proteasome by Analogues of Trypsin Inhibitor SFTI-1
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Conversion of Potato Industry Waste into Fodder Yeast Biomass
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New polish catalogue of typical flexible and semi-rigid pavements
PublicationThe paper covers the following topics important for the development of the new Polish Catalogue of typical flexible and semi-rigid pavements: reasons for preparing the new issue of the Catalogue of typical flexible and semi-rigid pavements, items introduced in the new issue, organise the terminology related to pavements, design traffic calculations and new equivalent axle load factors,...
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Effect of pine essential oil and rotating magnetic field on antimicrobial performance
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Evaluation of differences in expression pattern of three isoforms of the transforming growth factor beta in patients with lumbosacral stenosis
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Remediation of soils on municipal rendering plant territories using Miscanthus × giganteus
PublicationPhytoremediation, as a cost-effective, highly efficient, environmentally friendly, and green approach, gained attention to the removal of metals, including heavy metals, from contaminated soils. The toxic nature of heavy metals can have an adverse effect on human health and the ecosystem, and their removal remains a worldwide problem. Therefore, in this study, a field experiment was carried out to evaluate the potential of Miscanthus × giganteus...
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Impact of rotor geometry optimization on the off-design ORC turbine performance
PublicationThe paper describes the method of CFD based Nelder-Mead optimization of a 10 kW single-stage axial turbine operating in an ORC system working on R7100. The total-to-static isentropic efficiency is defined as an objective function. Multi-point linear regression is carried out to determine the significance of the objective function arguments and to pick up the set of particular variables and characteristic quantities (e.g. flow angles)...
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The effect of multiaxial geocomposite reinforcement on fatigue performance and crack propagation delay in double-layered asphalt beams
PublicationThe presented study investigates the effect of a recently developed multiaxial geocomposite made of polypropylene geogrid and non-woven fabric on the delay of crack propagation, based on four-point bending tests of large asphalt concrete beams – both for reinforced and non-reinforced specimens. Several approaches are described in this study, including analysis of stiffness modulus decrease and analysis of crack propagation using...
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In vitro enzyme kinetics and NMR-based product elucidation for glutathione S-conjugation of the anticancer unsymmetrical bisacridine C-2028 in liver microsomes and cytosol: major role of glutathione S-transferase M1-1 isoenzyme
PublicationThis work is the next step in studying the interplay between C-2028 (anticancer-active unsymmetrical bisacridine developed in our group) and the glutathione S-transferase/glutathione (GST/GSH) system. Here, we analyzed the concentration- and pH-dependent GSH conjugation of C-2028 in rat liver microsomes and cytosol. We also applied three recombinant human GST isoenzymes, which altered expression was found in various tumors. The...
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Inhibitors of Matriptase‐2 Based on the Trypsin Inhibitor SFTI‐1
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Assessing groundwater vulnerability to sea water intrusion in the coastline of the inner Puck Bay using GALDIT method
PublicationIn this research, GALDIT method was used to assess seawater intrusion in the coastal aquifer of the inner Puck Bay (Southern Baltic Sea). The impact of potential sea-level rise on groundwater vulnerability for years 2081-2100 was also considered. The study area was categorized into three classes of vulnerability: low, moderate and high. The most vulnerable area is the Hel Peninsula with northern part of the Kashubian Coastland....
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Assessing groundwater vulnerability to sea water intrusion in the coastline of the inner Puck Bay using GALDIT method
PublicationIn this research, GALDIT method was used to assess seawater intrusion in the coastal aquifer of the inner Puck Bay (Southern Baltic Sea). The impact of potential sea-level rise on groundwater vulnerability for years 2081-2100 was also considered. The study area was categorized into three classes of vulnerability: low, moderate and high. The most vulnerable area is the Hel Peninsula with northern part of the Kashubian Coastland....
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Estimation of Conservative Contaminant Travel Time through Vadose Zone Based on Transient and Steady Flow Approaches
PublicationEstimation of contaminant travel time through the vadose zone is needed for assessing groundwater vulnerability to pollution, planning monitoring and remediation activities or predicting the effect of land use change or climate change on groundwater quality. The travel time can be obtained from numerical simulations of transient flow and transport in the unsaturated soil profile, which typically require a large amount of data and...
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Studying road restraint systems to develop new guidelines
PublicationThe paper will present a proposed approach to such work along with preliminary results of numerical studies for selected problems using road safety devices such as safety barriers on horizontal curves, the effect of kerbs on bridges or the location of obstacles within the barrier’s working width. The paper will discuss assumptions to a methodology of numerical models, calculations and automated processing of data to help with assessing...
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Symulacje numeryczne stalowej bariery ochronnej na łuku drogi
PublicationW pracy wymieniono pewne czynniki związane z bezpieczeństwem ruchu drogowego, wskazując łuki poziome dróg jako miejsca, gdzie występuje istotna liczba groźnych w skutkach wypadków. W części pracy obejmującej symulacje numeryczne, zrealizowano serię badań spełniających warunki testu zderzeniowego TB11 ze zmiennym promieniem bariery. Oszacowano wpływ zróżnicowania geometrii na parametry bezpieczeństwa.
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Numerical Analysis of TB32 Crash Tests for 4-cable Guardrail Barrier System Installed on the Horizontal Convex Curves of Road
PublicationHorizontal curves are one of the elements of road infrastructure where statistically a relatively high number of accidents have been reported. In the last ten years in Poland approx. 10% of all road accidents happened on horizontal curves of roads and was responsible for approx. 14% of all fatalities on Polish roads. Thus, this issue is important and requires extensive research and proper road safety treatments. One possible measure...
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Evaluation of the Influence of Farming Practices and Land Use on Groundwater Resources in a Coastal Multi-Aquifer System in Puck Region (Northern Poland)
PublicationThis study focuses on the modeling of groundwater flow and nitrate transport in a multi-aquifer hydrosystem in northern Poland, adjacent to Puck Bay (Baltic sea). The main goal was to investigate how changes in land use and farming practices may affect groundwater recharge and submarine groundwater discharge (SGD) to the sea and the associated N-NO3 fluxes. An integrated modelling approach has been developed, which couples the...
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Designing Lubricating Properties of Vegetable Base Oils
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Same but different — Molecular comparison of human KTI12 and PSTK
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Objective, observer-independent evaluation of myocardial perfusion and function: the role of SPECT
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Eligible-and-enrolled vs. eligible-but-not-enrolled patients with chronic ischaemic heart failure in randomized clinical trials of myocardial regeneration
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Protein overproduction alters exosome secretion in Chinese hamster ovary cells
PublicationDespite the abundance of available cell lines, nearly 70% of all recombinant therapeutic proteins today are produced in Chi-nese hamster ovary (CHO) cells. The impact of protein overproduction on the secretion of exosomes by CHO cells has been investigated here. Increased secretion of extracellular vesicles (EVs) by protein overexpressing CHO cells was demonstrated with protein content assay, nanoparticle tracking analysis, and...
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Chromatin-associated microprocessor assembly is regulated by the U1 snRNP auxiliary protein PRP40
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Ability of Yeast Metabolic Activity to Reduce Sugars and Stabilize Betalains in Red Beet Juice
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Pro-Health and Anti-Cancer Activity of Fungal Fractions Isolated from Milk-Supplemented Cultures of Lentinus (Pleurotus) Sajor-caju
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Towards application of uncertainty quantification procedure combined with experimental procedure for assessment of the accuracy of the DEM approach dedicated for granular flow modeling
PublicationThere is a high demand for accurate and fast numerical models for dense granular flows found in many industrial applications. Nevertheless, before numerical model can be used its need to be always validated against experimental data. During the validation, it is important to consider how the measurement data sets, as well as the numerical models, are affected by errors and uncertainties. In this study, the uncertainty quantification...
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Multispecies invasion reduces the negative impact of single alien plant species on native flora
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The impact of resistance exercise range of motion on the magnitude of upper-body post-activation performance enhancement
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Cyanido-Bridged Clusters with Remote N-Oxide Groups for Branched Multimetallic Systems
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Atomic resolution crystal structure of HV-BBI protease inhibitor from amphibian skin in complex with bovine trypsin
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Cyclic Peptidic Furin Inhibitors Developed by Combinatorial Chemistry
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Badania systemów powstrzymujących pojazd przed wypadnięciem z drogi - cz. I
PublicationTransportation systems are designed and used so as to effectively and safely relocate people, goods and services. Despite this there are numerous hazards that disrupt or damage these systems. Risks such as extreme weather conditions, terrorist threats, landsliders or earthquakes are difficult to predict, manage and mitigate. One of the hazards for transportation systems are accidents, and their impact on the transport functioning...
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The effects of vehicle restraint systems on road safety
PublicationKey to understanding the needs and tools of road infrastructure management for preventing run-off-road crashes or minimising their consequences, is to identify the hazads and sources of hazards caused by wrong or improper use of road safety devices and identify errors in the desifn, structure, construction and operation of road safety devices. Studying such an extended scope of the problem required fieldwork and surveys with road...
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Badania systemów powstrzymujących pojazd przed wypadnięciem z drogi - cz. II
PublicationW artykule zaprezentowana została tematyka systemów powstrzymujących pojazd przed wypadnięciem z drogi. Podczas codziennego użytkowania dróg występuje szereg zagrożeń, które wpływają na bezpieczeństwo. Badanie, identyfikacja i klasyfikacja zagrożeń stanowią istotny element utrzymania dróg. Artykuł stanowi drugą część podjętej problematyki. Pierwsza została opublikowana w magazynie Mosty nr 3-4/19 str. 66-68.
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Potential for Prebiotic Stabilized Cornus mas L. Lyophilized Extract in the Prophylaxis of Diabetes Mellitus in Streptozotocin Diabetic Rats
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Narzędzia do kontroli jakości powietrza wewnętrznego / B. Zabiegała
PublicationPrzyjmuje się, że dorosły człowiek średnio 60% swojego życia spędza w domu, 30% w pracy, 5% w różnego rodzaju środkach transportu a tylko 3% na zewnątrz pomieszczeń. Powyższe liczby wskazują, że powietrze wewnętrzne może w istotny sposób oddziaływać na stan zdrowia i samopoczucie człowieka. Szeroko rozumiana kontrola jakości powietrza wewnętrznego jest więc niezbędnym elementem w zapewnieniu komfortu życia użytkownikom pomieszczeń...
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Salt Stress Reveals a New Role for ARGONAUTE1 in miRNA Biogenesis at the Transcriptional and Posttranscriptional Levels
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A Case Study on the Desired Selectivity in Solid‐State Mechano‐ and Slow‐Chemistry, Melt, and Solution Methodologies
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New D−π–D−π–A Systems Based on Phenothiazine Derivatives with Imidazole Structures for Photovoltaics
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Nitrogen and phosphorus compounds in coastal aquifers in Puck municipality area (northern Poland)
Publication1. Groundwater study shows local variations in chemical composition of selected aquifers caused by human impact The diversity is mainly manifested in • time variation of groundwater chemical composition of all analyzed parameters especially in shallow aquifers (Q1) • relationship between t he ground water chemical composition and depth of the aquifer where an inverse concentration distribution occurs higher concentrations are observed...
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Low-power microwave-induced fabrication of functionalised few-layer black phosphorus electrodes: A novel route towards Haemophilus Influenzae pathogen biosensing devices
PublicationIn this paper, various passivation schemes were applied at few-layer black phosphorus (FLBP) to achieve covalent functionalisation with 4-azidobenzoic acid, improving its electrochemical response intended for analytical and biosensing applications. The thermal and microwave assisted modification procedures in toluene and dime-thylformamide resulted in high reversibility of reactions on functionalised FLBP using a ferricyanide/ferrocya-nide...
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Excitation energy transfer in partly ordered polymer films differing in donor and acceptor transition moments orientation
PublicationBased on spectroscopic measurements selected properties of nonradiative Förster energy transport are studied in uniaxially stretched polyvinyl alcohol thin films for three systems differing in donor and acceptor transition moments orientation relative to the axis of stretching. In particular, donor – acceptor emission anisotropy spectra yield completely different regularities for these systems in uniaxially stretched films, whereas...
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Excitation energy transfer in partly ordered polymer films differing in donor and acceptor transition moments orientation
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Modelling the impact of the agricultural holdings and land-use structure on the quality of inland and coastal waters with an innovative and interdisciplinary toolkit
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Modelling the impact of the agricultural holdings and land-use structure on the quality of inland and coastal waters with an innovative and interdisciplinary toolkit
PublicationThe changes taking place in the marine coastal zones are extremely important, as about 40% of the human population currently lives in the coastal areas (within 100 kilometres of the coastline) increasing anthropogenic pressure on the marine ecosystems. Agriculture is a significant source of nutrients to the marine environment that increase hypoxia, eutrophication and may pose a threat to the services provided by ecosystems. In...
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Tissue Rheology as a Possible Complementary Procedure to Advance Histological Diagnosis of Colon Cancer
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Bladder cancer detection using a peptide substrate of the 20S proteasome
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Inhibitory and antimicrobial activities of OGTI and HV-BBI peptides, fragments and analogs derived from amphibian skin
PublicationA series of linear and cyclic fragments and analogs of two peptides (OGTI and HV-BBI) isolated from skin secretions of frogs were synthesized by the solid-phase method. Their inhibitory activity against several serine proteinases: bovine beta-trypsin, bovine alpha-chymotypsin, human leukocyte elastase and cathepsin G from human neutrophils, was investigated together with evaluation of their antimicrobial activities against Gram-negative...